|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 2 | Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster显示文摘Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness.To experimentally demonstrate the epidemiological results,we performed animal studies to infect male and female Syrian hamsters with SARS-CoV-2.Remarkably,high viral titer in nasal washings was detectable in male hamsters who presented symptoms of weight loss,weakness,piloerection,hunched back and abdominal respiration,as well as severe pneumonia,pulmonary edema,consolidation,and fibrosis.In contrast with the males,the female hamsters showed much lower shedding viral titers,moderate symptoms,and relatively mild lung pathogenesis.The obvious differences in the susceptibility to SARS-CoV-2 and severity of lung pathogenesis between male and female hamsters provided experimental evidence that SARS-CoV-2 infection and the severity of COVID-19 are associated with gender. | Lunzhi Yuan Huachen Zhu Ming Zhou Jian Ma Rirong Chen Yao Chen Liqiang Chen Kun Wu Minping Cai Junping Hong Lifeng Li Che Liu Huan Yu Yali Zhang Jia Wang Tianying Zhang Shengxiang Ge Jun Zhang Quan Yuan Yixin Chen Qiyi Tang Honglin Chen Tong Cheng Yi Guan Ningshao Xia | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
| 3 | Human umbilical cord mesenchymal stem cells for psoriasis:a phase 1/2a,single-arm study显示文摘Psoriasis is a common,chronic immune-mediated systemic disease that had no effective and durable treatment.Mesenchymal stem cells(MSCs)have immunomodulatory properties.Therefore,we performed a phase 1/2a,single-arm clinical trial to evaluate the safety and efficacy of human umbilical cord-derived MSCs(UMSCs)in the treatment of psoriasis and to preliminarily explore the possible mechanisms.Seventeen patients with psoriasis were enrolled and received UMsC infusions.Adverse events,laboratory parameters,PASl,and PGA were analyzed.We did not observe obvious side effects during the treatment and 6-month follow-up.A total of 47.1%(8/17)of the psoriasis patients had at least 40%improvement in the PASl score,and 17.6%(3/17)had no sign of disease or minimal disease based on the PGA score.And the efficiency was 25%(2/8)for males and 66.7%(6/9)for females.After UMSC transplantation(UMSCT),the frequencies of Tregs and CD4^(+)memory T cells were significantly increased,and the frequencies of T helper(Th)17 and CD4^(+)naive T cells were significantly decreased in peripheral blood(PB)of psoriasis patients.And all responders showed significant increases in Tregs and CD4^(+)memory T cells,and significant decreases in Th17 cells and serum IL-17 level after UMsCT.And baseline level of Tregs in responders were significantly lower than those in nonresponders.In conclusion,allogeneic UMSCT is safe and partially effective in psoriasis patients,and level of Tregs may be used as a potent biomarker to predict the clinical efficacy of UMSCT.Trial registration Clinical Trials NCT03765957. | Lamei Cheng Siqi Wang Cong Peng Xiao Zou Chao Yang Hua Mei Chuang Li Xian Su Na Xiao Qi Ouyang Mi Zhang Qiaolin Wang Yan Luo Minxue Shen Qun Qin Honglin Wang Wu Zhu Guangxiu Lu Ge Lin Yehong Kuang Xiang Chen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 2 |
| 4 | Design and Synthesis of a Series of Novel Macrocycle Janus Kinase 2 Inhibitors显示文摘Summary of main observation and conclusion Macrocycle has attracted the attention of many researchers in the field of medicinal chemistry due to its unique advantages and good prospects,but the difficulties in drug design and synthesis of macrocycle limit its applications.In this study,a series of macrocyclic derivatives designed from anaplastic lymphoma kinase(ALK)inhibitor lorlatinib were synthesized as Janus kinase 2(JAK2)selective inhibitors.Among them,17f had the best inhibitory activity(IC50=0.177μmol·L^-1)and selectivity for JAK2 over JAK1 and JAK3,which indicated that design of the macrocyclic derivatives might be a feasible strategy for the discovery of novel selective JAK2 inhihitors. | Yanling Wang Huan Ge Disha Wang Huan He Lu Li Yanyan Diao Zihao Shen Lili Zhu Shiliang Li Zhenjiang Zhao Honglin Li | 2019 | Chinese Journal of Chemistry2019，37，12： | 1 |
