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| 1 | Third generation of vortex identification methods:Omega and Liutex/Rortex based systems显示文摘A vortex is intuitively recognized as the rotational/swirling motion of fluids,but a rigorous and universally-accepted definition is still not available.Vorticity tube/filament has been regarded equivalent to a vortex since Helmholtz proposed the concepts of vorticity tube/filament in 1858 and the vorticity-based methods can be categorized as the first generation of vortex identification methods.During the last three decades,a lot of vortex identification methods,including 0,A,and Aci criteria,have been proposed to overcome the problems associated with the vorticity-based methods.Most of these criteria are based on the Cauchy-Stokes decomposition and/or eigenvalues of the velocity gradient tensor and can be considered as the second generation of vortex identification methods.Starting from 2014,the Vortex and Turbulence Research Team at the University of Texas at Arlington(the UTA team)focus on the development of a new generation of vortex identification methods.The first fruit of this effort,a new Omega(/2)vortex identification method,which defined a vortex as a connected region where the vorticity overtakes the deformation,was published in 2016.In 2017 and 2018,a Liutex(previously called Rortex)vector was proposed to provide a mathematical definition of the local rigid rotation part of the fluid motion,including both the local rotational axis and the rotational strength.Liutex/Rortex is a new physical quantity with scalar,vector and tensor forms exactly representing the local rigid rotation of fluids.Meanwhile,a decomposition of the vorticity to a rotational part namely Liutex/Rortex and an anti-symmetric shear part(RS decomposition)was introduced in 2018,and a universal decomposition of the velocity gradient tensor to a rotation part(7?)and a non-rotation part(NR、was also given in 2018 as a counterpart of the traditional Cauchy-Stokes decomposition.Later in early 2019,a Liutex/Rortex based Omega method called Omega-Liutex,which combines the respective advantages of both Liutex/Rortex and Omega methods,was developed.And a latest objective Omega method,which is still under development,is also briefly introduced.These advances are classified as the third generation of vortex identification methods in the current paper.To elaborate the advantages of the third-generation methods,six core issues for vortex definition and identification have been raised,including:(1)the absolute strength,(2)the relative strength,(3)the rotational axis,(4)the vortex core center location,(5)the vortex core size,(6)the vortex boundary.The new third generation of vortex identification methods can provide reasonable answers to these questions,while other vortex identification methods fail to answer all questions except for the approximation of vortex boundaries.The purpose of the current paper is to summarize the main ideas and methods of the third generation of vortex identification methods rather than to conduct a comprehensive review on the historical development of vortex identification methods. | Chaoqun Liu Yi-sheng Gao Xiang-rui Dong Yi-qian Wang Jian-ming Liu Yu-ning Zhang Xiao-shu Cai Nan Gui | 2019 | Journal of Hydrodynamics2019，31，2： | 82 |
| 2 | Diet and gastric cancer:a case-control study in Fujian Province,China显示文摘NTRODUCTIONChangleandFuqingcitiesarelocatedinthesoutheasternpartofFujianProvince,Chinawithahighincidenceofgastriccancer.Howev... | YE Wei Min 1, YI Ying Nan 1, LUO Ren Xia 2, ZHOU Tian Shu 3, LIN Ru Tao 1 and CHEN Gui Dong 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 12 |
