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| 1 | 儿童原发性颅内绒毛膜癌的临床特点、诊断与治疗显示文摘目的探讨儿童原发性颅内绒毛膜癌的临床特点、诊断、治疗方法及预后。方法回顾性分析2002年5月至2015年1月首都医科大学附属北京天坛医院神经外科收治的8例原发性颅内绒毛膜癌患者(7例经病理学检查证实,l例为临床诊断)。8例均为男性,平均年龄11岁。7例病变位于松果体区,1例位于鞍区;肿瘤平均直径为3—5cm。术前检查显示,8例患者血和脑脊液人绒毛膜促性腺激素(HCG)均极度升高。8例患者中,3例术前行诊断性放疗,1例术前行立体定向放疗。7例采用经胼胝体一穹隆间入路切除肿瘤,1例行放、化疗。随访时间为1~60个月,定期复查血HCG水平及头颅MRI。结果3例术前行诊断性放疗的患者中,2例出现肿瘤卒中。1例术前行立体定向放疗后出现肿瘤卒中。7例手术患者中,全切除5例,近全切除2例。至随访时4例存活,3例死亡。1例未行手术治疗的患者至随访时仍存活,肿瘤无复发。结论原发性颅内绒毛膜癌是罕见的儿童颅内恶性肿瘤,血HCG和脑脊液HCG明显升高现象有助于诊断。术前放疗可能增加肿瘤卒中风险,切除肿瘤或化疗显效前不推荐放疗。手术及联合化疗可能能够取得较好疗效。对于不宜手术的病例,可以进行化疗,并可追加放疗。 | 孙涛 田永吉 Liu Raynald 万伟庆 罗世琪 李春德 | 2015 | 中华神经外科杂志2015，31，11： | 3 |
| 2 | 移植人骨髓间充质干细胞促进大鼠脊髓损伤后的神经功能恢复显示文摘【目的】研究人骨髓间充质干细胞(human bone marrow stromal cells,h BMSCs)治疗大鼠脊髓损伤的可行性。【方法】从人的骨髓中分离、培养骨髓间充质干细胞。制作大鼠脊髓半横断模型,按照试验分组分为单纯损伤组和h BMSC移植组。术后按照不同时间点评价损伤和移植后的大鼠运动功能。6周后处死大鼠,分别观察两组大鼠损伤区域血管生长情况、营养因子表达情况以及移植细胞的轴突生长情况。【结果】免疫荧光检测发现,移植后6周,病变部位产生新轴突,h BMSCs移植组比单纯损伤组有更多的神经丝蛋白(neurofilaments,NF)的信号。透射电镜检查发现h BMSCs组有大量的新生轴突和血管。单纯损伤组中,仅检测到极少量的新轴突生长。采用Real-time PCR检测脊髓组织里的神经营养因子,显示移植h BMSCs可以使脊髓组织中神经营养因子的表达增加。移植h BMSCs后脊髓组织转录神经营养因子3(neurotrophin-3,NT-3)与血管内皮生长因子,(vascular endothelial growth factor,VEGF)的m RNA量在移植术后第2、3周明显高于单纯损伤组。移植h BMSCs的大鼠的BBB评分从损伤后第1周至第8周都比单纯损伤组大鼠的评分高,二者具有统计学差异。在损伤后的第4、6周所做的运动诱发电位结果表明,移植h BMSCs得大鼠的潜伏期与对照组相比明显缩短。【结论】h BMSCs具有促进神经功能恢复作用,其机制可能为h BMSCs在体内促进营养因子和VEGF表达和分泌,进而促进轴突再生和血管生成,使损伤的神经功能更好地恢复。 | 黄华 Raynald 安沂华 王晓东 潘琦 | 2016 | 武警后勤学院学报(医学版)2016，25，11： | 3 |
| 3 | 人骨髓间充质干细胞在脊髓损伤模型大鼠体内的存活与分化研究显示文摘目的观察人骨髓间充质干细胞(hBMSCs)在脊髓损伤大鼠体内存活与分化情况。方法采用全骨髓贴壁培养法,分离来自hBMSCs并进行流式细胞鉴定。制作大鼠脊髓半横断模型,按照实验分组为单纯损伤组与hBMSC移植组。6周后处死大鼠,用免疫荧光方法观察移植的hBMSCs在大鼠体内的存活及分化情况。结果本研究中所使用hBMSCs呈CD44,CD73,CD90和CD105阳性,CD11b、CD19、CD34和CD45表达为阴性。动物体内实验表明,移植后6周,免疫荧光激光共聚焦观察到由5-溴-2-脱氧尿苷(BrdU)标记的、存活的移植hBMSCs。移植的hBMSCs部分显示BrdU+/NeuN+与BrdU+/GFAP+的表达,与对照组相比较有显著性差异。结论移植到大鼠脊髓损伤部位的hBMSCs在局部存活并有分化成为神经元以及神经胶质细胞的潜能,为hBMSCs移植治疗脊髓损伤的临床应用提供理论依据。 | 黄华 Raynald 安沂华 潘琦 王晓东 | 2016 | 中国急救复苏与灾害医学杂志2016，0，8： | 3 |
| 4 | McCune-Albright综合征合并垂体腺瘤的临床分析显示文摘目的探讨McCune-Albright综合征(MAS)合并垂体腺瘤的临床特点、治疗方法及预后。方法回顾性分析2004年4月至2016年11月首都医科大学附属北京天坛医院神经外科收治的9例MAS合并垂体腺瘤患者的临床资料。9例患者中,男4例,女5例;平均年龄为42岁(31~59岁)。4例血生长激素水平升高,4例血催乳素水平升高,1例血甲状腺素水平异常。8例行经蝶窦入路切除垂体腺瘤(4例应用神经内镜手术,其中2例采用术中导航辅助;4例应用显微镜手术),1例行开颅手术切除垂体腺瘤。随访时间为6~151个月。结果肿瘤全切除7例,近全切除1例,部分切除1例。8例患者术后内分泌异常情况明显缓解,1例术后生长激素水平仍偏高,1例术后出现新发垂体功能低下。术前出现进行性视力下降的6例患者术后视力明显改善。随访期内8例病情稳定,无一例出现垂体腺瘤复发,颅骨纤维异常增殖情况稳定无进展;1例患者因心脏病死亡。结论MAS的临床表现形式多样,临床易误诊和漏诊,其合并的垂体腺瘤和内分泌功能异常可加重病情,早期诊断并积极治疗内分泌功能异常、制定个体化的诊疗策略可提高疗效,改善患者的预后。 | 李智 钱海燕 Raynald Liu 刘丕楠 | 2017 | 中华神经外科杂志2017，33，7： | 3 |
| 5 | Association of insulin resistance with serum ferritin and aminotransferases-iron hypothesis显示文摘AIM: To investigate the relationship of iron indices with diabetes mellitus(DM) in those without hemochromatosis.METHODS: This cross-sectional study examined data collected during the Third National Health and Nutrition Examination Survey(NHANES III). Only those who fasted properly and were not anemic with transferrin saturation < 45% were included(n = 6849). Insulin sensitivity and beta cell function were calculated from fasting glucose and insulin concentrations. Indices of iron metabolism were