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| 1 | AFP level and histologic differentiation predict the survival of patients with liver transplantation for hepatocellular carcinoma显示文摘BACKGROUND: In liver transplantation or resection for hepatocellular carcinoma (HCC), patient selection depends on morphological features. In patients with HCC, we performed a clinicopathological analysis of risk factors that affected survival after liver transplantation. METHODS: In 389 liver transplantations performed from 2004 to 2010, 102 were for HCC patients. Data were collected retrospectively from the Organ Transplantation Center Database. Variables were as follows: age, gender, preoperative alpha-fetoprotein (AFP) levels, Child-Pugh and MELD scores, prognostic staging criteria (Milan and UCSF), etiology, number of tumors, the largest tumor size, total tumor size, multifocality, intrahepatic portal vein tumor thrombosis, bilobarity, and histological differentiation. RESULTS: One hundred and two patients were evaluated. The 5-year overall survival rate was 56.5%. According to the UCSF criteria, 63% of the patients were within and 37% were beyond UCSF (P=0.03). Ten patients were excluded (one with fibrolamellary HCC and 9 because of early postoperative death without HCC recurrence), and 92 patients were assessed. The mean age of the patients was 56.5±6.9 years. Sixty-two patients underwent living donor liver transplantations. The mean follow-up time was 29.4±22.6 months. Fifteen patients (16.3%) died in the follow-up period due to HCC recurrence. Univariate analysis showed that AFP level, intrahepatic portal vein tumor thrombosis, histologic differentiation and UCSF criteria were significant factors related to survival and tumor recurrence. The 5-year estimated overall survival rate was 62.2% in allpatients. According to the UCSF criteria, and the 5-year overall survival rate was 66.7% within and 52.7% beyond the criteria (P=0.04). Multivariate analysis showed that AFP level and poor differentiation were independent factors. CONCLUSIONS: For proper patient selection in liver trans- plantation for HCC, prognostic criteria related to tumor biology (especially AFP level and histological differentiation) should be considered. Poor differentiation and higher AFP levels are indicators of poor prognosis after liver transplantation. | Onur Yaprak Murat Akyildiz Murat Dayangac Baha Tolga Demirbas Necdet Guler Gulen Bulbul Dogusoy Yildiray Yuzer Yaman Tokat | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 15 |
| 2 | Super-resolution imaging by optical incoherent synthetic aperture with one channel at a time显示文摘Imaging with an optical incoherent synthetic aperture (SA) means that the incoherent light from observed objects is processed over time from various points of view to obtain a resolution equivalent to single-shot imaging by the SA larger than the actual physical aperture. The operation of such systems has always been based on two-wave interference where the beams propagate through two separate channels. This limitation of two channels at a time is removed in the present study with the proposed SA where the two beams pass through the same single channel at any given time. The system is based on a newly developed self-interference technique named coded aperture correlation holography. At any given time,the recorded intensity is obtained from interference between two waves co-propagating through the same physical channel. One wave oriented in a particular polarization is modulated by a pseudorandom coded phase mask and the other one oriented orthogonally passes through an open subaperture. Both subapertures are multiplexed at the same physical window. The system is calibrated by a point spread hologram synthesized from the responses of a guide star. All the measurements are digitally processed to achieve a final image with a resolution higher than that obtained by the limited physical aperture. This unique configuration can offer alternatives for the current cumbersome systems composed of far apart optical channels in the large optical astronomical interferometers. Furthermore,the proposed concept paves the way to an SA system with a single less-expensive compact light collector in an incoherent optical regime that may be utilized for future ground-based or space telescopes. | ANGIKA BULBUL JOSEPH ROSEN | 2021 | Photonics Research2021，9，7： | 2 |
| 3 | Baclofen is effective in intractable hiccups induced by brainstem lesions显示文摘 | Boz C Velioglu S Bulbul I | 2001 | Neurol Sci2001，22，5： | 1 |
| 4 | Osteopontin:role in cell signaling and cancer progression 显示文摘 | Rangaswami H Bulbule A Kundu G C | 2006 | Trends Cell Biol2006，16，2： | 1 |
| 5 | Osteopontin:role in cell signaling and cancer progression显示文摘 | Rangsawami H Bulbule A Kundu GC | | 0，，02： | 1 |
| 6 | Polymer supported nitrite esters as di- azotising reagent 显示文摘 | Niyazi Bicak Hayal Bulbul | 2001 | Polymer Bulletin2001，46，2： | 1 |
| 7 | Primary peritonitis in children with nephrotic syndrome : results of a 5-year multicenter study 显示文摘 | Uncu N Bulbul M Yildiz N | 2010 | Eur J Pediatr2010，169，1： | 1 |
| 8 | Osteopontin: role in cell signaling and cancer progression 显示文摘 | Rangaswami H Bulbule A Kundu G C | 2006 | Trends Cell Biol2006，16，2： | 1 |
| 9 | Osteopontin: an emerging therapeutic target for anticancer therapy 显示文摘 | Jain S Chakraborty G Bulbule A | 2007 | Expert Opin Ther Targets2007，11，1： | 1 |
| 10 | Osteopontin: role in cell signaling and cancer progression显示文摘 | Rangaswami H Bulbule A Kundu G C | 2006 | Trends Cell Biol2006，16，2： | 1 |
| 11 | Osteopontin: role in cell signaling and cancer progression 显示文摘 | Rangaswam IH Bulbule A Kundu GC | 2006 | Trends Cell Biol2006，16，2： | 1 |
| 12 | Matrix metalloproteinase-2:mechanism and regulation of NF-kappa B-mediated activation and its role in cell motility and ECM-invasion显示文摘 | Philip S Bulbule A Kundu GC | 2004 | Glycoconj J2004，21，89： | 1 |
| 13 | Effects of different polishing methods on color stability of resin composites after accelerated aging 显示文摘 | Sirin Karaarslan E Bulbul M Yildiz E | 2013 | Dent Mater J2013，32，1： | 1 |
| 14 | The evaluation of polycythemic newborns:efficacy of partial exchange transfusion显示文摘 | Uslu S Ozdemir H Bulbul A | 2011 | J Matern Fetal Neonatal Med2011，24，12： | 1 |
| 15 | Central orexin-A increases gastric motility in rats显示文摘 | BULBUL M BABYGIRIJA R LUDWIG K | 2010 | Peptides2010，31，11： | 1 |
| 16 | Comparison of Kugel and Liehtenstein operations for inguinal hernia repair: results of a prospective randomized study显示文摘 | Dogru O Girgin M Bulbuller N | 2006 | World J Surg2006，30，3： | 1 |
| 17 | Percutaneously inserted central catheters in the newborns: A center’s experience in Turkey显示文摘 | Ali Bulbul Fusun Okan Asiye Nuhoglu | 2010 | Journal of Maternal-Fetal and Neonatal Medicine2010，，6： | 1 |
| 18 | Central orexin-A changes the gastrointestinal motor pattern from in- terdigestive to postprandial in rats显示文摘 | BULBUL M BABYGIRIJA R ZHENG J | 2010 | Autonomic Neuro- science-Basic Clinical2010，158，12： | 1 |
| 19 | Osteopontin: role in cell signaling and cancer progression 显示文摘 | Rangaswami H Bulbule A Kundu GC | 2006 | Trends Cell Biol2006，16，2： | 1 |
| 20 | Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation显示文摘 | Rangaswami H Bulbule A Kundu GC | 2004 | J Biol Chem2004，279，38： | 1 |
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