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| 1 | Tectonic thermal history and its significance on the formation of oil and gas accumulation and mineral deposit in Ordos Basin显示文摘The analyzing data on stratigraphic temperature measurement , thermal conductivity of the strata and radioactive heat production rate show that the present average geothermal gradient in the Ordos Basin is 2.93℃/100 m, and the average heat flow value is 61.78 mW/m2, which belongs to the mesothermal basin, and the value of the present geothermal gradient and heat flow in the east is higher than that in the west. The sandstone radioactive heat production rate of Zhiluo Group in Dongsheng Uranium deposits of Yimeng uplift is obviously higher in the mudstone, indicating that there exists a uranium anomaly. Based on studies of the present thermal field of the basin, the late-Mesozoic paleotemperature and paleogeothermal gradient are determined by using different kinds of paleotemperature methods. According to the anomaly of the late-Mesozoic paleotemperature gradient and magmatic event age, there was a tectonic thermal event in the early Cretaceous epoch of late-Mesozoic. This article rebuilds tectonic thermal history of different tectonic units by thermal history simulation using basin simulating software. The evolution of oil-gas and coal, and accumulation (mineralization) of mineral uranium are all controlled by the tectonic thermal history in the Ordos basin, especially by the tectonic thermal event that happened in the late Mesozoic. For both the gas source rocks of upper Paleozoic group and lower paleozoic group, the gas was largely generated in the early Cretaceous epoch of the late Mesozoic. The main petroleum generation period for Yanchang Group in Triassic system is the early Cretaceous epoch too, and the highest thermal maturity of the coal of Permo-Carboniferous, Triassic, and Jurassic reaches is the early Cretaceous epoch also. Early Cretaceous epoch is still one of the most important mineralizing periods of uranium. | REN ZhanLi ZHANG Sheng GAO ShengLi CUI JunPing XIAO YuanYuan XIAO Hui | 2007 | Science China Earth Sciences2007，50，z2： | 44 |
| 2 | Early tectonic uplift of the northern Tibetan Plateau显示文摘The Hexi Corridor is the northmost foreland basin of the Tibetan Plateau and its formation is controlled by the northern marginal fault of Tibet, Altyn Tagh Fault (ATF)-North Qilian Shan marginal Fault (NQF), and the southern Kuantan Shan-Longshou Shan Fault (KLF). So its study is important to understanding the mechanism of Tibet formation and its influence on global climate change. The oldest Cenozoic sediments in the Corridor is the Huoshaogou Formation which consists of terrigenous fine conglomerate, sandstone, sandy mudstone and mudstone, depositing in alluvial to lacustrine and fan delta sedimentary environments. Detailed paleomagnetic measurements of this sequence at Yumen clearly reveal eleven pairs of normal and reversed polarities. Fossil mammals found around the section support that most of the observed polarities can be well correlated with chrons between 13n and 18r of the standard geomagnetic polarity time scale, yielding ages of 40.2-33.35 Ma. The mean declinations of this sequence and its immediately above stratigraphy indicate an 18.3° rapid clockwise rotation of the Hexi Corridor. Since this sequence has been strongly folded and is capped by an angular unconformity, we think that the presence of the thick alluvial fan conglomeration at the bottom of the foreland basin may indicate the initial deformation and uplift of the northern Qilian Shan. This process could occur at latest at 40.2 Ma, driven by the faults NQF and KLF that thrust onto the Hexi corridor respectively from its southern and northern margins. These faults are in an early response to the collision of India with Asia, while the unconformable termination and rotation of the Huoshaogou Formation at ~33.35 Ma indicate other early episode of rapid tectonic deformation and uplift of the northern Tibet. | DAI Shuang FANG Xiaomin SONG Chunhui GAO Junping GAO Donglin LI Jijun | 2005 | Chinese Science Bulletin2005，50，15： | 30 |
