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| 1 | Restrictive model of compensated carbon tetrachloride-induced cirrhosis in rats显示文摘AIM: To develop a simplified and quick protocol to induce cirrhosis and standardize models of partial liver resection in rats.METHODS: In Fischer F344 rats two modified protocols of phenobarbital-carbon tetrachloride (CCl4) (dilution 50%) gavage to induce cirrhosis (frequency adjusted according to weight, but each subsequent dose was systematically administered) were tested, i.e. the rapid and slow protocols. Prothrombin time (PT) and total bili-rubin (TB) were also evaluated. Animals from the rapid group underwent 15% hepatectomy and animals from the slow group underwent 70% hepatectomy.RESULTS: Rapid protocol: This corresponded to 1 ga-vage/4 d over 6 wk (mortality 30%). Mean PT was 35.2 ± 2.8 s (normal: 14.5 s), and mean TB was 1.8 ± 0.2 mg/dL (normal: 0.1 mg/dL). Slow protocol: This cor-responded to 1 gavage/6 d over 9 wk (mortality 10%). Mean PT was 11.8 ± 0.2 s (normal: 14.5 s), and mean TB was 0.4 ± 0.04 mg/dL (normal: 0.1 mg/dL). Patho-logical analyses were performed in both protocols which showed persistent cirrhosis at 3 mo. Rat mortality in the rapid gavage group who underwent 15% hepatectomy and in the slow gavage group who underwent 70% hepatectomy was 50% and 70%, respectively.CONCLUSION: Our modified model is a simplified method to induce cirrhosis which is rapid (6 to 9 wk), efficient and stable up to 3 mo. Using this method, 'Child Pugh A' or 'Child Pugh BC' cirrhotic rats were obtained. Our models of cirrhosis and hepatectomy can be used in various situations focusing on postoperative survival. | Jean-Marc Regimbeau David Fuks Niaz Kohneh-Shahri Benot Terris Olivier Soubrane | 2008 | World Journal of Gastroenterology2008，14，45： | 8 |
| 2 | PRECIPITATION HARDENING IN B2-ORDERED NiAl BY Ni_(2)AlTi COMPOUND显示文摘Microstructural variations and correlated hardness changes in B2-ordered NiAl con- taining fine precipitation of NiAlTi have been investigated by means of transmission electron microscopy (TEM) and hardness tests. The amount of age hardening is not large as compared to the large microstructural variations during aging. TEM obser- vations have revealed that the L21 -type Ni2 AITi precipitates keep a lattice coherency with the NiA1 matrix at the beginning of aging. By longer periods of aging Ni2AITi precipitates lose their coherency and change their morphology to the globular ones surrounded by misfit dislocations. The temperature dependence of the yield strength of precipitate-containing B2-ordered NiAl was investigated by compression tests over the temperature range of 873-1273K. The fine precipitation of Ni2 A1Ti was found to enhance greatly the yield strength and the high-temperature strength is comparison with that of superalloy Mar-M200. | W.H. Tian, K. Ohishi and M. Nemoto 1)Department of Materials Physics and Chemistry, University of Science and Technology Beijing, Beijing 100083, China 2)Department of Materials Science and Engineering, Faculty of Engineering 36, Kyushu University, Fuk | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，5： | 7 |
| 3 | Metabolic syndrome and non-alcoholic fatty liver disease in liver surgery: The new scourges?显示文摘The aim of this topic highlight is to review relevant evidence regarding the influence of the metabolic syndrome(MS) and its associated liver manifestation, non-alcoholic fatty liver disease(NAFLD), on the development of liver cancer as well as their impact on the results of major liver surgery. MS and NAFLD, whose incidences are significantly increasing in Western countries, are leading to a changing profile of the patients undergoing liver surgery. A MEDLINE search was performed for relevant articles using the key words 'metabolic syndrome', 'liver resection', 'liver transplantation', 'non alcoholic fatty liver disease', 'non-alcoholic steatohepatitis' and 'liver cancer'. On one hand, the MS favors the development of primary liver malignancies(hepatocellular carcinoma and cholangiocarcinoma)either through NAFLD liver parenchymal alterations(steatosis, steatohepatitis, fibrosis) or in the absence of significant underlying liver parenchyma changes. Also, the existence of NAFLD may have a specific impact on colorectal liver metastases recurrence. On the other hand, the postoperative period following partial liver resection and liver transplantation is at increased risk of both postoperative complications and mortality. These deleterious effects seem to be related to the existence of liver specific complications but also higher cardio-vascular sensitivity in a setting of MS/NAFLD. Finally, the long-term prognosis after curative surgery joins that of patients operated on with other types of underlying liver diseases. An increased rate of patients with MS/NAFLD referred to hepatobiliary units has to be expected. The higher operative risk observed in this subset of patients will require specific improvements in their perioperative management. | Francois Cauchy David Fuks Alban Zarzavadjian Le Bian Jacques Belghiti Renato Costi | 2014 | World Journal of Hepatology2014，6，5： | 4 |
