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| 1 | Carcinosarcoma of the liver with mesenchymal differentiation显示文摘We report an extremely rare case where a mesenchymal differentiation, especially embryonal sarcoma, was demonstrated in cholangiocarcinoma. At autopsy, a yellowish-white tumor (15 cm x 12 cm) was found in the right hepatic lobe, and there were several daughter nodules in both hepatic lobes. Histologically, most of the main tumor and all of the daughter nodules examined showed sarcomatous changes (spindle cells, pleomorphic cells and hyalization). Histologic examination of a part of the main tumor disclosed a focus of adenocarcinoma within the tumor. The frequent transitions between the adenocarcinomatous areas and the sarcomatous areas suggested that sarcomatous transformation occurred in the cholangiocarcinoma and then spread rapidly. Immunohistochemically, the adenocarcinomatous elements were positive for cytokeratin, carcinoembryonic antigen (CEA) and epithelial membrane antigen, and negative in the sarcomatous cells. Vimentin was positive only in the sarcomatous elements. The findings of the present case support the view that carcinosarcomas represent carcinomas that develop sarcomatous elements via metaplasia of the epithelial element. | Shinichi Sumiyoshi Masataka Kikuyama Yuji Matsubayashi Fujito Kageyama Yoshihiro Ide Yoshimasa Kobayashi Hirotoshi Nakamura | 2007 | World Journal of Gastroenterology2007，13，5： | 6 |
| 2 | Dual androgen-response elements mediate androgen regulation of MMP-2 expression in prostate cancer cells显示文摘瞄准:描绘矩阵 metalloproteinases (MMP )-2 倡导者并且在导致雄激素的 MMP-2 表示包含了识别雄激素反应元素(AREs ) 。方法: MMP-2 mRNA 层次被反向的抄写聚合酶链反应(RT-PCR ) 决定。MMP-2promoter-driven 酶试金被用来决定碎片负责的导致 forandrogen 的活动。Chromatin-immunoprecipitation 试金和 elec-trophoretic 活动性移动试金(EMSA ) 被用来在 MMP-2 倡导者验证识别 AREs。结果:在 mRNA 水平的 Androgensignificantly 导致的 MMP-2 表示,它被雄激素对手 bicalutamide 堵住。包含基础对 -1591 到 -1259 的一个区域的删除(相对开始鳕鱼在上) MMP-2,倡导者导致了导致雄激素的记者活动的重要损失。直到 -562 bp 的 5 ′ - 区域的另外的删除进一步减少了 androgen-inducedMMP-2 倡导者活动。这二个区域的顺序分析揭示了二通常认为是主题。介绍变化在通常认为由指导地点的傻瓜发育不全途径的主题在导致雄激素的 MMP-2 倡导者活动的戏剧的损失被结果,显示通常认为主题为刺激雄激素的 MMP-2 被要求表示。最重要地,雄激素受体(AR ) 在雄激素处理以后在染色质 immunoprecipitationassay 在 vivo 与两个包含主题的倡导者区域交往了。而且, AR 明确地跳了到野类型然而并非变异是包含主题的探针在一在里面 vitro EMSA 试金。结论:二是主题被识别为在前列腺癌症房间的导致雄激素的 MMP-2 表示负责。 | Ben-Yi Li Xin-Bo Liao Atsuya Fujito J. Brantley Thrasher Fang-Yun Shen Ping-Yi Xu | 2007 | Asian Journal of Andrology2007，9，1： | 2 |
| 3 | Hand Assisted Retroperitoneoscopic Nephroureterectomy: Comparison With the Open Procedure显示文摘 | AKIHIRO KAWAUCHI AKIRA FUJITO OSAMU UKIMURA KIMIHIKO YONEDA YOICHI MIZUTANI TSUNEHARU MIKI | 2003 | The Journal of Urology2003，，3： | 2 |
| 4 | Triterpene esters from Eucalyptus tereticornis显示文摘 | WANG H C YASUO FUJITO | 1993 | Phytochemistry1993，33，1： | 1 |
| 5 | Early detection of platelet activation after coronary angioplasty显示文摘 | INOUE T HOSHI K FUJITO T | 1996 | Coron Artery Dis1996，7，： | 1 |
| 6 | Early detection of platelet activation after coronary angioplasty显示文摘 | Hoshi K Fujito T | 1996 | Coron Artery Dis1996，7，： | 1 |
| 7 | Establishment of an enzyme-linked immunosorbent assay for measurement of sotalol显示文摘 | Saita T Fujito H Nakano Y | 2004 | Biological & Pharmaceutical Bulletin2004，27，： | 1 |
| 8 | Early detection ofp latelet activation after coronary anglop lastly 显示文摘 | Inoun T Hoshi K Fujito T | 1996 | Coron Artery Dis1996，7，7： | 1 |
| 9 | Quantification of human amniotic fluid constituents by high- resolution proton nuclear magnetic resonance (NMR) spectroscopy显示文摘 | Sims CJ Fujito DT Burholt DR | 1993 | Prenal Diagn1993，13，6： | 1 |
| 10 | Protein binding and the metabolism of thiamylal enantiomers in vitro 显示文摘 | Fujito K Shuto H | 2000 | Anesth Analg2000，91，3： | 1 |
| 11 | Early detection of platelet activation after coronary angloplastry 显示文摘 | Inoun T Hoshi K Fujito T | 1996 | Coron Artery Dis1996，7，： | 1 |
| 12 | Field stabilization for high resolution solid state NMR magnet with ex- ternal field-lock 显示文摘 | Shinagawa H Fujito T Ohki S | 2008 | Bunseki Kagaku2008，57，1： | 1 |
| 13 | Development of a specific and sensitive enzyme-linked immunosorbent assay for the quanti- fication of imatinib 显示文摘 | Saita T Shin M Fujito H | 2013 | Biol Pharm Bull2013，36，12： | 1 |
| 14 | Laparoscopic correction of vesicoureteral reflux using lieh-Gregoir technique:initial experience and technical aspects显示文摘 | Kawauchi A Fujito A Soh J | 2003 | Int J Urol2003，10，2： | 1 |
| 15 | Further studies of lipid pea'oxidation in human paraquat poisoning 显示文摘 | Yasaka T Okudaira K Fujito H | 1986 | Arch Intern Med1986，146，4： | 1 |
| 16 | Clinical significance of neutrophil adhesion molecules expression after coronary angioplasty on the development of restenosis显示文摘 | Inoue T Sakai Y Fujito T | | 0，，： | 1 |
| 17 | Fertility-preserving treatment with progestin, and pathological criteria to predict responses, in young women with endometrial carcinoma显示文摘 | Yamazawa K Hirai M Fujito A | 2007 | Human Reprod2007，22，： | 1 |
| 18 | Triterpene esters from Eucalyptus tereticornis显示文摘 | Wang H C Yasuo Fujito | 1993 | Phytochemistry1993，33，1： | 1 |
| 19 | Fertility-preserving treatment with progestin,and pathological criteria to predict responses,in young women with endometrial cancer显示文摘 | Yamazawa K Hirai M Fujito A | | 0，，07： | 1 |
| 20 | AntiMüllerian hormone subatance from follicular fluid is positvely associated with success in o ocyte fertilization during in vitro fertilization显示文摘 | Takahashi C Fujito A Kazuka M | 2008 | Fertil Steril2008，89，： | 1 |
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