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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | The first pterosaur 3-D egg:Implications for Pterodaustro guinazui nesting strategies,an Albian filter feeder pterosaur from central Argentina显示文摘The increasing number of fossil pterosaur eggs sheds light on nesting environments and breeding behaviors of these extinct flying reptiles.Here we report the first partial three-dimensional egg of the pterosaur,Pterodaustro guinazui,from central Argentina.The specimen was discovered from the same Albian deposits as the exceptional P.guinazui embryo described in 2004.Microscopic characterizations indicate a pristine preservation of the 50 mm thick calcium carbonate,which differs significantly from the soft shell of Chinese pterosaur eggs.Estimate of the eggshell conductance implies that the nest had a minimum moisture content of 75%.This moisture estimate,combined with geological and taphonomical data,suggests that P.guinazui may have adopted a nesting strategy similar to those of grebes and flamingos rather than being buried on land,as previously hypothesized.Moreover,our results demonstrate that the nesting paleoenvironment of this pterosaur species was closely linked to a mesohaline lacustrine ecosystem in a basin governed by regional tectonic subsidence,a setting characteristic for the feeding and reproduction of modern flamingos. | Gerald Grellet-Tinner Michael B.Thompson Lucas E.Fiorelli Eloísa Argaaraz Laura Codorniú E.Martín Hechenleitner | 2014 | Geoscience Frontiers2014，5，6： | 2 |
| 3 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 4 | E- valuation of Photodynamic Therapy Using a Light-emitting Diode Lamp against Enterococcus faecalis in Extracted Hu- man Teeth 显示文摘 | Alejandro Rios Jianing He Gerald N Glickman eta/ | 2011 | Journal of Endodontics2011，37，： | 1 |
| 5 | Modeling the atmospheric deposition and stormwater washoff of nitrogen compounds 显示文摘 | Steven J Burian Gerald E Streit Timothy N McPherson Michael J Brown | | Environmental Modelling & Software0，200，161： | 1 |
| 6 | Cyclooxygenase - 2 is over - ex- pressed in Her - 2/neu - positive breast cancer - evidence for in- volvement of AP - 1 and PEA3 显示文摘 | Kotha S Larry N Gerald W | 2002 | J Biol Chem2002，277，18： | 1 |
| 7 | LvsA, a protein related to the mouse beige protein, is required for cytokinesis in Dictyostelium显示文摘 | Kwak E Gerald N Larochelle D A | 1999 | Mol Biol Cell1999，10，： | 1 |
| 8 | High levels of nucleotide diversity in the European rabbit ( Oryctolagus cuniculus) SRY gene 显示文摘 | GERALDES A ROGEL-GAILLARD C FERRAND N | 2005 | Animal Genetics2005，36，4： | 1 |
| 9 | Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C2C12 myoblasts via Toll-like receptor-4 and c-Jun NH2-terminal kinase pathways显示文摘 | FROST R A GERALD J N CHARLES H L | 2004 | American Journal of Physiology Cell Physiology2004，287，： | 1 |
| 10 | Faultcurrent contribution from synchronous machine andinverter based distributed generators显示文摘 | NATTHAPHOB N GERALD T H RAJA A | 2007 | IEEE Trans onPower Delivery2007，22，1： | 1 |
| 11 | Dissolved air flotation of surface water for spiral-wound module nanofiltration pre-treatment显示文摘 | GERALDES V ANI A MARIA N P | 2008 | Desalination2008，228，13： | 1 |
| 12 | Quantitative trace analysis of estriol in human plasma by negative ion chemical ionization gas chromatography-mass spectrometry asing a deuterated internal standard 显示文摘 | Hans Jsrg Leis Gtinter F Gerald N P | | J Chromatogr B0，794，2： | 1 |
| 13 | Nitric oxide as a modulator of apoptosis显示文摘 | LI Chtm-qi GERALD N W | 2005 | Cancer Letters2005，226，1： | 1 |
| 14 | Modeling the atmospheric deposition and stormwater washoff of nitro- gen compounds 显示文摘 | Steven J Burian Gerald E Streit Timothy N McPherson | 2001 | Environmental Modelling & Software2001，，161： | 1 |
| 15 | Does Perceived Organizational Support Mediate the Relationship between Procedural Justice and Behavior? 显示文摘 | Robert H M Gerald L B Brian P N | 1998 | Academy of Organizational Citizenship Management Journal1998，41，3： | 1 |
| 16 | An evaluation of coal preparation technologies for controlling trace element emissions 显示文摘 | Gerald H Jaisen N Roe - Hoan | 2000 | Fuel Processing Technolog2000，，6： | 1 |
| 17 | Numerical modeling of mass transfer in slits with semi-permeable membrane walls 显示文摘 | Geraldes V Semiao V Pinho M N | 2000 | Engineering Computations International Journal for Computer-Aided Engineering and Software2000，17，3： | 1 |
| 18 | Mer- cury fraetionation, bioavailability, and ecotoxicity in high-ly contaminated soils from chlor-alkali plants 显示文摘 | Gerald J Z Carmen-Mihaela N Christian B | 2006 | Envi- ronmental Toxicology and Chemistry2006，25，4： | 1 |
| 19 | Reference genome sequence of the model plant Setaria显示文摘 | Jeffrey L Bennetzen Jeremy Schmutz Hao Wang RyanPercifield Jennifer Hawkins Ana C Pontaroli Matt Estep Liang Feng Justin N Vaughn Jane Grimwood JerryJenkins Kerrie Barry Erika Lindquist Uffe Hellsten Shweta Deshpande Xuewen Wang Xiaomei Wu ThereseMitros Jimmy Triplett Xiaohan Yang Chu-Yu Ye Margarita Mauro-Her-rera Lin Wang Pinghua Li ManojSharma Rita Sharma Pamela C Ronald Olivier Panaud Elizabeth A Kellogg Thomas P Brutnell Andrew NDoust Gerald A Tuskan Daniel Rokhsar Katrien MDevos | 2012 | Nature Biotechnology2012，，30： | 1 |
| 20 | Integrated modeling of transport processes in fluid nanofihration membrane systems 显示文摘 | Pinho M N Semiao V Geraldes V | 2002 | Journal of Membrane Science2002，206，： | 1 |
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