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| 1 | 抗精神病药物致体重增加与5羟色胺2C受体基因启动子区多态性的关系显示文摘目的 探讨首发精神分裂症患者抗精神病药物 (APS)治疗过程中的体重增加与 5羟色胺 2C受体 (HTR2C)基因启动区 - 759C/T单核酸置换多态性有无相关。方法 采用PCR RFLP技术分析 1 1 7例首发精神分裂症患者 (男 58例 ,女 59例 )HTR2C基因 - 759C/T半合子 (男性 )或基因型 (女性 )分布频率 ,APS(利培酮或氯丙嗪 )单药治疗 1 0周 ,测定患者治疗前后的体重和体重指数 (BMI) ,并分析半合子或基因型与BMI变化值的相关性。结果 治疗后患者平均体重增加 (3 2± 3 5)kg或基础体重的 (5 7± 6 2 ) % ,体重变化范围为 - 7kg~ 1 2kg或 - 7 8%~ 32 %。 58例男性患者突变型半合子频率为 1 9% ,59例女性患者突变型纯合子频率为 0 % ,杂合子频率为 2 7 0 %。 - 759T半合子 (男性 )或杂合子 (女性 )在体重增加 >7%和体重增加 <7%的患者组分布差异有非常显著意义 (χ2 =2 2 35 ,P=0 0 0 0 1 ;χ2 =1 2 36 ,P =0 0 0 0 1 ) ;与携带 - 759T半合子或杂合子患者组相比 ,不携带者体重增加的危险度高 5~ 6倍 (OR =5 1 1 ,6 68)。结论 HTR2C基因启动区 - 759C/T单核酸置换多态性与APS治疗导致汉族精神分裂症患者体重增加相关联 ,而 - 759C→T单核酸置换是防止和限制体重增加的基因保护因素。 | 张志珺 张晓斌 姚志剑 孙静 姚辉 侯钢 张心保 陈建芳 Gavin P Reynolds | 2002 | 中华医学杂志2002，82，16： | 23 |
| 2 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 3 | 动态88小时:美国地质调查局国家地震信息中心对2011年3月11日M_W9.0日本地震的响应显示文摘引言
2011年3月11日日本本州岛东海岸附近海域发生的M9.0地震(Tohoku earthquake,以下称“东日本大地震”——译者注)及其引发的海啸造成数以万计的人员死亡,造成的财产损失可能超过1万亿美元,这是有历史记录以来最严重的自然灾害之一。 | Gavin P Hayes Paul S Earle Harley M Benz David J Wald Richard W Briggs 左玉玲(译) 郑需要(校) | 2011 | 国际地震动态2011，，8： | 4 |
| 4 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 5 | The definition and rendering of terrain maps显示文摘 | Miller Gavin S P | 1986 | Computer Graphics1986，20，4： | 2 |
| 6 | Reliability of ultrasound ovarian-adnexal reporting and data system amongst less experienced readers before and after training显示文摘BACKGROUND The 2018 ovarian-adnexal reporting and data system(O-RADS)guidelines are aimed at providing a system for consistent reports and risk stratification for ovarian lesions found on ultrasound.It provides key characteristics and findings for lesions,a lexicon of descriptors to communicate findings,and risk characterization and associated follow-up recommendation guidelines.However,the ORADS guidelines have not been validated in North American institutions or amongst less experienced readers.AIM To evaluate the diagnostic accuracy and inter-reader reliability of ultrasound ORADS risk stratification amongst less experienced readers in a North American institution with and without pre-test training.METHODS A single-center retrospective study was performed using 100 ovarian/adnexal lesions of varying O-RADS scores.Of these cases,50 were allotted to a training cohort and 50 to a testing cohort via a non-randomized group selection process in order to approximately equal distribution of O-RADS categories both within and between groups.Reference standard O-RADS scores were established through consensus of three fellowship-trained body imaging radiologists.Three PGY-4 residents were independently evaluated for diagnostic accuracy and inter-reader reliability with and without pre-test O-RADS training.Sensitivity,specificity,positive predictive value,negative predictive value(NPV),and area under the curve(AUC)were used to measure accuracy.Fleiss kappa and weighted quadratic(pairwise)kappa values were used to measure inter-reader reliability.Statistical significance was P<0.05.RESULTS Mean patient age was 40±16 years with lesions ranging from 1.2 to 22.5 cm.Readers demonstrated excellent specificities(85%-100%pre-training and 91%-100%post-training)and NPVs(89%-100%pre-training and 91-100%post-training)across the O-RADS categories.Sensitivities were variable(55%-100%pre-training and 64%-100%post-training)with malignant ORADS 4 and 5 Lesions pre-training and post-training AUC values of 0.87-0.95 and 0.94-098,respectively(P<0.001).Nineteen