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| 1 | Type I interferon:From innate response to treatment for COVID-19显示文摘Effective prophylactic and therapeutic interventions are urgentlyneeded to address the coronavirus disease 2019(COVID-19)pandemic.Various antiviral drugs have recently been tested.Type I interferon(IFN)is a regulatory protein involved in the innate immune response,with broad-spectrum antiviral activities and the ability to directly block viral replication and support the immune response to eliminate virus infection.Insufficient virus-induced type I IFN production is characteristic of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection,because SARS-CoV-2 suppresses the IFN response by interacting with essential IFN signaling pathways.Exogenous type I IFN is recommended for treating COVID-19.Unexpectedly however,angiotensin converting enzyme-2(ACE2)receptor,which acts as a SARS-CoV-2 receptor,was shown to be stimulated by IFN,raising doubts about the suitability of IFN use.However,further studies have excluded concerns regarding IFN administration.Type I IFNs,including IFN-α1b,have been used clinically as antiviral drugs for many years and have shown strong antiviral activity against SARS-CoV-2in vitro.Preliminary clinical studies of type I IFNs,especially when delivered via aerosol inhalation,have demonstrated efficacy for the treatment and prevention of COVID-19.Randomized controlled trials of IFN for COVID-19 treatment are ongoing. | Fuyu Lin Kunling Shen | 2020 | Pediatric Investigation2020，4，4： | 5 |
| 2 | Developing controllable hypermutable Clostridium cells through manipulating its methyl-directed mismatch repair system显示文摘Development of controllable hypermutable cells can greatly benefit understanding and harnessing microbial evolution.However,there have not been any similar sys-tems developed for Clostridium,an important bacterial genus.Here we report a novel two-step strategy for de-veloping controllable hypermutable cells of Clostridium acetobutylicum,an important and representative indus-trial strain.Firstly,the mutS/L operon essential for methyl-directed mismatch repair(MMR)activity was inactivated from the genome of C.acetobutylicum to generate hy-permutable cells with over 250-fold increased mutation rates.Secondly,a proofreading control system carrying an inducibly expressed mutS/L operon was constructed.The hypermutable cells and the proofreading control system were integrated to form a controllable hypermut-able system SMBMutC,of which the mutation rates can be regulated by the concentration of anhydrotetracycline(aTc).Duplication of the miniPthl-tetR module of the proof-reading control system further signifi cantly expanded the regulatory space of the mutation rates,demonstrating hypermutable Clostridium cells with controllable mutation rates are generated.The developed C.acetobutylicum strain SMBMutC2 showed higher survival capacities than the control strain facing butanol-stress,indicating greatly increased evolvability and adaptability of the controllable hypermutable cells under environmental challenges. | Guodong Luan Zhen Cai Fuyu Gong Hongjun Dong Zhao Lin Yanping Zhang Yin Li | 2013 | Protein & Cell2013，4，11： | 4 |
| 3 | In Situ Endothelialization of Intravascular Stents Coated with an Anti-CD34 Antibody Functionalized Heparin-collagen Multilayer显示文摘 | Lin Quankui Xin Ding Qiu Fuyu | 2010 | Biomaterials2010，31，： | 1 |
| 4 | TGF-β signaling in aortic aneurysm: another round of controversy显示文摘Aortic aneurysm (AA) is a common health problem with high mortality and no effective drugs. Transforming growth factor-β (TGF-β) superfamily members regulate various cellular processes, and TGF-β signaling has key roles in development, tissue homeostasis, and diseases. Interest in the role of TGF-β signaling in the pathogenesis of AAs has recently emerged, particularly since genetic studies demonstrated an association between gene mutations in components of TGF-β signaling and AAs. However, paradoxical discoveries have implicated dysregulated TGF-β signaling in aneurysm formation, complicating the precise functional role for TGF-β in aneurysm development and progression. Furthermore, interventions