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| 1 | Failure of interferon-γ pre-treated mesenchymal stem cell treatment in a patient with crohn's disease显示文摘Mesenchymal stem cells(MSC) are cells of stromal origin which exhibit unlimited self-renewal capacity and pluripotency in vitro.It has recently been observed that MSC may also exert a profound immunosuppressive and anti-inflammatory effect both in vitro and in vivo with consequent potential use in autoimmune disorders.We present the case of a patient suffering from childhood-onset, multidrug resistant and steroiddependent Crohn's disease who underwent systemic infusions of MSC, which led to a temporary reduction in CCR4, CCR7 and CXCR4 expression by T-cells, and a temporary decrease in switched memory B-cells, In addition, following MSC infusion, lower doses of steroids were needed to inhibit proliferation of the patient's peripheral blood mononuclear cells.Despite these changes, no significant clinical benefit was observed, and the patient required rescue therapy with infliximab and subsequent autologous hematopoietic stem cell transplantation.The results of biological and in vitro observations after MSC use and the clinical effects of infusion are discussed, and a brief description is provided of previous data on MSC-based therapy in autoimmune disorders. | Andrea Taddio Alberto Tommasini Erica Valencic Ettore Biagi Giuliana Decorti Sara De Iudicibus Eva Cuzzoni Giuseppe Gaipa Raffaela Badolato Alberto Prandini Andrea Biondi Alessandro Ventura | 2015 | World Journal of Gastroenterology2015，21，14： | 2 |
| 2 | Drug- induced immunophenotypic modulation in childhood ALL:Implications for minimal residual disease detection 显示文摘 | Gaipa G Basso G Maglia O | 2005 | Leukemia2005，19，1： | 1 |
| 3 | Drug-induced immunophenotypic modulation in childhood ALL:implication for minimal residual disease detection显示文摘 | Gaipa G Basso G Maglia O | 2005 | Leukemia2005，19，： | 1 |
| 4 | Time point-dependent concordance of flow cytometry and real-time quantitative polymerase chain reaction for minimal residual disease detection in childhood acute lymphoblastic leukemia显示文摘 | Gaipa G Cazzaniga G Valsecchi MG | | 0，，10： | 1 |
| 5 | Platelet-lysate-Expanded Mesenchymal Stromal Cells as a Salvage Therapy for Severe Resistant Graft-versus-Host Disease in a Pediatric Population显示文摘 | Giovanna Lucchini Martino Introna Erica Dander Attilio Rovelli Adriana Balduzzi Sonia Bonanomi Agnese Salvadè Chiara Capelli Daniela Belotti Giuseppe Gaipa Paolo Perseghin Paola Vinci Edoardo Lanino Patrizia Chiusolo Maria Grazia Orofino Sarah Marktel Jos | 2010 | Biology of Blood and Marrow Transplantation2010，，： | 1 |
| 6 | Treatment of Graft versus Host Disease with Mesenchymal Stromal Cells: A Phase I Study on 40 Adult and Pediatric Patients显示文摘 | Martino Introna Giovanna Lucchini Erica Dander Stefania Galimberti Attilio Rovelli Adriana Balduzzi Daniela Longoni Fabio Pavan Francesca Masciocchi Alessandra Algarotti Caterina Micò Anna Grassi Sara Deola Irene Cavattoni Giuseppe Gaipa Daniela Belotti P | 2013 | Biology of Blood and Marrow Transplantation2013，，： | 1 |
| 7 | Drug-inducedimmunophenotypic modulation in childhood ALL:implications for minimal residual disease detection显示文摘 | Gaipa G Basso G Maglia 0 | 2005 | Leukemia2005，19，1： | 1 |
| 8 | CD40 ligand-stimulated B cell precursor leukemic cells elicit interferon-gamma production by autologous bone marrow T cells in childhood acute lymphoblastic leukemia显示文摘 | Todisco E Gaipa G Biagi E | 2002 | Leukemia2002，16，10： | 1 |
| 9 | Drug-induced immunophenotypic modulation in childhood ALL,im- plications for minimal residual disease detection显示文摘 | GAIPA G BASSO G MAGLIA O | 2005 | Leukemia2005，19，： | 1 |
| 10 | Detection of minimal residual disease in pediatric acute lymphoblastic leukemia显示文摘 | Gaipa G Basso G Biondi A | 2013 | Cytometry B Clin Cytom2013，84，6： | 1 |
| 11 | Detection of minimal residual disease in pediatric acute lymphoblas- tic leukemia显示文摘 | GAIPA G BASSO G BIONDI A | 2013 | Cytometry B Clin Cytom2013，84，： | 1 |
| 12 | Effect of aplidin in acute lymphoblastic leukaemia cells 显示文摘 | Erba E Serafini M Gaipa G | 2003 | Br J Cancer2003，89，： | 1 |
| 13 | BIOMED-I concerted action report: flow cytometric immunophenotyping of precursor B-ALL with standardized triple-stainings显示文摘 | Lucio P Gaipa G van Lochem EG | 2001 | Leukemia2001，15，8： | 1 |
| 14 | Drug-induced immunophenotypic modulation in childhood ALL:implications for minimal residual disease detection显示文摘 | Gaipa G Basso G Maglia O | | 0，，： | 1 |
| 15 | CD40 ligand-stimulated B cell precursor leukemic cells elicit interferon-gamma production by autologous bone marrow T cells in childhood acute lymphoblastic leukemia显示文摘 | TODISCO E GAIPA G BIAGI E | 2002 | Leukemia2002，16，： | 1 |
| 16 | Drug-induced immunophenotypic modulation in childhood ALL: implication for minimal residual disease detection 显示文摘 | Gaipa G Basso G Maglia O | 2005 | Leukemia2005，19，： | 1 |
| 17 | 显示文摘 | Todisco E Gaipa G Biagi E et al | 2002 | Leukemia2002，16，10： | 1 |
| 18 | Detection of minimal residualdisease in pediatric acute lymphoblastic leukemia 显示文摘 | Gaipa G Basso G Biondi A | 2013 | Cytometry BClin Cytom2013，84，6： | 1 |
| 19 | Drug-induced immunophenotypic modulation in childhood ALL:implications for mini mal residual disease detection显示文摘 | Gaipa G Basso G Maglia O | 2005 | Leukemia2005，19，1： | 1 |
| 20 | Drug - induced immunophenotypic modulation in childhood ALL: Implications for minimal residual disease detection显示文摘 | Gaipa G Basso G Maglia O | 2005 | Leukemia2005，19，1： | 1 |
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