examined in the presence or absence of DM. We examined the relationship of insulin sensitivity and beta cell function with serum ferritin concentration. The influence of C-reactive protein and liver enzymes was also investigated.RESULTS: Serum ferritin concentration was significantly higher in diabetic subjects(P = 0.0001 to< 0.000001). The difference remained significant after adjustment for age, body mass index, alcohol consumption, and mineral/iron supplement(P = 0.03 to< 0.000001). In those who did not take insulin, serum ferritin concentration was negatively associated with insulin sensitivity(P = 0.05 to 0.00001), but not with beta cell function. The alanine aminotransferase was correlated with serum ferritin concentration(P = 0.02 to< 0.000001) but not with insulin sensitivity, suggesting the role of the liver in iron-associated insulin resistance.CONCLUSION: As most of diabetes is type 2 diabetes and insulin resistance is a cardinal feature of type 2diabetes, disordered iron metabolism could play a role in the pathogenesis of insulin resistance and type 2diabetes through its effect on liver function. | Jean Huang Rudruidee Karnchanasorn Horng-Yih Ou Wei Feng Lee-Ming Chuang Ken C Chiu Raynald Samoa | 2015 | World Journal of Experimental Medicine2015，5，4： | 2 |
| 6 | 间充质干细胞-透明质酸-多聚赖氨酸治疗脊髓损伤的实验研究显示文摘目的研究间充质干细胞—透明质酸—多聚赖氨酸复合物治疗脊髓损伤的可行性,评价其治疗效果并探讨其可能机制。方法从人骨髓中分离、培养人骨髓间充质干细胞(human bone marrow mesenchymal stem cell,hBMSC);制作大鼠脊髓半横断模型,按照实验分组分别将hBMSC、透明质酸-多聚赖氨酸(hyaluronic acid-poly-L-lysine,HA-PLL)、hBMSC-HA-PLL复合物注入损伤区域,单纯损伤组作为对照。术后按照不同时间点评价损伤和移植后的大鼠运动功能。8周后杀死大鼠,观察不同移植组体内轴突和血管生长的情况,对不同细胞、材料及复合物移植对大鼠脊髓损伤修复效果进行评估。结果 hBMSC移植组和hBMSC-HA-PLL移植组的大鼠运动功能的改善显著好于单纯损伤及HA-PLL移植组。电镜结果证实复合物移植组可显著促进轴突和血管生长,新生的轴突和血管结构较为完整。结论 hBMSC具有促进神经功能恢复的作用,将其与HA-PLL相结合,可以促进大鼠脊髓损伤修复,其机制可能包括材料框架作用和hBMSC在体内对大鼠神经细胞的营养作用以及促进微血管的生成。 | Raynald 李延滨 郭牧遥 黄华 张涵 于昊 李海龙 崔福斋 安沂华 | 2012 | 中国比较医学杂志2012，22，5： | 2 |
| 7 | Subsurface damage distribution characterization of ground surface using Abbott-Firestone curves 显示文摘 | Raynald Laheurte Philippe Darnis Nathalie Darbois | 2012 | Optics Express2012，20，13： | 1 |
| 8 | Structural characterization of a mechanically milled carbon nanotube/aluminum mixture 显示文摘 | Dominique Poirier Raynald Gauvin Robin A L Drew | 2009 | Compos Part A: Appl Sci Manuf2009，40，9： | 1 |
| 9 | Effect of Cu on the ultrastructural of Scenedesmus quadricauda and Chlorella vulgaris显示文摘 | Christian B Raynald C | 1989 | Int Revue ges Hydrobiol1989，74，1： | 1 |
| 10 | 小儿颅内胚胎癌1例显示文摘胚胎癌是最原始的生殖细胞肿瘤,有分化为成熟畸胎瘤和非成熟畸胎瘤的潜能。即使采用手术结合术后放化疗的综合治疗,其预后仍不理想。2012年6月.我院收治1例5岁女性颅内胚胎癌,现报道如下: | 李响 Raynald 朱婉春 宫剑 | 2016 | 中国临床神经外科杂志2016，21，1： | 1 |
| 11 | Current models of the mode of action of Bacillus thuringiensis insecticidal crystal proteins: A critical review显示文摘 | Vincent Vachon Raynald Laprade Jean-Louis Schwartz | 2012 | Journal of Invertebrate Pathology2012，，1： | 1 |
| 12 | CASINO : ANew Monte Carlo Code in C Language for Electron Beam Interaction-Part I: Description of the Program 显示文摘 | Pierre Hovington Dominique Drouin Raynald Gauvin | 1997 | Scanning1997，19，： | 1 |
