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| 1 | Diagnostic utility of endoscopic ultrasound-guided fineneedle aspiration biopsy for glomus tumor of the stomach显示文摘A 52-year-old man was referred for further investigation of a gastric submucosal tumor on the greater curvature of the antrum. Endoscopic ultrasonography demonstrated a hypoechoic solid mass, which was primarily connected to the muscular layer of the stomach. We performed endoscopic ultrasoundguided fine-needle aspiration biopsy. The pathological examination showed proliferation of oval-shaped cells with nest formation, which stained strongly positive for muscle actin, and negative for c-kit, CD34, CD56,desmin, S-100, chromogranin, and neuron-specific enolase. Therefore, we performed laparoscopy and endoscopy cooperative surgery based on the preoperative diagnosis of glomus tumor of the stomach. The final histological diagnosis confirmed the preoperative diagnosis. Although preoperative diagnosis of glomus tumor of the stomach is difficult with conventional images and endoscopic biopsy, endoscopic ultrasoundguided fine-needle aspiration biopsy is an essential tool to gain histological evidence of glomus tumor of the stomach for early diagnosis. | Shin Kato Kaoru Kikuchi Kenji Chinen Takahiro Murakami Fumihito Kunishima | 2015 | World Journal of Gastroenterology2015，21，22： | 7 |
| 2 | Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations显示文摘BACKGROUND We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with SLCO2 A1 gene(CEAS). Crohn's disease(CD) is a major differential diagnosis of CEAS, because these diseases share some clinical features. Therefore, there is a need to develop a convenient screening test to distinguish CEAS from CD.AIM To examine whether prostaglandin E major urinary metabolites(PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.METHODS This was a transactional study of 20 patients with CEAS and 98 patients with CD.CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of SLCO2 A1. We measured the concentration of PGEMUM in spot urine by radioimmunoassay, and the concentration was compared between the two groups of patients. We also determined the optimal cut-off value of PGE-MUM to distinguish CEAS from CD by receiver operating characteristic(ROC) curve analysis.RESULTS Twenty Japanese patients with CEAS and 98 patients with CD were enrolled.PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD(median 102.7 vs 27.9 μg/g × Cre, P < 0.0001). One log unit increase in PGE-MUM contributed to 7.3 increase in the likelihood for the diagnosis of CEAS [95% confidence interval(CI) 3.2-16.7]. A logistic regression analysis revealed that the association was significant even after adjusting confounding factors(adjusted odds ratio 29.6, 95%CI 4.7-185.7). ROC curve analysis revealed the optimal PGE-MUM cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with 95.0% sensitivity and 79.6% specificity.CONCLUSION PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD. | Yuichi Matsuno Junji Umeno Motohiro Esaki Yoichiro Hirakawa Yuta Fuyuno Yasuharu Okamoto Atsushi Hirano Shigeyoshi Yasukawa Fumihito Hirai Toshiyuki Matsui Shuhei Hosomi Kenji Watanabe Naoki Hosoe Haruhiko Ogata Tadakazu Hisamatsu Shunichi Yanai Shuji Kochi Koichi Kurahara Tsuneyoshi Yao Takehiro Torisu Takanari Kitazono Takayuki Matsumoto | 2019 | World Journal of Gastroenterology2019，25，14： | 5 |
| 3 | Magnifying endoscopy with narrow-band imaging is useful in the differential diagnosis between low-grade adenoma and early cancer of superficial elevated gastric lesions显示文摘 | Shinichiro Maki Kenshi Yao Takashi Nagahama Takahiro Beppu Takashi Hisabe Yasuhiro Takaki Fumihito Hirai Toshiyuki Matsui Hiroshi Tanabe Akinori Iwashita | 2013 | Gastric Cancer2013，，2： | 3 |
