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| 1 | WJC 6~th Anniversary Special Issues(3):Cardiomyopathy Hypertrophic cardiomyopathy in 2013:Current speculations and future perspectives显示文摘Hypertrophic cardiomyopathy(HCM),the most variable cardiac disease in terms of phenotypic presentation and clinical outcome,represents the most common inherited cardiomyopathic process with an autosomal dominant trait of inheritance.To date,more than 1400 mutations of myofilament proteins associated with the disease have been identified,most of them 'private' ones.This striking allelic and locus heterogeneity of the disease certainly complicates the establishment of phenotype-genotype correlations.Additionally,topics pertaining to patients' everyday lives,such as sudden cardiac death(SCD)risk stratification and prevention,along with disease prognosis,are grossly related to the genetic variation of HCM.This review incorporates contemporary research findings and addresses major aspects of HCM,including preclinical diagnosis,genetic analysis,left ventricular outflow tract obstruction and SCD.More specifically,the spectrum of genetic analysis,the selection of the best method for obstruction alleviation and the need for a unique and accuratefactor for SCD risk stratification are only some of the controversial HCM issues discussed.Additionally,future perspectives concerning HCM and myocardial ischemia,as well as atrial fibrillation,are discussed.Rather than enumerating clinical studies and guidelines,challenging problems concerning the disease are critically appraised by this review,highlighting current speculations and recommending future directions. | Georgios K Efthimiadis Efstathios D Pagourelias Thomas Gossios Thomas Zegkos | 2014 | World Journal of Cardiology2014，6，2： | 9 |
| 2 | Challenges and opportunities in the application of artificial intelligence in gastroenterology and hepatology显示文摘Artificial intelligence(AI)is an umbrella term used to describe a cluster of interrelated fields.Machine learning(ML)refers to a model that learns from past data to predict future data.Medicine and particularly gastroenterology and hepatology,are data-rich fields with extensive data repositories,and therefore fruitful ground for AI/ML-based software applications.In this study,we comprehensively review the current applications of AI/ML-based models in these fields and the opportunities that arise from their application.Specifically,we refer to the applications of AI/ML-based models in prevention,diagnosis,management,and prognosis of gastrointestinal bleeding,inflammatory bowel diseases,gastrointestinal premalignant and malignant lesions,other nonmalignant gastrointestinal lesions and diseases,hepatitis B and C infection,chronic liver diseases,hepatocellular carcinoma,cholangiocarcinoma,and primary sclerosing cholangitis.At the same time,we identify the major challenges that restrain the widespread use of these models in healthcare in an effort to explore ways to overcome them.Notably,we elaborate on the concerns regarding intrinsic biases,data protection,cybersecurity,intellectual property,liability,ethical challenges,and transparency.Even at a slower pace than anticipated,AI is infiltrating the healthcare industry.AI in healthcare will become a reality,and every physician will have to engage with it by necessity. | Chrysanthos D Christou Georgios Tsoulfas | 2021 | World Journal of Gastroenterology2021，27，37： | 5 |
| 3 | Restless legs syndrome is contributing to fatigue and low quality of life levels in hemodialysis patients显示文摘AIM To examine whether hemodialysis(HD) patients with restless legs syndrome(RLS) are subjects of greater fatigue and impaired quality of life(QoL) compared to HD patients without RLS.METHODS Eighty five stable HD patients participated in this study. According to their RLS status, the patients were dividedinto the RLS group(n = 23) and the non-RLS group(n = 62). QoL, fatigue, sleep quality, daily sleepiness and depression symptoms were assessed by using various questionnaires. Finally, biochemical parameters