| 3 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 4 | LBE-DEM coupled simulation of gas-solid two-phase cross jets显示文摘This paper establishes a lattice Boltzmann equation-discrete element method (LBE-DEM) coupled simulation method under the Eulerian-Lagrangian framework at first, and applies it to simulating a two-dimensional gas-solid two-phase cross jet. The gas phase is simulated by the lattice-Boltzmann method via the TD2G9 model; the solid phase is traced by the Lagrangian method and the inter-particle collision is calculated by the DEM method. Three values of the Stokes number St=10, 25, and 50 are simulated under the same mass loading. This paper focuses on the characteristics of vortex structure, particle distribution, and the reverse-flow/rebounding rate in cross jets. We analyze the characteristics of fluid vortex motion, particle cluster distribution, rebounding rate of particles and the influencing factors for them. The results show the existence of joint distribution of discrete clusters and discrete particles in cross jets. Meanwhile, it shows that a larger concentration of particles in the early stage of jet evolution or a smaller Stokes number under the same mass loading can produce a larger rebounding rate. However, the rebounding rate of particles at the late stage, in general, is stable. | GUI Nan XU WenKai GE Liang YAN Jie | 2013 | Science China(Technological Sciences)2013，56，6： | 6 |
| 5 | Protective Effect of Angiotensin(1-7) on Silicotic Fibrosis in Rats显示文摘Objective Silicosis, caused by inhalation of silica dust, is the most serious occupational disease in China and the aim of present study was to explore the protective effect of Ang (1-7) on silicotic fibrosis and myofibroblast differentiation induced by Ang Ⅱ. Methods HOPE-MED 8050 exposure control apparatus was used to establish the rat silicosis model. Pathological changes and collagen deposition of the lung tissue were examined by H.E. and VG staining, respectively. The localizations of ACE2 and a-smooth muscle actin (a-SMA) in the lung were detected by immunohistochemistry. Expression levels of collagen type Ⅰ, a-SMA, ACE2, and Mas in the lung tissue and fibroblasts were examined by western blot. Levels of ACE2, Ang (1-7), and Ang Ⅱ in serum were determined by ELISA. Co-localization of ACE2 and a-SMA in fibroblasts was detected by immunofluorescenee. Results Ang (1-7) induced pathological changes and enhanced collagen deposition in vivo. Ang (1-7) decreased the expressions of collagen type Ⅰ and a-SMA and increased the expressions of ACE2 and Mas in the silicotic rat lung tissue and fibroblasts stimulated by Ang Ⅱ. Ang (1-7) in creased the levels of ACE2 and Ang (1-7) and decreased the level of Ang Ⅱ in silicotic rat serum. A779 enhanced the protective effect of Ang (1-7) in fibroblasts stimulated by Ang Ⅱ. Conclusion Ang (1-7) exerted protective effect on silicotic fibrosis and myofibroblast differentiation induced by Ang Ⅱ by regulating ACE2-Ang (l-7)-Mas axis. | ZHANG Bo Nan XU Hong GAO Xue Min ZHANG Gui Zhen ZHANG Xin YANG Fang | 2019 | Biomedical and Environmental Sciences2019，32，6： | 5 |
| 6 | Elective neck dissection or "watchful waiting": optimal management strategy for early stage NO tongue carcinoma using decision analysis techniques显示文摘背景尽管舌头癌症是头和颈的普通疾病,在选任的颈解剖并且“警惕等待”之间的颈治疗的选择与早舞台为病人仍然保持争论没有口头的舌头 carcinoma.Methods 根据头和颈癌症的当前的状态,一个决定分析模型被创造为早舌头 cancer.Expected 价值( EV )比较二治疗策略根据遇见了定义 criteria.Sensitivity | SONG Tao BI Nan GUI Lai PENG Zhe | 2008 | Chinese Medical Journal2008，，17： | 5 |
| 7 | Numerical simulation of tetrahedral particle mixing and motion in rotating drums显示文摘 | Nan Gui Xingtuan Yang Jiyuan Tu Shengyao Jiang | 2018 | Particuology2018，16，4： | 5 |
| 8 | Study on a New Ultraviolet Sterilizer to the Surface Disinfection of the Ultrasound Probe显示文摘我们学习了消毒效果一新紫外(紫外) 超声探查上的 sterilizer 和它的利用出现。搬运人量的杀菌测试,模仿的即席试用,和有机物质影响测试被用来执行试验性的观察。人工地感染的探针为比较用 sterilizer 或一盏杀菌的灯被消毒。细菌的全部的数字和类型坚定、识别。我们的结果证明 sterilizer 在医院里在三个不同消毒方法之中有最好的消毒效果。sterilizer 没有超声探查仪器的著名损坏在一个医院背景被使用 2 年了。它有快消毒,高消毒效果,和与超声仪器的好相容性的优点,值得是在医药机构的支持的应用。 | CHEN Gui Qiu CHEN Yu Hao YI Liang YIN Jin GAO Qiong SONG Jiang Nan LI Shi Kang CHEN Pei Hou GUO Gui Ping | 2018 | Biomedical and Environmental Sciences2018，31，2： | 5 |
