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| 1 | Role of ethanol in the regulation of hepatic stellate cell function显示文摘Evidence has accumulated to suggest an important role of ethanol and/or its metabolites in the pathogenesis of alcohol-related liver disease. In this review, the fibrogenic effects of ethanol and its metabolites on hepatic stellate cells (HSCs) are discussed. In brief, ethanol interferes with retinoid metabolism and its signaling, induces the release of fibrogenic cytokines such as transforming growth factor β-1 (TGFβ-1) from HSCs, up-regulates the gene expression of collagen I and enhances type I collagen protein production by HSCs. Ethanol further perpetuates an activated HSC phenotype through extracellular matrix remodeling. The underlying pathophysiologic mechanisms by which ethanol exerts these pro-fibrogenic effects on HSCs are reviewed. | Jian-Hua Wang Robert G Batey Jacob George | 2006 | World Journal of Gastroenterology2006，12，43： | 16 |
| 2 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 3 | Matched-pair analysis of postoperative morbidity and mortality for pancreaticogastrostomy and pancreaticojejunostomy using mattress sutures in soft pancreatic tissue remnants显示文摘BACKGROUND:After pancreaticoduodenectomy,the incidence of postoperative pancreatic fistula remains high,especially in patients with 'soft' pancreatic tissue remnants.No 'gold standard' surgical technique for pancreaticoenteric anastomosis has been established.This study aimed to compare the postoperative morbidity and mortality of pancreaticogastrostomy and pancreaticojejunostomy for 'soft' pancreatic tissue remnants using modified mattress sutures.METHODS:Seventy-five patients who had undergone pancreaticogastrostomy and 75 who had undergone pancreaticojejunostomy after pancreaticoduodenectomy between 2002 and 2008 were retrospectively compared using matched-pair analysis.A modified mattress suture technique was used for the pancreaticoenteric anastomosis.Patients with an underlying 'hard' pancreatic tissue remnant,as in chronic pancreatitis,were excluded.Both groups were homogeneous for age,gender,and underlying disease.Postoperative morbidity,mortality,and preoperative and operative data were analyzed.RESULTS:There were no significant differences between the groups for the incidence of postoperative pancreatic fistula (10.7% in both).Postoperative morbidity and mortality,median operation time,median length of hospital stay,intraoperative blood loss,and the amount of intraoperatively transfused erythrocyte concentrates also did not significantly differ between the groups.Patient age >65 years (P=0.017),operation time >350minutes (P=0.001),and intraoperative transfusion of erythrocyte concentrates (P=0.038) were identified as risk factors for postoperative morbidity.CONCLUSIONS:Our results showed no significant differences between the groups in the pancreaticogastrostomy and pancreaticojejunostomy anastomosis techniques using mattress sutures for 'soft' pancreatic tissue remnants.In our experience,the mattress sutures are safe and simple to use,and pancreaticogastrostomy in particular is feasible and easy to learn,with good endoscopic accessibility to the anastomosis region.However,the location of the anastomosis and the surgical technique need to be individually evaluated to further reduce the incidence of postoperative pancreatic fistula. | Fritz Klein Marcus Bahra Matthias Glanemann Wladimir Faber Peter Warnick Andreas Andreou Safak Gül Dietmar Jacob | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 9 |
