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| 1 | Molecular basis of cleft palates in mice显示文摘Cleft palate, including complete or incomplete cleft palates, soft palate clefts, and submucosal cleft palates, is the most frequent congenital craniofacial anomaly in humans. Multifactorial conditions, including genetic and environmental factors, induce the formation of cleft palates. The process of palatogenesis is temporospatially regulated by transcription factors, growth factors, extracellular matrix proteins, and membranous molecules; a single ablation of these molecules can result in a cleft palate in vivo. Studies on knockout mice were reviewed in order to identify genetic errors that lead to cleft palates. In this review, we systematically describe these mutant mice and discuss the molecular mechanisms of palatogenesis. | Noriko Funato Masataka Nakamura Hiromi Yanagisawa | 2015 | World Journal of Biological Chemistry2015，6，3： | 2 |
| 2 | Hunt for mammalian sleep-regulating genes显示文摘Genetics is one of the various approaches adopted to understand and control mammalian sleep.Reverse genetics,which is usually applied to analyze sleep in gene-deficient mice,has been the mainstream field of genetic studies on sleep for the past three decades and has revealed that various molecules,including orexin,are involved in sleep regulation.Recently,forward genetic studies in humans and mice have identified gene mutations responsible for heritable sleep abnormalities,such as SIK3,NALCN,DEC2,the neuropeptide S receptor,andβ1 adrenergic receptor.Furthermore,the protein kinase A-SIK3 pathway was shown to represent the intracellular neural signaling for sleep need.Large-scale genome-wide analyses of human sleep have been conducted,and many gene loci associated with individual differences in sleep have been found.The development of genome-editing technology and gene transfer by an adeno-associated virus has updated and expanded the genetic studies on mammals.These efforts are expected to elucidate the mechanisms of sleep–wake regulation and develop new therapeutic interventions for sleep disorders. | Hiromasa Funato Masashi Yanagisawa | 2022 | Brain Science Advances2022，8，3： | 2 |
| 3 | Apoptosis/diffefentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukeamia cells显示文摘 | Miyazawa K Yaguchi M Funato K | 2001 | Leukemia2001，15，7： | 2 |
| 4 | Combination of 22-oxa-1,25-dihydroxyvitamin D3, a vitamin D3 derivative, with vitamin K2(VK2) synergistically enhances cell differentiation but suppresses VK2-inducing apoptosis in HL-60 cells显示文摘 | Funato K Miyazawa K Yaguchi M | 2002 | Leukemia2002，16，8： | 2 |
| 5 | Autoimmune neutropenia in pregnant women causing neonatal neutropenia显示文摘 | Kameoka J Funato T Miura T | 2001 | Br J Haematol2001，114，1： | 1 |
| 6 | Combination of 22-oxa1,25-dihydroxy vitaminD3,a vitam in D3 derivative,with vitamin K2 (VK2) synergistically enhances cell differentiation but suppresses VK2-inducing apoptosis in H L-60 cells显示文摘 | Funato K Miyazawa K Yaguchi M | 2002 | Leukemia2002，16，8： | 1 |
| 7 | Assessment of drug resistance in acute myeloid leukemia 显示文摘 | Funato T Harigae H Abe S | 2004 | Expert Rev Mlo Diagn2004，4，5： | 1 |
| 8 | Physiological re- sponses to interval training sessionsat veloc- ities associated with VO2max 显示文摘 | Rozenek R Funato K kubo J | 2007 | Strength Cond Res2007，21，1： | 1 |
| 9 | Quantitative PCR system 显示文摘 | FUNATO T SATOH J SASAKI T | 1998 | Rinsho Byon1998，46，5： | 1 |
| 10 | Effects of jaw clenching while wearing an occlusal splint on awareness of tiredness, bite force, and EEG power spectrum 显示文摘 | Narita N Funato M Ishii T | 2009 | J Prosthodont Res2009，53，3： | 1 |
| 11 | Failure in decection of Epstein-Barr virus and cytomegalovirus in specimen obtained by fine needle aspiration biopsy of thyroid in patients with subacute thyroiditis显示文摘 | Mori K Yoshida K Funato T | 1998 | Tohoku J Exp Med1998，186，1： | 1 |
| 12 | Effects of carbon in negative plates on cycle-life performance of valve-regulated lead/acid batteries显示文摘 | Masaaki Shiomi Takayuki Funato Kenji Nakamura Katsuhiro Takahashi Masaharu Tsubota | 1997 | Journal of Power Sources1997，，1： | 1 |
| 13 | Hepatopancreatoduodenectomy with wide lymph node dissection for locally advanced calcinoma of gallbladderlongterm results 显示文摘 | Sasaki R Takahashi M Funato O | 2002 | Hepatogastroenterology2002，49，46： | 1 |
| 14 | A Salmonella virulence protein that inhibits cellular trafficking显示文摘 | Uchiya K IMrbieri MA Funato K et ol | 1999 | EMBO J1999，18，14： | 1 |
| 15 | Distribution of thymic tissue in the mediastinal adipose tissue显示文摘 | Fukai I Funato Y Mizuno T | 1991 | J Thorac Cardiovasc Surg1991，101，6： | 1 |
| 16 | Genetic diagnosis for drug resistance in caneers显示文摘 | Funato T Fujimaki S Fujiwara J | 2000 | Rinsho Byori2000，48，2： | 1 |
| 17 | Effects of carbon in negative plates on cycle-life performance of valve-regulated lead/ acid battery显示文摘 | SHIOMI M FUNATO T NAKAMURA K | 1997 | J Power Sources1997，64，： | 1 |
| 18 | Combination of 22-oxa-1,25-dihydroxyvitamin D(3),a vitamin D(3)derivative,with vitamin K(2)(VK2)synergistically enhances cell differentiation but suppresses VK2-inducing apoptosis in HL-60 cells显示文摘 | Funato K Miyazawa K Yaguchi M | 2002 | Leukemia2002，16，8： | 1 |
| 19 | Ethanol-induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway显示文摘 | Kitagaki H Araki Y Funato K | 2007 | FEBS Lett2007，581，16： | 1 |
| 20 | Globus sensation and increased upper esophageal sphincter pressure with distal esophageal acid perfusion显示文摘 | Ryoji Tokashiki Nobutoshi Funato Mamoru Suzuki | 2010 | European Archives of Oto - Rhino - Laryngology2010，，5： | 1 |
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