| 3 | Cenozoic Stratigraphy Deformation History in the Central and Eastern of Qaidam Basin by the Balance Section Restoration and its Implication显示文摘Qaidam 盆,在 Qinghai 西藏高原的北边缘定位了,是大中生代新生代盆,和熊巨大的厚新生代阶层。自从 ∼55 妈,印第安人欧亚的板板碰撞的地质的事件是记录的井。在高分辨率的地层学基于最近的进步,平衡的节的一种技术被用于六东北西南地质的地震侧面在 Qaidam 盆中央、东方重建外壳的弄短变丑历史在新生代碰撞期间。结果证明 Qaidam 盆开始弄短对早碰撞将近同步的变丑,作为弱压缩表明,变丑在中间期间并且晚显著地增加了始新世,然后稍微变弱并且开始后来很快加速了晚中新世,特别第四级,反映这强大的有压缩性的变丑并且快速在 Qaidam 盆附近北西藏的高原高举。 | LIU Dongliang FANG Xiaomin GAO Junping WANG Yadong ZHANG Weilin MIAO Yunfa LIU Yongqian ZHANG Yuezhong | 2009 | Acta Geologica Sinica(English Edition)2009，83，2： | 16 |
| 4 | Evaluation of health benefit using Ben MAP-CE with an integrated scheme of model and monitor data during Guangzhou Asian Games显示文摘Guangzhou is the capital and largest city(land area:7287 km2)of Guangdong province in South China.The air quality in Guangzhou typically worsens in November due to unfavorable meteorological conditions for pollutant dispersion.During the Guangzhou Asian Games in November 2010,the Guangzhou government carried out a number of emission control measures that significantly improved the air quality.In this paper,we estimated the acute health outcome changes related to the air quality improvement during the 2010 Guangzhou Asian Games using a next-generation,fully-integrated assessment system for air quality and health benefits.This advanced system generates air quality data by fusing model and monitoring data instead of using monitoring data alone,which provides more reliable results.The air quality estimates retain the spatial distribution of model results while calibrating the value with observations.The results show that the mean PM_2.5concentration in November 2010 decreased by 3.5μg/m^3 compared to that in 2009 due to the emission control measures.From the analysis,we estimate that the air quality improvement avoided 106 premature deaths,1869 cases of hospital admission,and 20,026 cases of outpatient visits.The overall cost benefit of the improved air quality is estimated to be 165 million CNY,with the avoided premature death contributing 90%of this figure.The research demonstrates that Ben MAP-CE is capable of assessing the health and cost benefits of air pollution control for sound policy making. | Dian Ding Yun Zhu Carey Jang Che-Jen Lin Shuxiao Wang Joshua Fu Jian Gao Shuang Deng Junping Xie Xuezhen Qiu | 2016 | Journal of Environmental Sciences2016，28，4： | 13 |
| 5 | Design and demonstration of a next-generation air quality attainment assessment system for PM_(2.5)and O_3显示文摘Due to the increasingly stringent standards, it is important to assess whether the proposed emission reduction will result in ambient concentrations that meet the standards. The Software for Model Attainment Test—Community Edition(SMAT-CE) is developed for demonstrating attainment of air quality standards of O3 and PM2.5. SMAT-CE improves computational efficiency and provides a number of advanced visualization and analytical functionalities on an integrated GIS platform. SMAT-CE incorporates historical measurements of air quality parameters and simulated air pollutant concentrations under a number of emission inventory scenarios to project the level of compliance to air quality standards in a targeted future year. An application case study of the software based on the U.S. National Ambient Air Quality Standards(NAAQS) shows that SMAT-CE is capable of demonstrating the air quality attainment of annual PM2.5and 8-hour O3 for a proposed emission control policy. | Hua Wang Yun Zhu Carey Jang Che-Jen Lin Shuxiao Wang Joshua S.Fu Jian Gao Shuang Deng Junping Xie Dian Ding Xuezhen Qiu Shicheng Long | 2015 | Journal of Environmental Sciences2015，27，3： | 11 |
| 6 | Terrace dating as an archive of the run-through of the Sanmen Gorges显示文摘Analysis of morphological properties in the Sanmen Gorges region of the Yellow River shows that four river terraces have been developed at the entrance to the gorges. Commonly, thick aeolian loess-paleosol sequence was deposited on the terraces, which makes it easy to date the terraces. The dating of paleomagnetic, loess-paleosol sequence matching and thermoluminescence show that terraces T2, T3 and T4 were formed 0. 129 Ma, 0. 625 Ma and 0. 865 Ma ago, respectively. The formation of these terraces in this region indicates that the Yellow River has experienced four intensive downcutting events during the last 0.9 Ma. The Yellow River cut through the Sanmen Gorges and inpoured into the East China Sea no later than 0. 865 Ma. | PAN Baotian WANG Junping GAO Hongshan CHEN Yingying LI Jijun LIU Xiaofeng | 2005 | Progress in Natural Science:Materials International2005，15，12： | 9 |
