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| 1 | New eolian red clay sequence on the western Chinese Loess Plateau linked to onset of Asian desertification about 25 Ma ago显示文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene. | QIANG XiaoKe AN ZhiSheng SONG YouGui CHANG Hong SUN YouBin LIU WeiGuo AO Hong DONG JiBao FU ChaoFeng WU Feng LU FengYan CAI YanJun ZHOU WeiJian CAO JunJi XU XinWen AI Li | 2011 | Science China Earth Sciences2011，54，1： | 73 |
| 2 | Effect of cooling rates on dendrite spacings of directionally solidified DZ125 alloy under high thermal gradient显示文摘The dendrite morphologies and spacings of directionally solidified DZ125 superalloy were investigated under high thermal gradient about 500 K/cm. The results reveal that, with increasing cooling rate, both the spacings of primary and secondary dendrite arms decrease, and the dendrite morphologies transit from coarse to superfine dendrite. The secondary dendrite arms trend to be refined and be well developed, and the tertiary dendrite will occur. The predictions of the Kurz/Fisher model and the Hunt/Lu model accord basically with the experimental data for primary dendrite arm spacing. The regression equation of the primary dendrite arm spacings λ1 and the cooling rate Vc is λ1=0.013Vc-0.32. The regression equation of the secondary dendrite arm spacing λ2 and the cooling rate Vc is λ2=0.00258Vc-0.31, which gives good agreement with the Feurer/Wunderlin model. | ZHANG Weiguo LIU Lin ZHAO Xinbao HUANG Taiwen YU Zhuhuan QU Min FU Hengzhi | 2009 | Rare Metals2009，28，6： | 11 |
| 3 | An Efficient and Stable Ionic Liquid System for Synthesis of Ethylene Glycol via Hydrolysis of Ethylene Carbonate显示文摘An ionic liquid system of [Bmim]X/[Bmim]OH(X Cl,BF4,and PF6,) was developed for the hydroly-sis of ethylene carbonate to ethylene glycol. The important parameters,such as the variety of ionic liquids,molar ratio of [Bmim]X to [Bmim]OH,amount of ionic liquid,molar ratio of water to ethylene carbonate,reaction tem-perature,pressure and reaction time,were investigated systematically. Excellent yield(>93%) and high selectivity(99.5%) of ethylene glycol were achieved. Under the optimum reaction conditions,the ionic liquid system could be reused at least five times and the selectivity of ethylene glycol remained higher than 99.5%. | MENG Zhenying SUN Jian WANG Jinquan ZHANG Jianxin FU Zengzeng CHENG Weiguo ZHANG Xiangping | 2010 | Chinese Journal of Chemical Engineering2010，18，6： | 8 |
| 4 | Effect of cooling rate on MC carbide in directionally solidified nickel-based superalloy under high thermal gradient显示文摘A series of directional solidification experiments have been performed to study the effect of cooling rate on the precipitation behavior of MC carbide in nickel-based superalloy under the temperature gradient of 500 K·s-1.Results reveal that the morphology of MC carbide changes from coarse block to fine strip,then to Chinese-script,and their sizes reduce gradually with the increasing of cooling rate from 2.53 K·s-1 to 36.4 K·s-1.At low cooling rates,most of these carbides are found to be located at the grain boundary and interdendritic regions,while the coupled growth of some carbides and γ matrix in the center of γ grains is occurred at high cooling rate.The main elements forming MC carbide are Ta,W,and Hf. | Zhang Weiguo Liu Lin Fu Hengzhi | 2012 | China Foundry2012，9，1： | 4 |
| 5 | Effect of solidification parameters on the microstructures of a single crystal Ni-based superalloy AM3显示文摘A single crystal Ni-based superalloy AM3 was processed at withdraw rates of 3.5, 10, 50, 100, 200, and 500 μm·s-1, respectively.The as-cast microstructures and solidification segregation ratio were characterized with various withdraw rates.The shape and size of carbide microstructures were determined.As expected, the primary and secondary dendrite arm spacings (PDAS and SDAS) decrease with the increase of withdraw rate.The highest volume fraction of eutectic γ/γ' is observed at the 100 μm·s-1 withdraw rate.The volume fraction of eutectic γ/γ' does not appear to be a strong function of the withdraw rate.With increasing withdraw rate, interface morphologies change in the sequence of planar, cellular, and dendrite.There is a general refinement of the microstructure as the withdraw rate increases.EPMA analysis showed that withdraw rate does not have obvious influence on the segregation of elements. | Yu Zhuhuan Liu Lin Zhao Xinbao Zhang Weiguo Zhang Jun Fu Hengzhi | 2010 | China Foundry2010，7，3： | 4 |
