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| 1 | Sphincter-preserving R0 total mesorectal excision with resection of internal genitalia combined with pre-or postoperative chemoradiation for T4 rectal cancer in females显示文摘AIM: To evaluate the impact of chemoradiation admi- nistered pre- or postoperatively on prognosis in females following R0 extended resection with sphincter- preserving total mesorectal excision (TME) for locally advanced rectal cancer and to assess the association between chemoradiation and intra- and postoperative variables. METHODS: Twenty-one females were treated for locally advanced but preoperatively assessed as primarily resectable rectal cancer involving reproductive organs. Anterior resection with TME and excision of internal genitalia was combined with neo- or adjuvant chemoradiation. Two-year disease-free survival analysis was performed with the Kaplan-Meier method and log- rank test. The association between chemoradiation and other variables was evaluated with the Fisher’s exact test and Mann-Whitney test. RESULTS: Survival rate decreased in anaemic females (51.5% vs 57.4%), in patients older than 60 years (41.8% vs 66.7%) with poorly differentiated cancers (50.0% vs 55.6%) and tumors located ≤ 7 cm from the anal verge (42.9% vs 68.1%) but with the lack of importance. Patients with negative lymph nodes and women chemoradiated preoperatively had significantly favourable prognosis (85.7% vs 35.7%; P= 0.03 and 80.0% vs 27.3%; P = 0.01, respectively). Preoperative chemoradiation compared to adjuvant radiochemotherapy was not significantly associated with the duration of surgery, incidence of intraoperative bowel perforation and blood loss ≥ 1 L, rate of postoperative bladder and anorectal dysfunction, and minimal distal resection margin. It significantly influenced minimal radial margin (mean 4.2 mm vs 1.1 mm; P < 0.01). CONCLUSION: Despite involving internal genitalia, long-term disease-free survival and sphincter preservation may be achieved with combined-modality therapy for females with T4 locally advanced rectal carcinoma. Neoadjuvant chemoradiation does not compromise functional results and may significantly improve oncological outcomes probably due to enhanced radial clearance. | Bartlomiej Szynglarewicz Rafal Matkowski Piotr Kasprzak Daniel Sydor Jozef Forgacz Marek Pudelko Jan Kornafel | 2007 | World Journal of Gastroenterology2007，13，16： | 2 |
| 2 | The relationship of the expression of proliferation--related antigens Ki67 and PCNA in the cells of ductal breast cancer with the differentiation grade显示文摘 | Surowiak P Pudelko M Maciejczyk A | 2005 | Ginekol Pol2005，76，1： | 1 |
| 3 | Subsidiary control in Japanese, German and US multinational corporations : Direct control from headquarters versus indirect control through expatriation 显示文摘 | PUDELKO M TENZER H | 2013 | Asian Business & Management2013，12，4： | 1 |
| 4 | Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes in vitro显示文摘 | Gabryel B Trzeciak HI Pudelko A | | 0，，06： | 1 |
| 5 | Hypoxic signa- ling and the cellular redox tumor environment determine sensi- tivity to MTH1 inhibition显示文摘 | BRAUTIGAM L PUDELKO L JEMTH AS | 2016 | Cancer Res2016，76，8： | 1 |
| 6 | Influence of tamoxifen on cisplatin-sensitivity and estrogen receptors expression in ovarian carcinoma cell lines显示文摘 | Nowak-Markwitz E Maciejczyk A Pudelko M | 2010 | Ginekol Pol2010，81，3： | 1 |
| 7 | Piracetam and vinpocetine exert cytoprotective activity and prevent apoptosis of astrocytes in vitro in hypoxia and reoxygenation 显示文摘 | Adamek M Pudelko A | 2002 | Neurotoxicology2002，23，1： | 1 |
| 8 | Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes in vitro 显示文摘 | Gabryel B Trzeciak HI Pudelko A | 1999 | Pol J Pharmacol1999，51，6： | 1 |
| 9 | Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes inviro显示文摘 | Gabryel B Trzeciak HI Pudelko A | | 0，，06： | 1 |
| 10 | Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes in vitro显示文摘 | Gabryel B Trzeciak HI Pudelko A | 1999 | Pol J Pharmacol1999，51，6： | 1 |
| 11 | The contingent nature of bestpractices in national competitiveness : The case of American and Japa- nese innovation processes 显示文摘 | PUDELKO M MENDENHALL M E | 2009 | European Management Journal2009，27，： | 1 |
| 12 | The Japanese management met- amorphosis: What western executives need to know about current Jap- anese management practices 显示文摘 | PUDELKO M MENDENHALL M E | 2007 | Organizational Dynamics2007，36，3： | 1 |
| 13 | The relationship of the expression of proliferetron-related antigens Ki67 and PCNA in the cells of ductal breast cancer with the differentiation grade显示文摘 | Surowiak P Pudelko M Maciejczyk A | 2005 | Ginekol Pol2005，76，1： | 1 |
| 14 | Knock- down of the AKT3 (PKB ~/) , PI3KCA, and VEGFR2 genes by RNA interference suppresses glioblastoma multiforme T98G cells invasiveness in vitro 显示文摘 | Paul-Samojedny M Pudelko A Suchanek-Raft R | 2015 | Tumour Biol2015，36，5： | 1 |
| 15 | Erkl/2 and Akt kinases are involved in the protective effect of aniracetam in astrocytes subjected to simulated ischemia in vitro显示文摘 | Bozena Gabryel Anna Pudelko Andrizej Malecki | | Eur J Pharmacol0，494，23： | 1 |
| 16 | ERK 1/2 signaling pathway is involved in nicotine-mediated neuroprotection in spinal cord neurons 显示文摘 | Toborek M Son KW Pudelko A | 2007 | J Cel Biochem2007，100，2： | 1 |
| 17 | Universalities,Particularities and Singularities in Cross-National Management Research显示文摘 | | 2006 | International Studies of Management & Organizations2006，36，4： | 1 |
| 18 | Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes in vitro显示文摘 | Gabryel B Trzeciak HI Pudelko A | 1999 | Pol J Pharmacol1999，51，6： | 1 |
| 19 | Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes in vitro 显示文摘 | Gabryel B Trzeciak HI Pudelko A | 1999 | Pol J Pharmacol1999，51，6： | 1 |
| 20 | Influence of piracetam and oxiracetam on the content of high- energy phosphates and morphometry of astrocytes in vitro显示文摘 | Gabryel B Trzeciak HI Pudelko A | 1999 | Pol J Pharmacol1999，51，6： | 1 |
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