|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A high stable pH-temperature dual-sensitive liposome for tuning anticancer drug release显示文摘In order to improve the targeting and availability of liposomes to cancer cells,the temperature sensitivity of 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine(DPPC)and the pH sensitivity of PASP in PASP-g-C8 are incorporated in a drug delivery system.A composite pH-temperature dual-sensitive liposomes(CPTLPs)was obtained as an efficient drug delivery system.The bionic bilayer is self-assembled by cholesterol/cationic temperature-sensitive lipids as base layer and pH-sensitive octylamine grafted poly aspartic acid(PASP-g-C8)as anchors coated outside.Cytarabine(CYT)was chosen as a model drug.SEM and DLS were used to observe the morphology characteristics of CPTLPs in different micro environment.The results demonstrated that the CPTLPs remained active in both normal(pH7.4 and 37°C)and tumor tissues(pH 5.0 and 42°C).As a stable colloidal system,the zeta potential of CPTSLs was−41.6 mV.In vitro drug-release experiments,the CTY encapsulated dual-sensitive liposomes,CPTSLs(+),not only have significant pH-temperature sensitivity but have more prolonged release in vitro than control groups.MTT tests results indicated that the cell apoptotic effects induced by CPTSLs(+)were nearly 30%higher than the naked drug CTY in HepG2 cells,and 20%lower apoptotic in vero cells.The CPTSLs(+)sustained a stable emulsion form,less toxic effects on normal cells,and exhibited a good pH-temperature sensitivity,thus expected to be a promising tumor targeting drug delivery. | Yilin Zhao Fuli Cai Xiangyi Shen Haijia Su | 2020 | Synthetic and Systems Biotechnology2020，5，2： | 2 |
| 2 | RNA-binding protein QKI regulates contact inhibition via Yes-associate protein in ccRCC显示文摘Contact inhibition adjusts organ size to the proper size and ensures the cultured cells growing to a monolayer.By regulating the downstream coordinator YAP,the evolutionarily conserved Hippo transduction pathway attunes cell growth and death in response to cell contact inhibition,polarity,self-renewal,and differentiation.Dysregulation of this pathway is involved in various diseases such as cancer.RNA-binding protein QKI regulates cell proliferation,metabolism,division,and immunity in various cancer models,but its role in cancer cell contact inhibition remains unclear.In this study,we aimed to clarify the relationship between QKI and YAP,and the role of their interaction in cell contact inhibition.We found a lower QKI expression level in sparse condition,whereas a higher expression level in confluent condition by western blot analysis and immunofluorescence assay.QKI knockdown elevated cell proliferation and invasion both in vitro and in vivo.Strikingly,the results of CCK-8 assay,colony formation assay,and transwell assay showed that the phenomenon was in accord with the expression level of pYAP and reverse with YAP.Higher levels of Wnt3a and β-catenin were also found in xenografts of QKI-knockdown clear cell renal cell carcinoma (ccRCC) CAKI-1 cells by western blot analysis and immumohistochemical staining.Finally,a positive correlation between QKI and pYAP was found in clinical specimens by immunohistochemistry.Thus,as a negative regulator of YAP,QKI attuned the cell contact inhibition,leading to inhibition of cancer cell proliferation and invasion through Wnt and GPCR pathway. | Zheng Zhu Di Wei Xi'an Li Fuli Wang Fei Yan Zibao Xing Zhao Yan Huanyu Lu Dongsheng Zhai Ziehen Ye Geng Zhang Ping Meng Yu Zheng Jiarui Yuan Zifan Lu Jianlin Yuan | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 2 |
| 3 | Learning to recognize misaligned hyperfine orbital angular momentum modes显示文摘Orbital angular momentum(OAM)-carrying beams have received extensive attention due to their high-dimensional characteristics in the context of free-space optical communication.However,accurate OAM mode recognition still suffers from reference misalignment of lateral displacement,beam waist size,and initial phase.Here we propose a deep-learning method to exquisitely recognize OAM modes under misalignment by using an alignment-free fractal multipoint interferometer.Our experiments achieve 98.35% recognizing accuracy when strong misalignment is added to hyperfine OAM modes whose Bures distance is 0.01.The maximum lateral displacement we added with respect to the perfectly on-axis beam is about±0.5 beam waist size.This work offers a superstable proposal for OAM mode recognition in the application of free-space optical communication and allows an increase of the communication capacity. | Xiao Wang Yufeng Qian JingJing Zhang Guangdong Ma Shupeng Zhao RuiFeng Liu Hongrong Li Pei Zhang Hong Gao Feng Huang Fuli Li | 2021 | Photonics Research2021，9，4： | 1 |
