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| 1 | Cumulative positive fluid balance is a risk factor for acute kidney injury and requirement for renal replacement therapy after liver transplantation显示文摘AIM To analyze whether fluid overload is an independent risk factor of adverse outcomes after liver transplantation(LT).METHODS One hundred and twenty-one patients submitted to LT were retrospectively evaluated.Data regarding perioperative and postoperative variables previously associated with adverse outcomes after LT were reviewed.Cumulative fluid balance(FB) in the first 12 h and 4 d after surgery were compared with major adverse outcomes after LT.RESULTS Most of the patients were submitted to a liberal approach of fluid administration with a mean cumulative FBover 5 L and 10 L,respectively,in the first 12 h and 4 d after LT.Cumulative FB in 4 d was independently associated with occurrence of both AKI and requirement for renal replacement therapy(RRT)(OR = 2.3;95%CI:1.37-3.86,P = 0.02 and OR = 2.89;95%CI:1.52-5.49,P = 0.001 respectively).Other variables on multivariate analysis associated with AKI and RRT were,respectively,male sex and Acute Physiology and Chronic Health Disease Classification System(APACHE II) levels and sepsis or septic shock.Mortality was shown to be independently related to AST and APACHE II levels(OR = 2.35;95%CI:1.1-5.05,P = 0.02 and 2.63;95%CI:1.0-6.87,P = 0.04 respectively),probably reflecting the degree of graft dysfunction and severity of early postoperative course of LT.No effect of FB on mortality after LT was disclosed.CONCLUSION Cumulative positive FB over 4 d after LT is independently associated with the development of AKI and the requirement of RRT.Survival was not independently related to FB,but to surrogate markers of graft dysfunction and severity of postoperative course of LT. | Liana Codes Ygor Gomes de Souza Ricardo Azevedo Cruz D'Oliveira Jorge Luiz Andrade Bastos Paulo Lisboa Bittencourt | 2018 | World Journal of Transplantation2018，8，2： | 4 |
| 2 | Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers显示文摘Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients.However,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef market.Here,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)steers.The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus Prevotella.Archaeal community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers.The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency steers.However,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.Conclusions:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal communities.Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as p-RFI.The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants. | Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante Sarah Figueiredo Martins Bonilha Garret Suen Hilário Cuquetto Mantovani | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 3 | 小型轿车用福特DIATA柴油机的设计和开发显示文摘福特汽车公司研究实验室和德国FEV发动机技术公司合作,正在开发一种崭新的高速直喷式柴油机。它是美国能源部混合动力驱动系统开发计划的一部分。这种柴油机利用多种先进技术和创新的设计思想,将配有这种柴油机的福特P2000型混合动力电动概念车能满足非常严格的排放、燃料经济性和使用性能指标。这种柴油机的设计也适应了用传统的制造和装配设施,以可接受的成本进行批量生产的要求,采用常用的材料和生产工艺。本文将讨论该柴油机设计的一些特殊细节,如机体结构、气缸盖设计、NVH(噪声、振动和行驶不平顺性)的对策、以及支承设计方案的一些分析研究和硬件试验。此外,还将报告一些初期开发试验结果。 | Gomes E D Ecker H J Schellhase T 刘巽俊 | 1999 | 国外内燃机1999，31，5： | 3 |