targeting towards TGF-β signaling using losartan, which may represent a suitable therapeutic option for AAs, were subject to skepticism especially because of conflicting experimental results obtained from TGF-β antibody treatment without knowledge of the underlying mechanism. We propose a TGF-β aneurysm paradox, which would provide a good opportunity for the development of genetic mouse models of AA. These models would be used to clarify the mechanisms underlying TGF-β signaling, which would translate into novel pharmacologic therapies based on the new molecular discoveries. | Fuyu Lin Xiao Yang | 2010 | Journal of Genetics and Genomics2010，37，9： | 1 |
| 5 | Extraordinarily stable and wide-temperature range sodium/potassium-ion batteries based on 1D SnSe2-SePAN composite nanofibers显示文摘Developing electrodes with long lifespan and wide-temperature adaptability is crucial important to achieve high-performance sodium/potassium-ion batteries(SIBs/PIBs).Herein,the SnSe2-SePAN composite was fabricated for extraordinarily stable and wide-temperature range SIBs/PIBs through a coupling strategy between controllable electrospinning and selenylation,in which SnSe2 nanoparticles were uniformly encapsulated in the SePAN matrix.The unique structure of SnSe2-SePAN not only relieves drastic volume variation but also guarantees the structural integrity of the composite,endowing SnSe2-SePAN with excellent sodium/potassium storage properties.Consequently,SnSe2-SePAN displays a high sodium storage capacity and excellent feasibility in a wide working temperature range(-15 to 60℃:300 mAh g^(-1)/700 cycles/-15℃;352 mAh g^(-1)/100 cycles/60℃at 0.5 A g^(-1)).At room temperature,it delivers a record-ultralong cycling life of 192 mAh g^(-1)that exceeds 66000 cycles even at 15 A g^(-1).It exhibits extremely superb electrochemical performance in PIBs(157 mAh g^(-1)exceeding 15000 cycles at 5 A g^(-1)).The ex situ XRD and TEM results attest the conversion-alloy mechanism of SnSe2-SePAN.Also,computational calculations verify that SePAN takes an important role in intensifying the electrochemical performance of SnSe2-SePAN electrode.Therefore,this study breaks new ground on solving the polyselenide dissolution issue and improving the wide temperature workable performance of sodium/potassium storage. | Yiyi Wang Fuyu Xiao Xi Chen Peixun Xiong Chuyuan Lin Hong-En Wang Mingdeng Wei Qingrong Qian Qinghua Chen Lingxing Zeng | 2023 | InfoMat2023，5，9： | 1 |
| 6 | Electrochemical conversion of furfural to furoic acid:a more stable,efficient and energy-saving system显示文摘The paired electrolytic system is constructed by combining the valuable organic electro-oxidation and electro-reduction reactions,which can replace the ineffective water splitting half-reaction.By reducing the energy consumption of the electrolytic cell,the value-added electrolysis is realized.The indirect electrolysis method greatly reduces the dependence of the organic electrolysis reaction on electrode potential by introducing the redox mediators,which solves the problem on the matching of anode and cathode current under potentiostatic conditions.Here,we report a more stable,efficient and energy-saving linear paired electrochemical synthesis system that can simultaneously convert furfural to furoic acid at both the anode and cathode at higher current densities.Stable three-dimensional networked PbO_(2)is used as the anode and the catalytic amount of 2,2,6,6-tetramethyl-1-piperidinyloxy(TEMPO)is used as the mediator to realize the efficient conversion of furfural to furoic acid in a wide potential range.The cathode catalyzes two-electron oxygen reduction to hydrogen peroxide using Pb/RHPC gas-diffusion electrode,which mediates the oxidation of furfural to furoic acid simultaneously.In potentiostatic electrolysis,the selectivity of the furoic acid in the cathode and anode is 33.2%and 99.3%,respectively,and the total electron efficiency is 127.1%.The properties of the cathode and anode remain stable after the long-time electrolysis in a flow cell.By choosing a stable anode with high oxygen evolution overpotential and a gas-diffusion cathode with high hydrogen evolution overpotential,the electrolytic cell can be operated efficiently and stably by introducing reasonable mediated reactions.The two half-reactions have good compatibility during the electrolysis process,saving energy consumption by about 12.3%,for certain industrial application prospects. | Xinxin Li Linchuan Cong Haibo Lin Fangbing Liu Fuyu Han Nan Lin | 2022 | Science China Chemistry2022，65，12： | 0 |