| 6 | Distribution of branched glycerol dialkyl glycerol tetraethers in soils on the Northeastern Qinghai-Tibetan Plateau and possible production by nitrite-reducing bacteria显示文摘Branched glycerol dialkyl glycerol tetraethers(b GDGTs) are ubiquitous and abundant in soils, but their sources remain elusive. Recent studies demonstrate that the distributions of b GDGTs are sensitive to various environmental factors. In an effort to understand how and to what extent soil moisture(expressed as soil water content(SWC) or mean annual precipitation(MAP), p H and temperature may impact the distribution of b GDGTs, and to shed more light on the biological sources of b GDGTs in cold and arid regions, we investigated the distribution of b GDGTs as well as bacterial 16 S r RNA gene and functional genes involved in the N cycle(including amo A, nir S and nir K) in 41 surface soil samples from around Lake Qinghai and east of Qaidam Basin on the Northeastern Qinghai-Tibetan Plateau. We found that lower soil moisture reduced the fractional concentrations of cyclic b GDGTs and thus the cyclisation ratio of branched tetraethers(CBT) index correlated negatively with SWC and MAP, suggesting that soil moisture is an important factor controlling b GDGT distributions in soils in this arid and semi-arid region. Two subgroups of b GDGTs were assigned on the basis of cluster analysis, and b GDGT indices behaved differently in the two groups, hinting at different biosynthetic mechanisms for b GDGTs under different environmental conditions. Real time PCR results showed that nir S and nir K genes correlated significantly with the concentration of b GDGTs, suggesting that the nir S- or nir K-encoding bacteria involved in denitrification might potentially be an additional biological source for soil b GDGTs(besides Acidobacteria). Moreover, our results also support the application of new indices based on 5-methyl b GDGTs and 6-methyl b GDGTs in reconstructing past temperature and p H variations in this region. | SUN ChiJun ZHANG ChuanLun LI Fu Yan WANG HuanYe LIU WeiGuo | 2016 | Science China Earth Sciences2016，59，9： | 3 |
| 7 | Influence of directional solidification variables on primary dendrite arm spacing of Ni-based superalloy DZ125显示文摘The primary dendrite morphology and spacing of DZ125 superalloy have been observed during directional solidification under high thermal gradient about 500 K/cm.The results reveal that the primary dendrite arm spacing decreases from 94μm to 35.8μm with the increase of directional solidification cooling rate from 2.525 K/s to 36.4 K/s.The regression equation of the primary dendrite arm spacingsλ 1 versus cooling rate is λ 1 =0.013(GV)-0.32.The predictions of Kurz/Fisher model and Hunt/Lu model accord reasonably well with the experimental data.The influence of directional solidi fication rate under variable thermal gradient on the primary dendrite arm spacing has also been investigated. | Zhang Weiguo Liu Lin Huang Taiwen Zhao Xinbao Qu Min Yu Zhuhuan Fu Hengzhi | 2009 | China Foundry2009，6，4： | 3 |
