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| 1 | Gilbert's syndrome: High frequency of the (TA)_7 TAA allele in India and its interaction with a novel CAT insertion in promoter of the gene for bilirubin UDP-glucuronosyltransferase 1 gene显示文摘瞄准:在吉伯的症候群(GS ) 在 UDP-glucuronosyltransferase 1 (UGT1A1 ) 基因识别变体并且在印度在正常控制之中在 TA 插入和它的影响的印度,以及频率为 TA 插入和 GS 估计在纯合性之间的协会。方法:95 个 GS 盒子和 95 正常控制被选择。肝工作,另外的测试被做。倡导者和 UGT1A1 基因的所有 5 前 ons 被重新定序。对新奇 trinucleotide 插入的功能的评价被做由在 silico 分析并且由估计 UGT1A1,倡导者活动在 Hep G2 由适当构造的酶记者试金执行了房间线。结果:在 GS 病人之中, 80% 为 TA 插入是同型结合的,它比从另外的种族组的报告高好几倍。吝啬的 UCB 水平与仅仅这插入的一个拷贝在个人之中被提高,它不与有二个拷贝的那些显著地不同。在 UGT1A1 基因的许多新 DNA 变体被发现,包括在倡导者的插入在 GS 病人的一个子集(10%) 发现了的 trinucleotide (猫) ,然而并非在正常之中控制。In-silico 分析证明在倡导者和功能的分析的合拢 DNA 的显著变化在 UGT1A1 基因源于这插入的抄写效率显示出 20 褶层减小,显著地从而提高 UCB 水平。结论:GS 的基因传染病学越过种族组是可变的,在 UGT1A1 倡导者变体之中的上位相互作用调制胆红素 glucuronidation。 | Shabana Farheen Sanghamitra Sengupta Amal Santra Suparna Pal Gopal Krishna Dhali Meenakshi Chakravorty Partha P Majumder Abhijit Chowdhury | 2006 | World Journal of Gastroenterology2006，12，14： | 29 |
| 2 | Risk-adjustment in hepatobiliarypancreatic surgery显示文摘AIM: The present study evaluates the performance of the POSSUM, the American Society of Anesthetists (ASA),APACHE and Childs classification in predicting mortality and morbidity in hepatopancreaticobiliary (HPB) surgery.We describe especially the limitations and advantages of risk in stratifying the patients.METHODS: We investigated 177 randomly chosen patients undergoing eledive complex HPB surgery in a single institution with a total of 71 pre-operative and intra-operative risk factors.Primary endpoint was in-hospital mortality and morbidity.Ordered logistic regression analysis was used to identify individual predictors of operative morbidity and mortality.RESULTS: The operative mortality in the series was 3.95% .This compared well with the p-POSSUM and APACHE predicted mortality of 4.31% and 4.29% respectively. Postoperative complications amounted to 45% with 24 (13.6%)patients having a major adverse event. On multivariate analysis the pre-operative POSSUM physiological score (OR = 1.18,P = 0.009) was superior in predicting complications compared to the ASA (P = 0.108), APACHE (P = 0.117)or Childs classification (P = 0.136). In addition, serum sodium, creatinine, international normalized ratio (INR),pulse rate, and intra-operative blood loss were independent risk factors. A combination of the POSSUM variables and INR offered the optimal combination of risk factors for risk prognostication in HPB surgery.CONCLUSION: Morbidity for elective HPB surgery can be accurately predicted and applied in everyday surgical practice as an adjunct in the process of informed consent and for effective allocation of resources for intensive and high-dependency care facilities. | Hemant M Kocher Paris P Tekkis Palepu Gopal Ameet G Patel Simon Cottam Irving S Benjamin | 2005 | World Journal of Gastroenterology2005，11，16： | 3 |
| 3 | High efficiency double heterojunction polymer photovoltaic cells using highly ordered TiO2 nanotube arrays 显示文摘 | Gopal K M Karthik S Maggie P | 2007 | Appl Phys Lett2007，91，15： | 1 |