| 7 | Polo-like kinase 1 as a biomarker predicts the prognosis and immunotherapy of breast invasive carcinoma patients显示文摘Invasive breast carcinoma(BRCA)is associated with poor prognosis and high risk of mortality.Therefore,it is critical to identify novel biomarkers for the prognostic assessment of BRCA.Methods:The expression data of polo-like kinase 1(PLK1)in BRCA and the corresponding clinical information were extracted from TCGA and GEO databases.PLK1 expression was validated in diverse breast cancer cell lines by quantitative real-time polymerase chain reaction(qRT-PCR)and western blotting.Single sample gene set enrichment analysis(ssGSEA)was performed to evaluate immune infiltration in the BRCA microenvironment,and the random forest(RF)and support vector machine(SVM)algorithms were used to screen for the hub infiltrating cells and calculate the immunophenoscore(IPS).The RF algorithm and COX regression model were applied to calculate survival risk scores based on the PLK1 expression and immune cell infiltration.Finally,a prognostic nomogram was constructed with the risk score and pathological stage,and its clinical potential was evaluated by plotting calibration charts and DCA curves.The application of the nomogram was further validated in an immunotherapy cohort.Results:PLK1 expression was significantly higher in the tumor samples in TCGA-BRCA cohort.Furthermore,PLK1 expression level,age and stage were identified as independent prognostic factors of BRCA.While the IPS was unaffected by PLK1 expression,the TMB and MATH scores were higher in the PLK1-high group,and the TIDE scores were higher for the PLK1-low patients.We also identified 6 immune cell types with high infiltration,along with 11 immune cell types with low infiltration in the PLK1-high tumors.A risk score was devised using PLK1 expression and hub immune cells,which predicted the prognosis of BRCA patients.In addition,a nomogram was constructed based on the risk score and pathological staging,and showed good predictive performance.Conclusions:PLK1 expression and immune cell infiltration can predict post-immunotherapy prognosis of BRCA patients. | JUAN SHEN WEIYU ZHANG QINQIN JIN FUYU GONG HEPING ZHANG HONGLIANG XU JIEJIE LI HUI YAO XIYA JIANG YINTING YANG LIN HONG JIE MEI YANG SONG SHUGUANG ZHOU | 2024 | Oncology Research2024，32，2： | 0 |
| 8 | Progress in Electrolyte Engineering of Aqueous Batteries in a Wide Temperature Range显示文摘Aqueous rechargeable batteries are safe and environmentally friendly and can be made at a low cost;as such,they are attracting attention in the field of energy storage.However,the temperature sensitivity of aqueous batteries hinders their practical application.The solvent water freezes at low temperatures,and there is a reduction in ionic conductivity,whereas it evaporates rapidly at high temperatures,which causes increased side reactions.This review discusses recent progress in improving the performance of aqueous batteries,mainly with respect to electrolyte engineering and the associated strategies employed to achieve such improvements over a wide temperature domain.The review focuses on fi ve electrolyte engineer-ing(aqueous high-concentration electrolytes,organic electrolytes,quasi-solid/solid electrolytes,hybrid electrolytes,and eutectic electrolytes)and investigates the mechanisms involved in reducing the solidifi cation point and boiling point of the electrolyte and enhancing the extreme-temperature electrochemical performance.Finally,the prospect of further improving the wide temperature range performance of aqueous rechargeable batteries is presented. | Lingjun He Chuyuan Lin Peixun Xiong Hui Lin Wenbin Lai Jingran Zhang Fuyu Xiao Liren Xiao Qingrong Qian Qinghua Chen Lingxing Zeng | 2023 | Transactions of Tianjin University2023，29，5： | 0 |
