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| 1 | Zhuifeng tougu capsules (追风透骨胶囊) improve rheumatoid arthritis symptoms in rats by regulating the toll-like receptor 2/4-nuclear factor kappa-B signaling pathway显示文摘OBJECTIVE: To investigate the efficacy of Zhuifeng tougu capsules(追风透骨胶囊, ZFTG) in the treatment of rheumatoid arthritis(RA) in rats and study its mechanism, focusing on the toll-like receptor 2/4-nuclear factor kappa-B(TLR2/4-NF-κB) signaling pathway.METHODS: TypeⅡ collagen and an artificial climate box were used to construct the rat model of collagen-induced arthritis with wind-cold-dampness arthralgia syndrome. The rats were divided randomly into a control group, wind-cold-dampness syndrome model group, and high-, medium-,and low-dose ZFTG groups. The methotrexate(MTX) control group was treated with the corresponding drug intervention for 28 d. The joint temperature, pain threshold, joint swelling degree, and arthritis index(AI) score were measured. The production of C-reactive protein(CRP), erythrocyte sedimentation rate(ESR), and rheumatoid factors(RFs) in the blood was detected by enzyme-linked immunosorbent assay. The protein expression of TLR2, TLR4, and NF-κB in synovial tissues was detected by Western blotting, and the m RNA expression of TLR2, TLR4, and NF-κB was detected by real-time polymerase chain reaction.RESULTS: Compared with the model group, the joint temperature in each treatment group, the MTX control group, and MTX group recovered, the degree of foot swelling, pain threshold, AI score decreased, serum CRP, ESR, RF level and the levels of TLR2, TLR4, and NF-κB in synovial tissue were decreased(P < 0.05). Among them, the curative effect in the medium-dose and MTX groups was more evident(P < 0.01).CONCLUSION: ZFTG has a significant effect on RA in rats, and its mechanism may involve regulating CRP levels, the ESR, and RFs via the TLR2/4-NF-κB signaling pathway. | GONG Hui KUANG Gaoyan WU Yongrong LU Fangguo DENG Yihui HE Yanlin WANG Hengxin | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 2 |
| 2 | On the reachability problem of uncertain hybrid systems显示文摘 | GAOYan LYGEROS J QUINCAMPOIX M | 2007 | IEEE Transactions on Automatic Control2007，52，5： | 1 |
| 3 | High density and scale-up cultivation of recombinant CHO cell line and hybridomas with porous microcarrier Cytopore显示文摘 | Chengzu Xiao Zicai Huang Wengqing Li Xianwen Hu Wenlu Qu Lihua Gao Gaoyan Liu | 1999 | Cytotechnology (-)1999，，1： | 1 |
| 4 | Structural regulation of single-atom catalysts for enhanced catalytic oxidation performance of volatile organic compounds显示文摘The catalytic oxidation of volatile organic compounds(VOCs)is considered a feasible method for VOCs treatment by virtue of its low technical cost,high economic efficiency,and low additionally produced pollutants,which is of important social value.Singleatom catalysts(SACs)with 100%atom utilization and uniform active sites usually have high activity and high product selectivity,and promise a broad range of applications.Precise regulation of the microstructures of SACs by means of defect engineering,interface engineering,and electronic effects can further improve the catalytic performance of VOCs oxidation.In this review,we introduce the mechanisms of VOCs oxidation,and systematically summarize the recent research progress of SACs in catalytic VOCs total oxidation into CO_(2)and H_(2)O,and then discuss the effects of various structural regulation strategies on the catalytic performance.Finally,we summarize the current problems yet to be solved and challenges currently faced in this field,and propose future design and research ideas for SACs in catalytic oxidation of VOCs. | Fei Jiang Zhiyuan Zhou Chao Zhang Chao Feng Gaoyan Xiong Yunxia Wang Zhaoyang Fei Yunqi Liu Yuan Pan | 2023 | Nano Research2023，16，2： | 1 |
