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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Mammography of ductal carcinoma in situ of the breast: Review of 909 cases with radiographic–pathologic correlations显示文摘 | Béatrice Barreau Isabelle de Mascarel Caroline Feuga Gaétan MacGrogan Marie-Hélène Dilhuydy Véronique Picot Jean-Marie Dilhuydy Christine Tunon de Lara Emmanuel Bussières I. Schreer | 2005 | European Journal of Radiology2005，，1： | 2 |
| 3 | Hydrogen storage characteristics of Ti 2 Ni alloy synthesized by the electro-deoxidation technique显示文摘 | Mustafa Anik Bedri Baksan Tu?ba ?l?er Orbay Nilüfer Kü?ükdeveci Alanur Binal Aybar Re?at Can ?zden Hakan Ga?an Nur?en Ko? | 2014 | Intermetallics2014，，： | 2 |
| 4 | Particle swarm optimization to solving the economic dispatch considering the generator constraints显示文摘 | GAING Z L | 2003 | IEEE Transactions on Power Systems2003，18，3： | 1 |
| 5 | Localization of nitric oxide synthase during fracture healing显示文摘 | Zhu W Murre!l GA Lin J | 2002 | J Bone Miner Bes2002，17，8： | 1 |
| 6 | Obesity in pregnancy 显示文摘 | Davies GA Maxwell C McLeod L | 2010 | J Obstet Gynaecol Can2010，32，2： | 1 |
| 7 | Omi/HtrA2 protease mediates eisplatin-indueed cell death in renal cells显示文摘 | Cilenti L Kyriazis GA Sotmdarapandian MM | 2005 | Am J Physiol Renal Physiol2005，288，2： | 1 |
| 8 | Colorectal epithelial cell pro- liferative kinetics and risk factors for colon cancer in sporadic adenoma patients 显示文摘 | Bostick RM Fosdick L Grandits GA | 1997 | Cancer Epidemio! Biomarkers Prev1997，6，12： | 1 |
| 9 | Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase显示文摘 | Tong L Prieto GA Kramár EA | | 0，，49： | 1 |
| 10 | Genomic Sequencing and Molecular Characteristics of A Very Virulent Strain of Infectious Bursal Disease Virus Isolated in China显示文摘 | QI X L GA L QIN L T | | 0，，12： | 1 |
| 11 | Differential effects of angiotensin 1] on cardiac cell proliferation and intramyocardial perivascular fibrosis in vivo显示文摘 | McEwan PE Gray GA Sherry L | 1998 | Circulation1998，98，24： | 1 |
| 12 | Particle swarm optimization to solving the econom- ic dispatch considering the generator constraints 显示文摘 | GAING Z L | 2003 | Power Systems IEEE Transactions on2003，18，3： | 1 |
| 13 | GP73, a novel golgi - localized orotein uoregulated by viral infection显示文摘 | Kladney RD Bulla GA Guo L | 2000 | Gene2000，249，： | 1 |
| 14 | RNA interference (RNAi) inhibits growthofPlasmodiumfalciparum 显示文摘 | McRobert L McConkey GA | 2002 | Mol Biochem Parasitol2002，119，2： | 1 |
| 15 | GP73, a novel Golgi- localized protein upregulated by viral infection 显示文摘 | Kladney RD Bulla GA Guo L | 2000 | Gene2000，249，1： | 1 |
| 16 | Increased serum osteopontin levels in autistic children: relation to the disease severity显示文摘 | Al-ayadhi L Mostafa GA | 2011 | Brain Behav Immun2011，25，7： | 1 |
| 17 | Phosphate binders:new Products and challenges显示文摘 | Bellasi A Kooienga L Block GA | 2006 | Hemodial Int2006，10，5： | 1 |
| 18 | Effects of hypoxia on urinary organic acid and hypoxanthine excretion in fetal sheep显示文摘 | Walker V Bennet L Mills GA | 1996 | Pediatr Res1996，40，： | 1 |
| 19 | Effect of sodium intake on ability of human plasma to inhibit renal Na+ -K+ -adenosis triphosphatase in vitro显示文摘 | De Wardener HE MacGregor GA Clarkson EM Alahgband-Zadeh Bitensky L Chayen J | 1981 | Lancet1981，21，： | 1 |
| 20 | IL-6 Promotes com- pensatory liver regeneration in cirrhotic rat after partial hepa tectomy显示文摘 | Tiberio GA Tiherio L Benetti A et aI | 2008 | Cytokine2008，42，： | 1 |
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