| 8 | Feedback control for a class of second order hyperbolic distributed parameter systems显示文摘This paper deals with the problem of state feedback control for a class of the distributed parameter systems with the disturbance term. And the considered distributed parameter systems are composed of the second order hyperbolic partial differential equations. Two different classes of restrictions on the disturbance term are given, one is that the disturbance term satisfies the linear growth constraint condition to the state variables of the system, and the other is that the disturbance term obeys the bound constraint under the significance of L_2. Based on a variable structure method, the state feedback controllers are obtained by means of constructing appropriate Lyapunov functional. The closed-loop systems are globally asymptotically stable on W^(1,2)(0, 1) × L_2(0, 1) space under the effect of the state feedback control laws. Simulation results illustrate the effectiveness of the proposed method. | Qin FU Weiguo GU Panpan GU Jianrong WU | 2016 | Science China(Information Sciences)2016，59，9： | 3 |
| 9 | Inhibition of cervical cancer cell growth in vitro and in vivo by lentiviral-vector mediated shRNA targeting the common promoter of HPV16 E6 and E7 oncogenes显示文摘 | Jiansong Zhou Baohua Li Chanjuan Peng Fenfen Wang Zhiqin Fu Caiyun Zhou Die Hong Feng Ye Weiguo Lü Xing Xie | 2013 | Antiviral Research2013，，2： | 2 |
| 10 | Effect of carbon additions on the microstructure of a single crystal Ni-based superalloy AM3显示文摘The microstructure of experimental nickel-base single crystal superalloys with different levels of carbon has been studied. The results indicated that with increasing carbon addition, the liquidus temperature decreased obviously and the as-cast microstructures exhibited a decrease in the amount of γ/γ′ eutectic structure and an increase in the volume fraction of carbides. The carbides formed in these alloys were most script-type MC carbides which appeared continuous dendritic networks in the interdendritic region. The segregation behavior of element W was influenced by the carbon addition. | Yu Zhuhuan Liu Lin Zhao Xinbao Zhang Weiguo Zhang Jun Fu Hengzhi | 2010 | China Foundry2010，7，4： | 2 |
| 11 | Coordination of supply chain with a revenue-sharing contract under demand disruptions when retailers compete显示文摘 | ZHANG Weiguo FU Junhui LI Hongyi | 2012 | International Journal of Production Economics2012，138，1： | 1 |
| 12 | Carotid Artery Stenting Versus Carotid Endarterectomy: Systematic Review and Meta-Analysis显示文摘 | Zhenjie Liu Zhenyu Shi Yuqi Wang Bin Chen Ting Zhu Yi Si Weiguo Fu | 2009 | World Journal of Surgery2009，，3： | 1 |
| 13 | Treatment of Symptomatic Isolated Dissection of Superior Mesenteric Artery显示文摘 | Zhihui Dong Weiguo Fu Bin Chen Daqiao Guo Xin Xu Yuqi Wang | 2012 | Journal of Vascular Surgery2012，，： | 1 |
| 14 | Distribution of Alkaline Metal in BF at PZH Steel显示文摘 | Fu Weiguo Rao Jiating Cheng Qianhua | 2002 | PZH Steel Technical Report2002，25，6： | 1 |
| 15 | The relationship between human cytomegalovirus infection and atherosclerosis development显示文摘 | Ruizhen Chen Sidong Xiong Yingzhen Yang Weiguo Fu Yuqi Wang Junbo Ge | 2003 | Molecular and Cellular Biochemistry (-)2003，，1： | 1 |
| 16 | Coordina- tion of supply chain with a revenue-sharing contract under demand disruptions when retailers compete 显示文摘 | Zhang Weiguo Fu Junhui Li Hongyi | 2012 | International Journal of Production Economics2012，138，1： | 1 |
| 17 | OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2显示文摘Bone homeostasis is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption.Dysregulation of this process leads to multiple diseases,including osteoporosis.However,the underlying molecular mechanisms are not fully understood.Here,we show that the global and conditional osteoblast knockout of a deubiquitinase Otub1 result in low bone mass and poor bone strength due to defects in osteogenic differentiation and mineralization.Mechanistically,the stability of FGFR2,a crucial regulator of osteogenesis,is maintained by OTUB1.OTUB1 attenuates the E3 ligase SMURF1-mediated FGFR2 ubiquitination by inhibiting SMURF1’s E2 binding.In the absence of OTUB1,FGFR2 is ubiquitinated excessively by SMURF1,followed by lysosomal degradation.Consistently,adeno-associated virus serotype 9(AAV9)-delivered FGFR2 in knee joints rescued the