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| 1 | 中国新型冠状病毒肺炎疫情基本再生数评估显示文摘目的目前湖北省的新型冠状病毒肺炎(COVID-19)确诊和疑似病例的数量仍在增加。国内外多个团队对疫情发展进行了模型预测,但结论并不统一。因此,开展本次疫情的预测模型研究、评估COVID-19的基本再生数(basic reproduction number,R0),对于评估病毒的传播能力以及一系列控制措施的效果具有重要意义。方法收集从湖北省2020年1月17日到2月8日期间每天报告的确诊病例数等数据,分别采用指数增长方法(exponential growth,EG)、极大似然法(maximum likelihood estimation,ML)、序贯贝叶斯方法(sequential Bayesian method,SB)和时间相关基本再生数(time dependent reproduction numbers,TD)估计R0值。结果由观测病例数和4种方法预测的病例数的拟合情况可知,EG方法拟合效果最优。EG方法估计COVID-19湖北省R0的值为3.49(95%CI:3.42~3.58)。采取封城控制手段期间,EG方法估算R0值为2.95(95%CI:2.86~3.03)。结论在传染病流行初期,适合采用EG方法估算R0。同时需要采取及时有效的控制措施,进一步降低COVID-19的传播速率。 | 王莹 尤心怡 王奕婧 彭丽萍 杜志成 Stuart Gilmour Daisuke Yoneoka 顾菁 郝春 郝元涛 李菁华 | 2020 | 中华流行病学杂志2020，41，4： | 22 |
| 2 | Double-blind randomized sham controlled trial of intraperitoneal bupivacaine during emergency laparoscopic cholecystectomy显示文摘BACKGROUND: Intraperitoneal local anesthesia (IPLA) during elective laparoscopic cholecystectomy (el-LC) decreases post-operative pain. None of the studies have explored the efficacy of IPLA at emergency laparoscopic cholecystectomy (em-LC). A longer operative duration, the greater frequency of washing, and the inflammation associated with cholecystitis or pancreatitis are a few reasons why it cannot be assumed that a benefit in pain scores will be seen in em-LC with IPLA. This study was undertaken to assess the efficacy of IPLA in patients undergoing em-LC. METHODS: Double-blind randomized sham controlled trial was conducted of 41 consecutive subjects undergoing em-LC. IPLA was delivered by a combination of injection to the diaphragmatic and topical wash over the liver and gallbladder with bupivacaine or saline. The primary outcome was visual analogue scale pain scores until discharge. Secondary outcomes included pain scores in theatre recovery and analgesic consumption. RESULTS: One patient had a procedure converted to open and was excluded. There was no significant difference in pain scores in the ward or theatre recovery. Analgesic use, respiratory rate, oxygen saturation, duration to ambulation, eating, satisfaction scores, and time to discharge were comparable between the two groups. CONCLUSIONS: IPLA during em-LC does not influence postoperative pain. Other modalities of analgesia should be explored for decreasing the interval between diagnosis of acute admission and em-LC. | Keith J Roberts Jeff Gilmour Ruplay Pande James Hodson For Tai Lam Saboor Khan | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 3 |
| 3 | 汞污染渔业的恢复显示文摘本文中,我们综合了有关生态系统无机汞(Hg)载荷变化与鱼体内甲基汞(MeHg)浓度之间联系的现有信息。尽管人们普遍假定水生生态系统汞载荷的增加导致鱼体内甲基汞浓度的增加,验证这一假定的定量数据尚很有限。这里,我们研究了源于一系列出处的现有证据:关于被工业排放物污染的生态系统的研究;关于鱼类甲基汞对大气载荷的响应的观测资料;跨越空间和环境梯度的研究以及实验操作。本文概述了目前对从汞载荷到鱼体甲基汞的运输和转化所涉及的主要过程的了解情况。还结合影响与鱼体内甲基汞响应的时机和大小有关的汞循环和生物积累的其他因素探讨了汞载荷的作用。所得出的主要结论是,汞载荷的变化(增加或减少)将引起鱼体内甲基汞的反应,这种反应的时间和大小将根据生态系统特有的变量和所添加的汞的形态而变化。 | John Munthe R. A. (Drew) Bodaly Brian A. Branfireun Charles T. Driscoll Cynthia C. Gilmour Reed Harris Milena Horvat Marc Lucotte Olaf Malm 林宝法(译) | 2007 | AMBIO-人类环境杂志2007，36，1： | 2 |
| 4 | Lack of T-cell responses following autologous tumour lysate pulsed dendritic cell vaccination, in patients with relapsed osteosarcoma显示文摘 | Nourredine Himoudi Rebecca Wallace Kathryn Parsley Kimberly Gilmour Alpha-Umaru Barrie Karen Howe Rong Dong Neil Sebire Antony Michalski Adrian Thrasher John Anderson | 2012 | Clinical and Translational Oncology2012，，： | 2 |
