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| 1 | Classification of submucosal tumors in the gastrointestinal tract显示文摘This review is part two of three, which will present an update on the classification of gastrointestinal submucosal tumors. Part one treats of the diagnosis and part three of the therapeutic methods regarding gastrointestinal submucosal tumors. In the past there has been some confusion as to the classification of gastrointestinal submucosal tumors. Changes in classifications have emerged due to recent advances in mainly immunohistochemistry and electron microscopy. The aim of this paper is to update the reader on the current classification. Literature searches were performed to find information related to classification of gastrointestinal submucosal tumors. Based on these searches the twelve most frequent submucosal tumor types were chosen for description of their classification. The factors that indicate whether tumors are benign or malignant are mainly size and number of mitotic counts. Gastrointestinal stromal tumors are defined mainly by their CD117 positivity. In the future, there should be no more confusion between gastrointestinal stromal tumors and other types of submucosal tumors.2007 The WJG Press. All rights reserved. | Laura Graves Ponsaing Katalin Kiss Mark Berner Hansen | 2007 | World Journal of Gastroenterology2007，13，24： | 44 |
| 2 | PBL:教育实践和研究的未来挑战显示文摘本文是一篇有关PBL的评论性研究,根据现代学习理论,作者论述了四个有关学习的原则,解释了这些原则在PBL中的应用,并对已进行的研究进行了评议。 | Diana HJM Dolmans Willem De Grave Ineke HAP Wolfhagen Cees PM van der Vleuten 梅人朗 | 2008 | 复旦教育论坛2008，6，1： | 44 |
| 3 | Diabetes mellitus related bone metabolism and periodontal disease显示文摘Diabetes mellitus and periodontal disease are chronic diseases affecting a large number of populations worldwide.Changed bone metabolism is one of the important long-term complications associated with diabetes mellitus.Alveolar bone loss is one of the main outcomes of periodontitis,and diabetes is among the primary risk factors for periodontal disease.In this review,we summarise the adverse effects of diabetes on the periodontium in periodontitis subjects,focusing on alveolar bone loss.Bone remodelling begins with osteoclasts resorbing bone,followed by new bone formation by osteoblasts in the resorption lacunae.Therefore,we discuss the potential mechanism of diabetes-enhanced bone loss in relation to osteoblasts and osteoclasts. | Ying-Ying Wu E Xiao Dana T Graves | 2015 | International Journal of Oral Science2015，7，2： | 30 |
| 4 | 大别造山带磷灰石裂变径迹(AFT)年代学研究显示文摘大别山花岗岩与变质岩的AFT热年代分布于96.4~41.9Ma之间,围限径迹长度为11.5~14.0μm.热年代代表岩石差异通过100℃等温面时的冷却时代,这种差异性主要受控于NNE向区域构造,在北淮阳与合肥盆地,沉积岩样品(侏罗纪~早第三纪)AFT年代为128.8~62.0Ma,围限径迹长度为8.6~11.9μm,它们更多反映盆地埋藏加热的信息,合肥盆地与大别造山带之间存在构造耦合关系,95~90Ma属于大别山构造推隆取代伸展热窿的转折期,其成因可能与西太平洋域汇聚变化特性有关:商城-麻城与郯-庐两断裂之间左旋差异走滑与构造推隆作用,使得大别腹地伸展热窿在晚白垩世急剧萎缩.早第三纪时期,受西太平洋域汇聚速率急剧下降的影响,欧亚东缘表现出广泛的拉张环境,大别山60~40Ma带状热异常应与这种拉张作用有关;郯-庐热中心的冷却(70~40Ma)要比商城-麻城热中心(60~55Ma)缓慢,而大别腹地热隆区(60~40Ma)属于伸展热窿萎缩之残留.大别山早第三纪还遭受喜马拉雅山碰撞域的远场影响,这种影响多通过NWW向断裂来实现构造传递:进入渐新世一中新世,大别山冷却波动仍显现区域差异性,它们在时间上与南海盆地扩张、关闭事件相近. | 许长海 周祖翼 P.Van Den Haute R.A.Donelick J.De Grave 马昌前 P.W.Reiners | 2004 | 中国科学(D辑)2004，34，7： | 27 |
| 5 | Therapeutic procedures for submucosal tumors in the gastrointestinal tract显示文摘This review is part three of three and will present an update on the therapeutic options and procedures concerning gastrointestinal (GI) submucosal tumors (SMTs). The aim of this paper is to investigate the treatments of GI SMTs and to present a case of a gastrointestinal stromal tumor (GIST). Literature searches were performed to find information on therapy for GI SMTs. Based on these searches, the optimal therapeutic procedures could be outlined. The choice of treatment of localized tumors is endoscopic resection if possible or, alternatively, laparoscopic resection or surgical resection by an open procedure. However, benign SMTs should only be excised if symptoms are present, and GISTs should be treated with particular precautions. Irresectable or recurrent GISTs may be successfully treated with the tyrosine kinase inhibitor, imatinib. | Laura Graves Ponsaing Mark Berner Hansen | 2007 | World Journal of Gastroenterology2007，13，24： | 28 |
