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| 1 | Pyogenic liver abscess:An audit of 10 years’experience显示文摘AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy.METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were reviewed.Amoebic and hydatid abscesses were excluded.Demographic,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were recorded.RESULTS:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) d.Only 59%of patients were febrile at presentation;however,the serum C-reactive protein was elevated in all 47 in whom it was measured.Liver function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) cm.Causative organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial infarction.The initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their hospitalization.Serum hypoalbuminaemia[mean (95%CI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate analysis.CONCLUSION:PLA is a diagnostic challenge,because the presentation of this condition is non-specific.Intravenous antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage. | Tony CY Pang Thomas Fung Jaswinder Samra Thomas J Hugh Ross C Smith | 2011 | World Journal of Gastroenterology2011，17，12： | 46 |
| 2 | Response of microbial communities to biochar-amended soils:a critical review显示文摘Application of biochar to soils changes soil physicochemical properties and stimulates the activities of soil microorganisms that influence soil quality and plant performance.Studying the response of soil microbial communities to biochar amendments is important for better understanding interactions of biochar with soil,as well as plants.However,the effect of biochar on soil microorganisms has received less attention than its influences on soil physicochemical properties.In this review,the following key questions are discussed:(i)how does biochar affect soil microbial activities,in particular soil carbon(C)mineralization,nutrient cycling,and enzyme activities?(ii)how do microorganisms respond to biochar amendment in contaminated soils?and(iii)what is the role of biochar as a growth promoter for soil microorganisms?Many studies have demonstrated that biochar-soil application enhances the soil microbial biomass with substantial changes in microbial community composition.Biochar amendment changes microbial habitats,directly or indirectly affects microbial metabolic activities,and modifies the soil microbial community in terms of their diversity and abundance.However,chemical properties of biochar,(especially pH and nutrient content),and physical properties such as pore size,pore volume,and specific surface area play significant roles in determining the efficacy of biochar on microbial performance as biochar provides suitable habitats for microorgan-isms.The mode of action of biochar leading to stimulation of microbial activities is complex and is influenced by the nature of biochar as well as soil conditions. | Kumuduni Niroshika Palansooriya James Tsz Fung Wong Yohey Hashimoto Longbin Huang Jörg Rinklebe Scott X.Chang Nanthi Bolan Hailong Wang Yong Sik Ok | 2019 | Biochar2019，1，1： | 34 |
| 3 | 移植肝原发性无功能显示文摘 | 江春平 朱岳 John J Fung | 2003 | 中华肝胆外科杂志2003，9，5： | 6 |
| 4 | Liver transplantation in patients with incidental hepatocellular carcinoma/cholangiocarcinoma and intrahepatic cholangiocarcinoma: a single-center experience显示文摘BACKGROUND: Reports of liver transplantation(LT) in patients with mixed hepatocellular carcinoma/cholangiocarcinoma(HCC/CC) and intrahepatic cholangiocarcinoma(ICC) are modest and have been mostly retrospective after pathological categorization in the setting of presumed HCC. Some studies suggest that patients undergoing LT with small and unifocal ICC or mixed HCC/CC can achieve about 40%-60% 5-year post-transplant survival. The study aimed to report our experience in patients undergoing LT with explant pathology revealing HCC/CC and ICC.METHODS: From a prospectively maintained database, we performed cohort analysis. We identified 13 patients who underwent LT with explant pathology revealing HCC/CC or ICC. RESULTS: The observed recurrence rate post-LT was 31%(4/13) and overall survival was 85%, 51%, and 51% at 1, 3 and 5 years, respectively. Disease-free survival was 68%, 51%, and 41% at 1, 3 and 5 years, respectively. In our cohort, four patients would have qualified for exception points based on updated HCC Organ Procurement and Transplantation Network imaging guidelines. CONCLUSIONS: Lesions which lack complete imaging characteristics of HCC may warrant pre-LT biopsy to fully elucidate their pathology. Identified patients with early HCC/CC or ICC may benefit from LT if unresectable. Additionally, incorporating adjunctive perioperative therapies such as in the case of patients undergoing LT with hilar cholangiocarcinoma may improve outcomes but this warrants further investigation. | Mohammed Elshamy Naftali Presser Abdulrahman Y Hammad Daniel J Firl Christopher Coppa John Fung Federico N Aucejo | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 6 |
