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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | 石灰石的煅烧分解及其吸收二氧化碳机理显示文摘在天然气或合成气制氢过程中,借助于石灰石煅烧分解与石灰吸收二氧化碳的化学循环反应,去除反应产物,破坏化学平衡,可以连续地驱动化学反应进行,从而提高氢气的产率,同时控制温室气体二氧化碳的排放.在多功能热重反应器(TGR)内就化学循环反应过程中的颗粒尺寸、温度煅烧分解率等对吸附剂煅烧分解和吸收特性的影响进行了比较充分的实验研究.当吸收反应温度在500℃~620℃范围内时,CaO吸收二氧化碳的反应速率与石灰石中钙的利用率都维持在比较高的水平,石灰石分解后产生的氧化钙的利用率增长比石灰石的分解率增长慢,分解率高,吸热量也高,因此,简单地提高石灰石的分解率并不是提高石灰石钙利用率的最佳选择。 | 阎常峰 陈勇 李小森 Grace J R Jim Lim | 2006 | 煤炭转化2006，29，2： | 7 |
| 3 | 天然气自热重整模块化流化床膜反应器的测试显示文摘针对燃料电池等行业对分布式高纯度氢气的需求,研发了一种新型模块化流化床膜反应器用于中小规模天然气水蒸汽自热重整制氢。在一个天然气制氢测试平台上对该反应器进行了中试研究,测试了空气引入方式对床层温度均匀性的影响,钯膜组件及催化剂的工作性能,并将反应器尾气成分与平衡态最小自由能模型预测的结果进行了比较。测试结果表明该新型模块化流化床膜反应器适于天然气自热重整制氢。 | 解东来 Adris A M Lim C J Grace J R | 2009 | 太阳能学报2009，30，5： | 6 |
| 4 | 二维导流管喷动床的流动特征显示文摘带导流管的二维喷动床(2-DSBDP)是传统喷动床的改进型式,矩形床内设置的与床同厚的垂直导流管可以控制固体颗粒的循环速率, 同时使下行区中的气固移动床维持平推流. 本文实验测定了不同表观气速、床层高度、固体颗粒与气体入口尺寸时, 二维导流管喷动床的床压降及相应的空隙率,藉以阐述2-DSBDP的流动特征. | 罗保林 Freitas L A P Lim C J Grace J R | 2000 | 化工冶金2000，21，4： | 5 |
| 5 | Sulfation and Reaction Characteristics of Nine limestones显示文摘 | Maursen K Duo W Grace J R | 1999 | Fuel1999，79，2： | 2 |
| 6 | Hydrodynamics of spouted and spout-fluidized beds at high temperature 显示文摘 | Ye B Lim C J Grace J R | 1992 | The Canadian Journal of Chemical Engineering1992，70，5： | 2 |
| 7 | Does Nonalcoholic Fatty Liver Disease Predispose Patients to Hepatocellular Carcinoma in the Absence of Cirrhosis?显示文摘 | Guzman Grace Brunt Elizabeth M Petrovic Lydia M Chejfec Gregorio Layden Thomas J Cotler Scott J | 2008 | Archives of Pathology & Laboratory Medicine2008，，11： | 2 |
| 8 | Immortalization of primary human keratinocytes by the helix-loop-helix protein Id-1显示文摘 | Hasskarl J Grace M | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 9 | Characteristics of gas-solids fluidizad beds in different flow regimes显示文摘 | Bai D Issangya Y S Grace J R | 1999 | Industrial Engineering Chemistry Research1999，38，： | 1 |
| 10 | Overview and sortie issues related to co-firing biomass and coal 显示文摘 | Dai J J Sokhansanj S Grace J R | 2008 | Canadian Journal of Chemical Engineering2008，86，3： | 1 |
| 11 | Physico-chemical screening of phosphate-removing substrates for use in constructed wetland systems 显示文摘 | DRIZO A FROST C A GRACE J | 1999 | Water Research1999，33，17： | 1 |
| 12 | Equilib- rium modeling of gasification: a free energy minimization approach and its application to a circulating fluidized bed coal gasifier显示文摘 | LI X GRACE J R WATKINSON A P | 2001 | Fuel2001，80，2： | 1 |
| 13 | Carbonation in concrete infrastructure in the context of global climate change-Part 1 :Ex- perimental results and model development显示文摘 | TALUKDAR S BANTHIA N GRACE J R | 2012 | Cement & Concrete Composite2012，，34： | 1 |
| 14 | The relationship between species density and community biomazs in grazed and ungrazed coastal meadows显示文摘 | Grace J B Jutila H | 1999 | Oikos1999，85，2： | 1 |
| 15 | Global positioning guidance boosts projectile proficiency显示文摘 | GRACE J | 1999 | Signal1999，，12： | 1 |
| 16 | SOz removal and CO2 capture by limestone resulting from calcination/sulfation/carbonation cycles显示文摘 | Li Y Buchi S Grace J R | 2005 | Energy and Fuels2005，19，5： | 1 |
| 17 | Voidage profiles in a circulating fluidized bed of square cross-section显示文摘 | Zhou J Grace J R Qin S | 1994 | Chemical Engineering Science1994，49，19： | 1 |
| 18 | Biomass gasification in a circulating fluidized bed显示文摘 | Li X T Grace J R Lim C J | | 0，，02： | 1 |
| 19 | Evidence for indirect effects of pain cataslrophizing on clinical pain among myofasciai temporomandibular disorder participants: the mediating role of sleep disturbance显示文摘 | Buenaver LF Quartana P J Grace EG | 2012 | Pain2012，153，6： | 1 |
| 20 | A model-based tool to predict the propagation of infectious disease via airports 显示文摘 | Grace MH Paula J John HJ | 2012 | Travel Med Infect Dis2012，10，1： | 1 |
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