| 9 | Hot Deformation Behaviors in Ti-6Al-4V/(TiB+TiC)Composites显示文摘Thermal compression testing was investigated using the Gleeble 3800 thermal simulator,and thermal deformation behavior of particle-reinforced titanium matrix composites(TMCs)was studied under deformation temperatures of 750-900°C,strain rates of 0.001-1 s^(-1),and experimental deformation of 60%.According to obtained flow stress curves,the hot deformation characteristics were analyzed.Based on the Arrhenius hyperbolic sinusoidal model,the constitutive equation at high temperature was established.Based on the theory of dynamic material models,a hot processing map of TMCs at high temperature was established,and the peak region of power dissipation rate and the instability region in the hot processing map were both determined.At the same time,the corresponding microstructures in the peak power dissipation rate and rheological instability regions were observed.The results showed that flow stress decreased with increasing deformation temperature and increased with increasing strain rate.The thermal deformation activation energy of titanium matrix composites was 301.8 kJ/mol.The Ti-6Al-4V/(TiB+TiC)composites possessed only one instability zone under high-temperature compression at a strain of 0.5,with corresponding temperatures at 750-840°C and strain rates at 0.1-1 s^(-1).The optimal thermal deformation parameters included corresponding temperatures of 830-880°C and strain rates of 0.001-0.05 s^(-1).The microstructures corresponding to optimal hot working parameters in processing maps were more homogeneous than the microstructures in the instability zone,including the distribution uniformity of reinforcement and the degree of dynamic recrystallization,and no instability phenomena including abnormal grain growth,microcracks or intensive fracture of reinforcements were found,indicating that the hot processing map had a positive guiding effect on the option of desirable material thermal-working parameters. | Xuejian Lin Hongjun Huang Fuyu Dong Yue Zhang Xiaoguang Yuan Bowen Zheng Xiaojiao Zuo | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，12： | 0 |
| 10 | Geometric and Dynamical Characteristics of Sequences in Yitong Graben显示文摘GeometricandDynamicalCharacteristicsofSequencesinYitongGraben￥XieXinong;SunYongchuan(DeparmentofMineralResources,ChinaUnivers... | Xie Xinong Sun Yongchuan(Deparment of Mineral Resources, China University of Geosciences, Wuhan430074)Ding Zhengyan Lin Yanzong(Jinn Oilfield Administrative Bureau, Fuyu 131200) | 1994 | Journal of Earth Science1994，13，1： | 0 |
| 11 | Anaerobic oxidation of arsenite by bioreduced nontronite显示文摘The redox state of arsenic controls its toxicity and mobility in the subsurface environment. Understanding the redox reactions of arsenic is particularly important for addressing its environmental behavior. Clay minerals are commonly found in soils and sediments, which are an important host for arsenic. However, limited information is known about the redox reactions between arsenic and structural Fe in clay minerals. In this study, the redox reactions between As(Ⅲ)/As(Ⅴ) and structural Fe in nontronite NAu-2 were investigated in anaerobic batch experiments. No oxidation of As(Ⅲ) was observed by the native Fe(Ⅲ)-NAu-2. Interestingly, anaerobic oxidation of As(Ⅲ) to As(Ⅴ) occurred after Fe(Ⅲ)-NAu-2 was bioreduced. Furthermore, anaerobic oxidization of As(Ⅲ) by bioreduced NAu-2 was significantly promoted by increasing Fe(Ⅲ)-NAu-2 reduction extent and initial As(Ⅲ) concentrations. Bioreduction of Fe(Ⅲ)-NAu-2 generated reactive Fe(Ⅲ)-O-Fe(Ⅱ) moieties at clay mineral edge sites. Anaerobic oxidation of As(Ⅲ) was attributed to the strong oxidation activity of the structural Fe(Ⅲ) within the Fe(Ⅲ)-O-Fe(Ⅱ) moieties. Our results provide a potential explanation for the presence of As(Ⅴ) in the anaerobic subsurface environment. Our findings also highlight that clay minerals can play an important role in controlling the redox state of arsenic in the natural environment. | Ziwang Zhao Ying Meng Yahua Wang Leiming Lin Fuyu Xie Fubo Luan | 2021 | Journal of Environmental Sciences2021，33，12： | 0 |
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