| 9 | Analysis and correlation of fluid acceleration with vorticity and Liutex(Rortex)in swirling jets显示文摘The characteristics of the acceleration a and its correlation with the vortex core in the swirling flow are analyzed in this paper.The swirling flows of four swirl numbers(Sn=n S 0,0.10,0.20 and 0.36)are simulated by the direct numerical simulation,and the fluid mass particles from the inlet of the swirling flow are traced as a database for the current study.The correlations of the acceleration a with the vortex identification parameters of R andωare quantified,where R is the parameter of the“Liutex”-method proposed by Prof.Liu,and its early version is“Rortex”.The probability density functions of the included angles of a-R and a-ωare computed,which are used to clarify the geometrical configuration between a and R.The covariance coefficients between a and the parameters of various vortex core criteria(Q,λ2,ΩL,ΩR,ωand R)are computed and their relative levels of correlation are compared.Compared to the velocity,the expectation and the rms of the acceleration magnitudes and its projections on R and the plane perpendicular to R are computed for better explaining the correlation features between a and R.It is found that a and R are always either perpendicular or parallel to each other with the quantized included angles of∠(a,R)=kπ/2,(k=0,1,2).This confirms the role of R which works as the axis of the vortex exclusively. | Nan Gui Hou-bo Qi Liang Ge Peng-Xin Cheng Hao Wu Xing-tuan Yang Ji-yuan Tu Sheng-yao Jiang | 2019 | Journal of Hydrodynamics2019，31，5： | 4 |
| 10 | Bone Loss Induced by Simulated Microgravity,Ionizing Radiation and/or Ultradian Rhythms in the Hindlimbs of Rats显示文摘Objective To better understand the pathological causes of bone loss in a space environment, including microgravity, ionizing radiation, and ultradian rhythms. Methods Sprague Dawley(SD) rats were randomly divided into a baseline group, a control group, a hindlimb suspension group, a radiation group, a ultradian rhythms group and a combined-three-factor group. After four weeks of hindlimb suspension followed by X-ray exposure and/or ultradian rhythms, biomechanical properties, bone mineral density, histological analysis, microstructure parameters, and bone turnover markers were detected to evaluate bone loss in hindlimbs of rats. Results Simulated microgravity or combined-three factors treatment led to a significant decrease in the biomechanical properties of bones, reduction in bone mineral density, and deterioration of trabecular parameters. Ionizing radiation exposure also showed adverse impact while ultradian rhythms had no significant effect on these outcomes. Decrease in the concentration of the turnover markers bone alkaline phosphatase(b ALP), osteocalcin(OCN), and tartrate-resistant acid phosphatase-5 b(TRAP-5 b) in serum was in line with the changes in trabecular parameters. Conclusion Simulated microgravity is the main contributor of bone loss. Radiation also results in deleterious effects but ultradian rhythms has no significant effect. Combined-three factors treatment do not exacerbate bone loss when compared to simulated microgravity treatment alone. | ZHANG Ya Nan SHI Wen Gui LI He HUA Jun Rui FENG Xiu WEI Wen Jun WANG Ju Fang HE Jin Peng LEI Su Wen | 2018 | Biomedical and Environmental Sciences2018，31，2： | 4 |
