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| 1 | Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation显示文摘BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young children.Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.AIM To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT.METHODS We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative complications.The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/kg.Subsequently,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be analyzed.RESULTS High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period.During a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the LTr.Over a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection complications.Additionally,Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion.The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival,but with no impact in patient survival related to major complications.On the other hand,there was a significant decrease in both graft and patient survival,with high-volume RBC transfusion.CONCLUSION Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short-and long-term postoperative morbidity and mortality after PLDLT. | Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque | 2021 | World Journal of Gastroenterology2021，27，12： | 6 |
| 2 | Enhanced wheat yield by biochar addition under different mineral fertilization levels显示文摘 | José Antonio Alburquerque Pablo Salazar Vidal Barrón José Torrent María del Carmen del Campillo Antonio Gallardo Rafael Villar | 2013 | Agronomy for Sustainable Development2013，，3： | 2 |
| 3 | Composting of animal manures and chemical criteria for compost maturity assessment 显示文摘 | BERNAL M P ALBURQUERQUE J A MORAL R | 2009 | Bioresource Technology2009，，100： | 1 |
| 4 | Ethylene inhibitors and low kanamycin concentrations improve adventitious regeneration from apricot leaves显示文摘 | BURGOS L ALBURQUERQUE N | 2003 | Plant Cell Rep2003，21，12： | 1 |
| 5 | Composting of animal manures: A review显示文摘 | Bernal M P Alburquerque J A Moral R | 2009 | Bioresource Technology2009，100，22： | 1 |
| 6 | Composting of ani- mal manures and chemical criteria for compost maturity as- sessment:A review 显示文摘 | Bernal M P Alburquerque J A Moral R | 2009 | Bioresouree Technology2009，100，22： | 1 |
| 7 | Auxin pulses and a synergistic interaction between polyamines and ethylene inhibitors improve adventitious regeneration from apri- cot leaves and Agrobacterium-mediated transformation of leaf tissues 显示文摘 | PETRI C ALBURQUERQUE N PEREZ-TORNERO O BURGOS L | 2005 | Plant Cell Tiss Org Cult2005，82，： | 1 |
| 8 | Factors affecting gene transfer efficiency to apricot leaves during early Agrobacterium-mediated transformation steps显示文摘 | PETRI C ALBURQUERQUE N GARCIA-CASTILLO S EGEA J BURGOS L | 2004 | J Hortic Sci Biotech2004，79，5： | 1 |
| 9 | Composting of animal manures and chemical criteria for compost maturity assessment 显示文摘 | Bernal M P Alburquerque J A Moral R | 2009 | Bioresource Technology2009，100，22： | 1 |
| 10 | Composting of animal manures and chemical criteria for compost maturity assessment显示文摘 | Bernal M P Alburquerque J A Moral R | 2009 | Bioresource Technology2009，100，22： | 1 |
| 11 | Flower biology in apricot and its im- plications for breeding(review) 显示文摘 | Burgos L Alburquerque N Egea J | 2004 | Spanish Journal of Agricultural Research2004，，2： | 1 |
| 12 | Effects of the forced ventilation on composting of a solid olive-mill by-product (alperujo)managed by mechanical turning显示文摘 | CEGARRA J ALBURQUERQUE J A GONZALVEZ J | 2006 | Waste management2006，，26： | 1 |
| 13 | Low kanamycin concentration and ethylene inhibitors improve adventitious regeneration from apricot leaves显示文摘 | BURGOS L ALBURQUERQUE N | 2003 | Plant Cell Rep2003，21，12： | 1 |
| 14 | The effect of aminoglycoside antibiotics on the adventitious regeneration from apricot leaves and selection of nptII-transformed leaf tissues显示文摘 | PETRI C ALBURQUERQUE N BURGOS L | 2005 | Plant Cell Tiss Org Cult2005，80，： | 1 |
| 15 | Consequences to fertilization of the developmental stages of apricot ovules at anthesis显示文摘 | Alburquerque N Burgos L Egea J | 2000 | Journal of Horticultural Science Biotechnology2000，75，： | 1 |
| 16 | Enhanced wheat yield by biochar addition under different mineral fertilization levels显示文摘 | ALBURQUERQUE J A SALAZAR P BARRONV | 2013 | Agronomy for Sustainable Development2013，33，3： | 1 |
| 17 | Enhanced wheat yield by biochar addition under different mineral fertilization levels 显示文摘 | Alburquerque J A Salazar P Barr N V | 2013 | Agronomy for Sustainable Development2013，33，3： | 1 |
| 18 | Enhanced wheat yield by biochar addition under different mineral fertilization levels显示文摘 | Alburquerque J A Salazar P Barron V | 2013 | Agronomy for Sustainable Development2013，33，3： | 1 |
| 19 | Enhanced wheat yield by biochar addition under different mineral fertilization levels显示文摘 | ALBURQUERQUE J A SALAZAR P BARRON V | | 0，，03： | 1 |
| 20 | Composting of animal manures and chemical criteria for compost maturity assessment:A review显示文摘 | Bernal M P Alburquerque J A Moral R | 2009 | Bioresour Technol2009，100，22： | 1 |
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