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| 1 | Importance of bifurcation angle in bifurcation stenting显示文摘Bifurcation coronary lesions are relatively frequent in today's interventional cardiology practice,averaging between 10%-15% of all percutaneous coronary interventions(PCIs).1 Several problems inherent in the treatment of bifurcation lesions are periprocedural side branch(SB)compromise(composite of SB closure or appearance of significant ostial stenosis after main vessel(MV)stenting causing ischemia)frequently related to periprocedural myonecrosis,relatively higher restenosis rates especially in two-stent techniques,and higher rates of stent thrombosis in different time frames.1-4 The lead author and other investigators demonstrated that both periprocedural result and long-term results could be influenced by bifurcation angulations.The purpose of this study is to show why and how bifurcation angulations are important for bifurcation stenting. | Dobrin Vassilev Alexander Alexandrov Dan Le Katrina Nguyen James Nguyen Hung Phan Robert J. Gil | 2012 | Chinese Medical Journal2012，，22： | 7 |
| 2 | Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test显示文摘AIM:To study intestinal permeability(IP) and its relationship to the disease activity in patients with inflammatory bowel diseases(IBD)-Crohn's disease(CD) and ulcerative colitis(UC).METHODS:Fifty-eight patients with active IBD(32 with CD and 26 with UC) and 25 healthy controls consented to participate in the study.The clinical activity of CD was estimated using the Crohn's Disease Activity Index(CDAI),and the endoscopic activity of UC using the Mayo scoring system.IP was assessed by the rise in levels of iohexol,which was administered orally(25 mL,350 mg/mL) 2 h after breakfast.Three and six hours later serum(SIC mg/L) and urine(UIC g/mol) iohexol concentrations were determined by a validated HPLC-UV technique.RESULTS:In the CD group,SIC values at 3 h(2.95 ± 2.11 mg/L) and at 6 h after ingestion(2.63 ± 2.18 mg/L) were significantly higher compared to those of healthy subjects(1.25 ± 1.40 mg/L and 1.11 ± 1.10 mg/L,respectively,P < 0.05).UIC(g/mol) values were also higher in patients,but the differences were significant only for UIC at 6 h.Significant positive correlation(P < 0.05) was found between the CDAI and IP,assessed by SIC at 3 h(r = 0.60) and 6 h(r = 0.74) after the ingestion.In comparison to controls,SIC and UIC of UC patients were higher in the two studied periods,but the differences were significant at 6 h only.Significantly higher values of SIC(P < 0.05) were found in patients with severe endoscopic activity of UC compared to those of patients with mild and moderate activity(3.68 ± 3.18 vs 0.92 ± 0.69 mg/L).CONCLUSION:Serum levels of iohexol at 3 h and 6 h after its ingestion reflect increased IP,which is related to the disease activity in patients with IBD. | Vanya A Gerova Simeon G Stoynov Dimitar S Katsarov Dobrin A Svinarov | 2011 | World Journal of Gastroenterology2011，17，17： | 6 |
| 3 | Prolonged high-pressure balloon angioplasty of femoropopliteal lesions:Impact on stent implantation rate and mid-term outcome显示文摘ObjectivesTo 在 stent 培植率和回顾地注册的 femoropopliteal lesions.MethodsWe 的延长高压力 angioplasty 的中间的结果上估计影响从 2011 年 1 月的 620 个连续病人到 2011 年 12 月(75.6 ±12.3 年, 355 男性, 76.5% 在卢班 5-6 ) ,为批评手足局部缺血参考了并且提交了到 femoropopliteal 损害的延长高压的 angioplasty。延长高压的 angioplasty 的定义为至少 120 s 包括膨胀到至少 18 atm。程序的数据,和临床、仪器的后续被分析估计比较喜欢的培植率和中间的 outcomes.ResultsThe 接近的 stent 是 ipsilateral 在 433/620 病人(69.7%) 和在 164/620 (26.4%) 的 contralateral 转线路的大腿骨的 antegrade 并且腿弯部后退 +在 23/620 (3.7%)的大腿骨的 antegrade 。技术在 193/620 病人(31.2%) 在 427/620 病人(68.8%) 和 endoluminal angioplasty 包括了 subintimal angioplasty。延长高压力汽球 angioplasty 过程在 86.2% 是成功的(次要的 intra 程序的复杂并发症率 15.7 %) , stent 培植在 74 个病人(11.9%) 被执行,与脚关节臂的索引的重要改进(0.29 ±0.6 对 0.88 ±0.3, P <00.1 ) 并且卢班(5.3 ±0.8 对 0.7 ±1.9, P <0.01 ) , 86.7% 的主要明显率, Doppler 超声和在 18.1 ± 的吝啬的后续的 14.8% 的目标损害 revascularization 上的 18.6 % 的狭窄;6.4 个月(范围 1-24 月) 。第二等的明显率高是 87.7%.ConclusionsProlonged femoropopliteal 损害的压力 angioplasty 看起来安全、有效允许可接受的明显和狭窄在期中考试上评价。 | Gianluca Rigatelli Mariano Palena Paolo Cardaioli Fabio dell'Avvocata Massimo Giordan Dobrin Vassilev Marco Manzi | 2014 | Journal of Geriatric Cardiology2014，11，2： | 2 |
