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| 1 | Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex显示文摘在发炎和白血球过多症之间的潜在的交叉连接有一段时间被讨论了,但是支持这教义的试验性的证据是少见的。特别地,由煽动性的调停人理解为 proto-oncogenic 生长因素表情的潜在的 upregulation 负责的机制是重要的。这里,我们调查了高度煽动性的 cytokine interleukin-1 贝它的能力(IL-1β) 到导致干细胞因素(SCF ) 的生产,它是在造血的 myeloid 细胞的恶意的转变之上控制尖锐 myeloid 白血球过多症的前进的一个主要造血的生长因素。我们发现了那人的 IL-1β在 MCF-7 人的上皮的乳癌房间和那导致了 SCF 的表示 / 分泌物这个过程取决于组织缺氧可诱导的因素 1 (HIF-1 ) 抄写建筑群。我们也表明了 phosphatidylinositol-3 kinase (PI-3K ) 的一个关键角色 rapamycin (mTOR ) 的 /mammalian 目标在 IL-1β 的小径;导致的 HIF-1α在 MCF-7 房间的累积。重要地, mTOR 也被发现在 IL-1β 起一个作用;导致的 SCF 生产。而且,为 IL-1β 的积极关联的一个趋势;并且在健康人的施主的血浆的 SCF 层次被观察。总的来说,我们的结果表明那 IL-1β,它通常衔接天生、适应的免疫,通过 PI-3K/mTOR 小径和 HIF-1 抄写建筑群导致主要 haematopoietic/proleukaemic 生长因素 SCF 的生产。这些调查结果强烈支持在发炎和尖锐 myeloid 白血球过多症之间的串音。 | Rafal W Wyszynski Bernhard F Gibbs Luca Varani Daniela Iannotta Vadim V Sumbayev | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 2 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 3 | Heavy metal removal from sediments by biosurfactants显示文摘 | Catherine N Mulligan Raymond N Yong Bernard F Gibbs | 2001 | Journal of Hazardous Materials2001，，1： | 2 |
| 4 | Purification and identification of potentially bioactive peptides from enzyme-modified cheese显示文摘 | S S HA ILESELASSIE B H LEE B F GIBBS | 1999 | Journal of Dairy Science1999，82，8： | 1 |
| 5 | Contributing factorsin construction accidents 显示文摘 | HASLAM R A HIDE S A GIBB A G F | 2005 | Applied Ergonomics2005，36，40： | 1 |
| 6 | Re-engineering through pre-assembly: Client expectations and drivers 显示文摘 | GIBB A ISACK F | 2003 | Building Research & Information2003，31，2： | 1 |
| 7 | Surfactant-enhanced remediation of contaminated soil,a review显示文摘 | MULLIGAN C N YONG R N GIBBS B F | | Engineering Geology0，60，： | 1 |
| 8 | Heavy metal removal from sedimends by biosurfactants显示文摘 | Mulligan C N Yong R N Gibbs B F | 2001 | Journal of Hazardous Material2001，，85： | 1 |
| 9 | Ambroxol inhibits the release of histamine, leukotrienes and cytokinesfrom human leukocytes and mast cells显示文摘 | GIBBS B F SCHMUTZLER W VOLLRATHL I B et aI | 1999 | Inftamm Res1999，48，2： | 1 |
| 10 | The integration of information retrieval techniques within a soft- ware reuse environment显示文摘 | GIBB F MCCARTAN C O'DONNELL R | 2000 | Journal of Information Science2000，26，4： | 1 |
| 11 | Genetic analysis of four porcine avian influenza viruses isolated from Shandong 显示文摘 | Shi W F Gibbs M J Zhang Y Z | 2008 | China Arch Virol2008，153，： | 1 |
| 12 | Unravelling the pathophysi ology of complex regional pain syndrome:focus on sympathetically main- tained pain显示文摘 | Gibbs G F Drummond P D Finch P M | 2008 | Clin Exp Pharmacol Physiol2008，35，7： | 1 |
| 13 | Remediation Technolo- gies for Metal-Contaminated Soils and Groundwater:An Evaluation 显示文摘 | MULLIGAN C N YONG R N GIBBS B F | 2001 | Engineering Geology2001，60，1： | 1 |
| 14 | Metal removal from contaminated soil and sediments by the biosurfactant surfactin显示文摘 | Mulligan C N Yong R N Gibbs B F | 1999 | Environ Sci Technol1999，33，： | 1 |
| 15 | An evaluation of technologies for the heavy metal remediation of dredged sediments显示文摘 | Mulligan C N Yong R N Gibbs B F | 2001 | Journal of Hazardous Materials2001，85，： | 1 |
| 16 | Production and characterization of bioactive peptides from soy hydrolysate and soy-fermented food 显示文摘 | Gibbs B F Zougman A Masse R | 2004 | Food Research International2004，37，2： | 1 |
| 17 | Surfactant-enhanced remediation of contaminated soil a review显示文摘 | Mulligan C N Yong R N Gibbs B F | 2001 | Engineering Geology2001，60，14： | 1 |
| 18 | An evaluation of second-generation ebook read- ers显示文摘 | Gibson C Gibb F | 2011 | Electronic Library2011，29，3： | 1 |
| 19 | Histological typing of lung and pleural tumours: third edition 显示文摘 | Gibbs A R Thunnissen F B | 2001 | J Clin Pathol2001，54，7： | 1 |
| 20 | Prospective 10-month exercise intervention in premenarcheal girls: positive effects on bone and lean mass显示文摘 | Morris F L Naughton G A Gibbs J L | 1997 | J Bone Miner Res1997，12，9： | 1 |
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