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| 1 | Complement activation by phospholipids: the interplay of factor H and C1q显示文摘Complement proteins in blood recognize charged particles.The anionic phospholipid(aPL)cardiolipin binds both complement proteins C1q and factor H.C1q is an activator of the complement classical pathway,while factor H is an inhibitor of the alternative pathway.To examine opposing effects of C1q and factor H on complement activation by aPL,we surveyed C1q and factor H binding,and complement activation by aPL,either coated on microtitre plates or in liposomes.Both C1q and factor H bound to all aPL tested,and competed directly with each other for binding.All the aPL activated the complement classical pathway,but negligibly the alternative pathway,consistent with accepted roles of C1q and factor H.However,in this system,factor H,by competing directly with C1q for binding to aPL,acts as a direct regulator of the complement classical pathway.This regulatory mechanism is distinct from its action on the alternative pathway.Regulation of classical pathway activation by factor H was confirmed by measuring C4 activation by aPL in human sera in which the C1q:factor H molar ratio was adjusted over a wide range.Thus factor H,which is regarded as a down-regulator only of the alternative pathway,has a distinct role in downregulating activation of the classical complement pathway by aPL.A factor H homologue,β2-glycoprotein-1,also strongly inhibits C1q binding to cardiolipin.Recombinant globular domains of C1q A,B and C chains bound aPL similarly to native C1q,confirming that C1q binds aPL via its globular heads. | Lee Aun Tan Bingbin Yu Francis CJ Sim Uday Kishore Robert B Sim | 2010 | Protein & Cell2010，1，11： | 2 |
| 2 | Avoiding misdiagnosing neuroblastoma as Wilms tumor显示文摘 | Dickson PV Sims TL Streck CJ | 2008 | J Pediatr Surg2008，43，： | 1 |
| 3 | TPD52 and NFKBI gene expression levels correlate with G2 chromosomal radiosensitivity in lymphocytes of women with and at risk of hereditary breast cancer 显示文摘 | Sims AH Finnon P Miller CJ | 2007 | Int J Radiat Biol2007，83，6： | 1 |
| 4 | avoiding misdiagnosing neuroblastoma as Wilms tumor显示文摘 | Dickson PV Sims TL Streck CJ | 2008 | J Pediatr Surg2008，43，6： | 1 |
| 5 | Randomized controlled trial to prevent excessive weight gain in pregnant women 显示文摘 | Polley BA Wing RR Sims CJ | 2002 | Int J Obes Relat Metab Disord2002，26，： | 1 |
| 6 | Quantification of human amniotic fluid constituents by high- resolution proton nuclear magnetic resonance (NMR) spectroscopy显示文摘 | Sims CJ Fujito DT Burholt DR | 1993 | Prenal Diagn1993，13，6： | 1 |
| 7 | avoiding misdiagnosing neuroblastoma as Wilms tumor显示文摘 | Dickson PV Sims TL Streck CJ | 2008 | J Pediatr Surg2008，43，6： | 1 |
| 8 | Astrocytes in the aged rat spinal cord fail to increase GFAP mRNA following sciatic nerve axotomy显示文摘 | Kane CJ Sims TJ Giore SA | 1997 | Brain Res1997，759，1： | 1 |
| 9 | TPD52 and NFKB1 gene expression levels correlate with G2 chromosomal radiosensitivity in lymphocytes of women with and at risk of hereditary breast cancer显示文摘 | Sims AH Finnon P Miller CJ | 2007 | In/J Radiat Biol2007，83，6： | 1 |
| 10 | The influence of patient posi-tion on withdrawal force of thoracic epidural catheters显示文摘 | Sim WS Choi JW Lee CJ | 2012 | Anaesthesia2012，67，1： | 1 |
| 11 | Androgen receptor gene and male infertility显示文摘 | Yong EL Loy CJ Sim KS | 2003 | Hum Reprod Update2003，9，1： | 1 |
| 12 | Candida albieans chorioamnionitis associated with preterm labor and sudden intrauterine demise of one twin显示文摘 | Friebe-Hoffmann U Bender DP Sims CJ | 2000 | J Reprod Med2000，45，： | 1 |
| 13 | cDNA expression cloning of the IL-1 receptor,a member of the immunoglobulin superfamily显示文摘 | March CJ Cosman D | 1988 | Science1988，241，4865： | 1 |
| 14 | Online relationship marketing by Singapore hotel websites 显示文摘 | GAN L SIM CJ TAN HL TAN J | 2006 | Joumal of Travel & Tourism Marketing2006，23，： | 1 |
| 15 | Astrocytes in the aged rat spinalcord fail to increase GFAP mRNA following sciatic nerve axotomy显示文摘 | Kane CJ Sims TJ Gilmore SA | 1997 | Brain Res1997，759，1： | 1 |
| 16 | cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily显示文摘 | Sims JE March CJ Cosman D | 1988 | Science1988，241，4865： | 1 |
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