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| 1 | Role of polyethylene particles in peri-prosthetic osteolysis:A review显示文摘There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic loosening.It is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical scenario.The focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing surface.The review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including osteocytes.It explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for osteolysis.In particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional PEs.The caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge. | Gerald J Atkins David R Haynes Donald W Howie David M Findlay | 2011 | World Journal of Orthopedics2011，2，10： | 11 |
| 2 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 3 | HVOF-spray technology-poised for growth显示文摘 | Daniel W Parkerand Gerald L Kutner | 1991 | Advanced Materials & Processes1991，，4： | 2 |
| 4 | 基于颜色特征的含黄曲霉毒素玉米颗粒的检出方法显示文摘为快速准确识别出感染黄曲霉毒素的玉米颗粒,基于黄曲霉毒素在365 nm紫外光照射下可发出黄绿色荧光(bright greenish-yellow fluorescence,BGYF)的特性,提出了一种以颜色为特征量的感染毒素颗粒的检出方法。首先针对同一组玉米颗粒样本分别获取其在紫外光和可见光下的2幅图像,对可见光图像进行二值化、颗粒区域填充等预处理操作,得到玉米颗粒的轮廓与位置信息;然后将进行彩色增强后的紫外光图像与预处理后的可见光图像掩膜;最后在掩膜图像中通过RGB模型中G通道下的阈值作为分割参数识别玉米颗粒上的感染区域。结果表明,所提出的识别方法对能够发出荧光的含黄曲霉菌玉米颗粒识别准确率达到84%以上,对含有黄曲霉毒素的正确检出率可达77.8%以上,能够达到区分检测的要求。 | 褚璇 王伟 Lawrence Kurt C Ni Xinzhi Heitschmidt Gerald W 张楠楠 彭彦昆 | 2015 | 中国粮油学报2015，30，4： | 2 |
| 5 | Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials显示文摘 | Peter M Rothwell F Gerald R Fowkes Jill FF Belch Hisao Ogawa Charles P Warlow Tom W Meade | 2011 | The Lancet2011，，9759： | 2 |
| 6 | Clinical, pathologic ,and molecular spectrum of tumors associated with t(11;22) (p13;q12): desmop lastic small round cell tumor and its variants显示文摘 | Gerald W L Ladanyi M de Alava E | 1998 | J Clin Oncol1998，16，9： | 1 |
| 7 | Effect of angiogenesis in- hibition by Id loss and the contribution of bone-marrow-derived en- dothelial cells in spontaneous murine tumors 显示文摘 | Ruzinova MB Schoer RA Gerald W | 2003 | Cancer Cell2003，4，4： | 1 |
| 8 | Leptin is a four - helix bundle:secondary structure by NMR显示文摘 | Allen D K Gerald W B Lisa M C | 1997 | FEBS Letters1997，407，2： | 1 |
| 9 | Non-structural Fuzzy Decision Support System for Evaluation of Construction Safety Management System显示文摘 | Tam C M Tong Thomas K L Chiu Gerald C W Fung Ivan W H | 2002 | International Journal of Project Management2002，，20： | 1 |
| 10 | Hot-cor- rosion Resistance of Ni-Cr-A1-Y and Ni-18 % Si SI- loys in Sulfate Eutectic and Sulfate Plus Vanadate Melts at 973 K 显示文摘 | BRUCE M W FRED S P GERALD H M | 2002 | Oxidation of Metals2002，58，56： | 1 |
| 11 | Targeting glial physiology and glutamate cycling in the treatment of depression显示文摘 | Gerald W Valentine Gerard Sanacora | | 0，，05： | 1 |
| 12 | Thermal degradation of terpenes:Camphene,Δ3-Carene,Limonene and α-Terpinene显示文摘 | Gerald W Mcgraw Richard W Hemingway Leonard L Ingram JR | | 0，，： | 1 |
| 13 | Tectonic contraction across Los Angeles after removal of groundwater pumping effects 显示文摘 | Gerald W Bawden Wayne Thatcher Ross S Stein | 2001 | Nature2001，412，6849： | 1 |
| 14 | Male domi- nance, paternity, and relatedness in the Jamaican frut-eat- ing bat ( Artibeus jamaicensis) 显示文摘 | JORGE o JESUS E M GERALD S W | 2003 | Molecular Ecology2003，12，： | 1 |
| 15 | Expression of C-kit and C-kit ligand proteins in normal human tissues显示文摘 | Lammie A Drobnjak M Gerald W | 1994 | J Histochem Cytochem1994，42，： | 1 |
| 16 | Cyclooxygenase - 2 is over - ex- pressed in Her - 2/neu - positive breast cancer - evidence for in- volvement of AP - 1 and PEA3 显示文摘 | Kotha S Larry N Gerald W | 2002 | J Biol Chem2002，277，18： | 1 |
| 17 | Feign versus fight : influences of temperature, body size and Locomotor abilities on death feigning in neonate snakes 显示文摘 | GERALD W G | 2008 | Animal Behaviour2008，75，： | 1 |
| 18 | Analytical vali- dation of the GeXP analyzer and design of a workfIow for cancer-biomarker discovery using multiplexed gene-expression profiling显示文摘 | RAI A J KAMATH R M GERALD W | 2009 | Anal Bioanal Chem2009，393，5： | 1 |
| 19 | Ana- lytical validation of the GeXP analyzer and design of a workflow for cancer-biomarker discovery using multi- plexed gene-expression profiling 显示文摘 | RAI A J KAMATH R M GERALD W | 2009 | Anal Bioanal Chem2009，393，5： | 1 |
| 20 | A genetic algorithm-based heuristic for the dynamic integrated forward/reverse logistics network for 3PLs显示文摘 | Hyun Jeung Ko Gerald W Evans | 2007 | Computers & Operations Research2007，34，： | 1 |
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