| 7 | A case study of development and application of a streamlined control and response modeling system for PM_(2.5)attainment assessment in China显示文摘This article describes the development and application of a streamlined air control and response modeling system with a novel response surface modeling-linear coupled fitting method and a new module to provide streamlined model data for PM_(2.5) attainment assessment in China.This method is capable of significantly reducing the dimensions required to establish a response surface model,as well as capturing more realistic response of PM_(2.5) to emission changes with a limited number of model simulations.The newly developed module establishes a data link between the system and the Software for Model Attainment Test—Community Edition(SMAT-CE),and has the ability to rapidly provide model responses to emission control scenarios for SMAT-CE using a simple interface.The performance of this streamlined system is demonstrated through a case study of the Yangtze River Delta(YRD) in China.Our results show that this system is capable of reproducing the Community Multi-Scale Air Quality(CMAQ) model simulation results with maximum mean normalized error < 3.5%.It is also demonstrated that primary emissions make a major contribution to ambient levels of PM_(2.5) in January and August(e.g.,more than50%contributed by primary emissions in Shanghai),and Shanghai needs to have regional emission control both locally and in its neighboring provinces to meet China's annual PM_(2.5)National Ambient Air Quality Standard.The streamlined system provides a real-time control/response assessment to identify the contributions of major emission sources to ambient PM_(2.5)(and potentially O_3 as well) and streamline air quality data for SMAT-CE to perform attainment assessments. | Shicheng Long Yun Zhu Carey Jang Che-Jen Lin Shuxiao Wang Bin Zhao Jian Gao Shuang Deng Junping Xie Xuezhen Qiu | 2016 | Journal of Environmental Sciences2016，28，3： | 9 |
| 8 | An Ethylene-inhibited NF-YC Transcription Factor RhNF-YC9 Regulates Petal Expansion in Rose显示文摘The speed of flower opening is closely related to their ornamental period.Ethylene functions as a negative regulator involved in the regulation of the petal expansion process.In this study,we isolated a NF-YC transcription factor gene,RhNF-YC9,fromrose petals.RhNF-YC9 expression was induced at the early stages of flower opening but was inhibited by ethylene treatment.Silencing RhNF-YC9 decreased the speed of petal expansion from stage 2 to stage 5.The expressions of 11 cell expansion-related genes involved in cell wall loosening,cell turgor modulation,and cytoskeleton remodeling were significantly down-regulated in RhNF-YC9-silenced petals.We also found that silencing RhNF-YC9 decreased the expression of gibberellin acid(GA)biosynthetic gene RhGA20ox while significantly increasing the transcripts of GA catabolic gene RhGA2ox,reducing the accumulation of GA4 and GA7.The influence of ethylene treatment on the expression of RhGA20ox and RhGA2ox showed the same trend.These results together suggested that RhNF-YC9 positively regulated the speed of petal expansion and mediated the crosstalk between ethylene and GA.Our findings revealed a new insight into the function of NF-YC transcription factors involved in ethylene-regulated petal expansion. | Changxi Chen Nisar Hussain Yaru Wang Mingtong Li Lin Liu Meizhu Qin Nan Ma Junping Gao Xiaoming Sun | 2020 | Horticultural Plant Journal2020，6，6： | 9 |
