|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | (-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis显示文摘AIM: To investigate the effect of (-)-epigallocatechin- 3-gallate (EGCG) on growth of gastric cancer and its possible mechanism. METHODS: Heterotopic tumors were induced by subcutaneously injection of SGC-7901 cells in nude mice. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density (MVD) by immunohistology. Vascular endothelial growth factor (VEGF) protein level and activation of signal transducer and activator of transcription 3 (Stat3) were examined by Western blotting. VEGF mRNA expression was determined by RT-PCR and VEGF release in tumor culture medium by ELISA. VEGF-induced cell proliferation was studied by MTT assay, cell migration by gelatin modified Boyden chamber (Transwell) and in vitro angiogenesis by endothelial tube formation in Matrigel. RESULTS: Intraperitoneal injection of EGCG inhibited the growth of gastric cancer by 60.4%. MVD in tumor tissues treated with EGCG was markedly reduced. EGCG treatment reduced VEGF protein level in vitro and in vivo. Secretion and mRNA expression of VEGF in tumor cells were also suppressed by EGCG in a dose-dependent manner. This inhibitory effect was associated with reduced activation of Stat3, but EGCG treatment did not change the total Stat3 expression. EGCG also inhibited VEGF-induced endothelial cell proliferation, migration and tube formation. CONCLUSION: EGCG inhibits the growth of gastriccancer by reducing VEGF production and angiogenesis, and is a promising candidate for anti-angiogenic treatment of gastric cancer. | Bao-He Zhu, Wen-Hua Zhan, Zheng-Rong Li, Zhao Wang, Yu-Long He, Jun-Sheng Peng, Shi-Rong Cai, Jin-Ping Ma, Chang-Hua Zhang, Department of Gastrointestinal & Pancreatic Surgery, First Affiliated Hospital, Sun Yat-Sen University Gastric Center of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China | 2007 | World Journal of Gastroenterology2007，13，8： | 30 |
| 2 | Prognosis of 980 patients with gastric cancer after surgical resection显示文摘Background and Objective: Although surgery is the only possible means to cure gastric cancer, the prognosis is often discrepant. The American Joint Committee on Cancer/International Union against Cancer (AJCC/UICC) published the TNM classification of Malignant Tumors (seventh edition) for gastric cancer recently. This study aimed to use this new edition staging system to investigate the prognostic factors for gastric cancer. Methods: The clinicopathologic data of 980 patients with gastric cancer treated by surgical resection in our hospital between January 2000 and December 2006 were analyzed retrospectively. The overall survival rate was determined by using Kaplan-Meier method and log-rank test was used to determine significance. The prognosis was analyzed using univariate analysis and multivariate analysis with the Cox proportional hazards model. The 6th and 7th edition AJCC/UICC TNM staging systems were used to compare the survival outcomes for the cohort of patients. Results: The overall 1-, 3-, 5-year survival rates for the whole group were 82.5%, 58.7%, and 52.6%. The 5-year survival rates for patients with pTNM stage I, II, III, and IV disease classified by the 7th edition staging system were 93.2%, 72.4%, 39.1%, and 5.2%, respectively. In both univariate analysis and Cox multivariate analysis, age, tumor site, tumor size, histological type, resection type, radical resection, lymphatic/venous invasion, depth of invasion, nodal status, metastasis, retrieved lymph nodes, metastatic lymph node ratio, and adjuvant chemotherapy were prognostic factors with these patients. Conclusion: Compared with the 6th edition system, the new edition of TNM staging system for gastric cancer can accurately predict the survival after operation. | Wei Wang1,2, Yuan-Fang Li1,2, Xiao-Wei Sun1,2, Ying-Bo Chen1,2, Wei Li1,2, Da-Zhi Xu1,2, Xuan-Xiang Guan1,2, Chun-Yu Huang1,2, You-Qing Zhan1,2, Zhi-Wei Zhou1,2 1 State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China 2 Department of Gastric and Pancreatic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China | 2010 | Chinese Journal of Cancer2010，29，11： | 24 |
