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| 1 | Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test显示文摘AIM:To study intestinal permeability(IP) and its relationship to the disease activity in patients with inflammatory bowel diseases(IBD)-Crohn's disease(CD) and ulcerative colitis(UC).METHODS:Fifty-eight patients with active IBD(32 with CD and 26 with UC) and 25 healthy controls consented to participate in the study.The clinical activity of CD was estimated using the Crohn's Disease Activity Index(CDAI),and the endoscopic activity of UC using the Mayo scoring system.IP was assessed by the rise in levels of iohexol,which was administered orally(25 mL,350 mg/mL) 2 h after breakfast.Three and six hours later serum(SIC mg/L) and urine(UIC g/mol) iohexol concentrations were determined by a validated HPLC-UV technique.RESULTS:In the CD group,SIC values at 3 h(2.95 ± 2.11 mg/L) and at 6 h after ingestion(2.63 ± 2.18 mg/L) were significantly higher compared to those of healthy subjects(1.25 ± 1.40 mg/L and 1.11 ± 1.10 mg/L,respectively,P < 0.05).UIC(g/mol) values were also higher in patients,but the differences were significant only for UIC at 6 h.Significant positive correlation(P < 0.05) was found between the CDAI and IP,assessed by SIC at 3 h(r = 0.60) and 6 h(r = 0.74) after the ingestion.In comparison to controls,SIC and UIC of UC patients were higher in the two studied periods,but the differences were significant at 6 h only.Significantly higher values of SIC(P < 0.05) were found in patients with severe endoscopic activity of UC compared to those of patients with mild and moderate activity(3.68 ± 3.18 vs 0.92 ± 0.69 mg/L).CONCLUSION:Serum levels of iohexol at 3 h and 6 h after its ingestion reflect increased IP,which is related to the disease activity in patients with IBD. | Vanya A Gerova Simeon G Stoynov Dimitar S Katsarov Dobrin A Svinarov | 2011 | World Journal of Gastroenterology2011，17，17： | 6 |
| 2 | Adrenergic inneryation of the coronary arteries and the myocardium显示文摘 | Dolezel S Gerova M Gero J | 1978 | Acta Anat1978，100，3： | 1 |
| 3 | Prevalence of vitamin D deficiency and insufficiency in Bulgarian patients with chronic Hepatitis C viral infection显示文摘 | Daniela Ivanova Gerova Bistra Tzaneva Galunska Irina Ivanova Ivanova Iskren Andreev Kotzev Trifon Georgiev Tchervenkov Svetlozar Petrov Balev Dobrin Avramov Svinarov | 2014 | Scandinavian Journal of Clinical & Laboratory Investigation2014，，8： | 1 |
| 4 | Protein metabolism in coronary wall affected by cardiac load 显示文摘 | Gerova M | 1994 | Cell Mol Biol Res1994，40，2： | 1 |
| 5 | Histamine, 5 - hydroxytriptamine, collagen, mast cells and Ig- secreting cells in the small bowel disorders with diarrhea 显示文摘 | Stoianov SG Penchev PI Gerova VA | 2008 | J Gastrointestin Liver Dis2008，17，4： | 1 |
| 6 | Polyphenols and antioxidant capacity of Bulgarian medicinal plants 显示文摘 | Ivanova D Gerova D Chervenkov T | 2005 | J Ethnopharma2005，96，12： | 1 |
| 7 | Morphometric characteristics of cardiac hypertrophy induced by long-term inhibition of NO synthase显示文摘 | Gerova M Znojil V | 1996 | Physiol Res1996，45，： | 1 |
| 8 | Protein metabolism in coronary wall affected by cardiac load显示文摘 | Gerova M | 1994 | Cell MolBiol Res1994，40，2： | 1 |
| 9 | Endolysin of bacteriophage BFK 20 : evidence of a catalytic and a cell wall binding domain显示文摘 | GEROVA M HALGASOVA N UGORCAKOVA J | 2011 | FEMS Microbiology Letters2011，321，2： | 1 |
| 10 | Biomechanical signals in the coronary artery triggering the metabolicprocesses during cardiac overload显示文摘 | Gerova M | 1995 | Mol Cell Biomech1995，147，12： | 1 |
| 11 | The effect of anthropogenic activities on the chemical properties of groundwaters显示文摘 | Wittlin gerova Kriz L | | 0，，02： | 1 |
| 12 | Morphometric characteristics of cardiac hypertrophy induced by long-term inhibition of NO synthase显示文摘 | S1adek T Gerova M Znojil V | 1996 | Physiol Res1996，45，： | 1 |
| 13 | (+)-Cate- chin and (-) -epicatechin in Bulgarian fruits显示文摘 | TSANOVA-SAVOVA S RIBAROVA F GEROVA M | 2005 | Journal of Food Composition and Analysis2005，18，： | 1 |
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