| 4 | On-chip 3D rotation of oocyte based on a vibration-induced local whirling flow显示文摘We propose a novel on-chip 3D cell rotation method based on a vibration-induced flow.When circular vibration is applied to a microchip with micropillar patterns,a highly localized whirling flow is induced around the micropillars.The direction and velocity of this flow can be controlled by changing the direction and amplitude of the applied vibration.Furthermore,this flow can be induced on an open chip structure.In this study,we adopted a microchip with three micropillars arranged in a triangular configuration and an xyz piezoelectric actuator to apply the circular vibration.At the centre of the micropillars,the interference of the vibration-induced flows originating from the individual micropillars induces rotational flow.Consequently,a biological cell placed at this centre rotates under the influence of the flow.Under three-plane circular vibrations in the xy,xz or yz plane,the cell can rotate in both the focal and vertical planes of the microscope.Applying this 3D cell rotation method,we measured the rotational speeds of mouse oocytes in the focal and vertical planes as 63.7±4.0°s^(−1) and 3.5±2.1°s^(−1),respectively.Furthermore,we demonstrated the transportation and rotation of the mouse oocytes and re-positioned their nuclei into a position observable by microscope. | Takeshi Hayakawa Shinya Sakuma Fumihito Arai | 2015 | Microsystems & Nanoengineering2015，1，1： | 2 |
| 5 | Monophyletic origin and unique dispersal patterns of domestic fowls 显示文摘 | FUMIHITO A MIYAKE T TAKADA M | 1996 | Proc Natl Acad Sci USA1996，93，13： | 1 |
| 6 | Monophyletic origin and unique dispersal patterns of domestic fowls显示文摘 | FUMIHITO A MIYAKE T TAKADA M | 1996 | Proc Natl Acad Sci1996，93，： | 1 |
| 7 | Morphological comparison of the Mekong giant cat- fish, Pangasianodon gigas, with other pangasiid species 显示文摘 | FUMIHITO A | 1989 | Ichthyological Research1989，36，1： | 1 |
| 8 | One subspecies of the red junglefowl(Gallus gallus gallus)suffices as the matriarchic ancestor of all domestic breeds显示文摘 | Fumihito A Miyake T Sumi S | 1994 | Proc Natl Acad Sci USA1994，91，12： | 1 |
| 9 | Effect of high compost temperature on enzymatic activity and species diversity of culturable bacteria in cattle manure compost 显示文摘 | Fumihito Miyatake Kazunori Iwabuchi | 2005 | Bioresource Technology2005，96，16： | 1 |
| 10 | Generalized Assorted Pixel Camera: Postcapture Control of Resolution, Dynamic Range, and Spectrum 显示文摘 | Fumihito Yasuma Tomoo Misunaga Daisuke Iso | 2010 | IEEE Transactions on Image Processing (S1057-7149)2010，19，9： | 1 |
| 11 | Ef{ect of high compost tem- perature on enzymatic activity and species diversity o{ culturable bacteria in cattle manure compost 显示文摘 | Fumihito M Kazunori I | 2005 | Bioresource Technology2005，96，： | 1 |
| 12 | Clinical efficiency of vitrification on blastoeysts transfer cycles显示文摘 | Hisao Osada Fumihito Aono Masashige Kuwayama | 2003 | Fertil Steril2003，80，3： | 1 |
| 13 | Characterization of dairy cattle manure/wallboard paper compost mixture显示文摘 | Ronaldo B. Saludes Kazunori Iwabuchi Fumihito Miyatake Yoshiyuki Abe Yoshifumi Honda | 2008 | Bioresource Technology2008，，15： | 1 |
| 14 | One subspecies of the red jun glefowl (C-allus gallus gallus) suffices as the matriarchic ancestor of all domestic breeds显示文摘 | Fumihito A Miyake T Sumi S | 1994 | Proceedings of the National Academy of Sci ences of the United States of America1994，91，12： | 1 |
| 15 | Back stress and shape recoverability during reverse transformation in an Fe-based SMA显示文摘 | Fumihito Nishimura Noriko Watanabe | 1998 | Materials Science and Engineering1998，247，： | 1 |
| 16 | Thioredoxin-2 is an essential gene regulating mitochondria-dependent apoptosis 显示文摘 | TANAKA T FUMIHITO H YUKO Y I | 2002 | EMBO2002，21，7： | 1 |
| 17 | Structure and magnetic properties of 3d-4f heterometallic complexes containing di-2- pyridyl ketoximatez An approach to single-molecule magnets显示文摘 | FUMIHITO M TAKAYUKI I TAKASHI N | 2005 | Polyhedron2005，，： | 1 |
| 18 | One subspecies of the red junglefowl(Gallus gallus gallus) suffices as the matriarehic ancestor of all domestic breeds 显示文摘 | FUMIHITO A MIYAKE T SUMI S | 1994 | Proc Natl Acad Sci USA1994，91，12： | 1 |
| 19 | Monophyleticorigin and unique dispersal patterns of domestic fowls 显示文摘 | Fumihito A Miyake T Takada M | 1996 | Proc Natl Acad Sci USA1996，93，： | 1 |
| 20 | Monophyletic origin and unique dispersal patterns of domestic fowls显示文摘 | Fumihito A Miyake T Takada M | 1996 | Proc Natl Acad Sci USA1996，93，： | 1 |
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