| 13 | CASINO:A New Monte Carlo Code in C Language for Electron BeamInteractions-Part II : Tabulated Values of the Mott Cross Section 显示文摘 | Pierre Hovington Dominique Drouin Raynald Gauvin | 1997 | Scanning1997，19，： | 1 |
| 14 | CASINO:A New Monte Carlo Code in C Language for Electron BeamInteractions-Part III : Stopping Power at Low Energies 显示文摘 | Pierre Hovington Dominique Drouin Raynald Gauvin | 1997 | Scanning1997，19，： | 1 |
| 15 | Nonlinear damping calculation in cylindrical gear dynamic modeling显示文摘 | Raynald Guilbault Sebastien Lalonde Marc Thomas | 2012 | Journal of Sound and Vibration2012，331，： | 1 |
| 16 | 显示文摘 | Harfmut W Gundel Perig L amousin Raynald Seveno | 2001 | Journal of the European Ceramic Society2001，21，： | 1 |
| 17 | Helical Gear, Effects of Tooth Deviations and Tooth Modification on Load Sharing and Fillet Stresses显示文摘 | Raynald Guilbault Cloude Gosselin Louis Cloutier | 2006 | Journal of Mechanical Design Transactions of the ASME2006，128，： | 1 |
| 18 | Chonic activation of AMP kinase in NRF - 1 activation and mitochondrial bio- genesis显示文摘 | Raynald B Jian MR Kevin S | 2001 | Am J Physiol Endocrinol Metab2001，281，： | 1 |
| 19 | ElectricalProperties of Glass Microelectrodes显示文摘 | Otto F Schanne Marc Lavallee Raynald Laprade | 1968 | Proceedings of the IEEE1968，56，6： | 1 |
| 20 | Performance of automated CT ASPECTS in comparison to physicians at different levels on evaluating acute ischemic stroke at a single institution in China显示文摘Background:Our aim was to evaluate the sensitivity and specificity of the automated computer-based Alberta Stroke Program Early CT Score(e-ASPECTS)for acute stroke patients and compare the result with physicians at different levels.Methods:In our center,e-ASPECTS and 9 physicians at different levels retrospectively and blindly assessed baseline computed tomography(CT)images of 55 patients.Sensitivity,specificity,receiver-operating characteristic curves,Bland–Altman plots with mean score error,and Matthews correlation coefficients were calculated.Comparisons were made between the scores by physicians and e-ASPECTS with diffusion-weighted imaging(DWI)being the ground truth.Two methods for clustered data were used to estimate sensitivity and specificity in the region-based analysis.Results:In total,1100(55 patients×20 regions per patient)ASPECTS regions were scored.In the region-based analysis,sensitivity of e-ASPECTS was better than junior doctors and residents(0.576 vs 0.165 and 0.111,p<0.05)but inferior to senior doctors(0.576 vs 0.617).Specificity was lower than junior doctors and residents(0.883 vs 0.971 and 0.914)but higher than senior doctors(0.883 vs 0.809,p<0.05).E-ASPECTS had the best Matthews correlation coefficient of 0.529,compared to senior doctors,junior doctors,and residents(0.463,0.251,and 0.087,respectively).Conclusions:e-ASPECTS showed a similar performance to that of senior physicians in the assessment of brain CT of acute ischemic stroke patients with the Alberta Stroke Program Early CT score method. | Xiaochuan Huo Raynald Hailan Jin Yin Yin Guangming Yang Zhongrong Miao | 2021 | Chinese Neurosurgical Journal2021，7，4： | 1 |
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