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| 1 | Immune precision medicine for cancer:a novel insight based on the efficiency of immune effector cells显示文摘Cancer cell growth is associated with immune surveillance failure.Nowadays,restoring the desired immune response against cancer cells remains a major therapeutic strategy.Due to the recent advances in biological knowledge,efficient therapeutic tools have been developed to support the best bio-clinical approaches for immune precision therapy.One of the most important successes in immune therapy is represented by the applicational use of monoclonal antibodies,particularly the use of rituximab for B-cell lymphoproliferative disorders.More recently,other monoclonal antibodies have been developed,to inhibit immune checkpoints within the tumor microenvironment that limit immune suppression,or to enhance some immune functions with immune adjuvants through different targets such as Toll-receptor agonists.The aim is to inhibit cancer proliferation by the diminishing/elimination of cancer residual cells and clinically improving the response duration with no or few adverse effects.This effect is supported by enhancing the number,functions,and activity of the immune effector cells,including the natural killer(NK)lymphocytes,NKT-lymphocytes,γδT-lymphocytes,cytotoxic T-lymphocytes,directly or indirectly through vaccines particularly with neoantigens,and by lowering the functions of the immune suppressive cells.Beyond these new therapeutics and their personalized usage,new considerations have to be taken into account,such as epigenetic regulation particularly from microbiota,evaluation of transversal functions,particularly cellular metabolism,and consideration to the clinical consequences at the body level.The aim of this review is to discuss some practical aspects of immune therapy,giving to clinicians the concept of immune effector cells balancing between control and tolerance.Immunological precision medicine is a combination of modern biological knowledge and clinical therapeutic decisions in a global vision of the patient. | Jean-François Rossi Patrice Céballos Zhao-Yang Lu | 2019 | Cancer Communications2019，39，1： | 6 |
| 2 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 3 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 4 | New insights in drug development for the non - small cell lung cancer therapy 显示文摘 | GRIDELLI C ROSSI A MAIONE P | 2008 | Front Biosci2008，13，： | 1 |
| 5 | Cannabinoid CB2 receptor activation reduces mouse myocardial ischemia-repeffusion injury: involvement of cytokine/chemokines and PMN 显示文摘 | Di Filippo C Rossi F Rossi S | 2004 | J Leukoc Biol2004，75，3： | 1 |
| 6 | Vascular percu- taneous transcatheter embolisation with a new device: Amplatzer vascular plug 显示文摘 | Ferro C Petrocelli F Rossi UG | 2007 | Radiol Med2007，112，2： | 1 |
| 7 | Doubly fed induction machines diagnosis based on signature analysis of rotor modulating signals显示文摘 | STEFANI A YAZIDI A ROSSI C | 2008 | IEEE Transactions on Industry App- lications2008，44，6： | 1 |
| 8 | Proapoptotic effect of atorvastatin on sti- mulated rabbit smooth muscle cells显示文摘 | Baetta R Donetti E Comparato C Calore M Rossi A Teruzzi C | 1997 | Pharmacol Res1997，36，2： | 1 |
| 9 | Remodeling of second-order neurons in the retina of rd/rd mutant mice显示文摘 | STRETTOI E PIGNATELLI V ROSSI C | 2003 | Vision Res2003，43，8： | 1 |
| 10 | The Displacement Field of the Landers Earthquake Mapped By Radar Interferometry显示文摘 | Massonnet D Rossi M Carmona C | 1993 | Nature1993，364，： | 1 |
| 11 | Chaotic motions of a rigid rotor in short journal bearings 显示文摘 | Adiletta G Guido A R Rossi C | 1996 | Nonlinear Dynamics1996，，10： | 1 |
| 12 | A randomized study comparing triptorelin or expectant management following conservative laparoscopic surgery for symptomatic stage III-IV endometriosis显示文摘 | LOVERRO G CARRIERO C ROSSI A C | 2008 | Eur J Obstet Gynecol Reprod Biol2008，136，2： | 1 |
| 13 | Performance of ^18F- fluoro-ethyl-tyrosine (lSF-FET) PET for the differential diag- nosis of primary brain tumor: a systematic review and Metaanalysis 显示文摘 | Dunet V Rossi er C Buck A | 2012 | J Nucl Med2012，53，2： | 1 |
| 14 | Cadmium uptake byhydroxyapatite synthesized in different conditions and submittedto thermal treatment显示文摘 | Nilce CC Reinaldo C Rossi AM’ | 2002 | Environ Sci Technol2002，36，7： | 1 |
| 15 | Exenatide:a review from pharmacology to clinical practice显示文摘 | Gentilella R Bianchi C Rossi A | | 0，，06： | 1 |
| 16 | The Displacement Field of the Landers Earthquake Mapped by Radar Interfer- ometry显示文摘 | Massonnet D Rossi M Carmona C | 1993 | Nature1993，364，6433： | 1 |
| 17 | Tuberculous transverse myelitis: case report and review of the literature显示文摘 | PUTRUELE A M LEGARRETA C G LIMONGI L ROSSI S E | 2005 | Clin Pulm Med2005，12，： | 1 |
| 18 | Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF)显示文摘 | Rossi AG Haslett C Hirani N | 1998 | J Clin Invest1998，101，12： | 1 |
| 19 | NF-KB and virus infection: who con- trols whom显示文摘 | Santoro MG Rossi A Amici C | 2003 | EMBO J2003，22，11： | 1 |
| 20 | Estimation of ifosfamide /cisplatinum-induced renal toxicity by urinary protem analysis显示文摘 | Rossi RM Kist C Wutster U | 1994 | Pediatr Nophrol1994，8，： | 1 |
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