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| 1 | Possible mechanisms underlying treatment of Alzheimer’s disease with Traditional Chinese Medicine: active components, potential targets and synthetic pathways of Bulao Elixir显示文摘OBJECTIVE: To elucidate the mechanisms underlying the treatment of Alzheimer’s disease(AD) with Traditional Chinese Medicine(TCM), by examining the active components, potential targets and synthetic pathways of Bulao Elixir(BLE).METHODS: The Absorption, Distribution, Metabolism, Excretion(ADME)/Toxicology(T) calculation was used to screen the active components of Bulao Elixir. Based on the TCM Systems Pharmacology Analysis Platform(TCMSP database) and a text mining tool(GoPubMed database), we predicted and screened the active components of Bulao Elixir and its therapeutic targets for AD. Using the Database for Annotation, Visualization and Integrated Discovery(DAVID), we obtained the targets for AD. Cytoscape software was used to establish a network map of the active component-target and target-pathway of Bulao Elixir. Gene function, related biological processes and signaling pathways were analyzed using the DAVID database.RESULTS: Twelve active components were selected from 196 components of Bulao Elixir. Among 2209 targets, 102 effective targets were selected, and 30 important targets were identified via matching with the disease targets. After further analysis, 14 core targets were identified. Enrichment analysis revealed that most of these important targets were involved in multiple biological processes, including apoptosis, inflammatory reactions, and cell regulation cycles. The synthetic pathways for AD treatment were identified after analyzing and confirming the relevant pathways, providing potentially useful information for diagnosis and treatment methods for AD.CONCLUSION: The current study elucidated the potential treatment mechanisms of Bulao Elixir in AD using network pharmacology, providing a foundation for further clarification of its treatment targets. | Ren Beida Cheng Fafeng Wang Xueqian Wan Yuxiang Ji Wenting Du Xin Zhang Shuang Liu Shilling Ma Chongyang Xiong Yiliang Hao Gaoting Wang Qingguo | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 4 |
| 2 | Quantum Logic Networks for Probabilistic and Controlled Teleportation of Unknown Quantum States显示文摘We present simplification schemes for probabilistic and controlled teleportation of the unknown quantum states of both one particle and two particles and construct efficient quantum logic networks for implementing the new schemes by means of the primitive operations consisting of single-qubit gates, two-qubit controlled-not gates, Von Neumann measurement, and classically controlled operations. In these schemes the teleportation are not always successful but with certain probability. | GAOTing | 2004 | Communications in Theoretical Physics2004，42，2X： | 3 |
| 3 | Growth and atomic-scale characterizations of graphene on muhifaeeted textured Pt foils prepared by chemical vapor deposition显示文摘 | GaoT Xie S Gao Y Liu M Chen Y Zhang Y Liu Z | 2011 | ACS Nano2011，5，： | 1 |
| 4 | Two3DMet- aborganic Frameworks with Different Topologies, Thermal Stabilities and Magnetic Properties显示文摘 | GAOT WANGXZ GUHX etal | 2012 | Crys Eng Comm2012，14，： | 1 |
| 5 | A sensitive method for protein assays using a peptide-based nano-label:human glypican-3 detection for hepatocellular carcinomas diagnosis显示文摘 | Huang Y Li H GaoT | 2014 | Analyst2014，139，15： | 1 |
| 6 | Active treatment of localized renal tumors may not impact overall survival in pa- tients aged 75 years orolder显示文摘 | LANE BR ABOUASSALY R GAOT | 2010 | Cancer2010，116，13： | 1 |
| 7 | Adaptive Synchronization of a New Hyperehaotie System with Uncertain Parameters 显示文摘 | GAOT G CHEN Z Q YUAN Z Z | 2007 | Chaos Solitons & Fraetals2007，33，3： | 1 |
| 8 | FTIR investigation of the interaction oftumor cells treated with caffeic acid and chlorogenic acid显示文摘 | GaoT Y Ci Y X Jian H Y | | 0，，02： | 1 |
| 9 | Theanalysisoflocaladversereactionpro-ducedbyXueshuantonginjectioninfusion显示文摘 | YANGCC GAOT | 2002 | 时珍国医国药2002，13，5： | 1 |
