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| 1 | Human iPS Cells Loaded with MnO2-Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer显示文摘How to trigger strong anti-tumor immune responses has become a focus for tumor therapy.Here,we report the human-induced pluripotent stem cells(iPSs)to deliver MnO2@Ce6 nanoprobes into tumors for simultaneous photodynamic therapy(PDT)and enhanced immunotherapy.Ce6 photosensitizer was attached on manganese dioxide(MnO2)nanoparticles,and resultant MnO2@Ce6 nanoprobes were delivered into mitomycin-treated iPSs to form iPS-MnO2@Ce6 nanoprobes.The iPS-MnO2@Ce6 actively targeted in vivo tumors,the acidic microenvironment triggered interaction between MnO2 and H2O2,released large quantities of oxygen,alleviated hypoxia in tumor.Upon PDT,singlet oxygen formed,broken iPSs released tumor-shared antigens,which evoked an intensive innate and adaptive immune response against the tumor,improving dendritic cells matured,effector T cells,and natural killer cells were activated.Meanwhile,regulatory T cells were reduced,and then the immune response induced by iPS-MnO2@Ce6 was markedly stronger than the immune reaction induced by MnO2@Ce6(P<0.05).The iPS-MnO2@Ce6 markedly inhibited tumor growth and metastasis and reduced mortality in mice models with tumor.Human iPS s loaded with MnO2-based nanoprobes are a promising strategy for simultaneous PDT and enhanced immunotherapy against tumor and own clinical translational prospect. | Yanlei Liu Jingxing Yang Bin Liu Wen Cao Jingpu Zhang Yuming Yang Lijun Ma Jesus Martinez de la Fuente Jie Song Jian Ni Chunfu Zhang Daxiang Cui | 2020 | Nano-Micro Letters2020，12，10： | 2 |
| 2 | In- creased Thl, Th17 and pro-fibrotic responses in hepatitis C -infected patients are down -regulated after 12 weeks of treatment with pegylated interferon plus ribavirin 显示文摘 | Jimenez-Sousa MA Almansa R de La Fuente C | 2010 | Eur Cy- tokine Netw2010，21，2： | 1 |
| 3 | Intraindividual variability in cognitive performance in persons with chronic fatigue syndrome显示文摘 | Hunter MA Strauss E | 2001 | Clin Neuropsychol2001，15，2： | 1 |
| 4 | Lateral functional shift of the mandible: Part II, Effects on gene ex- pression in condylar cartilage 显示文摘 | Fuentes MA Opperman LA Buschang P | 2003 | Am J Orthod Dentofacial Orthop2003，123，2： | 1 |
| 5 | Standardized perfusion value:universal CT conlrast enhancement scale that correlates with fDG PET in lung nodules显示文摘 | Miles KA Gdflqths MR Fuentes MA | 2001 | Radiology2001，220，： | 1 |
| 6 | Standardized Perfusion Value:Universal CT Contrast enhancement Scale that Correlates with FDG PET in Lung Nodules显示文摘 | Miles KA Griffiths MR Fuentes MA | 2001 | Radiology2001，220，2： | 1 |
| 7 | Standardized perfusion value:universal CT contrast enhancement scale that correlates with FDG PET in lung nodules显示文摘 | Miles KA Griffiths MR Fuentes MA | 2001 | Radiology2001，220，2： | 1 |
| 8 | Scopadulciol, isolated from scoparia dulcis, induces β-catenin degradation and overcomes tumor necrosis factor-related apoptosis ligand resistance in ags human gastric adenocarcinoma cells显示文摘 | Fuentes RG Toum e K Arai MA | 2015 | J Nat Prod2015，78，4： | 1 |
| 9 | Standardized perfusion value: universal CT contrast enhancement scale that correlates with FDGPET in lung nodules显示文摘 | Miles KA Giffiths MR Fuentes MA | 2001 | Radiology2001，220，2： | 1 |
| 10 | Treatment with angiotensin receptor blockers before stroke could exert a favourable effect in acute cerebral infarction显示文摘 | Fuentes B Fernández-Domínguez J Ortega-Casarrubios MA | 2010 | J Hypertens2010，28，3： | 1 |
| 11 | WASP Confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B cell homeostasis and function 显示文摘 | Westerberg LS de la Fuente MA Wermeling F | 2008 | Blood2008，112，10： | 1 |
| 12 | General anesthesia delays the inflammatory response and increases survival for mice with endotoxic shock 显示文摘 | Fuentes JM Talamini MA Fulton WB | 2006 | Clin Vaccine Immunol2006，13，2： | 1 |
| 13 | Regulation of cell proliferation in rat mandibular condylar cartilage in explant culture by insulin-like growth factor-1and fibroblast growth factor-2显示文摘 | Fuentes MA Opperman LA Bellinger LL | | 0，，09： | 1 |
| 14 | Standardized perfusionvalue:universal CT contrast enhancement scale that correlateswith FDG PET in Lung nodules 显示文摘 | Miles - KA Griffiths MR Fuentes MA | 2001 | Radiology August2001，220，： | 1 |
| 15 | Sta?bility of LASEK with and without mitomycin C performed to correct myopia in thin corneas (A 15-month follow-up) 显示文摘 | De Benito-Llopis L Teus MA Sonches-Pina JM Fuentes I | 2008 | Am J Ophthalmol2008，145，： | 1 |
| 16 | Influence of previous diagnosis of diabetes mellitus in the stroke severity and in-hospital outcome in acute cerebral infarction显示文摘 | Ortega-Casarrubios MA Fuentes B San Jose B | 2007 | Neurologia2007，22，： | 1 |
| 17 | Breast cancer stem cells显示文摘 | Velasco-Velázquez MA Homsi N De La Fuente M | | 0，，04： | 1 |
| 18 | Standardized Perfusion Value: Universal CT Contrast Enhancement Scale that Correlates with FDG PET in Lung Nodules显示文摘 | Miles KA G-riffiths MR Fuentes MA | 2001 | Radiology2001，220，： | 1 |
| 19 | Psoriasis vulgaris lesions contain discrete populations of Th1and Thl7 T cells显示文摘 | Lowes MA Kikuchi T Fuentes Duculan J et a1 | 2008 | J Invest Dermatol2008，128，5： | 1 |
| 20 | General anesthesia delays the inflammatory response and increases survival for mice with endotoxic shock 显示文摘 | Fuentes JM Talamini MA Fulton WB | 2006 | Clin Vaccine lmmunol2006，13，2： | 1 |
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