| 5 | Analysis of the PINK1 gene in a cohort of patients with sporadic earlyonset parkinsonism in Taiwan显示文摘 | Fung HC Chen CM Hardy J Singleton AB Lee-Chen GJ Wu YR | 2006 | 中国生物学文摘2006，20，8： | 6 |
| 6 | 单个移植中心连续4000例肝移植后长期生存情况回顾显示文摘目的:评价大样本肝移植病人长期生存情况和分析影响移植疗效的动静态因素。背景回顾:自1983年以来肝移植被接受为治疗终末期肝病的主要选择之一,随着免疫抑制剂的发展、手术技术的不断完善、取肝及保存方法的改进,生存期获不断延长。虽然报告影响近期生存因素的文章甚众,但分析影响长期生存因素者却不多见。方法:回顾性分析1981年2月至1998年4月连续施行的4000例肝移植资料(随访至2000年3月),并对移植时供、受体年龄、受体性别和诊断以及移植年份等因素进行比较;也统计了再移植率、再移植原因和死亡原因。结果:全组的总生存率为59%,统计18年生存率为48%;小儿、女性和1990年以后接受移植的病人生存情况显著较好。以FK506为基础的免疫抑制剂使因急、慢性排斥反应而施行的再移植率显著下降。手术一年后,移植肝脏丧失功能病人死亡的曲线相对趋于平稳,疾病复发、恶性肿瘤和与年龄相关的并发症是移植物丧失功能的最主要因素。结论:随着年代的推移,病人和移植物的生存活情况获显著改善,由急性、慢性排斥反应所致的移植物失功已属十分罕见,与年龄相关和疾病相关的移植物失功,已构成肝移植患者长期生存的最大威胁。 | Zhu Yue Jain Ashok Fung John J 周光文 | 2002 | 外科理论与实践2002，7，2： | 5 |
| 7 | Split liver transplantation in adults显示文摘Split liver transplantation(SLT),while widely accepted in pediatrics,remains underutilized in adults. Advancements in surgical techniques and donor-recipient matching,however,have allowed expansion of SLT from utilization of the right trisegment graft to now include use of the hemiliver graft as well. Despite less favorable outcomes in the early experience,better outcomes have been reported by experienced centers and have further validated the feasibility of SLT. Importantly,more than two decades of experience have identified key requirements for successful SLT in adults. When these requirements are met,SLT can achieve outcomes equivalent to those achieved with other types of liver transplantation for adults. However,substantial challenges,such as surgical techniques,logistics,and ethics,persist as ongoing barriers to further expansion of this highly complex procedure. This review outlines the current state of SLT in adults,focusing on donor and recipient selection based on physiology,surgical techniques,surgical outcomes,and ethical issues. | koji hashimoto masato fujiki cristiano quintini federico n aucejo teresa diago uso dympna m kelly bijan eghtesad john j fung charles m miller | 2016 | World Journal of Gastroenterology2016，22，33： | 3 |
| 8 | 经颈静脉肝内门体分流术(TIPSS)与肝移植显示文摘目的 经颈静脉肝内门体分流术 (TIPSS)正逐渐成为控制食管曲张静脉破裂出血和肝移植之间的桥梁。目前国内没有有关TIPSS对原位肝移植手术影响的报道。方法 回顾性研究接受术前TIPSS治疗的肝移植病人 ,即评价TIPSS作为肝移植桥梁的有效性和是否影响移植手术。结果 匹兹堡移植中心 5例术前接受TIPSS的肝移植病人。行TIPSS与肝移植间隔时间为 9 6 (0 2~2 4 7)个月 ,3例病人在肝移植前能有效地控制出血。 4例病人的支架位于肝实质内 ,并不影响手术 ;1例部分突出于肝外门静脉 ,术中需要移去支架。术后随访时间平均 4 2 (2~ 7)个月 ,无门静脉血栓形成。手术时间和术中输血量无显著性差异。结论 TIPSS是一种有效的桥梁 ,并没有增加移植术后并发症发生率和死亡率 ;鉴于有潜在的手术风险 ,支架最好放置在肝实质内 ,但肝外支架并不构成移植手术的反指征。 | 周光文 蔡伟耀 李宏为 朱岳 Forrest Dodson John J Fung | 2002 | 中华肝胆外科杂志2002，8，11： | 3 |
| 9 | 肝移植后丙型肝炎复发的病毒基因型与组织病理学改变显示文摘目的 观察同种原位肝移植术 (OLT)后复发性丙型肝炎的病理学改变 ,并探讨不同基因型丙型肝炎病毒 (HCV)所致肝炎的各自特点。方法 收集 5 0例肝移植后HCVRNA病毒基因型检测资料及移植肝组织病理资料 ,评价HCV病毒基因型与肝炎活动度、肝纤维化分期、肝脂肪变程度的关系 ,分析复发性丙型肝炎的病理演变过程及特点。结果 5 0例患者可检测到HCV 1a、1b、2、3a和 4基因型 ,各基因型所致的丙型肝炎在肝炎活动度、肝纤维化分期上的差异无显著性 ,但在肝脂肪变方面的差异有显著性 ,HCV 3a型和HCV 2型感染组肝脂肪变程度明显高于HCV 1、4型感染组(P <0 .0 5 ) ;复发性丙型肝炎的演变过程为非特异性改变期—早期丙型肝炎期—典型丙型肝炎期—进展期丙型肝炎期 ;随术后时间的延长 ,肝炎活动度和肝纤维化分期均逐渐加重 (P <0 .0 5 ) ,而肝脂肪变程度则随术后时间的延长而逐渐减轻 ;有 12例合并排斥反应。结论 OLT后复发性丙型肝炎的病理改变与感染的病毒基因型有关 ;尽早确立诊断并给予治疗 ,对减缓肝硬化进程 ,延长移植肝的存活时间具有重要意义。 | 于颖彦 沈柏用 严佶祺 朱岳 John J Fung | 2004 | 中华器官移植杂志2004，25，1： | 3 |
| 10 | Post‐liver transplantation sarcopenia in cirrhosis: A prospective evaluation显示文摘 | Cynthia Tsien Ari Garber Arvind Narayanan Shetal N Shah David Barnes Bijan Eghtesad John Fung Arthur J McCullough Srinivasan Dasarathy | 2014 | J Gastroenterol Hepatol2014，，6： | 2 |
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| 14 | Optimization of an impact drive mechanism based on real-coded genetic algorithm 显示文摘 | Ha J L Fung R F Han C F | 2005 | Sensors and Actuators2005，121，2： | 1 |
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| 16 | Antioxidation of human low desity lipopro tein by unconjugated and conjugated bilirubins显示文摘 | Wu TW Fung KP Wu J | 1996 | Biochem-Pharmacol1996，51，6： | 1 |
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| 18 | A novel tool to assess systolic asynchrony and identify responders of cardiac resynchronization therapy by tissue synchronization imaging 显示文摘 | YU C M ZHANG Q FUNG J W | 2005 | J Am Coll Cardiol2005，45，5： | 1 |
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