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| 1 | Overexpression of P53 and its risk factors in esophageal cancer in urban areas of Xi′an显示文摘OverexpressionofP53anditsriskfactorsinesophagealcancerinurbanareasofXi′anQIAOGuiBin1,HANChengLong2,JIANGRenChao1,SUNChang?.. | QIAO GuiBin1, HAN ChengLong2, JIANG RenChao1, SUN ChangSheng3, WANG Yan3 and WANG YunJie3 | 1998 | World Journal of Gastroenterology1998，4，1： | 21 |
| 2 | The Impacts of Maternal Gestational Diabetes Mellitus (GDM) on Fetal Hearts显示文摘Objective To evaluate the fetal cardiac function in gestational diabetes mellitus (GDM) pregnancies under different maternal glycemic controls.Methods Forty four GDM mothers received 78 fetal echocardiographic evaluations at three gestational periods (<28,28-34 and ≥34 weeks) and were divided into poorly-(DM1) and well-(DM2) controlled groups according to their glycemic control at examination.Seventy uncomplicated mothers were selected as controls.Parameters of fetal cardiac anatomy and function were measured and analyzed.Results GDM fetuses' cardiac ventricular walls were thicker than controls',and the differences between DM1 and DM2 were not significant except for end-diastolic left ventricular walls.In both GDM groups,the aortic flow velocities increased earlier than pulmonary artery and DM1 fetuses changed earlier than DM2 ones.GDM fetuses' left atrial shortening fraction was smaller than the controls' in the period of ≥34 weeks and negatively correlated with thicknesses of left ventricular walls and interventricular septum in DM1 fetuses (r=-0.438 and -0.506).The right ventricular diastolic function in DM1 and DM2 fetuses decreased after the period of 28-34 weeks and in the period of ≥34 weeks respectively.Tei index of both left and right ventricles increased in DM1 group after the period of<28 weeks and in DM2 group only in the period of ≥34 weeks,with no significant differences between DM1 and DM2 groups in this period.Conclusion Fetuses of GDM mothers showed cardiac function impairments.Good maternal glycemic control may delay the impairments,but cannot reduce the degree.Some cardiac changes in GDM fetuses were similar to those in pregestational diabetic pregnancies except for several parameters and their changing time. | CHU Chen GUI Yong Hao PEN Yun Yun SHI Li Ye | 2012 | Biomedical and Environmental Sciences2012，25，1： | 20 |
| 3 | Efects of a bioartificial liver support system on a cetaminophen-induced acute liver failure canines显示文摘Seeinvitedcommentaryonpage286Subjectheadingsliversupportsystem;acuteliverfailure;canines;porcinehepatocytes;bioartificiallive... | XUE Yi Long 1, ZHAO Shi Feng 2, ZHANG Zuo Yun 1, WANG Yue Feng 1, LI Xin Jian 1, HUANG Xiao Qiang 3, LUO Yun 1, HUANG Ying Cai 4 and LIU Cheng Gui 1 | 1999 | World Journal of Gastroenterology1999，5，4： | 19 |
| 4 | Optimal time for mesenchymal stem cell transplantation in rats with myocardial infarction显示文摘Background:Bone marrow mesenchymal stem cell (MSC) transplantation is a promising strategy in the treatment of myocardial infarction (MI). However, the time for transplanting cells remains controversial. The aim of this study was to find an optimal time point for cell transplantation. Methods: MSCs were isolated and cultured from Sprague-Dawley (SD) rats. MI model was set up in SD rats by permanent ligation of left anterior descending coronary artery. MSCs were directly injected into the infarct border zone at 1 h, 1 week and 2 weeks after MI, respectively. Sham-operated and MI control groups received equal volume of phosphate buffered saline (PBS). At 4 weeks after MI, cardiac function was assessed by echocardiography; vessel density was analyzed on hematoxylin-eosin stained slides by light microscopy; the apoptosis of cardiomyocytes was evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay; the expressions of proteins were analyzed by Western blot. Results: MSC transplantation improved cardiac function, reduced the apoptosis of cardiomyocytes and increased vessel density. These benefits were more obvious in 1-week group than in 1-h and 2-week groups. There are more obvious in-creases in the ratio of bcl-2/bax and the expression of vascular endothelial growth factor (VEGF) and more obvious decreases in the expression of cleaved-caspase-3 in 1-week group than those in other two groups. Conclusion: MSC transplantation was beneficial for the recovery of cardiac function. MSC transplantation at 1 week post-MI exerted the best effects on increases of cardiac function, anti-apoptosis and angiogenesis. | Chen-yang JIANG Chun GUI Ai-na HE Xin-yang HU Jie CHEN Yun JIANG Jian-an WANG | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，8： | 18 |
| 5 | Report on Childhood Obesity in China (10): Association of Sleep Duration with Obesity显示文摘Objectives To explore the association of sleep duration with obesity among children in urban areas of China.Methods A total of 6 576 children(3 293 boys and 3 283 girls) aged 7-11 years were randomly selected from 36 primary schools in 6 metropolitan cities in China.A 7-day Physical Activity Recall was used to assess the sleep duration and physical activity level.The height,weight,waist circumference(WC) and percentage of body fat(%BF,as determined by bioelectrical impedance analysis technique) were measured by following the standardized operation procedures.The information on demography,lifestyle and eating habits was collected with a self-administered questionnaire from participants and their parents.Results The average sleep duration per night in the children was 9.7 h with the decreasing trends along with the increase of age(P<0.05).The sleep duration was negatively associated with body mass index(BMI) and WC in both boys and girls after adjustment for confounders(β value-0.23 and-0.82 for boys,-0.24 and-0.91 for girls,respectively,P<0.01).However,no significant association of sleep duration with %BF was found.Children who slept less than 9.0 h per night had a higher risk for overweight and obesity(OR=1.29,95% CI:1.01,1.64) and abdominal obesity(OR=1.38,95% CI:1.04,1.83) as compared with those who slept for 10.0-10.9 h.Conclusions Short sleep duration is associated with obesity.It is important to ensure adequate sleep duration of children and foster their healthy lifestyle at an early stage of life. | MENG Li Ping LIUAi Ling HU Xiao Qi ZHANG Qian DU Song Ming FANG Hong Yun MA Jun XU Gui Fa LI Ying GUO Hong Wei DU Lin MA Guan Sheng | 2012 | Biomedical and Environmental Sciences2012，25，2： | 16 |
| 6 | Self-microemulsifying drug delivery system for improving the bioavailability of huperzine A by lymphatic uptake显示文摘Huperzine A(Hup-A) is a poorly water-soluble drug with low oral bioavailability. A selfmicroemulsifying drug delivery system(SMEDDS) was used to enhance the oral bioavailability and lymphatic uptake and transport of Hup-A. A single-pass intestinal perfusion(SPIP) technique and a chylomicron flow-blocking approach were used to study its intestinal absorption, mesenteric lymph node distribution and intestinal lymphatic uptake. The value of the area under the plasma concentration–time curve(AUC) of Hup-A SMEDDS was significantly higher than that of a Hup-A suspension(P <0.01).The absorption rate constant(K_a) and the apparent permeability coefficient(P_(app)) for Hup-A in different parts of the intestine suggested a passive transport mechanism, and the values of K_a and P_(app) of Hup-A SMEDDS in the ileum were much higher than those in other intestinal segments. The determination of Hup-A concentration in mesenteric lymph nodes can be used to explain the intestinal lymphatic absorption of Hup-A SMEDDS. For Hup-A SMEDDS, the values of AUC and maximum plasma concentration(C_(max)) of the blocking model were significantly lower than those of the control model(P<0.05). The proportion of lymphatic transport of Hup-A SMEDDS and Hup-A suspension were about 40% and 5%,respectively, suggesting that SMEDDS can significantly improve the intestinal lymphatic uptake and transport of Hup-A. | Fang Li Rongfeng Hu Bin Wang Yun Gui Gang Cheng Song Gao Lei Ye Jihui Tang | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 15 |