bone mass loss in osteoblast-specific Otub1-deleted mice.Moreover,Otub1 mRNA level was significantly downregulated in bones from osteoporotic mice,and restoring OTUB1 levels through an AAV9-delivered system in ovariectomy-induced osteoporotic mice attenuated osteopenia.Taken together,our results suggest that OTUB1 positively regulates osteogenic differentiation and mineralization in bone homeostasis by controlling FGFR2 stability,which provides an optical therapeutic strategy to alleviate osteoporosis. | Qiong Zhu Yesheng Fu Chun-Ping Cui Yi Ding Zhikang Deng Chao Ning Fan Hu Chen Qiu Biyue Yu Xuemei Zhou Guan Yang Jiang Peng Weiguo Zou Cui Hua Liu Lingqiang Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 18 | Effects of tacrolimus (FK506) on sciatic nerve regeneration in rats显示文摘BACKGROUND:Tacrolimus(FK506) protects peripheral nerves located in damaged regions by inhibiting T lymphocyte proliferation and activation. OBJECTIVE:To evaluate the effect of FK506 on promoting regeneration of rat sciatic nerve. DESIGN,TIME AND SETTING:A randomized,controlled,animal study was performed at the Laboratory of the Department of Orthopedic Surgery,Dalian Medical University,China,from September 2007 to September 2008. MATERIALS:A total of 60 adult,male,Sprague-Dawley rats were equally and randomly divided into model,local administration and systemic administration groups.All rats received a neurotomy of bilateral sciatic nerves to establish models of nerve regeneration chambers.The powder and injection of FK506 were supplied by Fujisawa Pharmaceutical,Japan. METHODS:The regeneration chambers of the model group were infused with 0.2 mL saline.The systemic group were injected with 0.2 mL saline,followed by daily subcutaneous injections of FK506 (1 mg/kg),for 14 days.The local administration group was infused with 0.2 mL FK506(1μg/mL). MAIN OUTCOME MEASURES:Local immune response was observed using hematoxylin-eosin staining.Myelinated nerve fiber number,myelin sheath and nerve fiber thickness were observed using toluidine blue staining.Wet weight of gastrocnemius was evaluated.Compound muscle action potential amplitude,latency,and conduction time were recorded,and motor nerve conduction velocity was calculated using electrophysiology. RESULTS:The total number of myelinated nerve fibers in the local and systemic administration groups was significantly higher than in the model group.The density of myelinated nerve fibers, myelin sheath thickness and mean axon diameter were significantly increased in the systemic administration group compared with the model group(P<0.05).Lymphocyte infiltration was decreased in the local and systemic administration groups compared with the model group.The wet weight of rat gastrocnemius in the local and systemic administration groups were significantly greater compared with the model group(P<0.05).Motor nerve conduction velocity was the fastest in the systemic administration group,and the slowest in the model group.Compound muscle action potential amplitude was larger in the systemic administration group compared with the local administration and model groups(P<0.05). CONCLUSION:Systemic administration of FK506 can promote regeneration of rat sciatic nerve and recovery of neural function.Systemic administration produced better regeneration and recovery of function than local administration of FK506. | Weiguo Zhang Decheng Lu Shouyu Wang Chongyang Fu | 2009 | Neural Regeneration Research2009，4，5： | 1 |
| 19 | Selective synthesis of methylnaphthalenes in HSAPO-34 cages and their function as reaction centers in methanol-to-olefin catalysis显示文摘 | Song Weiguo Fu Hui James F Haw | 2001 | Phys Chem B2001，105，12： | 1 |
| 20 | Coordination of Supply Chain with a Revenue-sharing Contract under Demand Disruptions when Retailers Compete 显示文摘 | WeiGuo Zhang Junhui Fu Hongyi Li WeijunXu | 2012 | International Journal of Produ-ction Economics2012，，138： | 1 |
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