| 4 | Acute necrotizing pancreatitis as fi rst manifestation of primary hyperparathyroidism显示文摘We report the case of a female patient with severe acute necrotizing pancreatitis associated with hypercalcemia as first manifestation of primary hyperparathyroidism caused by a benign parathyroid adenoma.Initially the acute pancreatitis was treated conservatively.The patient subsequently underwent surgical resection of the parathyroid adenoma and surgical clearance of a large infected pancreatic pseudocyst.Although the association of parathyroid adenoma-induced hypercalcemia and acute pancreatitis is a known medical entity,it is very uncommon.The pathophysiology of hypercalcemia-induced acute pancreatitis is therefore not well known,although some mechanisms have been proposed.It is important to treat the provoking factor.Therefore,the cause of hypercalcemia should be identif ied early.Surgical resection of the parathyroid adenoma is the ultimate therapy. | Jeroen I Lenz Jimmy M Jacobs Bart Op de Beeck Ivan A Huyghe Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，23： | 9 |
| 5 | Management of severe perioperative bleeding: Guidelines from the European Society of Anaesthesiology显示文摘 | Sibylle A. Kozek-Langenecker Arash Afshari Pierre Albaladejo Cesar Aldecoa Alvarez Santullano Edoardo De Robertis Daniela C. Filipescu Dietmar Fries Klaus G?rlinger Thorsten Haas Georgina Imberger Matthias Jacob Marcus Lancé Juan Llau Sue Mallett Jens Mei | 2013 | European Journal of Anaesthesiology2013，，6： | 3 |
| 6 | Diagnostic approach to patients with cholestatic jaundice显示文摘 | Assy N Jacob G Spira G Edoute Y | 1999 | World Journal of Gastroenterology1999，5，3： | 3 |
| 7 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression显示文摘 | Jason M Hui Archana Sud Geoffrey C Farrell Priyanka Bandara Karen Byth James G Kench Geoffrey W McCaughan Jacob George | 2003 | Gastroenterology2003，，6： | 2 |
| 8 | Comparing the Schrdinger and spinless Salpeter equation for heavy-quark bound states 显示文摘 | Olsson M G and Suchyta C | 1986 | Phys Rev D1986，33，11： | 1 |
| 9 | Carcinoma in situ of the breast with indeter-minate features显示文摘 | Jacobs TW Pliss N Kouria G | 2001 | Am J Surg Pathol2001，25，2： | 1 |
| 10 | Causes of meta-bolic acidosis in canine hemorrhagic shock : role of unmeasuredions显示文摘 | BRUEGGER D KEMMING G I JACOB M | 2007 | Crit Care2007，11，6： | 1 |
| 11 | Water-gas shift:in situ spectroscopic studies of noble metal promoted ceria catalysts for CO removal in fuel cell reformers and mechanistic implications显示文摘 | Jacobs G Patterson P M Williams L | 2004 | Appl Phys A2004，262，2： | 1 |
| 12 | Effects of volume loading and pressor agents in idiopathic orthostatie tachyeardia 显示文摘 | Jacob G Shannon JR Black B | 1997 | Cir- culation1997，96，2： | 1 |
| 13 | Feedback on Student Writing:Taking the Middle Path显示文摘 | Jacobs G&Curtis | 1998 | Journal of Second Language Writing1998，，3： | 1 |
| 14 | Local oppugnant color texture pattern for image retrieval system显示文摘 | JACOB I J SRINIVASAGAN K G JAYAPRIYA K | 2014 | Pattern Recognition Letters2014，42，6： | 1 |
| 15 | Sulfation of extracellular polysaccharides of red microalgae: reparation, characterization and properties显示文摘 | Shimona G Anna M Jacob W | 2002 | Biochemical and Biophysical Methods2002，50，： | 1 |
| 16 | Qinghaosu-induced changes in the morphology of plasmodium inui显示文摘 | Jiang JB Jacobs G Liang DS | 1985 | Am J Trop Med Hyg1985，34，3： | 1 |
| 17 | 显示文摘 | JACOB G S LENNARZ W J | 1994 | Methods in Enzyme1994，230，： | 1 |
| 18 | Identification, purification, and characterization of a thiol-activated hemolysin(suilysin) of Streptococcus suis 显示文摘 | JACOBS A A C LOEFFEN P L W BERG A J G | 1994 | Infect Immun1994，62，5： | 1 |
| 19 | The vapour pressure and enthalpy of sublimation of ferrocene显示文摘 | JACOBS M H G VANEKEREN P J DEKRUIF C G | 1983 | The Journal of Chemical Thermodynamics1983，15，7： | 1 |
| 20 | Environmental Pollution显示文摘 | de Boer Jacob Wester Peter G van der Horst Aschwin Leonard Pim E G | 2003 | 122 : 632003，122，： | 1 |
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