| 4 | Impact of number of run-off vessels on interwoven nitinol mesh stents patency in the femoropopliteal segment显示文摘Objective To evaluate the impact of run-off vessels number on the outcomes of Supera stent(Abbott Vascular,Santa Clara,Calif,USA)for treatment of femoropopliteal occlusive disease.Methods We retrospectively evaluated the medical records of 188 consecutive patients(mean age 68.2±9.6 years,100 males)undergone angiography and woven mesh stent implantation in femoral or popliteal arteries or both arterial segments,in our institution between January 12014 and January 12018.Target lesion revascularization and major adverse limb events at 12-month were evaluated comparing patients with 1-,2-or 3-run-off vessels in the foot.Results Interventional success was achieved in 100%.Stent implantation involved in the femoral site in 56 patients(30.3%),the femoropopliteal in 92 patients(48.9%)and the popliteal site in 40 patients(21.3%).A significant improvement of ankle-brachial index(0.29±0.6 vs.0.88±0.3,P<0.001)and Rutherford class(5.3±0.8 vs.0.7±1.9,P<0.01)were observed before discharge.The median follow-up duration was 12.3 months(inter quartile range:11.0 to 13.9).During the follow-up period,52 patients(27.6%)had clinical events.Primary patency at 12 months was 72.4%.The primary patency significantly increased when the runoff status.Comparing the number of events among patients with different number of run-off vessels,a significant difference(P<0.001)was observed for patients having one(24.0%)and two run-off vessels(15.0%).Conclusions The outcomes of Supera stent in femoropopliteal occlusive disease depend strictly on the number of run-off vessels. | Gianluca Rigatelli Marco Zuin Fabio Dell’Avvocata Dobrin Vassilev Stefano Barison Sabrina Osti Alberto Mazza Alberto Sacco | 2020 | Journal of Geriatric Cardiology2020，17，9： | 2 |
| 5 | The topological relationship between the large-scale attributes and local interaction patterns of complex networks显示文摘 | Dobrin R Sergi D | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，17： | 1 |
| 6 | Meas- urement of multiple labeledsamples by beta spectrum unfolding显示文摘 | Dobrin R I Pavelescu M Dulama C N | 2011 | Romanian Journal of Physics2011，56，12： | 1 |
| 7 | Mechanicaland histologic changes in canine vein grafts显示文摘 | Dobrin PB Littooy FN Golan J | 1988 | JSurg Res1988，44，： | 1 |
| 8 | Inflammatory aspects of experimental aneurysms:effect of methylprednisolone and cyclosporine显示文摘 | Dobrin PB Baumgartner N Anidjar S | 1996 | Ann N Y Acad Sci1996，800，： | 1 |
| 9 | The topological relationship between the large-scale attributes and local interactionpatterns of complex networks显示文摘 | Vazquez A Dobrin R Sergi D | 2004 | Proceedings of the National Academy of Sciences2004，101，17： | 1 |
| 10 | The topological relationship between the large-scale attributes and local interaction patterns of complex networks显示文摘 | Vazquez A Dobrin R Sergi D | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，17： | 1 |
| 11 | Diabetic cardiomyopathy:signaling defects and therapeutic approaches显示文摘 | Dobrin JS Lebeche D | 2010 | Expert Rev Cardiovasc Ther2010，8，： | 1 |
| 12 | Mechanical factors predisposing to intimal hyperplasia and medial thickening in autogenous vein grafts 显示文摘 | Dobrin PB Littooy FN Endean ED | 1989 | Surgery1989，105，3： | 1 |
| 13 | Fast Watershed Algorithms:Analysis and Extensions显示文摘 | Dobrin B P Viero T Gabbouj M | 1994 | SHE Nonlinear Image Processing1994，，： | 1 |
| 14 | Influence of suture technique and suture material selection of the mechanics of end-to end and end-to side anastomoses显示文摘 | Baumgartner N Dobrin PB Morasch M | 1996 | J Thorac Cardiovasc Surg1996，111，： | 1 |
| 15 | Acute eosinophilic interstitial nephritis and renal failure with bone marrow -lymph node granulo- mas and anterior uveitis: a new syndrome 显示文摘 | Dobrin RS Vernier RL Fish AJ | 1975 | Am J Med1975，59，3： | 1 |
| 16 | Aggregation of topologicalmotifs in the Escherichia coli transcriptional regulatory network显示文摘 | Dobrin R Beg Q K Barabasi A L | 2004 | BMC Bioinformatics2004，，5： | 1 |
| 17 | The analysis of failed nuclear fuel rods by gamma computed tomography显示文摘 | DOBRIN R CRACIUNESCU T TUTURICI I L | 1997 | Journal of Nu clear Materials1997，246，1： | 1 |
| 18 | The effect of twist on microvascular anastomotic patency and angiographic luminal dimensions显示文摘 | lzquierdo R Dobrin PB Fu K | 1998 | JSurgRes1998，78，1： | 1 |
| 19 | Failure of elastin or collagen as possible critical connective tissue alterations underlying aneurysmal dilatation显示文摘 | Dobrin PB Mrkvicka R | 1994 | Cardiovasc Surg1994，2，4： | 1 |
| 20 | Aggregation of topological motifs in the Escherichia coli transcriptional regulatory network显示文摘 | Dobrin R Beg Q K Barabási A L | | 0，，05： | 1 |
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