| 9 | Instability characteristics of the East Asian Monsoon recorded by high-resolution loess sections from the last interglacial (MIS5)显示文摘The selection of high-resolution loess sections is needed in order to determine the climatic variability of the East Asian Monsoon during the last interglacial. Two sequences of S1 on the eastern and west-ern sides of the Liupan Mountain were both composed of five paleosol layers and four loess layers,indicating that there were five strong summer monsoon events and four strong winter monsoon events in MIS5. This corresponds with other records of the East Asian Monsoon,along with NGRIP and the North Atlantic records,implying that the climate of the Northern Hemisphere was very instable during the last interglacial. Two layers of paleosols and one layer of loess had developed during MIS5a and MIS5c. Compared with MIS5e,the climate in MIS5a and MIS5c fluctuated more intensively on a millen-nial scale,whereas the climate was relatively stable in MIS5e. | GUAN QingYu PAN BaoTian GAO HongShan LI BingYuan WANG JunPing SU Huai | 2007 | Science China Earth Sciences2007，50，7： | 5 |
| 10 | Intrastriatal glial cell line-derived neurotrophic factors for protecting dopaminergic neurons in the substantia nigra of mice with Parkinson disease显示文摘BACKGROUND:Substantia nigra is deep in position and limited in range,the glial cell line-derived neurotrophic factor(GDNF)injection directly into substantia nigra has relatively greater damages with higher difficulty.GDNF injection into striatum,the target area of dopaminergic neuron,may protect the dopaminergic neurons in the compact part of substantia nigra through retrograde transport.OBJECTIVE:To investigate the protective effect of intrastriatal GDNF on dopaminergic neurons in the substantia nigra of mice with Parkinson disease(PD),and analyze the action pathway.DESIGN:A controlled observation.SETTING:Neurobiological Laboratory of Xuzhou Medical College.MATERIALS:Twenty-four male Kunming mice of 7-8 weeks old were used.GDNF,1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)were purchased from Sigma Company(USA);LEICAQWin image processing and analytical system.METHODS:The experiments were carried out in the Neurobiological Laboratory of Xuzhou Medical College from September 2005 to October 2006.The PD models were established in adult KunMing mice by intraperitoneal injection of MPTP.The model mice were were randomly divided into four groups with 6 mice in each group:GDNF 4-day group,phosphate buffer solution(PSB)4-day group,GDNF 6-day group and PSB 6-day group.Mice in the GDNF 4 and 6-day groups were administrated with 1 μL GDNF solution(20 μg/L,dispensed with 0.01 mol/L PBS)injected into right striatum at 4 and 6 days after model establishment.Mice in the PSB 4 and 6-day groups were administrated with 0.01 mol/L PBS of the same volume to the same injection at corresponding time points.② On the 12th day after model establishment,the midbrain tissue section of each mice was divided into 3 areas from rostral to caudal sides.The positive neurons of tyroxine hydroxylase(TH)and calcium binding protein(CB)with obvious nucleolus and clear outline were randomly selected for the measurement,and the number of positive neurons in unit area was counted.MAIN OUTCOME MEASURES:Number of positive neurons of TH and CB in midbrain substantia nigra of mice in each group.RESULTS:All the 24 mice were involved in the analysis of results.The numbers of TH+ and CB+ neurons in the GDNF 4-day group(54.33±6.92,46.33±5.54)were obviously more than those in the PBS 4-day group(27.67±5.01,21.50±5.96,P < 0.01).The numbers of TH+ and CB+ neurons in the GDNF 6-day group(75.67±5.39,69.67±8.69)were obviously more than those in the PBS 6-day group(27.17±4.50,21.33±5.72,P < 0.01)and those in the GDNF 4-day group(P < 0.01).CONCLUSION:Intrastriatal GDNF can protect dopaminergic neurons in substantia nigra of PD mice,and it may be related to the increase of CB expression. | Chenghua Xiao Yanqiang Wang Hongmei Liu Hongjun Wang Junping Cao Dianshuai Gao | 2007 | Neural Regeneration Research2007，2，4： | 4 |