| 5 | Arabidopsis Transcriptional Activators CBF1, CBF2, and CBF3 have Matching Functional Activities显示文摘 | Sarah J. Gilmour Sarah G. Fowler Michael F. Thomashow | 2004 | Plant Molecular Biology2004，，5： | 2 |
| 6 | Arabidopsis thaliana CBF1 encodes an AP2 domain-containing transcriptional activator that binds to the C-repoat/DRE,a cis-acting DNA regulatory element that stimulates transcription in response to low temperature and water deficit显示文摘 | Stockinger E J Gilmour S J Thomashow M F | 1997 | Proceedings of the National Academy of Sciences of the USA1997，94，： | 1 |
| 7 | Sulfate stimulation of mercury methylation in freshwater sediments 显示文摘 | Gilmour C C | 1992 | Environ Sci Technol1992，26，11： | 1 |
| 8 | Hemodynamic disturbances in premature infants born after chorioamnionitis:Association with cord blood cytokine concentrations显示文摘 | Yanowitz TD Jordan JA Gilmour CH | 2002 | Pediatr Res2002，51，3： | 1 |
| 9 | Comparison of antialgal activity of brown-rotted wood and in situ analysis of lignin显示文摘 | PILLINGER J M GILMOUR I Ridge I | 1995 | Journal of Chemical Ecology1995，21，： | 1 |
| 10 | Low temperature regulation of the Arabidopsis CBF family of AP2 transcriptional activators as an early step in cold induced COR gene expression显示文摘 | Sarah J Gilmour Daniel G | 1998 | The Plant Journal1998，16，： | 1 |
| 11 | Experimental acute pancreatitis in the rat-a new model显示文摘 | Chetty U Gilmour HM Taylor TV | 1980 | Gut1980，21，2： | 1 |
| 12 | Measurement of Hg methylation in sediments using high specific-activity203Hg and ambient incubation显示文摘 | C. C. Gilmour G. S. Riedel | 1995 | Water Air & Soil Pollution (-)1995，，1： | 1 |
| 13 | Familial haemophagocytic lymphohistiocytosis:advances in the genetic basis, diagnosis and management显示文摘 | Gholam C Grigoriadou S Gilmour KC | 2011 | Clin Exp Immunol2011，163，3： | 1 |
| 14 | Oxidative stress and TNF-α induce histone acetylation and NF-κB/AP-1 activation in alveolar epithelial cells: Potential mechanism in gene transcription in lung inflammation显示文摘 | Irfan Rahman Peter S. Gilmour Luis Albert Jimenez William MacNee | 2002 | Molecular and Cellular Biochemistry2002，，1： | 1 |
| 15 | Lowtemperature regulation of the Arabidopsis CBF familyof AP2 transcriptional activators as an early step incold-induced COR gene expression 显示文摘 | Gilmour S J Zarka D G Stockinger E J | 1998 | The PlantJournal1998，16，4： | 1 |
| 16 | Sulfide controls on mercury speciation and the bioavailability in sediment pore waters显示文摘 | BENOIT J M GILMOUR C C MASON R P | 1999 | Environmental Science & Technology1999，33，： | 1 |
| 17 | Arabidopsis CBF1 overexpression induces COR genes and enhances freezing tolerance显示文摘 | Jaglo-Ottosen K R Gilmour S J Zarka D G | 1998 | Science1998，280，5360： | 1 |
| 18 | Effect of organic sulfonic acids as catalysts during phenol liquefaction of Pinus radiata bark显示文摘 | MUN S P GILMOUR I A JORDAN P J | 2006 | Journal of Industrial and Engineering Chemistry2006，12，5： | 1 |
| 19 | Arabidopsis thaliana CBF1 encodes an AP2 domain - con-taining transcriptional activator that binds to the C - repeat/DRE, a cis - acting DNA regulatory element that stimulates transcription in response to low temperature and water deficit显示文摘 | STOCHINGER E J GILMOUR S J THOMASHOW M F | 1997 | Proc Natl Acad Sci USA1997，94，： | 1 |
| 20 | Technology opportunities analysis:integrating technology monitoring, forecasting and assessment with strategic planning显示文摘 | Porter A L Jin X-Y Gilmour J E Cunningham S W Xu H Stanard C WangL | 1994 | SRA Journal (Society of Research Administrators)1994，，2： | 1 |
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