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	题名	作者	年代	出处	被引量
1	Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase显示文摘The interplay between inflammation and cancer progression is a growing area of research. A combination of clinical, epidemiological, and basic science investigations indicate that there is a relationship between inflammatory changes in the pancreas and neoplastic progression. Diets high in ω-6 polyunsaturated fatty acids provide increased substrate for arachidonic acid metabolism by cyclooxygenase-2(COX-2) and 5-lipoxygenase(5-LOX) to form eicosanoids. These eicosanoids directly contribute to pancreatic cancer cell proliferation. Both COX-2 and 5-LOX are upregulated in multiple cancer types, including pancreatic cancer. In vitro studies using pancreatic cancer cell lines have demonstrated upregulation of COX-2 and 5-LOX at both the mRNA and protein levels. When COX-2 and 5-LOX are blocked via a variety of mechanisms, cancer cell proliferation is abrogated both in vitro and in vivo.The mechanism of COX-2 has been shown to include effects on apoptosis as well as angiogenesis. 5-LOX has been implicated in apoptosis. The use of COX-2 and 5-LOX inhibitors in clinical studies in patients with pancreatic cancer has been limited. Patient enrollment has been restricted to those with advanced disease which makes evaluation of these drugs as chemopreventive agents difficult. COX-2 and 5-LOX expression have been shown to be present during the early neoplastic changes of pancreatic cancer, well before progression to invasive disease. This indicates that the ideal role for these interventions is early in the disease process as preventive agents, perhaps in patients with chronic pancreatitis or hereditary pancreatitis.	Lawrence M Knab Paul J Grippo David J Bentrem	2014	World Journal of Gastroenterology2014，20，31：	9
2	Stress, depression and cardiovascular dysregulation: A review of neurobiological mechanisms and the integration of research from preclinical disease models显示文摘	Angela J. Grippo Alan Kim Johnson	2009	Stress: The International Journal on the Biology of Stress2009，，1：	2
3	The Computer-Aided Design of Modular Fixturing Systems 显示文摘	Grippo P M Gandhi M V Thompson B S	1987	The Int J ofAdv ManufTechnology1987，2，2：	1
4	Increased suscepti-bility to ventricular arrhythmias in a rodent model of experimen-tal depression显示文摘	Grippo AJ Santos CM Johnson RF	2004	AmJ Physiol Heart Cir Physiol2004，286，3：	1
5	Attrition,abrasion,corrosion and abfraction revisited:A new perspective on tooth surface lesions显示文摘	Grippo JO Simring M Schreiner S	2004	J Am Dent Assoc2004，135，8：	1
6	A new augmented Lagrangian function for inequality constraints in nonlinear programming problems 显示文摘	DI PILLO G GRIPPO L	1982	Journal of Optimization Theory and Applications1982，36，：	1
7	Biological mechanisms in the relationship between depression and heart disease显示文摘	Grippo AJ Johnson AK	2002	Neurosci Biobehav Rev2002，26，8：	1
8	The effects of optic disc drusen on the latency of the pattern-reversal checkerboard and multifocal visual evoked potentials显示文摘	Grippo T M Ezon I Kanadani F N	2009	Invest Ophthalmol Vis Sci2009，50，9：	1
9	A nonmonotone line search technique for Newton' s method显示文摘	GRIPPO L LAMPARIELLO F LUCIDI S		0，，：	1
10	A comparison between multifocal and conventional VEP latency changes secondary to glaucomatous damage显示文摘	Grippo TM Hood DC Kanadani FN	2006	Invest Ophthalmol Vis Sci2006，47，12：	1
11	Effect of peginterferon alfa‐2a (40 KD ) on cytochrome P 450 isoenzyme activity显示文摘	Barbara J. Brennan Zhi‐Xin Xu Joseph F. Grippo	2013	Br J Clin Pharmacol2013，，2：	1
12	A Globally Convergent Version of the Polak-Rebiere Conjugate Gradient Method 显示文摘	GRIPPO L- LUCIDI S	1997	M athematicalProgramming1997，78，3：	1
13	The effects of optic disc drusen on the latency of the pattern-reversal checkerboard and multifocal visual evoked potentials显示文摘	Grippo TM Ezon I Kanadani FN	2009	Invest Ophthalmol Vis Sci2009，50，9：	1
14	A nonmonotone line search technique for newton' s method显示文摘	Grippo L Lampariello F Lucidi S	1986	SIAM Journal of Numerical Analysis1986，23，：	1
15	A globally convergent version of the Polak-Ribiere conjugate gradient method显示文摘	GRIPPO L LUCIDI S	1997	Math Prog1997，78，：	1
16	Increased susceptibilityto ventricular arrhythmias in a rodent model of experimental depression 显示文摘	Grippo AJ Santos CM Johnson RF	2004	Am J Physiol Heart Circ Physiol2004，286，2：	1
17	Predicion of ' awakening'and outcome in prolonged acute coma from severe traumatic brain injury:evidence for validity of short latency SEPs显示文摘	Amantini A Grippo A Fossi S		0，，01：	1
18	How to get more cast per blast显示文摘		1984	Coal Age1984，89，12：	1
19	On the convergence of the block nonlinear Gauss-Seidel method under convex constraints显示文摘	GRIPPO L SCIANDRONE M	2000	Opera- tions Research Letters2000，26，3：	1
20	A nonmonotone linesearch technique for Newton’s method 显示文摘	Grippo L Lampariello F Lucidi S	1986	SIAM Journal onNumerical Analysis1986，23，8：	1

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