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| 1 | Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection显示文摘AIM: To assess blood chitinase 3-like 1(CHi3L1) levels for 2 mo after minimally invasive colorectal resection(MICR) for colorectal cancer(CRC). METHODS: CRC patients in an Institutional Review Board approved data/plasma bank who underwent elective MICR for whom preoperative(PreO p), early postoperative(PostO p), and 1 or more late PostO p samples [postoperative day(POD) 7-27] available were included. Plasma CHi3L1 levels(ng/m L) were determined in duplicate by enzyme linked immunosorbent assay. RESULTS: PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/mL(n = 80). Significantly elevated(P < 0.001) median plasma levels(ng/mL) over PreOp levels were detected on POD1(667.7 CI: 495.7, 771.7; n = 79), POD 3(132.6 CI: 95.5, 173.7; n = 76), POD7-13(96.4 CI: 67.7, 136.9; n = 62), POD14-20(101.4 CI: 80.7, 287.4; n = 22), and POD 21-27(98.1 CI: 66.8, 137.4; n = 20, P = 0.001). No significant difference in plasma levels were noted on POD27-41. CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis. | HMC Shantha Kumara David Gaita Hiromichi Miyagaki Xiaohong Yan Sonali AC Hearth Linda Njoh Vesna Cekic Richard L Whelan | 2016 | World Journal of Gastrointestinal Oncology2016，8，8： | 4 |
| 2 | Berberine behind the thriller of marked symptomatic bradycardia显示文摘Berberine is used in traditional Chinese medicine for the treatment of congestive heart failure, hypertension, diabetes, and dyslipidaemia and has a good safety profile. We report a case of a 53-year-old sportsman referred to our hospital for the onset of fatigue and dyspnoea upon exertion after he started berberine to treat hypercholesterolaemia. An electrocardiogram showed sinus bradycardia (45 bpm), first-degree atrioventricular block, and competitive junctional rhythm. An ergometric stress test showed slightly reduced chronotropic competence and the presence of runs of competitive junctional rhythm, atrial tachycardia, and sinus pauses in the recovery. After 10 d of wash-out from berberine, the patient experienced a complete resolution of symptoms, and an ergometric stress test showed good chronotropic competence. An electrocardiogram Holtershowed a latent hypervagotonic state. This is the first case report that shows that berberine could present certain side effects in hypervagotonic people, even in the absence of a situation that could cause drug accumulation. Therefore, berberine's use should be carefully weighed in hypervagotonic people due to the drug's bradycardic and antiarrhythmic properties, which could became proarrhythmic, exposing patients to potential health risks. | Margherita Cannillo Simone Frea Cristina Fornengo Elisabetta Toso Giancarlo Mercurio Stefania Battista Fiorenzo Gaita | 2013 | World Journal of Cardiology2013，5，7： | 3 |
| 3 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 4 | Radiofrequency catheter ablation of atrial fibrillation:a cause of silent thromboembolism? Magnetic resonance imaging assessment of cerebral thromboembolism in patients undergoing ablation of atrial fibrillation显示文摘 | Gaita F Caponi D Pianelli M | 2010 | Circulation2010，122，17： | 1 |
| 5 | Cryoenergy catheter ablation:a new technique for treatment of permanent junctional reciprocating tachycardia in children显示文摘 | Gaita F Montefusco A Riccardi R | 2004 | J Cardiovasc Electrophysiol2004，15，3： | 1 |
| 6 | Limited Posterior Left Atrial Cryoablation in Patients With Chronic Atrial Fibrillation Undergoing Valvular Heart Surgery显示文摘 | Gaita F Gallottir R Calo L | 2000 | J Am Coll Cardiol2000，36，： | 1 |
| 7 | Short QT syndrome:a familial cause of sudden death显示文摘 | GAITA F GIUSTETTO C BIANCHI F | 2003 | Circulation2003，108，： | 1 |
| 8 | Short QT syndrome:a familial cause of sudden death显示文摘 | Gaita F Giustetto C Bianchi F | 2003 | Circulation2003，108，8： | 1 |
| 9 | Short QT syndrome : successful prevention of sudden cardiac death in an adolescent by implantable cardioveter defibrillator treatment for primary prophylaxis 显示文摘 | Schimpf R Bauersfeld U Gaita F el al | 2005 | Heart Rhythm2005，2，： | 1 |
| 10 | Idiopathic ventricular tachy-cardia with onset in the verapamil-sensitive left ventricle:theclinical characteristics and long-term follow-up of 37 pa-tients显示文摘 | Gaita F Giustetto C Libero L | 1995 | Ital Cardiol1995，25，6： | 1 |
| 11 | Short QT syndrome: A familial cause of sudden death显示文摘 | Gaita F Giustetto C Bianchi F | 2003 | Circulation2003，108，： | 1 |
| 12 | Short QT syndrome:a familial cause of sudden death显示文摘 | Gaita F Giustetto C Bianchi F | 2003 | Circulation2003，108，8： | 1 |
| 13 | Short QT syndrome: A familial cause of sudden death显示文摘 | Gaita F Giustetto C Bianchi F | 2003 | Circulatian2003，108，8： | 1 |
| 14 | Short QT syndrome:pharmacological treatment显示文摘 | Gaita F Giustetto C Bianchi F | 2004 | J Am Coll Cardiol2004，43，8： | 1 |
| 15 | Short QT syndrome:a familial cause of sudden death 显示文摘 | Gaita F Giustetto C Bianchi F | 2003 | Circulation2003，108，8： | 1 |
| 16 | Idiopathic verapamil-re-sponsive left ventricular tachycardia:clinical characteristics andlong-term follow-up of 33 patients显示文摘 | Gaita F Giustetto C Leclercq JF | 1994 | Eur Heart J1994，15，9： | 1 |
| 17 | Short QT syndrome : pharmacological treatment 显示文摘 | Gaita F Giustetto C Bianchi F el al | 2004 | J Am Coll Cardiol2004，43，8： | 1 |
| 18 | Magnetic resonance angiography virtual endoscopy in the assessment of pulmonary veins before radiofrequency ablation procedures for atrial fibrillation显示文摘 | S. Cirillo R. Bonamini F. Gaita Irene Tosetti M. Giuseppe M. Longo F. Bianchi L. Vivalda D. Regge | 2004 | European Radiology2004，，11： | 1 |
| 19 | Short QTsyndrome: a familial cause of sudden death显示文摘 | GAITA F GIUSTETTO C BIANCHI F | 2003 | Circulation2003，108，8： | 1 |
| 20 | The impact of diabetic neu- ropathy on balance and on the risk of fails in patients with type 2 diabetes mellitus : a cross-sectional study 显示文摘 | TIMAR B TIMAR R GAITA L | 2016 | PLoS One2016，11，01： | 1 |
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