| 5 | 5-8 Production of Residual Radionuclides by a 250 MeV Proton Beam显示文摘Spallation reactions which are induced by high-energy and high-current proton accelerators play an important role in many fields, such as environmental sciences, medicine, nuclear waste transmutation and energy amplification,etc[1;2]. The residual products are the most difficult ones to predict by the models. Moreover, there are very large discrepancies among the calculations based on different models. | Ju Yongqin Ma Fei Zhang Xueying Ge Honglin Chen Liang Zhang Hongbin | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 6 | 2-29 Study of Spallation Reaction by High EnergyProtons and Carbons显示文摘The spallation reaction was studied with 250 MeV proton beam and 400 MeV/u carbon beam at the HIRFL-CSRin Lanzhou. The neutron and residual radionuclide production were measured by using the off-line -spectroscopymethod. The radiation dose induced in spallation reaction was studied by using the thermoluminescent detectors.Moreover, an on-line neutron measurement method was developed by using a digital pulse shape discriminationsystem. All of the experimental method will be used to study the neurotics of the ADS system. | Zhang Xueying Ma Fei Zhang Hongbin Chen Liang Ju Yongqin Ge Honglin | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 7 | 2-30 Production of Residual Nuclides in Pb Irradiated by 400 MeV/u Carbon Ions显示文摘Irradiation experiment was performed at the HIRFL-CSR in Lanzhou. A Pb foil with 100 mm diameter and0.15 mm thickness was used to measure the mass-yield distributions of induced radionuclides. A natural Pb cylinderwith 100 mm diameter and 250 mm length was used as the beam dump behind the Pb foil. An ionization chamberwas placed in front of the Pb foil to monitor the beam current. The carbon beam with an energy of 400 MeV/uwas stopped in the Pb cylinder after through the Pb foil. The irradiation was lasted about 20 h to make the beamfluence enough. After irradiation, the gamma spectra of Pb foil were measured by a off-line -spectrometry method.The measurements were performed by using a high-purity germanium (HPGe) detector. | Ge Honglin Zhang Xueying Ma Fei Chen liang Zhang Hongbin Ju Yongqin Zhang Yanbin Li Yanyan Wang Bo | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 8 | 2-31 Study of Spallation Yield of Neutrons Produced in Thick Lead Target显示文摘The neutron yield from thick target of Pb irradiated with 250 MeV protons has been studied experimentally.The Pb target was surrounded by a water bath, where this size effectively contained most of the neutrons emittedfrom the target. The moderated neutrons were measured by the activity induced in an array of Au activation foils(with or without Cd cover). The axial coordinates of the foils without Cd cover were Z = -15, -10, -5, 0, 5, 10, 15,20 cm along the target axial, and the radial coordinates of the foils were R = 7.5, 12.5, 17.5, 22.5 and 27.5 cm abovethe target axial. The Au-foil activities were determined by measuring the peak intensities of the 412 keV line from198Au[1], and the results are shown in Fig. 1. | Ma Fei Zhang Xueying Ju Yongqin Zhang Hongbin Chen Liang Ge Honglin | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 9 | Generation of Hepatitis B virus PreS2-S antigen in Hansenula polymorpha显示文摘Despite the long availability of a traditional prophylactic vaccine containing the HBV surface antigen(HBsA g) and aluminum adjuvant, nearly 10% of the population remains unable to generate an effective immune response. Previous studies have indicated that hepatitis B virus(HBV) PreS 2-S is abundant in T/B cell epitopes, which induces a stronger immune response than HBsA g, particularly in terms of