| 11 | Response of grain size of Quaternary gravels to climate and tectonics in the northern Tibetan Plateau显示文摘The widely distributed thick gravel deposits along the rim of the Tibetan Plateau have been long thought to be the product of rapid tectonic uplift of the plateau. However, this has been challenged by recent works that suggest these thick gravels may be the result of climate change. In this paper we carried out a detailed field measurement of gravel grain sizes from the Jiuquan and Gobi Gravel Beds in the top of the Laojunmiao section in the Jiuxi Basin in the northern margin of Qilian Mts. (northern Tibetan Plateau). The results suggest that the grain sizes of the Jiuquan and Gobi Gravel Beds over the last 0.8 Ma are characterized by nine coarse-fine cycles having strong 100-ka and 41-ka periodicities that correlate well with the loess-paleosol monsoon record and isotopic global climatic record from deep sea sediments as well as by a long trend of coarsening in gravel grain size. The coarse gravel layers were formed during the warm-humid interglaciations while the fine layers correspond to the cold-dry glaciations. Because the paleoclimate in NW China began to get dramatically drier after the mid-Pleistocene, we think the persistent coarsening of gravel grain size was most probably caused by the rapid uplift of the northern Tibetan Plateau, and that the orbital scale cyclic variations in gravel grain size were driven by orbital forcing factors that were superimposed on the tectonically-forced long-term coarsening trend in gravel size. These findings also shed new light on the interaction results of climate and tectonics in relation to the uplift of the Tibetan Plateau. | FU KaiDao FANG XiaoMin GAO JunPing HAN WenXia LI LiLi | 2007 | Science China Earth Sciences2007，50，1： | 3 |
| 12 | Ambulatory blood pressure profile and stroke recurrence显示文摘Objectives To establish a new ambulatory blood pressure(ABP)parameter(24-hour ABP profile)and evaluated its performance on stroke outcome in ischaemic stroke(IS)or transient ischaemic attack(TIA)patients.Methods The prospective cohort consisted of 1996 IS/TIA patients enrolled for ABP monitoring and a 3-month follow-up for stroke recurrence as outcome.Profile groups of systolic blood pressure(SBP)were identified via an advanced functional clustering method,and the associations of the profile groups and conventional ABP parameters with stroke recurrence were examined in a Cox proportional hazards model.Results Three discrete profile groups(n=604,781 and 611 in profiles 1,2 and 3,respectively)in 24-hour ambulatory SBP were identified.Profile 1 resembled most to the normal diurnal blood pressure pattern;profile 2 also dropped at night,but climbed earlier and with higher morning surge;while profile 3 had sustained higher nocturnal SBP without significant nocturnal SBP decline.The incidence of stroke recurrence was 2.9%,3.9%and 5.5%in profiles 1,2 and 3,respectively.After adjustment for covariates,profile 3 was significantly associated with higher risk of stroke recurrence with profile 1 as reference(HR 1.76,95%CI:1.00 to 3.09),while no significant difference was observed between profiles 2 and 1(HR 1.22,95%CI:0.66 to 2.25).None of conventional ABP parameters showed significant associations with the outcome.Conclusions Ambulatory 24-hour SBP profile is associated with short-term stroke recurrence.Profiles of ABP may help improve identification of stroke recurrence by capturing the additive effects of individual ABP parameters. | Jie Xu Fei Jiang Anxin Wang Hui Zhi Yuan Gao Junping Tian Jinglin Mo Zimo Chen An-Ding Xu Benyan Luo Bo Hu Yuqing Zhang Xingquan Zhao Yilong Wang Hao Li Haipeng Shen Yongjun Wang | 2021 | Stroke & Vascular Neurology2021，6，3： | 3 |
| 13 | Randomized,multicenter,open-label trial of autologous cytokine-induced killer cell immunotherapy plus chemotherapy for squamous non-small-cell lung cancer:NCT01631357显示文摘Dear Editor,Cytokine-induced killer(CIK)cells have been recognized as a new type of anti-tumor effector cells.CIK cells are a mixture of T lymphocytes.Among them,CD3+/CD56+T cells,which are rare in uncultured peripheral blood,are the main effector cells.CIK cells can proliferate rapidly in vitro,with stronger antitumor activity,broader target tumor spectrum,and lower adverse effect than other reported antitumor effector cells.1 Their ease of production in vitro and antitumor potential have made them suitable candidates for cell therapy regimens in solid and hematopoietic tumor treatments.1,2 Our previous retrospective study showed that the median progression-free survival(PFS)and overall survival(OS)in untreated,advanced non-small-cell lung cancer(NSCLC)patients who received CIK cell immunotherapy plus chemotherapy(13 and 24 months,respectively)were significantly longer than in those who received chemotherapy