| 4 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 5 | Immunohistochemical study of the digestive tract of Oligosarcus hepsetus显示文摘AIM: To describe the histology of the digestive tract and to investigate the occurrence of endocrine cells in Oligosarcus hepsetus (O. hepsetus ). METHODS: The digestive tract (DT) of O. hepsetus was divided into esophagus, two stomach regions (glandular and non-glandular) and two intestinal regions (anterior and posterior). These specimens were processed by routine histological techniques and stained with hematoxylin-eosin, Gomori's trichrome, periodic acid Schiff (PAS) and Alcian blue (AB). An immunohistochemical method using avidin-biotin-peroxidase was employed.RESULTS: The esophagus is lined with a non-keratinized stratified squamous epithelium that is reactive to PAS and AB. The stomach has a mucosa lined with a simple columnar epithelium with mucus-secreting cells that are reactive only to PAS. The intestine has a simple columnar epithelium with a brush border and goblet cells that are reactive to PAS and AB. Somatostatin, serotonin and cholecystokinin immunoreactive cells were identified throughout the DT.CONCLUSION: This study revealed adaptations for the species' diet and showed that the distribution and relative frequency of immunoreactive cells are similar to those of other fish. | Danielle A Vieira-Lopes Nadja L Pinheiro Armando Sales Adriana Ventura Francisco G Araújo Iracema D Gomes Aparecida A Nascimento | 2013 | World Journal of Gastroenterology2013，19，12： | 2 |
| 6 | Alternative tissue engineering scaffolds based on starch: processing methodologies, morphology, degradation and mechanical properties显示文摘 | Gomes M E Godinho J S Tchalamov D | 2002 | Materials Science and Engineering2002，，19： | 2 |
| 7 | Chitosan microparticles as injectable scaffolds for tissue engineering 显示文摘 | CRUZ D M IVIRICO J L GOMES M M | 2008 | J Tissue Eng Regen Med2008，2，6： | 1 |
| 8 | Mrf4 determines skeletal muscle identity in Myf5,Myod double- mutant mice显示文摘 | KASSAR-DUCHOSSOY L GAYRAUD-MOREL B GOMES D | 2004 | Nature2004，431，77： | 1 |
| 9 | Comprehensive two-dimensional gas chromatography/mass spectrometric analysis of pepper voatiles显示文摘 | Cardeal Z L Gomes da Silva M D Marriott P J | 2006 | Rapid Commun Mass Spectrom2006，20，： | 1 |
| 10 | Fate of oxi- dized triglycerides during refining of seed oils 显示文摘 | GOMES T CAPONIO F DELCURATOLO D | 2003 | J Agric Food Chem2003，51，16： | 1 |
| 11 | Factors influencing the induction of endoxylanase by Thermoascus aurantiacus显示文摘 | Gomes D J Gomes J Steiner W | 1994 | Journal of Biotechnology1994，33，1： | 1 |
| 12 | Reflection Z-scan technique for measurements of optical properties of surface显示文摘 | Petrov D V Gomes A S L de Arauújo C B | | 0，，： | 1 |
| 13 | Supercritical fluid extraction of lipids from spent coffee grounds显示文摘 | Ricardo M C Joao F Gomes da Silva M D R | 2009 | Journal of Supercritical Fluids2009，51，： | 1 |
| 14 | Hydrogen peroxide pre - treatment induces salt - stress acclimation in maize plants 显示文摘 | Neto A D de A Prisco J T Eneas - Filho J Medeiros J V R Gomes -Filho E | 2005 | Journal of Plant Physiology2005，162，10： | 1 |
| 15 | A population- based study of the drug interaction between proton pump in- hibitors and clopidogrel显示文摘 | Juurlink D N Gomes T Ko D T | 2009 | CMA J2009，180，7： | 1 |
| 16 | Membranes for gas separation based on poly(1-trimethyls-ilyl-1-propyne)-silica nanocomposites显示文摘 | Gomes D Nunes S P Peinemann K V | 2005 | J Membr Sci2005，246，1： | 1 |
| 17 | Percutaneous endoscopic gastrostomy versus nasogastric tube feeding for adults with swallowing disturbances显示文摘 | Gomes CJ Lustosa SA Matos D | | 0，，： | 1 |
| 18 | Effect of high-pressure treatment on the activity of some polyphenoloxidases显示文摘 | Gomes M R A Ledward D A | 1996 | Food Chemistry1996，56，1： | 1 |
| 19 | Electrocoag- ulation mechanism for COD removal 显示文摘 | Moreno-Casillas H A Cocke D L Gomes J A G | 2007 | Separation Purification Technology2007，56，2： | 1 |
| 20 | Array comparative genomic hybridization in prenatal diagnosis:another experience显示文摘 | Vialard F Molina Gomes D Leroy N | 2009 | Fetal Diagn Ther2009，25，2： | 1 |
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