| 11 | Comparative assessment and analysis of Rortex vortex in swirling jets显示文摘Recently, a new definition, called Rortex, was proposed to quantify the purely rotational motion of fluids. In this work, based on the DNS data, the Rortex is used to assess and visualize the rotational motion and structure of the vortex in swirling jets in comparison with other kinds of vortex criteria, including Q , λ2,vorticity and Ω criteria. The Rortex vector,Ω, Q and criteria are found to be better than the vorticity criterion for the vortex core identification. The vector triangle formed by the Rortex R , the nonrotational shear S , and the vorticity R is analyzed to give mechanical explanations, especially of the effect of the non-rotational shear on the rotation of fluids. In addition, the probability density distributions (PDF) of the Rortex R , the nonrotational shear S, and the vorticity R are computed. The peak value of the PDF of the vorticity could be used to explain the pure rigid rotation effect and the combination effects of the rigid rotation and the non?rotational shear. | Nan Gui Liang Ge Peng-xin Cheng Xing-tuan Yang Ji-yuan Tu Sheng-yao Jiang | 2019 | Journal of Hydrodynamics2019，31，3： | 3 |
| 12 | LBE–DEM simulation of inter-phase heat transfer in gas–solid cross jets显示文摘Lattice-Boltzmann equation(LBE)–Discrete element method(DEM)coupled simulation of a twodimensional gas–solid cross jet is performed,focusing on the gas-particle two-way coupling effect on heat transfer characteristics.The Reynolds number is 1000,and particle Stokes numbers are 10,25,and 50 under the same number flow rate of particles.The gas phase temperature field and particle distribution as well as the inter-phase heat transfer characteristics are studied and analyzed.The dominating effects,i.e.the mean temperature difference and mean heat transfer coefficient between the gas–solid phases,for the pre-and post-collision stages of the cross jets are illustrated respectively.The change of dominating roles is related to the dynamical response characteristics of particles. | Nan Gui Wenkai Xu Liang Ge Jie Yan | 2014 | Chinese Science Bulletin2014，59，20： | 2 |
| 13 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 14 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 15 | A positive feedback regulatory loop involving the lncRNA PVT1 and HIF-1αin pancreatic cancer显示文摘Extreme hypoxia is among the most prominent pathogenic features of pancreatic cancer(PC).Both the long non-coding RNA(lncRNA)plasmacytoma variant translocation 1(PVT1)and hypoxic inducible factor-1α(HIF-1α)are highly expressed in PC patients and play a crucial role in disease progression.Reciprocal regulation involving PVT1 and HIF-1αin PC,however,is poorly understood.Here,we report that PVT1 binds to the HIF-1αpromoter and activates its transcription.In addition,we found that PVT1 could bind to HIF-1αand increases HIF-1αpost-translationally.Our findings suggest that the PVTl-HIF-1αpositive feedback loop is a potential therapeutic target in the treatment of PC. | Yiping Zhu Fang Wu Weiwei Gui Nan Zhang Erik Matro Linghua Zhu Daniel Turunen Eserberg Xihua Lin | 2021 | Journal of Molecular Cell Biology2021，13，9： | 2 |
| 16 | Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Monlb显示文摘 | Ximing Shao Yi Liu Qian Yu Zhihao Ding Wenyu Qian Lei Zhang Jianchao Zhang Nan Jiang Linfei Gui Zhiheng Xu Yang Hong Yifan Ma Yanjie Wei Xiaoqing Liu Changan Jiang Minyan Zhu Hongchang Li Huashun Li | 2016 | Cell Research2016，26，5： | 1 |
| 17 | Impact of Genetic Polymorphisms in Cytochrome P450 2E1 and Glutathione S-Transferases M1,T1,and P1 on susceptibility to Esophageal Cancer among High-Risk Individuals in China显示文摘 | Wen T Nan S Gui QW | 2000 | Biomark Prev2000，9，： | 1 |
| 18 | The common anesthetic, sevoflurane, induces apoptosis in A549 lung alveolarepithelial cells显示文摘 | Gui?Hua Wei Juan Zhang Da?Qing Liao Zhuo Li Jing Yang Nan?Fu Luo Yan Gu | 2014 | Molecular Medicine Reports2014，，1： | 1 |
| 19 | Inhibition of L-type Ca 2+ channels by curcumin requires a novel protein kinase-theta isoform in rat hippocampal neurons显示文摘 | Kangyong Liu Bo Gui Yinyi Sun Nan Shi Zhaohua Gu Ting Zhang Xiaojiang Sun | 2012 | Cell Calcium2012，，： | 1 |
| 20 | Gelcasting of PZT显示文摘 | GUO Dong CAI Kai LI Long-tu NAN Ce-wen GUI Zhi-lun | 2003 | Ceramics International2003，29，4： | 1 |
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