cytotoxic T lymphocyte(CTL) reaction. In the current study, the HBV PreS 2-S gene encoding an extra26 amino acids(PreS 2 C-terminus) located at the N-terminus of HBsA g was cloned into the pV CH1300 expression vector. Pre S2-S expressed in the methylotrophic yeast, Hansenula polymorpha, was produced at a yield of up to 250 mg/L. Subsequent purification steps involved hydrophobic adsorption to colloidal silica, ion-exchange chromatography and density ultracentrifugation. The final product was obtained with a total yield of ~15% and purity of ~99%. In keeping with previous studies, ~22 nm viruslike particles were detected using electron microscopy. The generated PreS 2-S antigen will be further studied for efficacy and safty in animals. | Xiaowei Xu Sulin Ren Xiaoxiao Chen Jun Ge Zhenxing Xu Hongying Huang Honglin Sun Yue Gu Tong Zhou Jianqiang Li Hanmei Xu | 2014 | Virologica Sinica2014，29，6： | 0 |
| 10 | Design,synthesis and SAR study of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors显示文摘The abnormal activation of JAK2 kinase is closely related to the occurrence and progression of myeloproliferative neoplasms(MPNs).At present,there is still an obvious unmet medical need for selective JAK2 inhibitors in clinic.In this paper,a class of 2-aminopyridine derivatives as potent and selective JAK2 inhibitors was obtained by combining drug design,synthesis and structure-activity relationship studies based on the previously identified lead Crizotinib.Among them,21 b exhibited high inhibitory activity against JAK2 with an IC_(50)of 9 nmol/L,moreover,it showed 276-and 184-fold selectivity over JAK1 and JAK3,respectively.Besides,21 b had a significant antiproliferative activity against HEL cells,and also inhibited the phosphorylation of JAK2 and its down-stream signaling pathway.These results indicated that2-aminopyridine compound 21 b had the potential to be developed as a selective JAK2 inhibitor for further study. | Dandan Liu Huan Ge Fangling Xu Yufang Xu Wenjun Liu Honglin Li Lili Zhu Yanyan Diao Zhenjiang Zhao | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 11 | Fragmentation Cross-section Measurements of 80 MeV/u^(12)C ions on Thick Targets显示文摘Accelerator-Driven Systems(ADS)are one of the proposed options for the transmutation of long lived nuclides and minor actinid es based on spallation reaction.The creation and the accumulation of stable and radioactive nuclides in the target material during the irradiation is a very important issue for safety concerns target handling and disposal after irradiation. | Ge Honglin Zhang Xueying Chen Liang Ju Yongqin Zhang Yanbin Zhang Hongbin Ma Fei | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 12 | Reactivity Monitoring Using the Pulsed Neutron Source Method for the Lead-Based Zero Power Reactor显示文摘The Accelerator Driven Sub-critical System(ADS)has an extensive application prospect in energy production and transmutation.In the operation of an ADS facility,the subcritical reactivity monitoring is of great significance for safety reasons.Hence,a lead-based zero power reactor VENUS-II has been built in Bejjing. | Chen Liang Ma Fei Zhang Xueying Ge Honglin Ju Yongqin Zhang Yanbin Zhang Hongbin | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 13 | PHASE INTERFACE SEGREGATION OF Mg IN A Ni-BASE SUPERALLOY IN100显示文摘The segregation of Mg to phase interfaces in a nickel base superalloy IN 100 has been investi-gated using EPT(Electron Microprobe Technique).AES(Auger Electron Spectroscopy)and EDS analyses on thin TEM film.The results show that Mg segregates to the phase inter-faces of MC/γ and γ′/γ.The segregation concentration and layer thickness of Mg onMC/γ phase interface are larger than that on γ′/γ phase interface.Mg is not only a grainboundary segregation element,but also a phase interface segregation one. | GE Honglin | 1989 | Acta Metallurgica Sinica(English Letters)1989，2，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员