| 7 | Inflammatory bowel disease in Hubei Province of China显示文摘InflammatoryboweldiseaseinHubeiProvinceofChinaXIABing1,S.SHIVANANDA2,ZHANGGuiShui1,YIJiYun1,JBACRUSIUS3andASPEN~A3Subjecthe... | XIA Bing 1, S. SHIVANANDA 2, ZHANG Gui Shui 1, YI Ji Yun 1, JBA CRUSIUS 3 and AS PE N~ A 3 | 1997 | World Journal of Gastroenterology1997，3，2： | 12 |
| 8 | Large-scale real-world radio signal recognition with deep learning显示文摘In the past ten years, many high-quality datasets have been released to support the rapid development of deep learning in the fields of computer vision, voice, and natural language processing. Nowadays, deep learning has become a key research component of the Sixth-Generation wireless systems(6G) with numerous regulatory and defense applications. In order to facilitate the application of deep learning in radio signal recognition, in this work, a large-scale real-world radio signal dataset is created based on a special aeronautical monitoring system-Automatic Dependent Surveillance-Broadcast(ADS-B). This paper makes two main contributions. First, an automatic data collection and labeling system is designed to capture over-the-air ADS-B signals in the open and real-world scenario without human participation. Through data cleaning and sorting, a high-quality dataset of ADS-B signals is created for radio signal recognition. Second, we conduct an in-depth study on the performance of deep learning models using the new dataset, as well as comparison with a recognition benchmark using machine learning and deep learning methods.Finally, we conclude this paper with a discussion of open problems in this area. | Ya TU Yun LIN Haoran ZHA Ju ZHANG Yu WANG Guan GUI Shiwen MAO | 2022 | Chinese Journal of Aeronautics2022，35，9： | 9 |
| 9 | A prospective study of vertical transmission of hepatitis C virus显示文摘AprospectivestudyofverticaltransmissionofhepatitisCvirusSUNDeGui1,LIUCaiYun1,MENGZongDa2,SUNYongDe2,WANGShuCong1,YANGYu... | SUN De Gui 1, LIU Cai Yun 1, MENG Zong Da 2, SUN Yong De 2, WANG Shu Cong 1, YANG Yu Qi 1, LIANG Zheng Lun 3 and ZHUANG Hui 3 | 1997 | World Journal of Gastroenterology1997，3，2： | 8 |
| 10 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 11 | A new naphthoquinoneimine derivative from the marine algal-derived endophytic fungus Aspergillus niger EN-13显示文摘也就是,从海洋的棕色的水藻 Colpomenia sinuosa 的内部织物被孤立的 endophytic 真菌曲霉属菌尼日尔 EN-13 的耕作导致了新 naphthoquinoneimine 衍生物的描述 5,7-dihydroxy-2-[1-(4-methoxy-6-oxo-6H-pyran-2-yl )-2-phenylethylamino]-[1,4]naphthoquinone。新混合物的结构包括 2D NMR 技术, EIMS,和 HR-ESI-MS 根据各种各样的 NMR 分光镜的分析被建立。这项复合显示的中等抗真菌的活动。 | Yi Zhang Xiao Ming Li Chang Yun Wang Bin Gui Wang | 2007 | Chinese Chemical Letters2007，18，8： | 7 |
| 12 | Annexin5 Is Essential for Pollen Development in Arabidopsis显示文摘 | Jingen Zhu Shunjie Yuan Guo Wei Dong Qian Xiaorong Wu Honglei Jia Mengyuan Gui Wenzhe Liu Lizhe An Yun Xiang | 2014 | Molecular Plant2014，7，4： | 6 |
| 13 | Synthesis of a New Polysiloxane Modified Polyurethane显示文摘In this paper, a new polymer of polysiloxane modified polyurethane was synthesized by using H-containing silicone oil, toluene diisocyanate(TDI), 1,4-butanediol and unsaturated polyether. | Wei Feng JIANG Shi Gui ZHAO Yun Xia QI | 2006 | Chinese Chemical Letters2006，17，5： | 4 |