| 10 | Study of the screw rotor with different stocks and leads for twin screw multiphase pump 显示文摘 | CAO F GAOT Y XING ZW | 2009 | Journal of Mechanical Engineer- ing Science2009，223，11： | 1 |
| 11 | DefectGlikestructuresofgrapheneoncopperfoilsforstrainreliefinvestigatedbyhighGresolutionscanningtunnelingmicroscopy 显示文摘 | ZhangY GaoT GaoY etal | 2011 | ACSNano2011，5，5： | 1 |
| 12 | Mechanical thrombectomy with combined stent retriever and contact aspiration versus stent retriever alone for acute large vessel occlusion:data from ANGEL-ACT registry显示文摘Background and purpose An analysis of the ASTER 2 trial revealed similar final recanalisation levels and clinical outcomes in acute large vessel occlusion(LVO)stroke between stent retrieval(SR)alone as a first-line mechanical thrombectomy(MT)technique(SR alone first-line)and concomitant use of contact aspiration(CA)plus SR as a first-line MT technique(SR+CA first-line).The purpose of the present study was to compare the safety and efficacy of SR+CA first-line with those of SR alone first-line for patients with LVO in China.Methods We conducted the present study by using the data from the ANGEL-ACT registry.We divided the selected patients into SR+CA first-line and SR alone first-line groups.We performed logistic regression and generalised linear models with adjustments to compare the angiographic and clinical outcomes,including successful/complete recanalisation after the first technique alone and all procedures,first-pass successful/complete recanalisation,number of passes,90-day modified Rankin Scale,procedure duration,rescue treatment and intracranial haemorrhage within 24 hours.Results Of the 1233 enrolled patients,1069(86.7%)received SR alone first-line,and 164(13.3%)received SR+CA first-line.SR+CA first-line was associated with more thrombectomy passes(3(2-4)vs 2(1-2);β=1.77,95%CI=1.55 to 1.99,p<0.001),and longer procedure duration(86(60-129)min vs 80(50-122)min;β=10.76,95%CI=1.08 to 20.43,p=0.029)than SR alone first-line group.Other outcomes were comparable(all p>0.05)between the two groups.Conclusions Patients undergoing SR+CA first-line had more thrombectomy passes and longer procedure duration than patients undergoing SR alone first-line.Additionally,we suggested that SR+CA first-line was not superior to SR alone first-line in final recanalisation level,first-pass recanalisation level and 90-day clinical outcomes in the Chinese population. | Xiaochuan Huo Dapeng Sun Mingkai Hu Raynald Baixue Jia Xu Tong Gaoting Ma Anxin Wang Ning Ma Feng Gao Dapeng Mo Zhongrong Miao the ANGEL-ACT Study group | 2023 | Stroke & Vascular Neurology2023，8，4： | 1 |
| 13 | Atomic scale electronic structure of the ferromagnetic semiconductor Cr2Ge2Te6显示文摘Cr_2Ge_2Te_6is an intrinsic ferromagnetic semiconductor with van der Waals type layered structure,thus represents a promising material for novel electronic and spintronic devices.Here we combine scanning tunneling microscopy and first-principles calculations to investigate the electronic structure of Cr_2Ge_2Te_6.Tunneling spectroscopy reveals a surprising large energy level shift and change of energy gap size across the ferromagnetic to paramagnetic phase transition,as well as a peculiar double-peak electronic state on the Cr-site defect.These features can be quantitatively explained by density functional theory calculations,which uncover a close relationship between the electronic structure and magnetic order.These findings shed important new lights on the microscopic electronic structure and origin of magnetic order in Cr_2Ge_2Te_6. | Zhenqi Hao Haiwei Li Shunhong Zhang Xintong Li Gaoting Lin Xuan Luo Yuping Sun Zheng Liu Yayu Wang | 2018 | Science Bulletin2018，63，13： | 1 |
| 14 | Fcr receptor-Mediated inflammation Inhibits Axon Regeneration 显示文摘 | ZhangG BogdanovaN GaoT | 2014 | PloS one2014，9，88： | 1 |
| 15 | A hyperchaos generatedfrom Chen's system显示文摘 | GaoT Chen Z Yuan Z | 2006 | Int J Mod Phys C2006，17，4： | 1 |
| 16 | Ethnic Chinese networks and international investment: Evidence from inwardFDI in China显示文摘 | GaoT | 2003 | Journal of Asian Economics2003，14，4： | 1 |