| 5 | A Novel Design of Multi-light LAPS Based on Digital Compensation of Frequency Domain显示文摘 | Zhang Qingtao Wang Ping Parak Wolfgang J Michael George Zhang Gaoyan | 2001 | Sensors and Actuators B2001，73，： | 1 |
| 6 | 显示文摘 | GAOYan LIUHong-bo WANGLi(高雁 刘洪波 王丽) | | 中国光学与应用光学0，，： | 1 |
| 7 | Design and trafficability study of flexible wheel for planetary exploration rover 显示文摘 | I Li Wen Gao Feng Xu Gaoyan | 2007 | Journal of Beijing Institute of Technology ( English Edition)2007，16，3： | 1 |
| 8 | Artificial mouth model systems and their contribution to caries research显示文摘 | Gaoyan Tang Hak-Kong Yip Terry W | 2003 | J Dent2003，31，1： | 1 |
| 9 | Synthesis and properties of degradable poly (vinyl alcohol) hydrogel显示文摘 | Congming X Gaoyan Z | 2003 | Polymer Degradation and Stability2003，81，： | 1 |
| 10 | The current situation and progress of 4-DOF parallel robot显示文摘 | Wang Yanqing Zhong Gaoyan | 2010 | Applied Mechanics and Materials2010，37，38： | 1 |
| 11 | Facile and efficient way to synthesize the radical cyelization precursor methyl-3-(tert-butyl ( ( E)-3-( 2, 2-diphenylcyclopropyl )-2-propenyl ) amino )-3-oxo-2- (phenylseleno) propanoate for kinetic research显示文摘 | Yu Jindi Lian Gaoyan Zhang Danwei | 2007 | Synthetic Communications2007，37，1： | 1 |
| 12 | Synthesis and properties of degradable poly (vinyl alcohol) hydrogel显示文摘 | Gaoyan z | 2003 | Polymer Degradation and Stability2003，81，： | 1 |
| 13 | Position geometric error modeling, identification and compensation for large 5-axis machi- ning center prototype 显示文摘 | ZHONG Gaoyan | 2015 | International Journal of Ma- chine Tools ga Manufacture2015，89，3： | 1 |
| 14 | High density and scale-up cultivation of recombinant CHO cell line and hybridomas with porous microcarrier Cytopore显示文摘 | Chengzu Xiao Zicai Huang Wengqing Li Xianwen Hu Wenlu Qu Lihua Gao Gaoyan Liu | 1999 | Cytotechnology (-)1999，，1： | 1 |
| 15 | Study of Linear and Nonlinear Optical Properties of Four Derivatives of Substituted Aryl Hydrazones of 1,8-Naphthalimide显示文摘Four 1,8-naphthalimide hydrazone molecules with different electron-donating groups have been applied in the study of linear and nonlinear optical(NLO)properties.These compounds showed strong green emission in solution.Their NLO properties such as two-photon absorption(TPA)behavior with femtosecond laser pulses ca.800 nm and excited-state absorption(ESA)behavior with nanosecond laser pulses at 532 nm were investigated.Compound 4 presented the largest two-photon cross section(550 GM)among them due to two factors:the conjugated length of compound 4 is the longest and the electron-donating ability of compound 4 is the strongest.Different from TPA behavior,compound 2 showed the best nonlinear absorption properties at 532 nm and its nonlinear absorption coef-ficient and third-order nonlinear optical susceptibilitiesχ^(3)were up to 1.41×10^(−10) MKS and 4.65×10^(−12) esu,re-spectively.Through the modification of the structure,the nonlinear optical properties of these compounds at differ-ent wavelengths(532 and 800 nm)were well tuned.The great broad-band nonlinear optical properties indicate hy-drazones are good candidates for organic nonlinear optical absorption materials. | Peiyang Gu Xufeng Xu Feng Zhou Tingting Zhao Gaojie Ye Gaoyan Liu Qinghua Xu Jianfeng Ge Qingfeng Xu Jianmei Lu | 2014 | Chinese Journal of Chemistry2014，32，3： | 0 |