| 14 | Development of DArT markers for a linkage map of flue-cured tobacco显示文摘Tobacco(Nicotiana tabacum) is one of the most economically important nonfood crops,and flue-cured tobacco accounts for approximately 80% of world tobacco production.An extremely narrow genetic diversity in the tobacco pool has led to a low efficiency of PCR-based molecular markers(such as AFLP and SSR).Diversity Arrays Technology(DArT) is a high-throughput hybridisation-based marker system that has been developed in many plants including wheat,which,like tobacco,has a complex genome.In this study,we developed a tobacco DArT chip that included 7680 representative sequence tags based on typical tobacco accessions.The 1076 DArT markers of flue-cured tobacco were identified and most(82.1%) of their polymorphism information contents(PICs) were greater than 0.4.An integrated linkage map that included 851 markers(238 DArT and 613 SSR),which is the highest density map of flue-cured tobacco to date,was constructed.This chip-based DArT system provides an alternative in high-throughput marker genotyping for tobacco. | LU XiuPing GUI YiJie XIAO BingGuang LI YongPing TONG ZhiJun LIU Yun BAI XueFei WU WeiRen XIA Ling HUTTNER Eric KILIAN Adrzej FAN LongJiang | 2013 | Chinese Science Bulletin2013，58，6： | 4 |
| 15 | Design and Synthesis of a Highly Stable Six-hydrogen-bonded Serfassembly Yellowish Green Electroluminescent Molecular Duplex显示文摘This paper describes the design, synthesis and characterization of a hydrogen-bonded molecular duplex with 1,8-naphthalimide fluorescent pendants. The two oligoamide molecular strands, with complementary hydrogen bond sequences of DDADAA and AADADD, can form an ultra stable self-assembly duplex. Its molecular structure was confirmed by 1H NMR and ESI-MS, and its photoluminescence properties were determined. The resulting duplex exhibited a dramatically enhanced photoluminescence (PL) quantum efficiency of 63.7% compared to the corresponding 1,8-naphthalimide segment (32.4%), suggesting that the formation of the duplex with larger molecular weight could successfully inhibit the quenching of the fluorescent pendant. This novel duplex is a prospective candidate for new electroluminescent emitter. | Guang Dong LEI Yi YI Zhi Yun LU Ming Gui XIE | 2005 | Chinese Chemical Letters2005，16，9： | 3 |
| 16 | Controlling dispersion and morphology of MoS2 nanospheres by hydrothermal method using SiO2 as template显示文摘Monodispersed MoS_2 nanospheres were successfully synthesized by using SiO_2 as hard template. The size and morphology of the MoS_2 nanospheres could be finely controlled by the content of SiO_2 and sulfur precursors. Furthermore, higher surface area of monodispersed MoS_2 nanospheres exhibited high reaction rate for hydrodesulfurization(HDS) of dibenzenethiophene(DBT). | Zhenwei Zhang Peng Wang Fei Wang Yaqing Li Wei Lu Xingmao Jiang Xia Gui Zhi Yun | 2018 | Chinese Journal of Chemical Engineering2018，26，5： | 3 |
| 17 | Improved One-pot Synthesis of 4,6-Dihydroxyisophthalic Acid and 2,3-Dihydroxyterephthalic Acid显示文摘An improved method for the large-scale preparation of 4,6-dihydroxyisophthalic acid and 2,3-dihydroxyterephthalic acid has been developed. Compared to the previous procedures, this new process requires much lower CO2 pressure of 0.3 Mpa and shorter reaction time, thus providing a convenient access for large-scale synthesis. The yield is high (93% and 65%, respectively), and the oxidation of phenol is nearly inhibited, neither decolorization nor further chromatographic purification is required. | Guang Dong LEI Li Xin LI Zhi Yun LU Ming Gui XIE | 2005 | Chinese Chemical Letters2005，16，8： | 3 |