| 6 | Diagnostic procedures for submucosal tumors in the gastrointestinal tract显示文摘This review is part one of three, which will present an update on diagnostic procedures for gastrointestinal (GI) submucosal tumors (SMTs). Part two identifies the classification and part three the therapeutic methods regarding GI SMTs. Submucosal tumors are typically asymptomatic and therefore encountered incidentally. Advances in diagnostic tools for gastrointestinal submucosal tumors have emerged over the past decade. The aim of this paper is to provide the readers with guidelines for the use of diagnostic procedures, when a submucosal tumor is suspected. Literature searches were performed to find information on diagnostics for gastrointestinal submucosal tumors. Based on the searches, the optimal diagnostic procedures and specific features of the submucosal tumors could be outlined. Standard endoscppy, capsule endoscopy and push-and-pull enteroscopy (PPE) together with barium contrast X-ray do not alone provide sufficient information, when examining submucosal tumors. Endoscopic ultrasound (EUS), computed tomography (CT), magnetic resonance imaging (MRI) and fluorodeoxyglucose-labeled positron emission tomography (FDG-PET) are recommended as supplementary tools. | Laura Graves Ponsaing Katalin Kiss Annika Loft Lise Ingemann Jensen Mark Berner Hansen | 2007 | World Journal of Gastroenterology2007，13，24： | 25 |
| 7 | Exhuming the Meso-Cenozoic Kyrgyz Tianshan and Siberian Altai-Sayan:A review based on low-temperature thermochronology显示文摘Thermochronological datasets for the Kyrgyz Tianshan and Siberian Altai-Sayan within Central Asia reveal a punctuated exhumation history during the Meso-Cenozoic.In this paper,the datasets for both regions are collectively reviewed in order to speculate on the links between the Meso-Cenozoic exhumation of the continental Eurasian interior and the prevailing tectonic processes at the plate margins.Whereas most of the thermochronological data across both regions document late Jurassic-Cretaceous regional basement cooling,older landscape relics and dissecting fault zones throughout both regions preserve Triassic and Cenozoic events of rapid cooling,respectively.Triassic cooling is thought to reflect the Qjangtang- Eurasia collision and/or rifting/subsidence in the West Siberian basin.Alternatively,this cooling signal could be related with the terminal terrane-amalgamation of the Central Asian Orogenic Belt.For the Kygyz Tianshan,late Jurassic-Cretaceous regional exhumation and Cenozoic fault reactivations can be linked with specific tectonic events during the closure of the Palaeo-Tethys and Neo-Tethys Oceans,respectively.The effect of the progressive consumption of these oceans and the associated collisions of Cimmeria and India with Eurasia probably only had a minor effect on the exhumation of the Siberian Altai-Sayan.More likely,tectonic forces from the east(present-day coordinates) as a result of the building and collapse of the Mongol-Okhotsk orogen and rifting in the Baikal region shaped the current Siberian Altai-Sayan topography.Although many of these hypothesised links need to be tested further,they allow a first-order insight into the dynamic response and the stress propagation pathways from the Eurasian margin into the continental interior. | Stijn Glorie Johan De Grave | 2016 | Geoscience Frontiers2016，7，2： | 13 |