| 17 | Large deformation contact of a rubber notch with a rigid wedge显示文摘 | Gao Y C GaoT | 2000 | Int J Solids Struct2000，37，： | 1 |
| 18 | Endovascular treatment for acute ischaemic stroke due to medium vessel occlusion:data from ANGEL-ACT registry显示文摘Objectives To investigate the safety and efficacy of endovascular treatment(EVT)for acute medium vessel occlusion(MeVO)in the anterior circulation and to explore the independent predictors of the 90-day good outcome for such patients.Methods Data from ANGEL-ACT Registry were analysed in our study.The outcomes,such as the modified Rankin Scale(mRS)at 90 days,successful recanalisation rate and symptomatic intracranial haemorrhage(SICH)rate,were compared between MeVO and acute large vessel occlusions(LVO).Then,the independent predictors of the good outcome at 90 days in MeVO patients were determined by the logistic regression analyses.Results We included 1032 subjects in the analysis,of which,147 were MeVO and 885 were LVO.mRS at 90 days distribution(3(0-4)vs 3(0-5),common odds ratio(OR)=1.00,95%confidence interval(CI)0.73 to 1.38,p=0.994),SICH rate(4.8%vs 8.9%;OR=0.59,95%CI 0.26 to 1.34,p=0.205)and successful recanalisation rate(89.8%vs 89.7%;OR=1.0095%CI 0.51 to 1.93,p=0.992)were similar between the MeVO and LVO groups after adjusting for the confounders.We identified that baseline neutrophil-to lymphocyte ratio≤4.1(OR=2.13,95%CI 1.14 to 3.99,p=0.019),baseline National Institutes of Health Stroke Scale≤14(OR=1.96,95%CI 1.02 to 3.80,p=0.045)and mechanical thrombectomy passes≤1(OR=2.16,95%CI 1.14 to 4.11,p=0.021)were independent predictors of the 90-day good outcome in MeVO patients undergoing EVT.Conclusions Patients with MeVO achieved similar 90-day mRS,SICH rate and successful recanalisation rate after EVT compared with patients with LVO.Several independent predictors of 90-day good outcome in MeVO patients undergoing EVT were determined,which should be highly considered in MeVO stroke management. | Dapeng Sun Raynald Xiaochuan Huo Baixue Jia Xu Tong Anxin Wang Gaoting Ma Ning Ma Feng Gao Dapeng Mo Zhongrong Miao 无 | 2023 | Stroke & Vascular Neurology2023，8，1： | 0 |
| 19 | Endovascular therapy in acute anterior circulation large vessel occlusive patients with a large infarct core(ANGEL-ASPECT):protocol of a multicentre randomised trial显示文摘Background The benefit of stroke thrombectomy for large infarct core still lacks robust randomised controlled studies.Aim To demonstrate the design of a clinical trial on endovascular therapy for acute anterior circulation large vessel occlusion(LVO)patients with large infarct core volume.Design ANGEL-ASPECT is a multicentre,prospective,randomised,open-label,blinded End-point trial to evaluate whether best medical management(BMM)combined with endovascular therapy improves neurological functional outcomes as compared with BMM alone in acute LVO patients with Alberta Stroke Program Early CT Score(ASPECTS)of 3-5 on non-contrast CT or infarct core volume range of 70-100 mL(defined as rCBF<30%on CT perfusion or ADC<620 on MRI)up to 24 hours from symptom onset or last seen well.Study outcomes The primary efficacy outcome is 90(±7)days modified Rankin Scale.Symptomatic intracranial haemorrhage within 48 hours from randomisation is the primary safety outcome.Discussion The ANGEL-ASPECT trial will screen patients with large infarct core(ASPECTS 3-5 or 70-100 mL)through image evaluation criteria within 24 hours and explore the efficacy and safety of endovascular therapy compared with BMM. | Xiaochuan Huo Gaoting Ma Xuelei Zhang Yuesong Pan Xu Tong Dapeng Sun Liping Liu Yilong Wang David S Liebeskind Yongjun Wang Vitor Mendes Pereira Zeguang Ren Zhongrong Miao | 2023 | Stroke & Vascular Neurology2023，8，2： | 0 |
| 20 | Quantum Logic Network for Probabilistic Cloning Quantum States显示文摘We construct efficient quantum logic network for probabilistic cloning the quantum states used in imple mented tasks for which cloning provides some enhancement in performance. | GAOTing YANFeng-Li WANGZhi-Xi | 2005 | Communications in Theoretical Physics2005，43，1： | 0 |
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