| 18 | Restriction of iron loading into developing seeds by a YABBY transcription factor safeguards successful reproduction in Arabidopsis显示文摘Iron(Fe)storage in plant seeds is not only necessary for seedling establishment following germination but is also a major source of dietary Fe for humans and other animals.Accumulation of Fe in seeds is known to be low during early seed development.However,the underlying mechanism and biological significance remain elusive.Here,we show that reduced expression of Arabidopsis YABBY transcription factor INNER NO OUTER(INO)increases embryonic Fe accumulation,while transgenic overexpression of INO results in the opposite effect.INO is highly expressed during early seed development,and decreased INO expression increases the expression of NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 1(NRAMP1),which encodes a transporter that contributes to seed Fe loading.The relatively high embryonic Fe accumulation conferred by decreased INO expression is rescued by the nramp1 loss-of-function mutation.We further demonstrated that INO represses NRAMP1 expression by binding to NRAMP1-specific promoter region.Interestingly,we found that excessive Fe loading into developing seeds of ino mutants results in greater oxidative damage,leading to increased cell death and seed abortion,a phenotype that can be rescued by the nramp1 mutation.Taken together,these results indicate that INO plays an important role in safeguarding reproduction by reducing Fe loading into developing seeds by repressing NRAMP1 expression. | Li Sun Yun Qi Wei Kang Hao Wu Jing Ying Yan Jie Na Xu Yun Rong Wu Gui Xin Li Ji Ming Xu Nicholas P.Harberd Zhong Jie Ding Shao Jian Zheng | 2021 | Molecular Plant2021，14，10： | 3 |
| 19 | Continuous production of biodiesel from cottonseed oil and methanol using a column reactor packed with calcined sodium silicate base catalyst显示文摘Sodium silicate and that calcined at 400 °C for 2 h were used to catalyze the transesterification of cottonseed oil with methanol. Calcined sodium silicate(CSS) catalyst exhibited much higher catalytic activity and stability. A maximum biodiesel yield of 98.9% was achieved at methanol/oil mole ratio of 12:1, reaction temperature65 °C, reaction time 3.0 h, and CSS/oil mass ratio of 2 wt%. After 7 consecutive reactions without any treatment,biodiesel yield reduced to 82.5%. Considering technological and economic feasibility, CSS base catalyst supported on θ rings was prepared for continuous transesterification. The maximum yield was 99.1% under optimum conditions(reaction temperature 55 °C, methanol velocity 1 ml·min-1, oil velocity 3 ml·min-1, and 5 tower sections). These results indicate that this new continuous biodiesel production process and apparatus present a great potential for industrial application in biodiesel. | Xia Gui Sichen Chen Zhi Yun | 2016 | Chinese Journal of Chemical Engineering2016，24，4： | 3 |
| 20 | Static and dynamic studies of adsorption by four macroporous resins to enrich oridonin from Rabdosia rubescens显示文摘Oridonin,one of the active ingredients in Rabdosia rubescens(R.rubescens),has been reported to induce cell apoptosis and cell cycle arrest in many cancers.Conventional extraction methods tend to result in unsatisfied enrichment and poor quality of oridonin present in a given biomass.This paper aims to evaluate the performance and separation characteristics of four different macroporous resins to arrive at the most suitable methodology for the isolation and purification of highquality oridonin.Static absorption kinetics,thermodynamic and dynamic adsorption were evaluated.HP20 was selected for further study due to its high adsorption capacity of 32 mgg 1 and desorption ratio with 98.5%.The pseudosecondorder model was considered to be the most suitable for kinetic results,and Langmuir model was chosen to better describe the absorption thermodynamics.Under optimum conditions(flow rate of 4 ml min 1,bed depth with 6 cm and initial concentration of 2.15 mg·ml^1),the effective content of oridonin increased from 33.9%to 79.1%in the dry extract with a recovery of 81%and the purity of oridonin improved from 76%to 93%.The results confirm that HP20 provides an efficient method to purify most oridonin from R.rubescens. | Ling Meng Xia Gui Zhi Yun | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 3 |
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