| 4 | A 52-week open-label study of the safety and tolerability of paliperidone palmitate in patients with schizophrenia 显示文摘 | Gopal S Vijapurkar U Lim P | 2011 | J Psychopharmacol2011，25，5： | 1 |
| 5 | Oligosacchrides and glycoconjugates in bo- vine milk and colostrum显示文摘 | GOPAL P K GILL H S | 2000 | Br J Nutr2000，84，： | 1 |
| 6 | Antibiotic susceptibility profiles of new probiotic Lactobacillus and Bifidobacterium strains显示文摘 | ZHOU J S PILLIDGE C J GOPAL P K | 2005 | International Journal of Food Microbiology2005，98，2： | 1 |
| 7 | comparison of two- and three-dimensional echocardiography with cineventriculography for measurement of left ventricular volume in patients 显示文摘 | SAPIN P M SCHRODER K M GOPAL A S | 1994 | J Am Coll Cardiol1994，24，5： | 1 |
| 8 | Chemical struc tures of amphidionols 5 and 6 isolated from marine dinoflagellate Amphidinium klebsii and their cholesterol-dependent membrane disruption 显示文摘 | Gopal K P Matsumori N Konoki K | 1997 | J Mar Biotechnol1997，5，23： | 1 |
| 9 | Intravitreal voriconazole for drug-resistant fungal endophthalmitis : ease series 显示文摘 | Sen P Gopal L Sen PR | 2006 | Retina2006，26，： | 1 |
| 10 | Selection of optimum conditions for maximum material removal rate with surface finish and damage as constraints in SiC grinding显示文摘 | Gopal A V Rao P V | | 0，，： | 1 |
| 11 | Renewable energy source water pumping systems--a literature review 显示文摘 | GOPAL C MOHANRAJ M CHANDRAMOHAN P | 2013 | Renewable and Sustainable Energy Reviews2013，，25： | 1 |
| 12 | Increased cell density decreases eysteine proteinase inhibitor activity and increases invasive ability of two prostate tumor cell lines显示文摘 | COLELLA R GOODWYN E GOPAL P | 2002 | Cancer Letters2002，185，2： | 1 |
| 13 | An investigation on glycerol biosynthesis by an osmophilie yeast in a bioreaetor 显示文摘 | Sahoo D K Gopal P Agarwal G P | 2001 | Process Biochemistry2001，，36： | 1 |
| 14 | Understanding GDSS in Symbolic context:Shifting the focus from technology to interaction显示文摘 | Gopal A and Pushkala P | 2000 | MIS Quarterly2000，24，3： | 1 |
| 15 | In vitro adherence properties of Lactobacillus rhamnosus DR20 and Bifido-bacterium lactis DR10 strains and their antagonistic activity against an enterotoxigenic Escherichia coli 显示文摘 | Gopal P K Prasad J Smart J | 2001 | International Journal of food Microbiology2001，67，： | 1 |
| 16 | 显示文摘 | Gopal K M Karthik S Maggie P | 2007 | Appl Phys Lett2007，91，15： | 1 |
| 17 | 查看详情显示文摘 | Reddy R R Ahammed Y N Gopal K R Azeem P A Rao T V R | | 0，，： | 1 |
| 18 | MIR-451 and Ima- tinibmesylate inhibit tumor growth of Glioblastoma stem cells显示文摘 | Hilah G Gopal P Andrew A | 2008 | Biochem Biophys Res Commun2008，8，31： | 1 |
| 19 | Selection and characterization of Lactobacillus and Bifidobacterium strains for use as probiotics 显示文摘 | PRASAD J SMART J B GOPAL P K | 1998 | Internat Dairy J1998，8，： | 1 |
| 20 | Biofuel production from tapioca starch industry wastew- ater using a hybrid anaerobic reactor 显示文摘 | KAMARAJ A GOPAL N O VENKATACHALAM P et ol | 2006 | Energy Sustain Dev2006，10，3： | 1 |
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