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| 1 | Systematic review of novel ablative methods in locally advanced pancreatic cancer显示文摘Unresectable locally advanced pancreatic cancer with or without metastatic disease is associated with a very poor prognosis.Current standard therapy is limited to chemotherapy or chemoradiotherapy.Few regimens have been shown to have a substantial survival advantage and novel treatment strategies are urgently needed.Thermal and laser based ablative techniques are widely used in many solid organ malignancies.Initial studies in the pancreas were associated with significant morbidity and mortality,which limited widespread adoption.Modifications to the various applications,in particular combining the techniques with high quality imaging such as computed tomography and intraoperative or endoscopic ultrasound has enabled real time treatment monitoring and significant improvements in safety.We conducted a systematic review of the litera-ture up to October 2013.Initial studies suggest that ablative therapies may confer an additional survival benefit over best supportive care but randomised studies are required to validate these findings. | Margaret G Keane Konstantinos Bramis Stephen P Pereira Giuseppe K Fusai | 2014 | World Journal of Gastroenterology2014，20，9： | 30 |
| 2 | Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC. | Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini | 2018 | World Journal of Gastroenterology2018，24，36： | 14 |
| 3 | Lactic acid bacteria as pro-technological,bioprotective and health-promoting cultures in the dairy food industry显示文摘Lactic acid bacteria (LAB) constitute pivotal microorganisms for the food industry due to their considerable technological and functional potential.Fermented dairy products,that is ancient traditions worldwide,still have been accepted and consumed today for their nutritional and organoleptic attributes.In accordance with the current trends in the market and greater awareness of consumer well-being,a detailed assessment of the health effects of dairy product consumption has been undertaken with particular reference to the production of bioactive metabolites including i.e.,γ-aminobutyric acid,conjugated linoleic acid,bioactive peptides,exopolysaccharides as well as vitamins during LAB fermentation.The long histories of yogurt,kefir,and traditional fermented milk drink as sources of some certain probiotic bacteria as well as the opportunity to bio-fortify the matrix with bioactive microbial compounds in situ make fermented dairy products an attractive model in the efforts to develop sustainable functional food systems.Therefore,this review provides the main biochemical characteristics and biotechnological application of LAB as pro-technological,bioprotective,and health-promoting in the food chain. | Duygu Ağagündüz Teslime Özge Şahin Şerife Ayten Birsen Yılmaz Bartu Eren Güneşliol Pasquale Russo Giuseppe Spano Fatih Özogul | 2022 | Food Bioscience2022，47，3： | 2 |
| 4 | Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23–01): a phase 3 randomised controlled trial显示文摘 | Viviana Galimberti Bernard F Cole Stefano Zurrida Giuseppe Viale Alberto Luini Paolo Veronesi Paola Baratella Camelia Chifu Manuela Sargenti Mattia Intra Oreste Gentilini Mauro G Mastropasqua Giovanni Mazzarol Samuele Massarut Jean-Rémi Garbay Janez Zgajn | 2013 | Lancet Oncology2013，，4： | 2 |
| 5 | Novel approaches to the treatment of non-small cell lung cancer显示文摘 | Carlos G Ferreira Cynthia Huisman Giuseppe Giaccone | 2002 | Critical Reviews in Oncology and Hematology2002，，1： | 2 |
| 6 | Patients'Knowledge, Attitudes, and Behavior Toward Hospital-associated Infections in Italy显示文摘 | Abbate R Di Giuseppe G Marinelli E | 2008 | Am J Infect Control2008，36，1： | 1 |
| 7 | Elisabetta, GiudiceClotting profiles in newborn maltese kids during the first week of life 显示文摘 | Giuseppe P Cristiano B Claudia G | 2008 | J Vet Diagn Investm2008，20，2： | 1 |
| 8 | Classification of polyolefins from building and construction waste using NIR hyperspectral imaging system显示文摘 | Silvia S Aldo G Giuseppe B | 2012 | Resources Conservation andRecycling2012，61，： | 1 |
| 9 | Biomarkers of response to epidermal growth factor receptor inhibitors in non-small cell lung cancer working group:standardization for use in the clinical trial setting显示文摘 | David AE Giuseppe G Bruce EJ | | 0，，： | 1 |
| 10 | Elderly patients on dialysis: Epidemiology of an epidemic显示文摘 | GIUSEPPE P MARIO S BARBARA P G | 1996 | Nephrol Dail Transplant1996，11，9： | 1 |
| 11 | Robust maximum likelihood estimation in the linear model显示文摘 | Giuseppe C Laurent E G | 2001 | Automatica2001，37，4： | 1 |
| 12 | Endovascular treatment of carotid artery stenosis: evidences from randomized controlled trials and actual indications显示文摘 | Federica I Fabio M Giuseppe G | 2011 | Monaldi archives for chest disease2011，76，4： | 1 |
| 13 | Role of inflammation in atherosclerosis显示文摘 | LUIGI G S ELENA B GIUSEPPE S | 2007 | The Journal of Nuclear Medicine2007，48，11： | 1 |
| 14 | Biomarkers of response to epidermal growth factor receptor inhibitors in non-small-cell lung cancer working group:standardization for use in the clinical trial setting显示文摘 | David AE Giuseppe G Bruce EJ | 2008 | J Clin Oncol2008，26，6： | 1 |
| 15 | Time course and determinants of left ventricular function recovery after primary angioplasty in patients with AMI显示文摘 | Sheiban I Fragasso G Giuseppe MC | 2001 | JACC2001，38，2： | 1 |
| 16 | Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens显示文摘 | Giuseppe Zamboni Jutta Lüttges Paola Capelli Luca Frulloni Giorgio Cavallini Paolo Pederzoli Alexander Leins Daniel Longnecker Günter Kl?ppel | 2004 | Virchows Archiv2004，，6： | 1 |
| 17 | L-2',3'-Didehydro- 2',3'-dideoxy-3'~fluoronucleosides: synthesis, anti-HIV activity, chemical and enzymatic stability, and mechanism of resistance显示文摘 | Youhoon C Giuseppe G Judy SM | 2003 | J Med Chem2003，46，15： | 1 |
| 18 | Clinical significance of expression of human cytomegalovirus pp67 late transcript in heart, lung, and bone marrow transplant recipients as determined by nucleic acid sequence-based amplification 显示文摘 | Giuseppe G Fausto B Jaap MM | 1999 | J Clin Microbiol1999，4，： | 1 |
| 19 | A family of Shc related proteins with conserved PTB,CH1 and SH2 regions显示文摘 | Pelicci G Dente L De Giuseppe A | 1996 | Oncogene1996，13，3： | 1 |
| 20 | Acid-sensinge ion channels(ASICs)as pharmacological targets for neurodegenerative diseases显示文摘 | Zhi G X Giuseppe P Minghua L | 2008 | Curr Opin Pharmacol2008，8，1： | 1 |
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