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| 1 | Molecular basis of cleft palates in mice显示文摘Cleft palate, including complete or incomplete cleft palates, soft palate clefts, and submucosal cleft palates, is the most frequent congenital craniofacial anomaly in humans. Multifactorial conditions, including genetic and environmental factors, induce the formation of cleft palates. The process of palatogenesis is temporospatially regulated by transcription factors, growth factors, extracellular matrix proteins, and membranous molecules; a single ablation of these molecules can result in a cleft palate in vivo. Studies on knockout mice were reviewed in order to identify genetic errors that lead to cleft palates. In this review, we systematically describe these mutant mice and discuss the molecular mechanisms of palatogenesis. | Noriko Funato Masataka Nakamura Hiromi Yanagisawa | 2015 | World Journal of Biological Chemistry2015，6，3： | 2 |
| 2 | Nature:科学家鉴别出调节机体睡眠的两个关键基因显示文摘近日,刊登在国际杂志Nature上的一项研究报告中,来自西南医学中心等机构的研究人员通过研究鉴别出了两个关键的核心基因,这两个基因能够帮助调节机体深度睡眠和做梦的水平,相关研究或为阐明相关的基因控制睡眠的网络提供新的线索。此前研究者通过对小鼠进行研究发现了能够控制机体快速眼动睡眠的基因,同时该基因还能够诱导深度睡眠。而第二个基因能够控制机体对快速眼动睡眠的需求量,相关研究为科学家们提供了一个关键的切入点来帮助解释睡眠工作的机制,同时研究者还鉴别出了治疗睡眠障碍的潜在靶点。 | Hiromasa Funato, Chika Miyoshi, Tomoyuki Fujiyama, Takeshi Kanda, Makito Sato, Zhiqiang Wang, Jing Ma, Aya Ikkyu, Miyo Kakizaki, Noriko Hotta-Hirashima, Satomi Kanno, Haruna Komiya, Fuyuki Asano, Takato Honda, Staci J. Kim, Kanako Harano, Hiroki Muramoto, Toshiya Yonezawa, Shinichi Miyazaki, Linzi Connor, Yu Hayashi, Qinghua Liu, Joseph S. Takahashi Masashi Yanagisawa Hiromasa Funato Makito Sato Masashi Yanagisawa Shin Nakane, Jun Tomita Kazuhiko Kume Seiya Mizuno, Fumihiro Sugiyama Satoru Takahashi Vivek Kumar Joseph S. Takahashi Vivek Kumar Ikuo Miura, Tomohiro Suzuki Shigeharu Wakana Atsushi Watanabe Manabu Abe Kenji Sakimura Yu Hayashi Qinghua Liu Joseph S. Takahashi Masashi Yanagisawa Masashi Yanagisawa | 2017 | 现代生物医学进展2017，17，6： | 0 |
| 3 | Identification of shared and unique gene families associated with oral clefts显示文摘Oral clefts, the most frequent congenital birth defects in humans, are multifactorial disorders caused by genetic and environmental factors. Epidemiological studies point to different etiologies underlying the oral cleft phenotypes, cleft lip(CL),CL and/or palate(CL/P) and cleft palate(CP). More than 350 genes have syndromic and/or nonsyndromic oral cleft associations in humans. Although genes related to genetic disorders associated with oral cleft phenotypes are known, a gap between detecting these associations and interpretation of their biological importance has remained. Here, using a gene ontology analysis approach, we grouped these candidate genes on the basis of different functional categories to gain insight into the genetic etiology of oral clefts. We identified different genetic profiles and found correlations between the functions of gene products and oral cleft phenotypes. Our results indicate inherent differences in the genetic etiologies that underlie oral cleft phenotypes and support epidemiological evidence that genes associated with CL/P are both developmentally and genetically different from CP only, incomplete CP, and submucous CP. The epidemiological differences among cleft phenotypes may reflect differences in the underlying genetic causes. Understanding the different causative etiologies of oral clefts is important as it may lead to improvements in diagnosis, counseling, and prevention. | Noriko Funato Masataka Nakamura | 2017 | International Journal of Oral Science2017，9，2： | 0 |
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