including iron, ferritin, hemoglobin, hematocrit and parathormone were assessed. RESULTS The HD patients with RLS scored worse in all the questionnaires used in the study(P < 0.05). The patients with RLS were more likely to receive the HD therapy on the morning shift, whilst 43.5% of the RLS patients reported to experience the RLS symptoms also during HD. The severity of RLS was correlated with fatigue, depression score and sleep quality(P < 0.05). CONCLUSION HD patients with RLS are subject to lower QoL related parameters and greater fatigue compared to HD patients without RLS. RLS should be successfully managed in order to improve the QoL of the sufferers. | Christoforos D Giannaki Michael Hadjigavriel Akis Lazarou Aristos Michael Loukas Damianou Efthimios Atmatzidis Ioannis Stefanidis Georgios M Hadjigeorgiou Giorgos K Sakkas Marios Pantzaris | 2017 | World Journal of Nephrology2017，6，5： | 3 |
| 4 | Role of three-dimensional printing and artificial intelligence in the management of hepatocellular carcinoma:Challenges and opportunities显示文摘Hepatocellular carcinoma(HCC)constitutes the fifth most frequent malignancy worldwide and the third most frequent cause of cancer-related deaths.Currently,treatment selection is based on the stage of the disease.Emerging fields such as three-dimensional(3D)printing,3D bioprinting,artificial intelligence(AI),and machine learning(ML)could lead to evidence-based,individualized management of HCC.In this review,we comprehensively report the current applications of 3D printing,3D bioprinting,and AI/ML-based models in HCC management;we outline the significant challenges to the broad use of these novel technologies in the clinical setting with the goal of identifying means to overcome them,and finally,we discuss the opportunities that arise from these applications.Notably,regarding 3D printing and bioprinting-related challenges,we elaborate on cost and cost-effectiveness,cell sourcing,cell viability,safety,accessibility,regulation,and legal and ethical concerns.Similarly,regarding AI/ML-related challenges,we elaborate on intellectual property,liability,intrinsic biases,data protection,cybersecurity,ethical challenges,and transparency.Our findings show that AI and 3D printing applications in HCC management and healthcare,in general,are steadily expanding;thus,these technologies will be integrated into the clinical setting sooner or later.Therefore,we believe that physicians need to become familiar with these technologies and prepare to engage with them constructively. | Chrysanthos D Christou Georgios Tsoulfas | 2022 | World Journal of Gastrointestinal Oncology2022，14，4： | 2 |
| 5 | Imaging of filtering blebs after implantation of the Ex-PRESS shunt with the use of the Visante optical coherence tomography显示文摘AIM: To analyze the features of the filtering blebs following implantation of the Ex-PRESS glaucoma device(model P-50) with the aid of the Visante anterior segment optical coherence tomography(AS-OCT)METHODS: Five patients with open angle glaucomas were included in the study. They all underwent implantation of the Ex-PRESS device under a scleral flap. The surgical procedure was augmented with the use of mitomycin C subconjunctivally. The filtering blebs were analyzed with the Visante AS-OCT with the scans taken along the axis of the implantation of the glaucoma device.RESULTS: All filtering blebs were graded as diffuse functioning. The morphological characteristics of the blebs were similar to those of the trabeculectomy.However the use of the Ex-PRESS implant tend to form a characteristic episcleral lake at the site of the plate of the implant. CONCLUSION: The use of the Ex-PRESS implant produces filtering blebs similar to those of the trabeculectomy with the formation of a characteristic episcleral lake at the site of the plate of the implant. | Aristeidis Konstantinidis Georgios D Panos Magdalini Triantafylla Georgios Labiris Efthimia Tsaragli Zisis Gatzioufas Vassilios Kozobolis | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 2 |
