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| 1 | BCLC策略:预后预测和治疗推荐2022版更新显示文摘2018版BCLC预后和治疗推荐策略发布后,肝细胞癌(简称HCC)的研究又取得了重大进展。本次更新基于肝癌各领域的研究进展结果。重点关注影响策略的重要研究进展。虽然近年的研究结果成绩斐然,但将其引入为临床医生和研究者提供行动依据的循证模型指南来说证据效力依然不够确切。本文对该问题进行分析,阐述了为HCC患者制定个体化治疗临床决策所需的批判性思维和专业知识。 | Reig M Forner A Rimola J Ferrer-Fabrega J Burrel M Garcia-Criado A Kelley RK Galle PR Mazzaferro V Salem R Sangro B Singal AG Vogel A Fuster J Ayuso C Bruix J 刘永凡(摘译) 崔笑(摘译) 耿小平(审校) | 2022 | 肝胆外科杂志2022，30，5： | 80 |
| 2 | Adding pegylated interferon to a current nucleos(t)ide therapy leads to HBsAg seroconversion in a subgroup of patients with chronic hepatitis B显示文摘 | Jens M. Kittner Martin F. Sprinzl Annette Grambihler Arndt Weinmann J?rn M. Schattenberg Peter R. Galle Marcus Schuchmann | 2012 | Journal of Clinical Virology2012，，1： | 2 |
| 3 | Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein显示文摘AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regulating cy-totoxicity and gene transfer mediated by wild-type (wt) PV H-1 were explored in two pairs of isogenic human hepatoma cell lines with different p53 status. Further-more,H-1 PV infection was combined with cytostatic drug treatment. RESULTS: While the HCC cells with different p53 status studied were all susceptible to H-1 PV-induced apoptosis,the cytotoxicity of H-1 PV was morepronounced in p53-negative than in p53-positive cells. Apoptosis rates in p53-negative cell lines treated by genotoxic drugs were further enhanced by a treatment with H-1 PV. In flow cytometric analyses,H-1 PV infection resulted in a reduction of the mitochondrial transmembrane potential. In addition,H-1 PV cells showed a significant increase in PML expression. Knocking down PML expression resulted in a striking reduction of the level of H-1 PV infected tumor cell death. CONCLUSION: H-1 PV is a suitable agent to circumvent the resistance of p53-negative HCC cells to genotoxic agents,and it enhances the apoptotic process which is dependent on functional PML. Thus,H-1 PV and its oncolytic vector derivatives may be considered as therapeutic options for HCC,particularly for p53-negative tumors. | Maike Sieben Kerstin Herzer Maja Zeidler Vera Heinrichs Barbara Leuchs Martin Schuler Jan J Cornelis Peter R Galle Jean Rommelaere Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 2 |
| 4 | hnpaet of oxidized low density lipoprotein on vascular cells显示文摘 | Galle J Hansen-Hagge T Wanner C | 2006 | Atherosclerosis2006，185，2： | 1 |
| 5 | Oxidized LDL and its compound lysophosphatidylcholine potentiate Ang K- induced vasoconstiction by stimulation of RhoA显示文摘 | Galle J Mameghani A Bolz SS | 2003 | J Am Soc Nephrol2003，14，6： | 1 |
| 6 | Optimization andfiltering for human motion capture显示文摘 | Gall J Rosenhahn B Brox T | 2010 | International Journalof Computer Vision2010，87，12： | 1 |
| 7 | Experimental investigadom on there crystallization of eold-rolled nickel显示文摘 | Liao G J Le Gall R Saindrenan G | 1998 | Materials Science and Technology1998，14，5： | 1 |
| 8 | A tandemly repeated sequence at the termini of the extra chromosomal ribosonal RNA genes in Tetrahymena显示文摘 | Blackburn E H Gall J G | 1978 | Mol Biol1978，120，： | 1 |
| 9 | Renal denervation therapy for hypertension : pathways for moving development forward 显示文摘 | White WB Galls ZS Enegar J | 2015 | Am Soc Hypertens2015，9，5： | 1 |
| 10 | Secoviridae:a proposed family of plant viruses within the order Picornavirales that combines the families Sequiviridae and Comoviridae,the unassigned genera Cheravirus and Sadwavirus and the proposed genus Torradovirus显示文摘 | SANFACON H WELLINK J LE GALL O | 2009 | Archives of Virol2009，，154： | 1 |
| 11 | The role of ABO blood groups in the incidence of deep vein thrombosis 显示文摘 | Wautrecht J C Galle C Motte S | 1998 | Thromb Haemost1998，79，3： | 1 |
| 12 | Modeling the severity of illness of ICU patients:a system update显示文摘 | Le Gall J R | 1994 | JAMA1994，273，13： | 1 |
| 13 | Effect of microstructure on the fatigue of hot-rolled and cold-drawn Ni-Ti shape memory alloys 显示文摘 | GALL K TYBER J WILKESANDERS G ROBERTSON S W R1TCHIE R O MAIER H J | 2008 | Materials Science and Engineering A2008，486，12： | 1 |
| 14 | Instrumented micro-indentation of NiTi shape-memory alloys显示文摘 | GALL K JUNTUNEN K MAIER H J SEHITOGLU H CHUMLYAKOV Y I | 2001 | Acta Materialia2001，49，： | 1 |
| 15 | Hepatitis B vires nucleic acids associated with human peripheral blood mononuclear cells do not originate from replicating virus显示文摘 | Kock J Theilmann L Galle P | 1996 | Hepatology1996，23，3： | 1 |
| 16 | Gly - oxidized LDL impair endothelial function more potently than oxidized LDL:Role of enhanced oxidative stress显示文摘 | Galle J Schneider R Winner B | 1998 | Atherosclerosis1998，138，： | 1 |
| 17 | Analgesic effect of low-dose intrathecal morphine after spinal fusion in children显示文摘 | Aubineau JV Berniere J Desjeux L Murat I | 2001 | Anesthesiology2001，94，3： | 1 |
| 18 | Assessment of a new test to detect Legionella urinary antigen for the diagnosis of legionnaires' disease显示文摘 | Dominguez J Gall N Blanco S | 2001 | Diagn Microbiol Infect Dis2001，41，4： | 1 |
| 19 | Atherogenic lipoproteins, oxidative stress, and cell death显示文摘 | Galle J Heermeier K Wanner C | 1999 | Kidney Int Suppl1999，71，： | 1 |
| 20 | Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis显示文摘 | Daubiné F Le Gall C Gasser J | 2007 | J Natl Cancer Inst2007，99，4： | 1 |
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