| 8 | Biogenesis of Mammalian MicroRNAs:A Global View显示文摘MicroRNAs (miRNAs) are approximately 22-nucleotide-long non-coding RNAs that are important regulators of gene expression in eukaryotes. miRNAs are first transcribed as long primary transcripts, which then undergo a series of processing steps to produce the single-stranded mature miRNAs. This article reviews our current knowledge of the mechanism and regulation of mammalian miRNA expression and points out areas of research that may enhance our understanding of how the specificity and efficiency of miRNA production is controlled in vivo. | Paul Graves Yan Zeng | 2012 | Genomics, Proteomics & Bioinformatics2012，10，5： | 12 |
| 9 | RANKL deletion in periodontal ligament and bone lining cells blocks orthodontic tooth movement显示文摘The bone remodeling process in response to orthodontic forces requires the activity of osteoclasts to allow teeth to move in the direction of the force applied. Receptor activator of nuclear factor-κB ligand(RANKL) is essential for this process although its cellular source in response to orthodontic forces has not been determined. Orthodontic tooth movement is considered to be an aseptic inflammatory process that is stimulated by leukocytes including T and B lymphocytes which are presumed to stimulate bone resorption. We determined whether periodontal ligament and bone lining cells were an essential source of RANKL by tamoxifen induced deletion of RANKL in which Cre recombinase was driven by a 3.2 kb reporter element of the Col1α1 gene in experimental mice(Col1α1.CreER^(TM+).RANKL^(f/f)) and compared results with littermate controls(Col1α1.CreER^(TM-).RANKL^(f/f)). By examination of Col1α1.CreER^(TM+).ROSA26 reporter mice we showed tissue specificity of tamoxifen induced Cre recombinase predominantly in the periodontal ligament and bone lining cells. Surprisingly we found that most of the orthodontic tooth movement and formation of osteoclasts was blocked in the experimental mice, which also had a reduced periodontal ligament space. Thus, we demonstrate for the first time that RANKL produced by periodontal ligament and bone lining cells provide the major driving force for tooth movement and osteoclastogenesis in response to orthodontic forces. | Chia-Ying Yang Hyeran Helen Jeon Ahmed Alshabab Yu Jin Lee Chun-Hsi Chung Dana T. Graves | 2018 | International Journal of Oral Science2018，10，1： | 10 |
| 10 | Apatite-fission-track geochronology and its tectonic correlation in the Dabieshan orogen,central China显示文摘AFT data of granitoid and metamorphic samples from the Dabieshan orogen have an age range between 96.4 Ma and 41.9 Ma coupled with confined track lengths of 11.5—14.0 μm, reflecting the cooling time of rocks differentially through the 100℃± isotherm. The Juras- sic-Eogene sediments from the North Huaiyang and Hefei basin, however, yield their AFT ages of 128.8—62.0 Ma with mean track lengths of 8.6—11.9 μm, recording a complicated thermal de- velopment of the basin. These AFT data structurally allowing the coupling between the orogen and the basin are to a great extent considered as the result from the control of NNE-trending regional tectonics. It took place approximately at 95—90 Ma that the orogen developed with an abrupt shift from the doming extension to the differential transtension, which is assumed to be related with the changes of the convergence between the Western Pacific and Eurasia plates. The differentially sinistral strike-slipping from the transtension between Tanlu and Shang- cheng-Macheng faults brought the doming extension of the orogen shrunk sharply in Late Cre- taceous. In