| 6 | Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis显示文摘Bacteria of the human intestinal microflora have a dual role.They promote digestion and are part of a defense mechanism against pathogens.These bacteria could become potential pathogens under certain circumstances.The term“bacterial translocation”describes the passage of bacteria of the gastrointestinal tract through the intestinal mucosa barrier to mesenteric lymph nodes and other organs.In some cases,the passage of bacteria and endotoxins could result in blood stream infections and in multiple organ failure.Open elective abdominal surgery more frequently results in malfunction of the intestinal barrier and subsequent bacterial translocation and blood stream infections than laparoscopic surgery.Postoperative sepsis is a common finding in patients who have undergone non-elective abdominal surgeries,including trauma patients treated with laparotomy.Postoperative sepsis is an emerging issue,as it changes the treatment plan in surgical patients and prolongs hospital stay.The association between bacterial translocation and postoperative sepsis could provide novel treatment options. | Christos Doudakmanis Konstantinos Bouliaris Christina Kolla Matthaios Efthimiou Georgios D Koukoulis | 2021 | World Journal of Gastrointestinal Pathophysiology2021，12，6： | 2 |
| 7 | Surgical management of aortopulmonary window and associated lesions显示文摘 | Eldad E Ovadia D GeorgiOS P.G | | 0，，02： | 1 |
| 8 | Distal posterior tibial artery perforatorflaps for the management of calcaneal and Achilles tendon injuries in diabetic and non - diabetic patients 显示文摘 | Ioarmis A Ignatiadis Georgios D | 2011 | Diabet Foot Ankle2011，，2： | 1 |
| 9 | Recent Advances in High- Voltage Direct- Current Power Transmission Systems 显示文摘 | Agelidis Vassilios G Demetriades Georgios D Flourentzou Nikolas | 2006 | 206 - 2132006，，： | 1 |
| 10 | Pillared graphene: A new 3-D network nanostructure for enhanced hydrogen storage显示文摘 | Georgios K D Emmanuel T George E F | 2008 | Nano Lett2008，8，10： | 1 |
| 11 | Statistical Tests for Presence of Cyclostationary 显示文摘 | Amod V D Georgios B G | 1994 | IEEE Transactions on signal pro- cessing1994，42，9： | 1 |
| 12 | Use of culture,PCR analysis,and DNA microarrays for detection of campylobacter jejuni and campylobacter coli from chicken feces显示文摘 | Georgios K Dang D B Marianne L | 2004 | Clinical Microbiology2004，42，9： | 1 |
| 13 | An investigation into the temperature sta- bility of a guided wave structural health monitoring system using permanently attached sensors显示文摘 | Georgios Konstantinidis Paul D Wilcox Bruce WDrinkwater | 2007 | IEEE Sensors Journal2007，7，5： | 1 |
| 14 | VSC-based HVDC power transmission systems:an overview显示文摘 | NIKOLAS F VASSILIOS G GEORGIOS D | 2009 | IEEE Transactions on Power Electronics2009，24，3： | 1 |
| 15 | Investigating cultural differences in virtual software teams 显示文摘 | GEORGIOS D LINDA M | 2001 | The Electronic Journal on Information Systems in Developing Countries (EJISDC)2001，，4： | 1 |
| 16 | Determination of Anabolic Steroidsin Muscle Tissue by Liquid Chromatography - tandem Mass Spectrometry 显示文摘 | George K Georgios T Themistoklis D | 2009 | Journal of Chromato - graphy A2009，1216，： | 1 |
| 17 | VSC-based HVDC power transmis- sion systems: an overview显示文摘 | Nikolas Flourentzou Vassilios G Agelidis Georgios D Demetriades | 2009 | IEEE Transactions on Power Electronics2009，24，3： | 1 |
| 18 | Methane steam reforming at microscales:Operation strategies for variable power output at millisecond contact times显示文摘 | Georgios D Stefanidis Dionisios G Vlachos Niket S Kaisare | | 0，，01： | 1 |
| 19 | Probabilistic framework and performance evaluation for prioritized call admission control in next generation networks显示文摘 | GEORGIOS I T DIMITRIOS G S JOHN D K | 2011 | Computer Communications2011，34，11： | 1 |
| 20 | Application and validation of a LC/fluorescenee method for the determina- tion of amoxicillin in sheep serum and tissue cage fluid 显示文摘 | Georgios D Georgios B Georgios K | 2009 | J Pharrn Biomed Anal2009，49，4： | 1 |
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