| 3 | Expression of calreticulin is associated with infiltration of T-cells in stage ⅢB colon cancer显示文摘AIM: To investigate the correlation between expression of calreticulin and infiltration of lymphocytes in stage ⅢB colon cancer. METHODS: Sixty-eight pathologically-confirmed speci-mens were obtained from stage ⅢB (T3N1M0) colon cancer patients who underwent radical resection between January 1999 and May 2002 at the Cancer Center of Sun Yat-Sen University, Guangzhou, China. Immuno-histochemical analysis was performed to show infiltration of lymphocytes and expression of calreticulin in colon cancer. Association between calreticulin expression, infiltration of lymphocytes, and 5-year survival rate of patients was assessed. RESULTS: The expression level of calreticulin was lower in cancer nest than in its adjacent normal epithelium since 61.8% (42/68) of the samples were stained with calreticulin in colon cancer. The expression of calreticulin in colon cancer was associated with the infi ltration of CD45RO+ cells rather than with that of CD3+ cells. In addition, the stronger expression of calreticulin and the higher infiltration of CD3+ and CD45RO+ cells in colon cancer were associated with the higher 5-year survival rate of patients. CONCLUSION: Expression of calreticulin is associated with infiltration of T-cells, which implies that a low expression level of molecular marker may represent a new mechanism underlying immune escape in colon cancer. | Rui-Qing Peng, Ya Ding, Xing Zhang, Yi-Xin Zeng, Xiao- Shi Zhang, State Key Laboratory of Oncology in South China, Biotherapy Center, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Ying-Bo Chen, Zhi-Wei Zhou, State Key Laboratory of Oncology in South China, Department of Gastric and Pancreatic Oncology, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Rong Zhang, State Key Laboratory of Oncology in South China, Department of Endoscopy, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Xing-Juan Yu, Yi-Xin Zeng, State Key Laboratory of Oncology in South China, Department of Experimental Research, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China | 2010 | World Journal of Gastroenterology2010，16，19： | 16 |
| 4 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 5 | Comparative studies on epithelial lesions at gastric cardia and pyloric antrum in subjects from a high incidence area for esophageal cancer in Henan,China显示文摘ComparativestudiesonepitheliallesionsatgastriccardiaandpyloricantruminsubjectsfromahighincidenceareaforesophagealcancerinHena... | GAO ShanShan1, ZHOU Qi1, LI YongXin1, BAI YongMin1, ZHENG ZuoYu1, ZOU JianXiang1, LIU Gang1, FAN ZongMin1, QI YiJun1, ZHAO Xin1 and WANG LiDong1,2Keywords esophageal neoplasms stomach neoplasms gastric ca | 1998 | World Journal of Gastroenterology1998，4，4： | 8 |
| 6 | 胃粘膜幽门螺旋菌感染发病学探讨——江苏省3013例胃粘膜病理组织学观察显示文摘从江苏省3013例胃粘膜病理组织学观察中发现幽门螺旋菌(HP)检出率为58.71%。它对胃粘膜有直接致病作用,可能是慢性活动性胃炎的病原,但不能提示它与胃癌有直接的病因学联系。50岁以下的男性、集体生活者可能为易感人群。宿主、环境因素在HP发病学中的作用值得重视。 | The Jiongsu Pathologica Research Association of Gastric Cancer | 1991 | 临床与实验病理学杂志1991，7，4： | 3 |
| 7 | Japanese Classification of Gastric Carcinoma – 2nd English Edition – Response assessment of chemotherapy and radiotherapy for gastric carcinoma: clinical criteria显示文摘 | Japanese Gastric Cancer Association | 2001 | Gastric Cancer2001，，1： | 2 |
| 8 | Textbook Outcome as a measure of surgical quality assessment and prognosis in gastric neuroendocrine carcinoma:A large multicenter sample analysis显示文摘Objective:Quality assurance is crucial for oncological surgical treatment assessment.For rare diseases,singlequality indicators are not enough.We aim to develop a comprehensive and reproducible measurement,called the'Textbook Outcome'(TO),to assess the quality of surgical treatment and prognosis of gastric neuroendocrine carcinoma(G-NEC)patients.Methods:Data from patients with primary diagnosed G-NEC included in 24 high-volume Chinese hospitals from