Eogene, the full-grown transtension that dominated in East Asia was caused mainly by a rapid decrease of the rates of the Western Pacific convergence, which can be therefore re- garded as a major mechanism creating the zonal anomalies of 60—40 Ma in the orogen. The thermal anomaly of 70—40 Ma zonally along the Tanlu fault cooled more slowly than the anomaly of 60—55 Ma zoning along the Shangcheng-Macheng fault, but the 60—40 Ma anomaly trending E-W in hinterlands of the orogen seems to be relicts of the doming extension as a result of inten- sive rebuilding by the transtension. In addition, the orogen was also reactivated by the far-field effect from India-Asia collision in Eogene, where major NWW-trending faults played an important role in facilitating such far-field tectonic transferring. In Oligocene to Miocene, the Dabieshan orogen remained a few thermal disturbances with their AFT ages particularly in coincidence with the time of opening and closing of the South China Sea. | P. Van Den Haute R. A. Donelick J. De Grave MA Changqian P. W. Reiners | 2005 | Science China Earth Sciences2005，48，4： | 9 |
| 11 | Assessment of the cardiovascular and gastrointestinal autonomic complications of diabetes显示文摘The global prevalence of diabetes mellitus is increasing; arguably as a consequence of changes in diet, lifestyle and the trend towards urbanization. Unsurprisingly, the incidence of both micro and macrovascular complications of diabetes mirrors this increasing prevalence. Amongst the complications with the highest symptom burden, yet frequently under-diagnosed and sub-optimally treated, is diabetic autonomic neuropathy, itself potentially resulting in cardiovascular autonomic neuropathy and gastrointestinal(GI) tract dysmotility. The aims of this review are fourfold. Firstly to provide an overview of the pathophysiological processes that cause diabetic autonomic neuropathy. Secondly, to discuss both the established and emerging cardiometric methods for evaluating autonomic nervous system function in vivo. Thirdly, to examine the tools for assessing pan-GI and segmental motility and finally, we will provide the reader with a summary of putative non-invasive biomarkers that provide a pathophysiological link between lowgrade neuro inflammation and diabetes, which may allow earlier diagnosis and intervention, which in future may improve patient outcomes. | Christina Brock Birgitte Brock Anne Grave Pedersen Asbjorn Mohr Drewes Niels Jessen Adam D Farmer | 2016 | World Journal of Diabetes2016，7，16： | 5 |
| 12 | Stage of change and motivation to healthier lifestyle in non-alcoholic fatty liver disease显示文摘 | Elena Centis Simona Moscatiello Elisabetta Bugianesi Stefano Bellentani Anna Ludovica Fracanzani Simona Calugi Salvo Petta Riccardo Dalle Grave Giulio Marchesini | 2012 | Journal of Hepatology2012，，： | 5 |
| 13 | 医疗器械采购的全球最佳实践显示文摘为了应对日益膨胀的医疗支出,各国政府和医疗机构采取了包括对医疗器械进行竞争性招标在内的多种成本控制方法。虽然此举可以增加采购方的议价能力,从而降低采购成本,但对从根本上降低整体医疗开支仍收效甚微。 | Ken Graves 陈玮 | 2012 | 中国医疗器械信息2012，18，1： | 4 |
| 14 | Meso-Cenozoic tectonic evolution of the Talas-Fergana region of the Kyrgyz Tien Shan revealed by low-temperature basement and detrital thermochronology显示文摘This study provides new low-temperature thermochronometric data, mainly apatite fission track data on the basement rocks in and adjacent to the Talas-Fergana Fault, in the Kyrgyz Tien Shan in the first place.In the second place, we also present new detrital apatite fission track data on the Meso-Cenozoic sediments from fault related basins and surrounding intramontane basins. Our results confirm multistaged Meso-Cenozoic tectonic activity, possibly induced by the accretion of the so-called Cimmerian blocks to the Eurasian margin. New evidence for this