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| 1 | Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option显示文摘We present a case of a patient with hypersplenism secondary to portal hypertension due to hepato-splenic schistosomiasis, which was accompanied by severe and refractory thrombocytopenia. We performed spleen ablation and measured the total spleen and ablated volumes with contrast-enhanced computed tomography and volumetry. No major complications occurred, thrombocytopenia was resolved, and platelet levels remained stable, which allowed for early treatment of the patient's underlying disease. Previous work has shown that splenic radiofrequency ablation is an attractive alternative treatment for hypersplenism induced by liver cirrhosis. We aimed to contribute to the currently sparse literature evaluating the role of radiofrequency ablation(RFA) in the management of hypersplenism. We conclude that splenic RFA appears to be a viable and promising option for the treatment of hypersplenism. | Guilherme Lopes P Martins Joao Paulo G Bernardes Marcello S Rovella Raphael G Andrade Publio Cesar C Viana Paulo Herman Giovanni Guido Cerri Marcos Roberto Menezes | 2015 | World Journal of Gastroenterology2015，21，20： | 17 |
| 2 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 3 | Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells显示文摘AIM To examine the influence on apoptotic mechanisms following inhibition of polo-like kinases as therapeuticallyapproach for cholangiocellular cancer treatment. METHODS As most cholangiocarcinomas are chemotherapyresistant due to mechanisms preventing tumor cell death, we investigated the effect of Cisplatin on cholangiocellular carcinoma(CCA) cell lines KMCH-1 and Mz-Ch-1. Polo-like kinases(PLK) are important regulators of the cell cycle and their inhibition is discussed as a potential therapy while PLK inhibition can regulate apoptotic mediators. Here, cells were treated with PLK inhibitor BI6727(Volasertib), Cisplatin, and in combination of both compounds. Cell viability was assessed by MTT; apoptosis was measured by DAPI staining and caspase-3/-7 assay. Western blot and q RT-PCR were used to measure expression levels of apoptosis-related molecules Bax and Bcl-2. RESULTS The cell viability in the CCA cell lines KMCH-1 and Mz-Ch-1 was reduced in all treatment conditions compared to vehicle-treated cells. Co-treatment with BI6727 and cisplatin could even enhance the cytotoxic effect of cisplatin single treatment. Thus, co-treatment of cisplatin with BI6727 could slightly enhance the cytotoxic effect of the cisplatin in both cell lines whereas there was evidence of increased apoptosis induction solely in Mz-Ch-1 as compared to KMCH-1. Moreover, PLK inhibition decreases protein levels of Bcl-2; an effect that can be reversed by the proteasomal degradation inhibitor MG-132. In contrast, protein levels of Bax were not found to be altered by PLK inhibition. These findings indicate that cytotoxic effects of Cisplatin in Mz-Ch-1 cells can be enhanced by co-treatment with BI6727.CONCLUSION In conclusion, BI6727 treatment can sensitize CCA cells to cisplatin-induced apoptosis with proteasomal Bcl-2 degradation as an additional pro-apoptotic effect. | Svenja Sydor Sami Jafoui Lena Wingerter Sandra Swoboda Joachim C Mertens Guido Gerken Ali Canbay Andreas Paul Christian D Fingas | 2017 | World Journal of Gastroenterology2017，23，22： | 5 |
| 4 | Social Network Growth with Assortative Mixing显示文摘 | MICHELE C GUIDO C LUCIANO P | 2004 | Physica A2004，338，1： | 1 |
| 5 | Chaotic motions of a rigid rotor in short journal bearings 显示文摘 | Adiletta G Guido A R Rossi C | 1996 | Nonlinear Dynamics1996，，10： | 1 |
| 6 | US,CT,MR and percutaneous biopsy of adrenal myelolipomas显示文摘 | GUIDO L STEFANO C CLAUDIA DELL′A | 1995 | Eur Radiol1995，5，： | 1 |
| 7 | Chaotic Motions of a Rigid Rotor in Short Journal Bearing 显示文摘 | Adiletta G Guido A R Rossi C | 1996 | Nonlinear Dynamics1996，10，6： | 1 |
| 8 | Chaotic motions of a rotor in short journal bearings显示文摘 | Adiletta G Guido A R Rossi C | 1996 | Nonlinear Dynamics1996，10，： | 1 |
| 9 | Chaoic motions of a rigid rotor in the short journal bearings显示文摘 | A R Guido C Rossi | 1996 | Nonlinear Dynamics1996，10，3： | 1 |
| 10 | Hormonal responses to partial drying of the root system of Helianthus annuls显示文摘 | Maria A Pittance A Baggily L Guido C | 1994 | J Exp Boot1994，45，270： | 1 |
| 11 | Chaotic motions of a rigid rotor in the short journal bearings 显示文摘 | ADILETTA G GUIDO A R ROSSI C | 1996 | Nonlinear Dynamics1996，10，3： | 1 |
| 12 | The bigi- nelli reaction with an imidazolium-tagged recyclable iron catalyst : Kinetics, mechanism, and antitumoral activity显示文摘 | Ramos L M Guido B C Nobrega C C | 2013 | Chemistry A European Journal2013，19，13： | 1 |
| 13 | Chaotic motions of a rigid rotor in short journal beatings显示文摘 | Adiletta G Guido A R Rossi C | 1996 | Nonlinear Dynamics1996，，10： | 1 |
| 14 | Chaos motions of a rigid rotor in the short journal bearings 显示文摘 | Adileftta G Guido A R Rossi C | 1996 | Nonlinear Dynamics1996，10，3： | 1 |
| 15 | Microwave abalation of hepatocellular carcinoma using a new pereutaneous device: preliminary results 显示文摘 | Guido P Benedetta M Pameladi C | 2013 | Anticancer Res2013，33，12： | 1 |
| 16 | Chaotic motion of a rigid rotor in short journal bearing 显示文摘 | ADILETTA G GUIDO A R ROSSI C | 1996 | Nonlinear Dynamics1996，10，3： | 1 |
| 17 | Human spermatogenesis in vitro:respective effects of follicle-stimulating hormone and testosterone on meiosis,spermiogenesis,and Sertoli cell apoptosis显示文摘 | Tesarik J Guido M Mendoza C | 1998 | Clin Endocrinol Metab1998，83，： | 1 |
| 18 | Blood pressure load, proteinuria and renal function in pre-hypertensive children 显示文摘 | Lubrano R Travasso E Raggi C Guido G Masciangelo R Elli M | 2009 | Pediatr Nephrol2009，24，4： | 1 |
| 19 | Chaotic motions of a rigid rotor in short journal bearings显示文摘 | Adiletta G Guido A R Rossi C | 1996 | Nonlinear Dynamics1996，10，6： | 1 |
| 20 | Chaotic motions of a rigid rotor in short journal bearings显示文摘 | Adiletta G Guido A R Rossi C | 1996 | Nonlinear Dynamics1996，10，6： | 1 |
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