|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | DNA and histone methylation in gastric carcinogenesis显示文摘Epigenetic alterations contribute significantly to the development and progression of gastric cancer,one of the leading causes of cancer death worldwide.Epigenetics refers to the number of modifications of the chromatin structure that affect gene expression without altering the primary sequence of DNA,and these changes lead to transcriptional activation or silencing of the gene.Over the years,the study of epigenetic processes has increased,and novel therapeutic approaches that target DNA methylation and histone modifications have emerged.A greater understanding of epigenetics and the therapeutic potential of manipulating these processes is necessary for gastric cancer treatment.Here,we review recent research on the effects of aberrant DNA and histone methylation on the onset and progression of gastric tumors and the development of compounds that target enzymes that regulate the epigenome. | Danielle Queiroz Calcagno Carolina Oliveira Gigek Elizabeth Suchi Chen Rommel Rodriguez Burbano Marília de Arruda Cardoso Smith | 2013 | World Journal of Gastroenterology2013，19，8： | 14 |
| 2 | Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma显示文摘AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways. | Danielle Queiroz Calcagno Mariana Ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira Ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2006 | World Journal of Gastroenterology2006，12，38： | 9 |
| 3 | Melatonin lowers edema after spinal cord injury显示文摘Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin(100 mg/kg, i.p.) could reduce the water content of the spinal cord, and suppress the expression of aquaporin-4 and glial fibrillary acidic protein after spinal cord injury. This suggests that the mechanism by which melatonin alleviates the damage to the spinal cord by edema might be related to the expression of aquaporin-4 and glial fibrillary acidic protein. | Cheng Li Xiao Chen Suchi Qiao Xinwei Liu Chang Liu Degang Zhu Jiacan Su Zhiwei Wang | 2014 | Neural Regeneration Research2014，9，24： | 5 |
| 4 | 左心质量与脑磁共振成像和认知功能的关系显示文摘左心室质量(1eft ventricularmass,LVM)被证实可以作为长期暴露于数个危险因素下时造成的靶器官损害的评估标准。有关中年LVM和晚期认知表现之间联系的资料很少。纳入StrongHeart研究(SHS,1993—1995)及其附属的CDCAI(脑血管病及其对美国印第安人的影响)研究(2010—2013)中721名成年研究对象(平均基础年龄56岁),这些人群心血管病风险较高。 | 黄洁 叶鹏 Haring B Omidpanah A Suchy Dicey AM Best LG Verney SP Shibata DK Cole SA Ali T Howard BV Buchwald D Devereux RB | 2017 | 中华高血压杂志2017，25，10： | 4 |
| 5 | Prognostic significance of vascular endothelial growth factor polymorphisms in colorectal cancer patients显示文摘AIM To investigate the associations of the genetic polymor-phisms of vascular endothelial growth factor A(VEGF-A)-1498C>T and-634G>C, with the survival of patients with colorectal cancer(CRC). METHODS A prospective cohort consisting of 131 Brazilians patients consecutively operated on with a curative intention as a result of sporadic colorectal carcinoma was studied. DNA was extracted from peripheral blood and its amplification and allelic discrimination for each genetic polymorphism was performed using the technique of polymerase chain reaction(PCR) in real-time. The real-time PCR technique was used to identify the VEGF-A-1498C>T(rs833031) and-634G>C(rs2010963) polymorphisms. Genotyping was validated for VEGF-A-1498C>T polymorphism in 129 patients and for VEGF-A-634G>C polymorphism in 118 patients. The analysis of association between categorical variables was performed using logistic regression, survival by Kaplan-Meier method and multivariate analysis by the Cox regression method. RESULTS In the univariate analysis there was a significant association(OR = 0.32; P = 0.048) between genotype CC of the VEGF-A-1498C>T polymorphism and the presence of CRC liver metastasis. There was no association between VEGF-A-1498C>T polymorphism and VEGF-A-634G>C polymorphism with further clinical or anatomopathologic variables. The genotype CC of the VEGF-A-1498C>T polymorphism was significantly