of 22(86%)misclassified cases in pre-training were related to mischaracterization of dermoid features or wall/septation morphology.Fifteen of 17(88%)of posttraining misclassified cases were related to one of these two errors.Fleiss kappa inter-reader reliability was‘good’and pairwise inter-reader reliability was‘very good’with pre-training and post-training assessment(k=0.76 and 0.77;and k=0.77-0.87 and 0.85-0.89,respectively).CONCLUSION Less experienced readers in North America achieved excellent specificities and AUC values with very good pairwise inter-reader reliability.They may be subject to misclassification of potentially malignant lesions,and specific training around dermoid features and smooth vs irregular inner wall/septation morphology may improve sensitivity. | Prayash Katlariwala Mitchell P Wilson Yeli Pi Baljot S Chahal Roger Croutze Deelan Patel Vimal Patel Gavin Low | 2022 | World Journal of Radiology2022，14，9： | 2 |
| 7 | Proteome survey reveals modularity of the yeast cell machinery 显示文摘 | GAVIN A C ALOY P GRANDI P | 2006 | Nature2006，440，7084： | 1 |
| 8 | Attentional asymmetries-cause or consequence of human right handedness显示文摘 | Gavin Buckingham David P Carey | 2014 | Frontiers in Psy- chology2014，5，： | 1 |
| 9 | Proteome survey reveals modularity of the yeast cell machinery 显示文摘 | GAVIN A C ALOY P GRANDI P | 2006 | Na- ture2006，440，7084： | 1 |
| 10 | In the eyes of the be- holder: Transformational leadership, positive psychological capital, and performance显示文摘 | Gooty J Gavin M Johnson P B | 2009 | Journal of Leadership & Orga- nizational Studies2009，15，4： | 1 |
| 11 | The Definition and rendering of terrain maps显示文摘 | Miller Gavin S P | 1986 | ACM SIGGRAPH Computer Graphics1986，20，4： | 1 |
| 12 | In the eyes of tile beholder: Transformational leadership,positive psychological capital and per- formance显示文摘 | Gooty J Gavin M Johnson P | 2009 | Journal of Leadership and Organization Studies2009，15，5： | 1 |
| 13 | High-order limit state functions in the response surface method for structural reliability analysis 显示文摘 | Gavin H P Yau S C | 2008 | Structural Sofety2008，30，2： | 1 |
| 14 | The Wnt family of cell signalling molecules in postimplantation development of the mouse显示文摘 | McMahon A P Gavin B J Parr B | 1992 | Ciba Found Symp1992，165，： | 1 |
| 15 | Electro-rheological damper I : analysis and design 显示文摘 | Gavin H P Hanson R I) Filisko F E | 1996 | Transactions of the ASME Journal Applied Mechanic1996，63，： | 1 |
| 16 | Histone modifications,DNA methylation,and schizophrenia显示文摘 | Gavin D P Sharma R P | 2010 | Neurosci Biobehav Rev2010，34，6： | 1 |
| 17 | Characterization of genes encoding translation initiation factor elF-2gamma in mouse and human:sex chromosome localiza-tion,escape from X-inactivation and evolution显示文摘 | Ellis P S Mazeyrat S Duthie S Brockdorff N Mattei M-G Gavin M A Affara N A Brown G M Simpson E Mitchell M J Scott D M | 1998 | Hum Mol Genet1998，7，： | 1 |
| 18 | The role of ion mobility spectrometry-mass spectrometry in the analysis of protein reference standards显示文摘 | Caroline P Gavin O Alison E A | 2013 | Analytical Chemistry2013，85，15： | 1 |
| 19 | Systemic arterial expression of matrixmetalloproteinases 2 and 9 in acute Kawasaki disease显示文摘 | Gavin P J Crawford S E Shulman S T | 2003 | Vasc Biol2003，23，4： | 1 |
| 20 | Shaft capacity of continuous flight auger piles in sand 显示文摘 | Gavin K G Cadogan D Casey P | 2009 | Journal of Geotechnical and Geoenvironmental Engineering2009，135，6： | 1 |
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