October 2005 to September 2018 were analyzed.TO included receiving a curative resection,≥15 lymph nodes examined,no severe postoperative complications,hospital stay≤21 d,and no hospital readmission≤30 d after discharge.Hospital variation in TO was analyzed using a case mix-adjusted funnel plot.Prognostic factors of survival and risk factors for non-Textbook Outcome(non-TO)were analyzed using Cox and logistic models,respectively.Results:TO was achieved in 56.6%of 860 G-NEC patients.TO patients had better overall survival(OS),disease-free survival(DFS),and recurrence-free survival(RFS)than non-TO patients(P<0.05).Moreover,TO patients accounted for 60.3%of patients without recurrence.Multivariate Cox analysis revealed non-TO as an independent risk factor for OS,DFS,and RFS of G-NEC patients(P<0.05).Increasing TO rates were associated with improved OS for G-NEC patients,but not hospital volume.Multivariate logistic regression revealed that nonlower tumors,open surgery,and>200 mL blood loss were independent risk factors for non-TO patients(P<0.05).Conclusions:TO is strongly associated with multicenter surgical quality and prognosis for G-NEC patients.Factors predicting non-TO are identified,which may help guide strategies to optimize G-NEC outcomes. | Qiyue Chen Zhongliang Ning Zhiyu Liu Yanbing Zhou Qingliang He Yantao Tian Hankun Hao Wei Lin Lixin Jiang Gang Zhao Ping Li Chaohui Zheng Changming Huang on behalf of the Study Group for Gastric Neuroendocrine Tumors | 2021 | Chinese Journal of Cancer Research2021，33，4： | 2 |
| 9 | Japanese classification of gastric carcinoma,2nd english edition显示文摘 | Japanese Gastric Cancer Association | | 0，，： | 2 |
| 10 | Endoscopic ligation for benign and malignant lesions of upper digestive tract显示文摘EndoscopicligationforbenignandmalignantlesionsofupperdigestivetractCHENYuLong1,CHENYongZhong1,ZOUJianXiang1andLIXueLi2Su... | CHEN Yu Long 1, CHEN Yong Zhong 1, ZOU Jian Xiang 1 and LI Xue Li 2 Keywords esophageal and gastric varices polyp liver neoplasms | 1997 | World Journal of Gastroenterology1997，3，3： | 2 |
| 11 | 胃癌的手术治疗(附1,487例分析)显示文摘从我省胃癌协作组12个协作单位在1978至1984年底收治的1,487例胃癌病例治疗情况来看——手术率为84.2%,切除手术率为54.4%,切除手术患者的3和5年生存率分别为28.7%及18.9%,虽取得了较大成绩,疗效还不令人满意。根据本组协作单位临床经验,患者的年龄、病期、肿瘤大小、组织学类型、胃癌浆膜侵犯程度、淋巴结转移情况、肿瘤部位、手术方式、联合脏器切除情况等,都是影响胃癌疗效的因素。提高胃癌疗效的关键是早期诊断和早期治疗,因而,须努力提高胃瘤的早期确诊率。此外,合理的外科治疗对提高胃癌疗效亦非常重要。我们认为应大力推广清除第二站淋巴结根治术;适当开展扩大根治术及联合脏器切除术式;而对不能作根治手术的患者也要争取作姑息性切除,使其延长生存期。 | Tan Chun-Qi Co-operative Group for Gastric Cancer of Hunan Province,Changsha | 1989 | 中国肿瘤临床1989，16，1： | 2 |
| 12 | nternational显示文摘 | Toki T Shiozawa T Hosake N Minimal deviation adenocarcinoma of the uterine cervix has abnormal ex pression of sex steroid receptors CA125 and gastric mucin | 1997 | J Gynecol Pathol1997，16，2： | 1 |
| 13 | Benefit of adju- vant chemotherapy for resectable gastric cancer: a meta- analysis显示文摘 | GASTRIC Group Paoletti X Oba K | 2010 | JAMA2010，303，7： | 1 |
| 14 | Gastric cancer treated in 1991 in Japan:data analysisof nationwide registry显示文摘 | Japanese Gastric Cancer Association Registration Committee Maruyama K Kaminishi M Hayashi K | | 0，，： | 1 |
| 15 | Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial显示文摘 | Wong BC Lam SK Wong WM China Gastric Cancer Study Group | 2004 | JAMA2004，291，2： | 1 |
| 16 | Japanese classification of gastric carcinoma-2nd English edition显示文摘 | Japanese Gastric Cancer Association | 1998 | Gastric Cancer1998，1，1： | 1 |
| 17 | Japan Classification Of Gastric Carcinoma-2nd English Edition显示文摘 | Japanese Gastric Cancer Association | 1981 | Gastric Cancer1981，1，： | 1 |
| 18 | Japanese classification of gastric carcinoma-2nd english edition显示文摘 | Japanese Gastric Cancer Association | 1998 | Gastric Cancer1998，1，： | 1 |
| 19 | Japanese classification of gastric carcinoma: 3rd English edition 显示文摘 | Japanese Gastric Cancer Association | 2011 | Gastric Cancer2011，14，： | 1 |
| 20 | Role of chemotherapy for advanced/recurrent gastric cancer:an individual-patient-data meta-analysis显示文摘 | GASTRIC Group Oba K Paoletti X | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员