multi-staged thermo-tectonic activity is found in the data of both basement and Meso-Cenozoic sediment samples in or close to the Talas-Fergana Fault.Zircon(U-Th)/He and apatite fission track data constrain rapid Late TriassiceE arly Jurassic and Late JurassiceE arly Cretaceous basement cooling in the Kyrgyz Tien Shan around 200 Ma and 130 -100 Ma respectively. Detrital apatite fission track results indicate a different burial history on both sides of the Talas-Fergana Fault. The apatite fission track system of the Jurassic sediments in the Middle Tien Shan unit east of the Talas-Fergana Fault is not reset, while the Jurassic sediments in the Fergana Basin and Yarkand-Fergana Basin, west of the fault zone, are partially and in some cases even totally reset. The totally reset samples exhibit Oligocene and Miocene ages and evidence the Cenozoic reactivation of the western Kyrgyz Tien Shan as a consequence of the India-Eurasia convergence. | Simon Nachtergaele Elien De Pelsmaeker Stijn Glorie Fedor Zhimulev Marc Jolivet Martin Danisík Mikhail M.Buslov Johan De Grave | 2018 | Geoscience Frontiers2018，9，5： | 4 |
| 15 | Problem‐based learning: future challenges for educational practice and research显示文摘 | Diana H J MDolmans WillemDe Grave Ineke H A PWolfhagen Cees P MVan Der Vleuten | 2005 | Medical Education2005，，7： | 4 |
| 16 | The Raman modes of the Aurivillius phases: temperature and polarization dependence 显示文摘 | GRAVES P R HUA G MYHRA S | 1995 | J Solid State Chem1995，114，： | 3 |
| 17 | Impact of Preoperative Ureteral Stenting on Outcome of Ureteroscopic Treatment for Urinary Lithiasis显示文摘 | John M. Shields Vincent G. Bird Reid Graves Orlando Gómez-Marín | 2009 | The Journal of Urology2009，，6： | 3 |
| 18 | Two-year results of a feasibility study on antireflux transoral incisionless fundoplication using EsophyX显示文摘 | Guy-Bernard Cadière Nathalie Sante Jaime E. Graves Anna K. Gawlicka Amin Rajan | 2009 | Surgical Endoscopy2009，，5： | 2 |
| 19 | Effects of GnRH treatment on superovulatory responses of dairy cows显示文摘 | Wubiset A Graves C N Spahr S L | 1986 | Theriogenology1986，25，： | 2 |
| 20 | Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight显示文摘Neuropeptide Y(NPY) is widely expressed in the central nervous system and influences many physiological processes.It is located within the rat quantitative trait locus(QTL) for alcohol preference on chromosome 4.Alcohol-nonpreferring(NP) rats consume very little alcohol,but have significantly higher NPY expression in the brain than alcohol-preferring(P) rats.We capitalized on this phenotypic difference by creating an Npy knockout(KO) rat using the inbred NP background to evaluate NPY effects on alcohol consumption.Zinc finger nuclease(ZNF) technology was applied,resulting in a 26-bp deletion in the Npy gene.RT-PCR,Western blotting and immunohistochemistry confirmed the absence of Npy mRNA and protein in KO rats.Alcohol consumption was increased in Npy^(+/-) but not Npy^(-/-) rats,while Npy^(-/-) rats displayed significantly lower body weight when compared to Npy^(+/+) rats.In whole brain tissue,expression levels of Npy-related and other alcohol-associated genes,Npy1 r,Npy2r,Npy5 r,Agrp,Mc3 r,Mc4r,Crh and CrMr,were significantly greater in Npy^(-/-) rats,whereas Pome and Crhr2 expressions were highest in Npy^(+/-) rats.These findings suggest that the NPY-system works in close coordination with the melanocortin(MC) and corticotropin-releasing hormone(CRH) systems to modulate alcohol intake and body weight. | Bin Qiu Richard L.Bell Yong Cao Lingling Zhang Robert B.Stewart Tamara Graves Lawrence Lumeng Weidong Yong Tiebing Liang | 2016 | Journal of Genetics and Genomics2016，43，7： | 2 |
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