alone(6 and 10 months,respectively).2 But so far,there is no prospective,multicenter clinical study in lung cancer.Based on our previous study,we designed this randomized,multicenter,open-label trial to further evaluate the clinical efficacy of CIK cell immunotherapy plus chemotherapy in patients with advanced squamous NSCLC(ClinicalTrials.gov number,NCT01631357). | Liang Liu Quanli Gao Jingting Jiang Junping Zhang Xin Song Jiuwei Cui Yunbin Ye Zhiyu Wang Xinwei Zhang Xiubao Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 14 | Anti-proliferative effect of the extract of Guangzao (Fructus Choerospondiatis) on cultured rat cardiac fibroblasts显示文摘OBJECTIVE: To ascertain if total flavonoids of Guangzao(Fructus Choerospondiatis)(TFFC) extracted from Guangzao(Fructus Choerospondiatis) can inhibit angiotensin Ⅱ-induced proliferation of cardiac fibroblasts(CFs).METHODS: CFs were cultured by the differential attachment method. A model of cell proliferation was established by stimulation with Ang Ⅱ. Cardiac fibroblasts growth was determined using a hemocytometer. Cell proliferation was detected by methyl thiazole tetrazolium. Lactate dehydrogenase activitywas measured by chemical colorimetric method.RESULTS: Proliferation of TFFC-treated(25, 50,100 mg/L) fibroblasts was significantly less than that of cells in the angiotensin Ⅱ group(P < 0.01),and TFFC inhibited proliferation in a dose-dependent manner. These inhibitory effects were partly blocked by pretreatment with NG-nitro-L-arginine methyl ester(L-NAME) and 1H-[1,2,4]-oxadiazole-[4,3-a]-quinoxalin-1-one(ODQ).CONCLUSION: TFFC inhibited angiotensinⅡ-induced proliferation of cardiac fibroblasts via a mechanism that probably involves activation of the NO-cyclic guanosine monophosphate signaling pathway. | Jia Lei Yang Yumin Zhu Deli Gao Xiaohui Wang Xiaoling Xing Huihui Bao Junping Shu Liang | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 2 |
| 15 | An efficient CRISPR/Cas9 platform for targeted genome editing in rose(Rosa hybrida)显示文摘The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-related nuclease 9(Cas9)system enables precise,simple editing of genes in many animals and plants.However,this system has not been applied to rose(Rosa hybrida)due to the genomic complexity and lack of an efficient transformation technology for this plant.Here,we established a platform for screening single-guide RNAs(sgRNAs)with high editing efficiency for CRISPR/Cas9-mediated gene editing in rose using suspension cells.We used the Arabidopsis thaliana U6-29 promoter,which showed high activity for driving sgRNA expression,to modify the CRISPR/Cas9 system.We used our highly efficient optimized CRISPR/Cas9 system to successfully edit RhEIN2,encoding an indispensable component of the ethylene signaling pathway,resulting in ethylene insensitivity in rose.Our optimized CRISPR/Cas9 system provides a powerful toolbox for functional genomics,molecular breeding,and synthetic biology in rose. | Chengpeng Wang Yang Li Na Wang Qin Yu Yonghong Li Junping Gao Xiaofeng Zhou Nan Ma | 2023 | Journal of Integrative Plant Biology2023，65，4： | 1 |
| 16 | Tenofovir disoproxil fumarate therapy in patients with chronic hepatitis B and advanced fibrosis or compensated cirrhosis显示文摘Background and aims:Tenofovir disoproxil fumarate(TDF)is the first-line therapy for chronic hepatitis B.This interim analysis presents the efficacy and safety data for TDF at Week 144 in patients with chronic hepatitis B and advanced fibrosis or compensated cirrhosis from China.Methods:Patients were assessed for incidence of newly diagnosed hepatocellular carcinoma(HCC)and disease progression,liver stiffness measurement(LSM),virological suppression(serum hepatitis B virus DNA<20 IU/mL),alanine aminotransferase normalization,hepatitis B e antigen(HBeAg)loss and seroconversion,histological liver fibrosis score,and safety at Week 144.Results:Overall,197 patients were enrolled.At Week 144,the incidence of newly diagnosed HCC was observed in 2.1%patients,and the incidence of disease progression was observed in 3.6%patients.The mean(standard deviation)change in LSM from baseline was5.1(5.85)kPa.Serum hepatitis B virus DNA<20 IU/mL was observed in 94.1%patients,alanine aminotransferase normalization