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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia显示文摘Natural killer(NK)cells are innate cytotoxic lymphoid cells(ILCs)involved in the killing of infected and tumor cells.Among human and mouse NK cells from the spleen and blood,we previously identified by single-cell RNA sequencing(scRNAseq)two similar major subsets,NK1 and NK2.Using the same technology,we report here the identification,by single-cell RNA sequencing(scRNAseq),of three NK cell subpopulations in human bone marrow.Pseudotime analysis identified a subset of resident CD56^(bright) NK cells,NK0 cells,as the precursor of both circulating CD56dim NK1-like NK cells and CD56^(bright) NK2-like NK cells in human bone marrow and spleen under physiological conditions.Transcriptomic profiles of bone marrow NK cells from patients with acute myeloid leukemia(AML)exhibited stress-induced repression of NK cell effector functions,highlighting the profound impact of this disease on NK cell heterogeneity.Bone marrow NK cells from AML patients exhibited reduced levels of CD160,but the CD160high group had a significantly higher survival rate. | Adeline Crinier Pierre-Yves Dumas Bertrand Escalière Christelle Piperoglou Laurine Gil Arnaud Villacreces Frédéric Vély Zoran Ivanovic Pierre Milpied Émilie Narni-Mancinelli Éric Vivier | 2021 | Cellular & Molecular Immunology2021，18，5： | 5 |
| 3 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence显示文摘 | Juan C. Acosta Ana O’Loghlen Ana Banito Maria V. Guijarro Arnaud Augert Selina Raguz Marzia Fumagalli Marco Da Costa Celia Brown Nikolay Popov Yoshihiro Takatsu Jonathan Melamed Fabrizio d’Adda di Fagagna David Bernard Eva Hernando Jesús Gil | 2008 | Cell2008，，6： | 2 |
| 4 | Assessment of metal contamination in donana national park (spain) using crayfish (proeamburus elarkia) 显示文摘 | Sanchez Lopez F J Gil Garcia M D Martinez Vidal J | 2004 | Environmental Monitoring and Assessment2004，，93： | 1 |
| 5 | (1995) Linear time Euclidean distance transform algorithms 显示文摘 | Breu H Gil J Kirkpatrick D | 1995 | IEEE Transactions on Pattern Analysis and Machine Intelli- gence1995，17，5： | 1 |
| 6 | The time -resolved fluorescencc- based PCA3 test on urinary sediments after digital rectal examination; a Dutch multicenter validation of the diagnostic performance 显示文摘 | Van Gils MP Hessels D van Hooij O | 2007 | Clin Cancer Res2007，13，： | 1 |
| 7 | Deterruination of photoirradiated high polar benzoylureas in tomato by HPLC with luminol chemiluminescence detection显示文摘 | Martinez Galera M Gil Gareia M D Santiago Valverde R | 2008 | Talanta2008，76，4： | 1 |
| 8 | The effect of using PSE meat in the manufacture of dry-cured ham显示文摘 | BANON S GIL M D MARIA-VICTORIA G M V | 1998 | Food Research and Technology1998，206，2： | 1 |
| 9 | Thermal behaviour and kinetics of coal/biomass blends during co-combustion显示文摘 | Gil M V Casal D Pevida C | 2010 | Bioresource Technology2010，101，14： | 1 |
| 10 | Adsorption of chromium (VI) ion from aqueous solution by succinylated mercerized cellulose functionalized with quaternary ammonium groups显示文摘 | Leandro Vinícius Alves Gurgel Júlio César Perin de Melo Jorge Carvalho de Lena Laurent Frédéric Gil | 2009 | Bioresource Technology2009，，13： | 1 |
| 11 | The determinants of side branch compromise after main vessel stenting in coronary bifurcation lesions显示文摘 | Vassilev D Gil RJ Koo BK | 2012 | Kardiol Pol2012，70，10： | 1 |
| 12 | Lower-limb robotic rehabilitation: literature review and challenges显示文摘 | DAZ I GIL J J SNCHEZ E | 2011 | Journal of Robotics2011，2011，75： | 1 |
| 13 | Determination of parts per trillion levels of benzoylurea pesticides in groundwater by high-performance liquid chromatography-electrospray ionization mass spectrometry显示文摘 | Garrido Frenich A Gil Garcia M D Arrebola F J | 2000 | Chromatographia2000，52，910： | 1 |
| 14 | Stepped-impedance lowpass filters with spurious pass-band suppression显示文摘 | J Garcia-Garcia J Bonache F Falcone J D Baena F Martin I Gil T Lopetegi M A G Laso A Marcotegui R Marques M Sorolla | 2004 | Electronic Letters2004，40，14： | 1 |
| 15 | Scanning probe microscopy显示文摘 | Colton Richard J Baselt David R Dufrêne Yves F Green John-Bruce D Lee Gil U | 1997 | Chemical Biology1997，1，3： | 1 |
| 16 | Influence of plaque composition on mechanism ofpercutanous transluminal coronary balloon angio-plasty assessed by ultrasound imaging显示文摘 | Gil R,Ruygrok D Prati F | 1996 | AmHeart J,1996，131，3： | 1 |
| 17 | Ingrowth of human mesenchymal stem cells into porous silk particle reinforced silk composite scaffolds:An in vitro study显示文摘 | Rockwood D N Gil E S Park S H | 2011 | Acta biomaterialia2011，7，1： | 1 |
| 18 | The role of angiotensin receptor 1blockers in restenosis prevention after percutaneous coronary interventions显示文摘 | VASSILEV D DOGANOV A GIL R J | 2010 | Kardiol Pol2010，68，： | 1 |
| 19 | Thermal behavior and kinetics of coal/biomass blends during co- combustion 显示文摘 | GIL M V CASAL D PEVIDA C | 2010 | Bioresource Technology2010，101，14： | 1 |
| 20 | In vivo regulation of the dsRNA dependent protein kinase PKR by the cellular glucoprotein p67显示文摘 | Gil J Esteban M Roth D | 2000 | Biochemistry2000，39，16： | 1 |
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