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| 1 | Evolving landscape and novel treatments in, metastatic castrate-resistant prostate cancer显示文摘为阉割抵抗的前列腺癌症(CRPC ) 的治疗选择在最近的年里进展了并且显著地与这好攻击、致命的疾病为病人改进了眼界。CRPC 的生物学的进一步的理解导致了几新指向的治疗并且继续强调雄激素受体(AR ) 的重要性指导了治疗。治疗风景很快生物学上正在改变并且推进基本原理,基于 biomarker 的进行中的临床的试用被需要。我们在 CRPC 考察主要临床的试用的最近的结果。新并且 investigational 代理人现在包括 angiogenesis,微导管,女伴, AR 和细胞内部的 kinases 的禁止者在临床的评估被考察,以及免疫疗法, radiopharmaceuticals 和指向骨头的代理人。在为 CRPC 的预后的最近的改进为进一步的改进带继续的乐观主义。对治疗的临床的考验和抵抗的机制的进一步的理解的有头脑的计划将允许在耐心的照顾的继续的进步。 | Paul J Toren Martin E Gleave | 2013 | Asian Journal of Andrology2013，15，3： | 5 |
| 2 | Exogenous cytokinin application to Actinidia chinensis var. deliciosa ‘Hayward’ fruit promotes fruit expansion through water uptake显示文摘Exogenous application of a cytokinin-like compound forchlorfenuron(CPPU)can promote fruit growth,although often at the expense of dry matter(DM),an important indicator of fruit quality.Actinidia chinensis var.deliciosa‘Hayward’fruit are very responsive to CPPU treatments,but the mechanism underlying the significant fruit weight increase and associated decrease in DM is unclear.In this study,we hypothesised that CPPU-enhanced growth increases fruit carbohydrate demand,but limited carbohydrate supply resulted in decreased fruit DM.During fruit development,CPPU effects on physical parameters,metabolites,osmotic pressure and transcriptional changes were assessed under conditions of both standard and a high carbohydrate supply.We showed that CPPU increased fruit fresh weight but the dramatic DM decrease was not carbohydrate limited.Enhanced glucose and fructose concentrations contributed to an increase in soluble carbohydrate osmotic pressure,which was correlated with increased water accumulation in CPPU-treated fruit and up-regulation of water channel aquaporin gene PIP2.4 at 49 days after anthesis.Transcipt analysis suggested that the molecular mechanism contributing to increased glucose and fructose concentrations was altered by carbohydrate supply.At standard carbohydrate supply,the early glucose increase in CPPU fruit was associated with reduced starch synthesis and increased starch degradation.When carbohydrate supply was high,the early glucose increase in CPPU fruit was associated with a general decrease in starch synthesis but up-regulation of vacuolar invertase and fructokinase genes.We conclude that CPPU affected fruit expansion by increasing the osmotically-driven water uptake and its effect was not carbohydrate supply-limited. | Simona Nardozza Helen L Boldingh Mark W Wohlers Andrew P Gleave Zhiwei Luo Guglielmo Costa Elspeth A MacRae Michael J Clearwater Annette C Richardson | 2017 | Horticulture Research2017，4，1： | 2 |
| 3 | Introducing the clusterin gene into human renal cell carcinoma cells enhances their metastatic potential 显示文摘 | Miyake H Gleave ME Arakawa S | 2002 | J Urol2002，167，5： | 1 |
| 4 | Intermittent androgen suppression delays progression to androgen-dependent regulation of prostate-specific antigen gene in the LNCaP prostate turnout model显示文摘 | Sato N Gleave ME Bruehovsky N | 1996 | J Steroid Biochem Mol Biol1996，58，2： | 1 |
| 5 | Overexpression of clusterin in transitional cell carcinoma of the bladder is related to disease progression and recurrence显示文摘 | Miyake H Gleave M Kamidono S | 2002 | Urology2002，59，1： | 1 |
| 6 | Clinico- pathological and treatment-related factors influencing survival in parotid cancer显示文摘 | Renehan AG Gleave EN Slevin N J | 1999 | Br J Cancer1999，80，12： | 1 |
| 7 | Intermittent androgen suppression in the treatment of prostate cancer: a preliminary report 显示文摘 | Bruchovsky N Gleave ME | 1995 | Urology1995，45，5： | 1 |
| 8 | Port Activities and the Spatial Structure of Cities: the Case of Freetown, Sierra Leone显示文摘 | Gleave M B | 1997 | Journal of Transport Geography1997，，4： | 1 |
| 9 | Visualizing the Signatures of Social Roles in Online Discussion Groups显示文摘 | Welser H Gleave E Fisher D | 2007 | Journal of Social Structure2007，8，2： | 1 |
| 10 | Efficient transformation of Actinidia arguta by reducing the strength of basal salts in the medium to alleviate callus browning显示文摘 | Han M L Gleave A P Wang T C | 2010 | Plant B iotechnology Reporter2010，4，： | 1 |
| 11 | Transformation of citrus embryogenie cells using particle bombardment and production of transgenic embryos显示文摘 | Yao J L Wu J H Gleave A P | 1996 | Plant Sei1996，113，： | 1 |
| 12 | Clinical significance of the tumour capsule in the treatment of parotid pleomorphie adenomas 显示文摘 | McGurk M Renehan A Gleave EN | 1996 | Br J Surg1996，83，12： | 1 |
| 13 | Clinical significance of the tumour capsule in the treat- ment of parotid pleomorphic adenomas显示文摘 | MCGURK M RENEHAN A GLEAVE E N | 1996 | Br J Surg1996，83，： | 1 |
| 14 | A Note on Methods for Measuring Industrial Agglomeration 显示文摘 | Dan O' Donoghue Bill Gleave | 2004 | Regional Stud- ies2004，38，4： | 1 |
| 15 | Insulin receptor expression by human prostate cancers显示文摘 | Cox ME Gleave ME Zakikhani M | 2009 | Prostate2009，69，1： | 1 |
| 16 | Multi-parametric MRI enhances detection of significant tumor in patients on active surveillance for prostate cancer显示文摘 | H. Abdi F. Pourmalek H. Zargar T. Walshe A.C. Harris S.D. Chang Christopher Eddy A.I. So M.E. Gleave L. Machan S.L. Goldenberg P.C. Black | 2014 | Urology2014，，： | 1 |
| 17 | Overexpression of clusterin in transitional cell carcinoma of the bladder is related to disease progression and recurrence显示文摘 | Miyake H Gleave M Kamidono S | 2002 | Urology2002，59，： | 1 |
| 18 | Radical prostatectomy in high-risk prostate cancer显示文摘 | Ischia J Gleave M | 2013 | IntJ Urol2013，20，3： | 1 |
| 19 | Intermittent androgen suppression delays progression to androgen-independent regulation of prostate-specific antigen gene in the LNCaP prostate tumour model显示文摘 | Sato N Gleave ME Bruchovsky N | 1996 | J Steroid Biochem Mol Biol1996，58，2： | 1 |
| 20 | Introducing the clusterin gene into human renal cell carcinoma cells enhances their metastatic potential显示文摘 | Miyake H Gleave M Arakawa S | | 0，，05： | 1 |
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