| 16 | Network Modeling and Operation Optimization of Electricity-HCNG-Integrated Energy System显示文摘Hydrogen-enriched compressed natural gas(HCNG)has great potential for renewable energy and hydrogen utilization.However,injecting hydrogen into the natural gas network will change original fluid dynamics and complicate compressed gas's physical properties,threatening operational safety of the electricity-HCNG-integrated energy system(E-HCNG-IES).To resolve such problem,this paper investigates effect of HCNG on gas network dynamics and presents an improved HCNG network model,which embodies the influence of blending hydrogen on the pressure drop equation and line pack equation.In addition,an optimal dispatch model for the E-HCNG-IES,considering the“production-storage-blending-transportation-utilization”link of the HCNG supply chain,is also proposed.The dispatch model is converted into a mixed-integer second-order conic programming(MISOCP)problem using the second-order cone(SOC)relaxation and piecewise linearization techniques.An iterative algorithm is proposed based on the convex-concave procedure and bound-tightening method to obtain a tight solution.Finally,the proposed methodology is evaluated through two E-HCNGIES numerical testbeds with different hydrogen volume fractions.Detailed operation analysis reveals that E-HCNG-IES can benefit from economic and environmental improvement with increased hydrogen volume fraction,despite declining energy delivery capacityand line pack flexibility. | Yue Qiu Suyang Zhou Wei Gu Yuping Lu Xiao-Ping Zhang Gaoyan Han Kang Zhang Hongkun Lyu | 2023 | CSEE Journal of Power and Energy Systems2023，9，4： | 0 |
| 17 | 懒妈妈的检讨书显示文摘300天,无声无息地溜过。转眼间你已满十个月,这个月身高体重没长,反倒更瘦了些,由“长条状”小宝变成了“面条状”。宝贝,妈妈觉得对不起你。 | gaoyan | 2009 | 饮食科学2009，，2： | 0 |
| 18 | The difference of clinical characteristics of patients with COVID-19 in Fourth-tier city and Wuhan显示文摘Objective:This study mainly analyzed the clinical characteristics of patients with COVID-19 in Suining,one of China’s fourth-tier cities,and Wuhan and compared data between the 2 cities.Methods:A retrospective analysis of the clinical data of 68 patients with COVID-19 diagnosed at Wuhan Red Cross Hospital and 17 patients diagnosed at Suining Central Hospital,was conducted.Results:Among the 68 patients with COVID-19 in Wuhan,30(44.1%)had hypertension,and 25(36.8%)had diabetes.Three out of the 17 patients in Suining(17.6%)had hypertension,and 2 patients(11.8%)had diabetes.In the clinical classification,there were 1(5.9%)and 23(33.8%)patients with severe COVID-19 in Suining and Wuhan,respectively.Chest CT showed that lung consolidation occurred in 2(11.8%)and 26(38.2%)patients with COVID-19 in Suining and Wuhan,respectively.The proportion of patients with diabetes or hypertension,severe COVID-19,lung consolidation in Wuhan was significantly higher than that in Suining.The laboratory tests suggested that percentage of elevated C-reactive protein(CRP)(58.8%),ALT(33.8%),blood glucose(45.6%),creatine kinase(CK)(33.8%)or D-dimer(47.1%)of patients in Wuhan were significantly increased than those in Suining(29.4%,5.9%,17.6%,5.9%,and 17.7%,respectively).Conclusion:The incidence of COVID-19 in fourth-tier city and the disease severity were significantly lower than that in Wuhan. | Xiaojuan Wu Chaoping Wang Gaoyan He Baolin Jia Li Luo Xiaobin Luo | 2021 | Infectious Diseases Research2021，2，3： | 0 |
| 19 | The Application of Developmental Social Policy in the path Choice of Urban minimum guarantee object to get rid of Poverty显示文摘 | TANG Gaoyan | 2018 | International English Education Research2018，，2： | 0 |
| 20 | 灵猴显示文摘 | 编辑 设计/ 张阳丹璐 ZhangYangdanu 高燕 GaoYan | 2022 | 中华奇石2022，，12： | 0 |
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