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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Hypertriglyceridemia-induced pancreatitis: A case-based review显示文摘Hypertriglyceridemia is an established cause of pancreatitis. In a case-based approach, we present a review of hypertriglyceridemia and how it can cause pancreatitis. We outline how to investigate and manage such patients. A 35 year old man presented to the emergency department with abdominal pain and biochemical evidence of acute pancreatitis. There was no history of alcohol consumption and biliary imaging was normal. The only relevant past medical history was that of mild hyperlipidemia, treated with diet alone. Physical exam revealed epigastric tenderness, right lateral rectus palsy, lipemia retinalis, bitemporal hemianopsia and a delay in the relaxation phase of his ankle reflexes. Subsequent laboratory investigation revealed marked hypertriglyceridemia and panhypopituarism. An enhanced CT scan of the head revealed a large suprasellar mass impinging on the optic chiasm and hypothalamus. The patient was treated supportively; thyroid replacement and lipid lowering agents were started. He underwent a successful resection of a craniopharyngioma. Post- operatively, the patient did well on hormone replacement therapy. He has had no further attacks of pancreatitis. This case highlights many of the factors involved in the regulation of triglyceride metabolism. We review the common causes of hypertriglyceridemia and the proposed mechanisms resulting in pancreatitis. The incidence and management of hypertriglyceridemia- induced pancreatitis are also discussed. | S Ian Gan Alun L Edwards Christopher J Symonds Paul L Beck | 2006 | World Journal of Gastroenterology2006，12，44： | 35 |
| 3 | Microporous polymeric composites from bicontinuous microemulsion polymerization using a polymerizable nonionic surfactant 显示文摘 | Gan L M Lin J Poon L P | 1997 | Polymer1997，38，： | 3 |
| 4 | Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray显示文摘 | Wang K Gan L Jeffery E | | 0，，： | 2 |
| 5 | Multiple elements regulate nuclear/cytoplasmic shuttling of FOXOl:characterization of phosphorylation and 14-3-3-dependent and-independent meehanisms显示文摘 | Zhao X Gan L Pan H | 2004 | J Biochem2004，378，3： | 1 |
| 6 | 1,8-Naphthalimides for non-doping OLEDs:the tunable emission color from blue,green to red显示文摘 | Gan J A Song Q L Hou X Y | 2004 | J Photochem Photobiol A:Chem2004，162，： | 1 |
| 7 | An anticoagulant peptide from the human hookworm,Ancylostoma duodenale that inhibits coagulation factorsⅩa andⅪa显示文摘 | Gan W Deng L Yang C | 2009 | FEBS Lett2009，583，12： | 1 |
| 8 | Synthesis of single crystalline TiO2 nanotubes 显示文摘 | LIU S M GAN L M LIU L H | 2002 | Chemistry of Materials2002，14，3： | 1 |
| 9 | Pharmacokinetics of plantamajoside and acte- oside from Plantago asiatica in rats by liquid chromatography - mass spectrometry 显示文摘 | Li Y Gan L Li GQ et 81 | 2014 | J Pharm Biomed Anal2014，89，： | 1 |
| 10 | Augmented Zagreb index of connected graphs, MATCH commun显示文摘 | Huang Y Liu B Gan L | 2012 | Math Comput Chem2012，67，： | 1 |
| 11 | The measurement and deconvolution of time jitter in equivalent-time waveform samplers显示文摘 | Gans W L | 1983 | IEEE Transactions on Instrumentation and Measurement1983，32，1： | 1 |
| 12 | Application of luminescent BSA-capped CdS quantum dots as a fluorescence probe for the detection of Cu2+显示文摘 | Han S Q Lu J L Gan Z G | 2008 | J Chin Chem Soc2008，55，5： | 1 |
| 13 | Polymerization of methylmethacrylate in ternary oil - in - water microemulsions 显示文摘 | GAN L M CHEW C H NG S C | 1993 | Polymer1993，34，14： | 1 |
| 14 | Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostare-restricted expression 显示文摘 | Nelson P S Gan L Ferguson C | 1999 | Proc Natl Acad Sci USA1999，96，6： | 1 |
| 15 | Characterisation of vegetable oils by surface acoustic wave sensing electronic nose显示文摘 | GAN H L CHEMAN Y B TAN C P | 2005 | Food Chemistry2005，89，： | 1 |
| 16 | Self-assembled liquid crystal- line nanoparticles as a novel ophthalmic delivery system for dexa- methasone : improving preocular retention and ocular bioavailabili- ty 显示文摘 | GAN L HAN S SHEN J Q | 2010 | Int J Pharm2010，396，12： | 1 |
| 17 | Novel NSAIDs ophthalmic formula- tion: flurbiprofen axetil emulsion with low irritancy and improvedanti-inflammation effect显示文摘 | Shen J Gan L Zhu C | 2011 | Int J Pharm2011，412，12： | 1 |
| 18 | Molecular dynamics simulation of neck growth in laser sintering of different-sized gold nanoparticles under different heating rates 显示文摘 | YANG L GAN Y ZHANG Y | 2012 | Applied Physics A2012，106，6： | 1 |
| 19 | Dynamic effect of di-2-(ethylhexyl) phthalate on testicular toxicity: epigenetic changes and their impact on gene expression显示文摘 | Wu S Zhu J Li Y Lin T Gan L Yuan X | 2010 | Int J Toxicol2010，29，2： | 1 |
| 20 | 查看详情显示文摘 | Lei L M Wu Y S Gan N Q | | 0，，： | 1 |
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