| 4 | Model of chromophore coupling in allophycocyanin aggregation显示文摘A new model is proposed to study the interaactions among chromphores in APC trimer. Using this model, the electronic transition frequencies are calculated. The results are in good agreement with the experimental. | Fuli Zhao Xiguang Zheng Jingmin Zhang Hezhou Wang Jingquan Zhao Lijin Jiang | 1998 | Chinese Science Bulletin1998，43，14： | 1 |
| 5 | Mie Resonance-Based Dielectric Metamaterials 显示文摘 | ZHAO Qian ZHOU Ji ZHANG Fuli | 2009 | Materials Today2009，12，12： | 1 |
| 6 | Linear and nonlinear photophysical properties of ZnSe/CdS/ZnS core/shell/shell typeⅡnanocrystals显示文摘In this work,one kind of typeⅡZnSe/CdS/ZnS core/shell/shell nanocrystals(NCs)is synthesized,and their linear and nonlinear photophysical properties are investigated.Through measurements of the temperaturedependent photoluminescence spectra of NCs,their excitonic properties,including the coefficient of the bandgap change,coupling strength of the exciton acoustic phonons,exciton longitudinal optical(LO)phonons,and LO–phonon energy are revealed.Femtosecond transient absorption spectroscopy was employed to obtain insight into ultrafast processes occurring at the interface of ZnSe and CdS,such as those involving the injection of photoinduced electrons into the CdS shell,interfacial state bleaching,and charge separation time.At the end,their multiphoton absorption spectra were determined by using the z-scan technique,which yielded a maximum twophoton absorption cross section of 3717 GM at 820 nm and three-photon absorption cross section up to 3.9×10^-77cm^6·s^2·photon^-2at 1220 nm,respectively.The photophysical properties presented here may be important for exploiting their relevant applications in optoelectronic devices and deep-tissue bioimaging. | YANG GAO XIN QIU FULI ZHAO SHUYU XIAO JUNZI LI XIAODONG LIN RUI CHEN AND TINGCHAO HE | 2020 | Photonics Research2020，8，9： | 1 |
| 7 | The Influential Factors and Charactristics of Triassic Yanchang Formation Reservior in the Zichang Delta,Ordos Basin,China显示文摘Based on the theory of sedimentary petrology,mineral petrology,reservoir geology,well logging geology,exploitation geology and petroleum geology,and reservoir engineering,in combination with outcrop,core,thin section,scanning electron microscope,mercury intrusion and X-ray et al,this paper discussed the characteristics of the low penetrability reservoir of Chang 2 member and | LI Airong WU Fuli ZHAO Liang ZHANG Lushe | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 1 |
| 8 | Dominant changes in the breast muscle lipid profiles of broiler chickens with wooden breast syndrome revealed by lipidomics analyses显示文摘Background: Chicken is the most consumed meat worldwide and the industry has been facing challenging myopathies. Wooden breast(WB), which is often accompanied by white striping(WS), is a serious myopathy adversely affecting meat quality of breast muscles. The underlying lipid metabolic mechanism of WB affected broilers is not fully understood.Results: A total of 150 chickens of a white-feathered, fast-growing pure line were raised and used for the selection of WB, WB + WS and control chickens. The lipids of the breast muscle, liver, and serum from different chickens were extracted and measured using ultra performance liquid chromatography(UPLC) plus Q-Exactive Orbitrap tandem mass spectrometry. In the breast, 560 lipid molecules were identified. Compared to controls, 225/225 of 560 lipid molecules(40.2%) were identified with differential abundance(DA), including 92/100 significantly increased neutral lipids and 107/98 decreased phospholipids in the WB/WB + WS groups, respectively. The content of monounsaturated fatty acids(MUFA) was significantly higher, and the polyunsaturated fatty acids(PUFA) and saturated fatty acids(SFA) were significantly lower in the affected breasts. In the liver, 434 lipid molecules were identified, and 39/61 DA lipid molecules(6.7%/14.1%) were detected in the WB and WB + WS groups, respectively. In the serum, a total of 529 lipid molecules were identified and 4/44 DA lipid molecules(0.8%/8.3%) were detected in WB and WB + WS group, respectively. Compared to controls, the content of MUFAs in the serum and breast of the WB + WS