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| 1 | Single small molecule-assembled nanoparticles mediate efficient oral drug delivery显示文摘Oral drug delivery,which requires surviving the harsh environment in the gastrointestinal(Gl)tract and penetrating the intestinal epithelium,has not bee n achieved using simple formulatio n nan oparticles(NPs).Medici nal natural products(MNPs)have bee n widely used in traditi onal medicine for disease management through oral consumption.However,most pharmacologically active compounds within MNPs do not have the properties suitable for oral applicatio ns.We hypothesize that some MNPs contain n atural nano materials that can convert those compounds into oral formulations by forming NPs.After screening 66 MNPs,we identified five classes of small molecules that form NPs,many of which are capable of efficient drug encapsulation and Gl penetration.We show that one of them,dehydrotrametenolic acid(DTA),is capable of mediating oral delivery for effective disease treatment.We determined that DTA NPs assemble through hydrogen bonding and penetra怕the Gl tract via apical sodium-depe ndent bile acid tran sporter.Our study reveals a no vel class of single comp orient,small molecule-assembled NPs for oral drug delivery,and suggests a n ovel approach to modernizi ng MNPs through nano material discovery. | Xin Yang Chao Ma Zeming Chen Jun Liu Fuyao Liu Rongbin Xie Haitian Zhao Gang Deng Ann TChen Ningbo Gong Lei Yao Pengjian Zuo Kangkang Zhi Jiacheng Wang Xiaobin Gao Jing Wang Louzhen Fan Jiangbing Zhou | 2019 | Nano Research2019，12，10： | 4 |
| 2 | Experimental Study on Insulation Properties of Epoxy Casting Resins Using High-frequency Square Waveforms显示文摘Although the transmission efficiency of high-voltage high-frequency transformers improve as the rated frequency increases,their insulation performance is severely affected.Through a high-frequency experimental platform,insulation tests on epoxy casting resins are carried out using high-frequency square wave signals.Subsequently,the variations of discharge inception and flashover voltages with frequency were analyzed based on the Secondary Electron Emission Avalanche(SEEA)model.The breakdown characteristics of epoxy casting resins are studied based on the Weibull distribution analysis and inverse power function model.Finally,an insulation test standard is proposed based on the breakdown characteristics of epoxy casting resins for dry-type HV-HF transformers.The results show that,the flashover voltages are noticeably reduced with the increase of frequency while the discharge inception is hardly affected by frequency.Moreover,the drop in breakdown voltages and insulation lifetime shortening are caused by high-frequency thermal effects.Also,the applied voltages of epoxy resin cast dry-type HV-HF transformers are recommended to be 3.27 to 3.49 times their maximum operating voltages in 1min applied withstand tests.The applied voltages of the induced withstand tests should be 2.20 to 2.52 times their maximum operating voltages. | Yikun Zhao Guoqiang Zhang Dong Han Kang Li Zongjia Qiu Fuyao Yang | 2021 | CSEE Journal of Power and Energy Systems2021，7，6： | 1 |
| 3 | A review on surface coating strategies for anti-hygroscopic of high energy oxidizer ammonium dinitramide显示文摘Ammonium dinitramide(ADN),which has the advantages of high energy density,no halogen and low characteristic signal,is not only considered as a new high-energy oxidizer that is expected to replace the traditional oxidizer ammonium perchlorate(AP)in solid propellants,but also a good performance explosive in itself.However,due to the strong hygroscopicity of ADN,its application in solid propellants and explosives is greatly limited.Solving the hygroscopicity of ADN is the key to realize the wide application of ADN.In this paper,we systematically review the research progress of anti-hygroscopic strategies of ADN coating.The surface coating methods are focusing on solvent volatilization,solvent-non-solvent,melt crystallization and atomic layer deposition technology.The characteristics of the different methods are compared and analyzed,and the basis for the classification and selection of the coating materials are introduced in detail.In addition,the feasibility of material for surface coating of ADN is evaluated by several compatibility analysis methods.It is highly expected that the liquid phase method(solvent volatilization method,solvent-non-solvent method)would be the promising method for future ADN coating because of its effective,safety and facile operation.Furthermore,polymer materials,are the preferred coating materials due to their high viscosity,easy adhesion,good anti-hygroscopic effect,and heat resistance,which make ADN weak hygroscopicity,less sensitive,easier to preserve and good compatibility. | Hongyu Yang Fuyao Chen Yiwen Hu Qiangqiang Lu Lei Xiao Yinglei Wang Fengqi Zhao Wei Jiang Gazi Hao | 2024 | Defence Technology(防务技术)2024，33，3： | 0 |
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