| 4 | Multicentre European study of preoperative biliary drainage for hilar cholangiocarcinoma显示文摘 | O. Farges J. M. Regimbeau D. Fuks Y. P. Le Treut D. Cherqui P. Bachellier J. Y. Mabrut M. Adham F. R. Pruvot J. F. Gigot | 2012 | Br J Surg2012，，2： | 2 |
| 5 | Safety of Liver Resection for Hepatocellular Carcinoma After Sorafenib Therapy: A Multicenter Case-Matched Study显示文摘 | Louise Barbier David Fuks Patrick Pessaux Fabrice Muscari Yves-Patrice Treut Sandrine Faivre Jacques Belghiti | 2013 | Annals of Surgical Oncology2013，，11： | 2 |
| 6 | High dose radiation delivered by intensity modulated conformal radiotherapy improves the outcome of localized prostate cancer显示文摘 | Zelefsky MJ Fuks Z Hunt M | 2001 | J Urol2001，166，3： | 1 |
| 7 | Radiation-induced apoptosis of endothelial cells in the murine central nervous system:protection by fibroblast growth factor and sphingomyelinase deficiency显示文摘 | Pena LA Fuks Z Kolesnick RN | 2000 | Cancer Res2000，60，2： | 1 |
| 8 | Polarimetric bright- ness temperatures of sea surfaces measured with aircraft K- and Ka-band radiometers显示文摘 | Yueh S H Wilson W J Fuk K Li | 1997 | IEEE Transactions on Geoscience and Remote Sensing1997，35，5： | 1 |
| 9 | Adjuvant cyclophophamide doxorubicin vincristine and prednisone chemotherapy after radiation therapy in stage Ⅰ low-grade and intermediate-grade non-Hodgkin's lyraphoma显示文摘 | Yahalon R Varsos G Fuks Z | 1993 | Cancer1993，71，： | 1 |
| 10 | Severed corticospinat axons recover electrophysiologic control of muscle activity after x-ray therapy in lesioned adult spinal cord显示文摘 | Kalderon N Fuks Z | 1996 | Proc Natl Acad Sci USA1996，93，11： | 1 |
| 11 | Progressive pre- operative pneumoperitoneum preparation ( the Goni Moreno Protocol ) prior to large incisional hernia surger- y: volumetric, respiratory and clinical impacts 显示文摘 | Sabbagh C Dument F Fuks D | 2012 | Hernia2012，16，1： | 1 |
| 12 | Formation of nano-crystalline structure at the interface in Cu-C composite显示文摘 | Berner A Fuks D Ellis D E | 1999 | Applied Surface Science1999，，： | 1 |
| 13 | Structural recovery in lesioned adult mammalian spinal cord by x-irradiation of the lesion site显示文摘 | Kalderon N Fuks Z | 1996 | Proc Natl Acad Sci USA1996，93，11： | 1 |
| 14 | DNA methylation and histone modifications: teaming up to silence genes显示文摘 | Fuks F | 2005 | CurrOpin Genet Dev2005，15，： | 1 |
| 15 | The role of radiation therapy in the control of pain from pancreatic carcinoma 显示文摘 | Minsky BD Hilaris B Fuks Z | 1988 | J Pain Symptom Man-age1988，3，3： | 1 |
| 16 | Clinical experience with Intensity modulated radiation tlierapy(IMRT)in prostate cancer显示文摘 | Zelefsky MJ Fuks Z Happersett L | 2000 | Radiother Oncol2000，55，3： | 1 |
| 17 | Carcinoembryonie antigen, a human tumor marker, functions as an intercellular adhesion molecule 显示文摘 | Benchimol S Fuks A Jothy S | 1989 | Cell1989，57，2： | 1 |
| 18 | Intensity-modulated radio- therapy 显示文摘 | Leibel SA Fuks Z Zelefsky MJ | 2002 | Cancer J2002，8，2： | 1 |
| 19 | Minimally invasive liver resection for huge(≥10cm)tumors:an international multicenter matched cohort study with regression discontinuity analyses显示文摘Background:The application and feasibility of minimally invasive liver resection(MILR)for huge liver tumours(≥10 cm)has not been well documented.Methods:Retrospective analysis of data on 6,617 patients who had MILR for liver tumours were gathered from 21 international centers between 2009-2019.Huge tumors and large tumors were defined as tumors with a size≥10.0 cm and 3.0-9.9 cm based on histology,respectively.1:1 coarsened exact-matching(CEM)and 1:2 Mahalanobis distance-matching(MDM)was performed according to clinically-selected variables.Regression discontinuity analyses were performed as an additional line of sensitivity analysis to estimate local treatment effects at the 10-cm tumor size cutoff.Results:Of 2,890 patients with tumours≥3 cm,there were 205 huge tumors.After 1:1 CEM,174 huge tumors were matched to 174 large tumors;and after 1:2 MDM,190 huge tumours were matched to 380 large tumours.There was significantly and consistently increased intraoperative blood loss,frequency in the application of Pringle maneuver,major morbidity and postoperative stay in the huge tumour group compared to the large tumour group after both 1:1 CEM and 1:2 MDM.These findings were reinforced in RD analyses.Intraoperative blood transfusion rate and open conversion rate were significantly higher in the huge tumor group after only 1:2 MDM but not 1:1 CEM.Conclusions:MILR for huge tumours can be safely performed in expert centers It is an operation with substantial complexity and high technical requirement,with worse perioperative outcomes compared to MILR for large tumors,therefore judicious patient selection is pivotal. | Tan-To Cheung Xiaoying Wang Mikhail Efanov Rong Liu David Fuks Gi-Hong Choi Nicholas LSyn Charing CChong Iswanto Sucandy Adrian KHChiow Marco VMarino Mikel Gastaca Jae Hoon Lee TPeter Kingham Mathieu D’Hondt Sung Hoon Choi Robert PSutcliffe Ho-Seong Han Chung Ngai Tang Johann Pratschke Roberto ITroisi Brian KPGoh International Robotic and Laparoscopic Liver Resection Study Group Collaborators | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 1 |
| 20 | Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in 'mice显示文摘 | Paris F Fuks Z Kang A | | Science0，，： | 1 |
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