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| 1 | Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI显示文摘AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVueüà-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrastenhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The f inal diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVueüà -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specif icity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specif icity of CEUS for the identif ication of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVueüà-enhanced sonography emerges as the most sensitive, most specif ic and thus most accurate imaging modality for the characterization of focal liver lesions. | Hervé Trillaud Jean-Michel Bruel Pierre-Jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis | 2009 | World Journal of Gastroenterology2009，15，30： | 34 |
| 2 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 3 | Absorptive capacity and new product development显示文摘 | Stock G N Greis N P Fischer W A | 2001 | Journal of High Technology Management Research2001，12，1： | 1 |
| 4 | Ab- sorptive Capacity and New Product Development 显示文摘 | STOCK G N GREIS N P FISCHER W A | 2001 | Journal of High Technology Management Re- search2001，12，1： | 1 |
| 5 | Photoaffinity cross-linking of Alzheimer's disease amyloid fibrils reveals interstrand contact regions between assembled beta-amyloid peptide subunits显示文摘 | EGNACZYK G F GREIS K D STIMSON E R | 2001 | Biochemistry2001，40，11： | 1 |
| 6 | Absorptive ca- pacity and new product development 显示文摘 | Stock G N Greis N P Fischer W A | 2001 | The Jour- nal of High Technology Management Research2001，12，1： | 1 |
| 7 | Absorptive capac- ity and new product development 显示文摘 | Stock G N Greis N P Fischer W A | 2001 | The Journal of High Technology Management Research2001，12，1： | 1 |
| 8 | FischerAbsorptive Capacity and New Product Development显示文摘 | Stock G N N P Greis W A | 2001 | Journal of High Technology Management Research2001，12，1： | 1 |
| 9 | Enterprise logistics and supply chain structure:The role of fit显示文摘 | Stock G N Greis N P Kasarda J D | | 0，，05： | 1 |
| 10 | Firm size and dynamic technological innovation 显示文摘 | Stock G N Greis N P Fischer W A | 2002 | Teehnovation2002，22，9： | 1 |
| 11 | Intermittent self-dilatation after internal urethrotomy for primary urethral strictures:a case-control study显示文摘 | LAURITZEN M GREIS G SANDBERG A | 2009 | Scand J Urol Nephrol2009，43，3： | 1 |
| 12 | Enterprise logistics and supply chain structure: the role of fit显示文摘 | Stock G N Greis N P Kasarda J D | 2000 | Journal of Operations Management2000，5，： | 1 |
| 13 | Enterprise logistics and supply chain structure: the role of fit 显示文摘 | Stock G N Greis N P Kasarda J D | 2000 | Journal of Operations Management2000，18，5： | 1 |
| 14 | Determining the value of dedicated multimodat cargo facilities in a multi-region distribution network 显示文摘 | Warsing D P Souza G C Greis N P | 2001 | European Journal of Operational Research2001，133，2： | 1 |
| 15 | Enterprise logistics and supply chain structure: the role of fit显示文摘 | STOCK G N GREIS N P KASARDA J D | 2000 | Journal of Operations Management2000，18，5： | 1 |
| 16 | Logistics,Strategy,and structure:A conceptual framework显示文摘 | Stock G N Greis N P Kasarda J D | | 0，，01： | 1 |
| 17 | Glenohumeral artic- ular contact areas and pressures following labral and os- seous injury to the anteroinferior quadrant of the glenoid显示文摘 | Greis P E Scuderi M G Mohr A | 2002 | J Shoulder Elbow Surg2002，11，5： | 1 |
| 18 | Game-Theoretic Analysis of Cooperation Among Supply Chain Agents显示文摘 | Mahesh N G Greys S C | 2008 | European Journal of Operational Research2008，187，3： | 1 |
| 19 | The hypolipidemic natural product Commiphora mukul and its component guggulsterone inhibit oxidative modification of LDL 显示文摘 | WANG X GREI L J LEDINSKI G | 2004 | Atherosclerosis2004，172，2： | 1 |
| 20 | Absorptive capacity and new product development 显示文摘 | Stock G N Greis N P Fischer W A | 2001 | Journal of High Technology Management Research2001，12，： | 1 |
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