in 33.5%patients,HBeAg loss in 35.6%patients,and HBeAg seroconversion in 14.4%patients.Among patients with stage F3 or F4 fibrosis at baseline by LSM,38.3%patients regressed to stage F0/1,and 22.0%of patients regressed to stage F2 at Week 144.Overall,67.7%patients experienced≥1 adverse events,13.8%patients experienced TDF-related adverse events,and 16.4%patients experienced serious(none were TDF-related).Conclusions:At Week 144 of TDF treatment,low incidence of HCC and disease progression were reported.Virological suppression was observed in 94.1%patients,which was associated with fibrosis regression.No new safety events were identified. | Huiying Rao Jia Shang Qing Xie Jianqi Lian Pujun Gao Junping Shi Xinyue Chen Jiefei Wang Min Xu Liaoyun Zhang Yingren Zhao QingMao Maorong Wang Wei Zhao Zong Zhang Jidong Jia Hong Tang Jiming Zhang Xin Zheng Chang Liu Lai Wei | 2022 | iLIVER2022，1，3： | 1 |
| 17 | Isolation and expression of McF3H gene in the leaves of crabapple显示文摘 | Hongxiang Shen Jie Zhang Yuncong Yao Ji Tian Tingting Song Jian Geng Junping Gao | 2012 | Acta Physiologiae Plantarum2012，，4： | 1 |
| 18 | Agrobacterium tumefaciens-mediated transformation of modern rose(Rosa hybrida)using leaf-derived embryogenic callus显示文摘Rose(Rosa hybrida)is widely used for cut flowers and as garden plants.Stable and efficient transformation system is required for functional genomics of rose.Here,we established an efficient transformation method for rose using Agrobacterium tumefaciens-mediated transformation of embryogenic callus.Expanding rose leaves were used as explants to induce somatic embryos,which were subjected to transformation with A.tumefaciens strain GV3101 using Green Fluorescence Protein(GFP)as a marker gene.It took about 8 months to generate transgenic shoots from embryogenic callus.PCR,RT-PCR,Southern and Western blotting,as well as stereoscopic fluorescence microscopy analysis demonstrated that GFP transgenes integrated stably into the rose genome.According to our data,a transformation efficiency of up to 6%can be achieved by following this optimized protocol. | Guoqin Liu Yuan Yuan Hui Jiang Ying Bao Guogui Ning Liangjun Zhao Xiaofeng Zhou Hougao Zhou Junping Gao Nan Ma | 2021 | Horticultural Plant Journal2021，7，4： | 1 |
| 19 | Ethylene-influenced flower opening and expression of genes encoding Etrs , Ctrs , and Ein 3 s in two cut rose cultivars显示文摘 | Hui Tan Xiaohui Liu Nan Ma Jingqi Xue Wangjin Lu Jinghe Bai Junping Gao | 2006 | Postharvest Biology and Technology2006，，2： | 1 |
| 20 | CmNF-YB8 affects drought resistance in chrysanthemum by altering stomatal status and leaf cuticle thickness显示文摘Drought is a major abiotic stress that limits plant growth and development.Adaptive mechanisms have evolved to mitigate drought stress,including the capacity to adjust water loss rate and to modify the morphology and structure of the epidermis.Here,we show that the expression of CmNF-YB8,encoding a nuclear factor Y(NF-Y)B-type subunit,is lower under drought conditions in chrysanthemum(Chrysanthemum morifolium).Transgenicchrysanthemumlinesinwhich transcript levels of CmNF-YB8 were reduced by RNA interference(CmNF-YB8-RNAi)exhibited enhanced drought resistance relative to control lines,whereas lines overexpressing CmNF-YB8(CmNF-YB8-OX)were less tolerant to drought.Compared to wild type(WT),CmNF-YB8-RNAi plants showed reduced stomatal opening and a thicker epidermal cuticle that correlated with their water loss rate.We also identified genes involved in stomatal adjustment(CBLinteracting protein kinase 6,CmCIPK6)and cuticle biosynthesis(CmSHN3)that are more highly expressed in CmNF-YB8-RNAi lines than in WT,CmCIPK6 being a direct downstream target of CmNF-YB8.Virus-induced gene silencing of CmCIPK6 or CmSHN3 in the CmNFYB8-RNAi background abolished the effects of CmNF-YB8-RNAi on stomatal closure and cuticle deposition,respectively.CmNF-YB8 thus regulates CmCIPK6 and CmSHN3 expression to alter stomatal movement and cuticle thickness in the leaf epidermis,thereby affecting drought resistance. | Tianle Wang Qian Wei Zhiling Wang Wenwen Liu Xin Zhao Chao Ma Junping Gao Yanjie Xu Bo Hong | 2022 | Journal of Integrative Plant Biology2022，64，3： | 1 |
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