group were both significantly increased, and the content of SFAs in two tissues were both significantly decreased. Only five lipid molecules were consistently increased in both liver and serum in WB + WS group.Conclusions: We have found for the first time that the dominant lipid profile alterations occurred in the affected breast muscle. The relative abundance of 40.2% of lipid molecules were changed and is characteristic of increased neutral lipids and decreased phospholipids in the affected breasts. Minor changes of lipid profiles in the liver and serum of the affected groups were founded. Comprehensive analysis of body lipid metabolism indicated that the abnormal lipid profile of WB breast may be independent of the liver metabolism. | Ranran Liu Fuli Kong Siyuan Xing Zhengxiao He Lu Bai Jiahong Sun Xiaodong Tan Di Zhao Guiping Zhao Jie Wen | 2022 | Journal of Animal Science and Biotechnology2022，13，6： | 1 |
| 9 | Excitation energy transfer mechanisms in allophycocyanin(Ⅰ)——Energy transfer mechanisms in monomer显示文摘The mechanisms of excitation energy transfer within allophycocyanin monomer with the theory of generalized master equation (GME) and the technique of time-resolved fluorescence anisotropic spectroscopy are studied. In the case of known information of its structure and spectra, the theory applied is based on the assumption that the coupling interaction between two chromophores is fairly weak. The theory correctly predicts the experimentlly observed rate for excitation energy transfer in allophycocyanin monomer. Based on the results, the energy transfer mechanism can be described as Frster and these processes cannot take place from the high vibrational levels of donor to acceptor. | ZHANG Jingmin, ZHENG Xiguang, ZHAO Fuli, WANG Hezhou, ZHANG Jianping, ZHAO Jingquan and JIANG Lijin State Key Laboratory for Ultrafast Laser Spectroscopy, Zhongshan University, Guangzhou 510275, China Institute of Photographic Chemistry , Chinese Academy of Sciences , Beijing 100101, China | 1999 | Chinese Science Bulletin1999，44，11： | 1 |
| 10 | Intermit-tent Chaos and Sliding Window Symbol SequenceStatistics-based Early Fault Diagnosis for HydraulicPump on Hydraulic Tube Tester 显示文摘 | Zhao Zhen Jia Mingxing Wang Fuli | 2009 | MechanicalSystems and Signal Processing2009，23，5： | 1 |
| 11 | 200 nm–1000 nm spectra of light emitted in the impact of 40Ar10+ upon Al and Si solid surfaces显示文摘 | Xiao’an Zhang Yongtao Zhao Fuli Li Zhihu Yang Guoqing Xiao Wenlong Zhan | 2003 | Science in China Series G: Physics Mechanics and Astronomy2003，，5： | 1 |
| 12 | Stage-based soft-transition multiple PCA modeling and on-line monitoring strategy for batch processes 显示文摘 | Zhao Chunhui Wang Fuli Lu Ningyun | 2007 | Journal of Process Control2007，17，9： | 1 |
| 13 | Improved batch process monitoring and quality prediction based on multiphase statistical analysis显示文摘 | ZHAO Chunhui WANG Fuli LU Ningyun | 2008 | Industrial and Engineering Chemistry Research2008，47，3： | 1 |
| 14 | Dissimilarity analysis based batch process monitoring using moving windows 显示文摘 | ZHAO Chunhui WANG Fuli JIA Mingxing | 2007 | AIChE J2007，53，5： | 1 |
| 15 | Population spatialization in China based on night-time imagery and land use data显示文摘 | Chuiqing Zeng Yi Zhou Shixin Wang Fuli Yan Qing Zhao | 2011 | International Journal of Remote Sensing2011，，24： | 1 |
| 16 | Inter mittent Chaos and Sliding Window Symbol Sequence Statistics-based Early Fault Diagnosis for Hydraulic Pump on Hydraulic Tube Tester显示文摘 | Zhao Zhen Jia Mingxing Wang Fuli Wang Shu | 2009 | Mechanical Systems and Signal Processing2009，23，5： | 1 |
| 17 | Stage-based soft-transition multiple PCA modeling and on-line monitoring strategy for batch processes显示文摘 | Chunhui Zhao Fuli Wang Ningyun Lu Mingxing Jia | 2007 | Journal of Process Control2007，，9： | 1 |
| 18 | Intermittent Chaos and Sliding Window Symbol Sequence Statistics - based Early Fault Diagnosis for Hydraulic Pump on Hy- draulic Tube Tester 显示文摘 | ZHAO Zhen JIA Mingxing WANG Fuli | 2009 | Mechanical Systems and Signal Processing2009，23，5： | 1 |
| 19 | Stage-based soft-transition multiple PCA modeling and on-line monitoring strategy for batch processes显示文摘 | Zhao Chunhui Wang Fuli Lu Ningyun | 2007 | Journal of Process Control2007，17，9： | 1 |
| 20 | Voltage tunable short wire-pair type of metamaterial infiltrated by nematic liquid crystal 显示文摘 | ZHANG Fuli ZHAO Qian ZHANG Weihong | 2010 | Applied Physics Letters(S0003-6951)2010，97，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员