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| 1 | Structural analysis of receptor-like kinase SOBIR1 reveals mechanisms that regulate its phosphorylation-dependent activation显示文摘Plant leucine-rich repeat(LRR)receptor-like kinases(RLKs)and LRR receptor-like proteins(RLPs)comprise a large family of cell surface receptors that play critical roles in signal perception and transduction.Both LRR-RLKs and LRR-RLPs rely on regulatory LRR-RLKs to initiate downstream signaling pathways.BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1/SOMATIC EMBRYOGENESIS RECEPTOR KINASE 3(BAK1/SERK3)and SUPPRESSOR OF BIR1-1(SOBIR1)are important and extensively studied regulatory LRR-RLKs with distinct functions.Although the regulatory mechanism of BAK1 activation has been studied in detail,the activation mechanism of SOBIR1 remains poorly understood.Here,the crystal structures of the catalytically inactive kinase domain of SOBIR1(SOBIR1-KD)from Arabidopsis thaliana were determined in complexes with AMP-PNP and Mg^(2+).The results show that SOBIR1-KD contains a uniquely long β3-αC loop and adopts an Src-like inactive conformation with an unusual architecture at the activation segment,which comprises three helices.Biochemical studies revealed that SOBIR1 is transphosphorylated by BAK1 following its autophosphorylation via an intermolecular mechanism,and the phosphorylation of Thr529 in the activation segment and the β3-αC loop are critical for SOBIR1 phosphorylation.Further functional analysis confirmed the importance of Thr529 and the β3-αC loop for the SOBIR1-induced cell death response in Nicotiana benthamiana.Taken together,these findings provide a structural basis for the regulatory mechanism of SOBIR1 and reveal the important elements and phosphorylation events in the special stepwise activation of SOBIR1-KD,the first such processes found in regulatory LRR-RLKs. | Xue Wei Yulu Wang Su Zhang Tianyi Gu Gabryel Steinmetz Haiyan Yu Guoguang Guo Xin Liu Shilong Fan Fengzhong Wang Yangnan Gu Fengjiao Xin | 2022 | Plant Communications2022，3，2： | 2 |
| 2 | High costs as a slow down factor of thoracoscopic lobectomy development in Poland-an institutional experience 显示文摘 | Piwkowski C Gabryel P Galecki B | 2013 | Wideochir Inne Tech Malo Inwazyjne2013，8，4： | 1 |
| 3 | Role of astrocytes in pathogenesis of ischemic brain injury显示文摘 | Gabryel B Trzeciak HI | 2001 | Neurotox Res2001，3，2： | 1 |
| 4 | Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes in vitro显示文摘 | Gabryel B Trzeciak HI Pudelko A | | 0，，06： | 1 |
| 5 | Quantification of mefformin by the HPLC method in brain regions,cerebrospinal fluid and plasma of rats treated with lipopolysaccharide显示文摘 | Labuzek K Suchy D Gabryel B | | 0，，： | 1 |
| 6 | Quantification of metformin by the HPLC method in brain regions, cerebrospinal fluid and plasma of rats treated with lipopolysaccharide 显示文摘 | Abuzek K Suchy D Gabryel B | 2010 | Pharmacol Rep2010，62，5： | 1 |
| 7 | Quantification of met-formin by the HPLC method in brain regions,cerebrospinal fluid and plasma of rats treated with lipopolysaccharide显示文摘 | Labuzek K Suchy D Gabryel B | | 0，，05： | 1 |
| 8 | AICAR(5-aminoimidazole-4-carboxamide-1-β-4-ribonucleoside)increases the production of tox-ic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures显示文摘 | Labuzek K Liber S Gabryel B | 2010 | Neurotoxicology2010，31，1： | 1 |
| 9 | Kinetics of growth of spinel MgA12O4 on alumina particulate in aluminium alloys containing magnesium显示文摘 | Gabryel C M Mcledod A D | 1992 | Metallurgical and Materials Transactions1992，23，： | 1 |
| 10 | Immunophilin ligands decrease release of proinflammatory cytokines (IL-1β,TNF-α and IL-2) in rat astrocyte cultures exposed to simulated ischemia in vitro显示文摘 | GABRYEL B LABUZEK K MALECKI A | 2004 | Pol J Pharmacol2004，56，1： | 1 |
| 11 | Immunophilin ligans decrease release of pro-inflammatory cytokines(IL-1beta,TNF-alpha and IL-2)in rat astrocyte cultures exposed to simulated ischemia in vitro显示文摘 | Gabryel B Labuzek K Malecki A | 2004 | Pol J Pharmacol2004，56，1： | 1 |
| 12 | Activation of cP-LA2and sPLA2in astrocytes exposed to simulated ischemiain vitro显示文摘 | Gabryel B Chalimoniuk B Stolecka A | 2007 | Cell Biology International2007，31，9： | 1 |
| 13 | Video-assisted thoracic surgery pneumonectomy:the first case report in Poland显示文摘 | Piwkowski C Gabryel P Kasprzyk M | 2012 | Wideochir Inne Tech Malo Inwazyjne2012，7，3： | 1 |
| 14 | Immunophilin ligands decrease release of pro-inflammatory cytokines ( IL-1β, TNF-α and IL- 2) in rat astrocyte cultures exposed to simulated ischemia in vitro 显示文摘 | Gabryel B Labuzek K Malecki A | 2004 | Pol J Pharmacol2004，56，1： | 1 |
| 15 | Activation of cPLA2 and sPLA2 in astrocytes exposed to simulated ischemia in vitro显示文摘 | Gabryel B Chalimoniuk M Stolecta A | 2007 | Cell Biol lnt2007，31，9： | 1 |
| 16 | Piracetam and vinpocetine exert cytoprotective activity and prevent apoptosis of astrocytes in vitro in hypoxia and reoxygenation 显示文摘 | Adamek M Pudelko A | 2002 | Neurotoxicology2002，23，1： | 1 |
| 17 | AICAR (5 1-beta- 4-ribofuranoside) increases the production of toxic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures 显示文摘 | LABUZEK K LIBER S GABRYEL B | 2010 | Neurotoxicology2010，31，1： | 1 |
| 18 | Role of astrocytes in pathogenesis of ischemic brain injury显示文摘 | Gabryel B Trzeciak HI | 2001 | Neurotox Res2001，3，2： | 1 |
| 19 | Role of astrocytes in pathogenesis of ischemic brain injury显示文摘 | Gabryel B Trzeciak HI | 2001 | Neurotox Res2001，3，2： | 1 |
| 20 | Immunophilin ligands decrease release of pro-inflammatory cytokines (IL-lbeta, TNF-alpha and IL-2 in rat astrocyte cultures exposed to simu- lated ischemia in vitro显示文摘 | Gabryel B Labuzek K Malecki A | 2004 | Pol J Pharmacol2004，56，1： | 1 |
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