correlated with the 5-year survival(P = 0.032), but not significant difference(P = 0.27) was obtained with the VEGF-A-634G>C polymorphism with the 5-year survival in the univariate analysis. The genotype CT(HR = 2.79) and CC(HR = 4.67) of the polymorphism VEGF-A-1498C>T and the genotype CC(HR = 3.76) of the polymorphism VEGF-A-634C>G acted as an independent prognostic factor for the risk of death in CRC patients. CONCLUSION The CT and CC genotypes of the VEGF-A-1498C>T and the CC genotype of the VEGF-A-634C>G polymorphisms are prognostic factors of survival in Brazilians patients with sporadic colorectal carcinoma. | Gilmar Ferreira do Espírito Santo Bianca Borsatto Galera Elisabeth Carmen Duarte Elisabeth Suchi Chen Lenuce Azis Amilcar Sabino Damazo Gabriela Tognini Saba Flávia de Sousa Gehrke Ismael Dale Cotrim Guerreiro da Silva Jaques Waisberg | 2017 | World Journal of Gastrointestinal Oncology2017，9，2： | 4 |
| 6 | Chemoprotective potentials of homoisoflavonoids and chalcones of Dracaena cinnabari:modulations of drug-metabolizing enzymes and antioxidant activity显示文摘 | Machala M Kubinova R Suchy V | 2001 | Phytother Res2001，15，2： | 1 |
| 7 | Human bile salt export pump promoter is transactivated by the famesoid X receptorlbile acid receptor显示文摘 | Ananthanarayanan M Balasubramanian N Makishima M Man- gelsdorf D J Suchy FJ | 2001 | J Biol Chem2001，276，28： | 1 |
| 8 | Broadband spectroscopy using two Suzaku observations ofthe HMXB GX 301-2 显示文摘 | Suchy S Fiirst F Pottschmidt K | 2012 | The Astrophysical Journal2012，745，2： | 1 |
| 9 | The protein kinase pUL97 of human cytomegalovirus interacts with and phosphotvlatles the DNA polymerase processivity factor pUIA4 显示文摘 | Marschall M Freitag M Suchy P | 2003 | Viroleoy2003，311，1： | 1 |
| 10 | Activation of alkaline peroxide delignificationusing a vanadium peroxide complex显示文摘 | Suchy M Argyropoulos D S | 2000 | Tappi Journal2000，83，6： | 1 |
| 11 | Effect of SiO2 on densification and microstructure development in Nd:YAG transparent ceramics 显示文摘 | STEVENSON A J LI Xin MART1NEZ M A ANDERSON J M SUCHY D L KUPP E R DICKEY1 Z C MUELLER K T MESSING G L | 2011 | J Am Ceram Soc2011，94，： | 1 |
| 12 | The distribution and accumulation of phthalates in the organs and tissues of chicks after the administration of feedstuffs with different phthalate concentrations 显示文摘 | Jarosova A Harazim J Suchy P | 2009 | Veterinami Medicina2009，54，42： | 1 |
| 13 | Ezetimibe-a new approach in hypercholesterolemia management显示文摘 | Suchy D Labuzek K Stadnicki A | 2011 | Pharmacol Rep2011，63，13： | 1 |
| 14 | Geochemical study of calcite veins in the Silurian and Devonian of the Barrandian Basin (Czech Republic ): evidence for widespread post Variscan fluid flow in the central part of the Bohemian Massif显示文摘 | SUCHY Y HEIJLEN W SYKORIVA J | 2000 | Sedimentary Geology2000，131，3： | 1 |
| 15 | Establishment of artemisinin combination therapy as first line treatment for combating malaria:Artemisia annua cultivation in India needed for providing sustainable supply chain of artemisinin显示文摘 | Sushil Kumar Suchi Srivastava | 2005 | Current Sci2005，89，7： | 1 |
| 16 | Effect of home mechanical ventilation on inspiratory muscle strength in COPD 显示文摘 | Schnhofer B Polkey MI Suchi S | 2006 | Chest2006，130，6： | 1 |
| 17 | The IL-6 and COX-2 expression related to sensitivity of chemoradiotherapy and progno- sis in esophageal carcinoma显示文摘 | Okamnra S Fujiwara H Suchi K | 2009 | Gan to Kagaku Ryoho Cancer Chemotherapy2009，36，12： | 1 |
| 18 | Role of the thromboxane A2 receptor in the vasoactive response to ischemia-reperfusion injury显示文摘 | MAZOLEWSKI P G ROTH A C SUCHY H | 1999 | Plast Reconstr Surg1999，104，： | 1 |
| 19 | Bile Salt Excretory Pump: Biology and Pathobiology显示文摘 | Frederick J. Suchy M. Ananthanarayanan | 2006 | Journal of Pediatric Gastroenterology and Nutrition ( Suppl )2006，，1： | 1 |
| 20 | Ezetimibe-a new approach in hypercholesterolemia management显示文摘 | SUCHY D LABUZEK K STADNICKI A | | 0，，06： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员